Improving blood pressure control in patients with diabetes mellitus and high cardiovascular risk

Patients with diabetes mellitus and symptomatic coronary artery disease are also likely to be hypertensive and, overall, are at very high cardiovascular (CV) risk. This paper reports the findings of a posthoc analysis of the 1113 patients with diabetes mellitus in the ACTION trial: ACTION itself showed that outcomes in patients with stable angina and hypertension were significantly improved when a long-acting calcium channel blocking drug (nifedipine GITS) was added to their treatment regimens. This further analysis of the ACTION database in those patients with diabetes has identified a number of practical therapeutic issues which are still relevant because of potential outcome benefits, particularly in relation to BP control. For example, despite background CV treatment and, specifically, despite the widespread use of ACE Inhibitor drugs, the addition of nifedipine GITS was associated with significant benefits: improvement in BP control by an average of 6/3 mmHg and significant improvements in outcome. In summary, this retrospective analysis has identified that the addition of nifedipine GITS resulted in improved BP control and significant outcome benefits in patients with diabetes who were at high CV risk. There is evidence to suggest that these findings are of direct relevance to current therapeutic practice

A multiplexed single electron transistor for application in scalable solid-state quantum computing

Single Electron Transistors (SETs) are nanoscale electrometers of unprecedented sensitivity, and as such have been proposed as read-out devices in a number of quantum computer architectures. We show that the functionality of a standard SET can be multiplexed so as to operate as both read-out device and control gate for a solid-state qubit. Multiplexing in this way may be critical in lowering overall gate densities in scalable quantum computer architectures.Comment: 3 pages 3 figure

A near-real-time full-parallax holographic display for remote operations

A near real-time, full parallax holographic display system was developed that has the potential to provide a 3-D display for remote handling operations in hazardous environments. The major components of the system consist of a stack of three spatial light modulators which serves as the object source of the hologram; a near real-time holographic recording material (such as thermoplastic and photopolymer); and an optical system for relaying SLM images to the holographic recording material and to the observer for viewing

Entanglement in a Valence-Bond-Solid State

We study entanglement in Valence-Bond-Solid state. It describes the ground state of Affleck, Kennedy, Lieb and Tasaki quantum spin chain. The AKLT model has a gap and open boundary conditions. We calculate an entropy of a subsystem (continuous block of spins). It quantifies the entanglement of this block with the rest of the ground state. We prove that the entanglement approaches a constant value exponentially fast as the size of the subsystem increases. Actually we proved that the density matrix of the continuous block of spins depends only on the length of the block, but not on the total size of the chain [distance to the ends also not essential]. We also study reduced density matrices of two spins both in the bulk and on the boundary. We evaluated concurrencies.Comment: 4pages, no figure

In vitro effect of canine hyperimmune sera on TNFa activity

[Introduction]: Septic shock in dogs is caused by cardiovascular and vasomotor failure associated with an uncontrolled intrinsic release of inflammatory mediators [1–5]. The syndrome is characterized by cardiovascular dysfunction, vascular permeability alterations, pulmonary oedema and tissue hypoxia resulting from microthrombi which may culminate in disseminated intravascular coagulation and catastrophic multiple organ failure [6,7]. Systemic bacterial infection, particularly by Gram-negative enterobacteria, haemorrhagic trauma, gastric dilation/volvulus and pancreatitis are the major underlying causes leading tosepsis [8,9]. Because of haemodynamic instability and associated hypovolemia, fluid replacement therapy is generally applied to restore effective circulating volume. The use of fresh frozen plasma has been recommended in cases of coagulopathies as it has been recognized to assist restoration of haemodynamic stability [1,5,10,11]. There is increasing evidence that the drivers of the haemodynamic instability are inflammatory mediators (particularly TNFa) activated primarily by bacterial endotoxin [3,4,12,13]

Estate Tax— Possession or Enjoyment under 2036—\u3ci\u3eO\u27Malley v. United States\u3c/i\u3e (F. Supp. 1963)

As of yet the courts have not been faced squarely with the question of whether in the case of income-producing property, a retained possession or enjoyment is enough to tax it to one\u27s estate under section 2036 of the Internal Revenue Code. Thus far there has either been no transfer of the property in question or the courts have found a retention of the right to the income. It is inevitable, however, that the issue will one day have to be faced. The answer is not clear, but in looking at the reasons for the joint resolution that amended the statute in 1931, and the later Congressional interpretation of the statute in the conference report of 1949, the balance is on the side of recognizing a distinction between income-producing and non-income-producing property. On the other hand, the dicta propounded by the courts thus far seems to find no distinction between income-producing and non-income-producing property so far as the possession or enjoyment section of the statute is concerned. I. The O’Malley Facts II. Possible Effects of the O’Malley Interpretation III. The History of “Right to Income” IV. Judicial Reaction to “Right to Income” V. Conclusio

Formation and Development of Caring Ministries Based on Neighboring Evangelism Model

This paper reports a project that evolved within the context of three congregations in Northern California. The intent of the project was to create an awareness of the concept of Neighboring Evangelism and assist interested church members in developing indigenous ministries that would reflect both the uniqueness of the Church\u27s spiritual gifts and the uniqueness of the community\u27s needs.https://digitalcommons.andrews.edu/hrsa/1066/thumbnail.jp

Estate Tax— Possession or Enjoyment under 2036—\u3ci\u3eO\u27Malley v. United States\u3c/i\u3e (F. Supp. 1963)

As of yet the courts have not been faced squarely with the question of whether in the case of income-producing property, a retained possession or enjoyment is enough to tax it to one\u27s estate under section 2036 of the Internal Revenue Code. Thus far there has either been no transfer of the property in question or the courts have found a retention of the right to the income. It is inevitable, however, that the issue will one day have to be faced. The answer is not clear, but in looking at the reasons for the joint resolution that amended the statute in 1931, and the later Congressional interpretation of the statute in the conference report of 1949, the balance is on the side of recognizing a distinction between income-producing and non-income-producing property. On the other hand, the dicta propounded by the courts thus far seems to find no distinction between income-producing and non-income-producing property so far as the possession or enjoyment section of the statute is concerned. I. The O’Malley Facts II. Possible Effects of the O’Malley Interpretation III. The History of “Right to Income” IV. Judicial Reaction to “Right to Income” V. Conclusio

Analysis and Geometric Optimization of Single Electron Transistors for Read-Out in Solid-State Quantum Computing

The single electron transistor (SET) offers unparalled opportunities as a nano-scale electrometer, capable of measuring sub-electron charge variations. SETs have been proposed for read-out schema in solid-state quantum computing where quantum information processing outcomes depend on the location of a single electron on nearby quantum dots. In this paper we investigate various geometries of a SET in order to maximize the device's sensitivity to charge transfer between quantum dots. Through the use of finite element modeling we model the materials and geometries of an Al/Al2O3 SET measuring the state of quantum dots in the Si substrate beneath. The investigation is motivated by the quest to build a scalable quantum computer, though the methodology used is primarily that of circuit theory. As such we provide useful techniques for any electronic device operating at the classical/quantum interface.Comment: 13 pages, 17 figure