Gestión de almacén y administración de la calidad total en un depósito aduanero, Callao 2018

El presente trabajo titulado de Gestión de almacén y Administración de la Calidad Total en un depósito aduanero, Callao 2018, tuvo como objetivo determinar la relación entre la Gestión de Almacén y la Administración de la Calidad Total en un Depósito Aduanero del Callao. Se tuvo como referencia a las teorías de Julio Anaya (2011) con su libro Almacenes: Análisis desarrollando la Gestión de almacén desarrollando las características, las técnicas de manutención, estructura y capacidad de almacenaje y los procesos operativos; se tomó las bases teóricas de Render y Heizer (2014) con su libro Principios de Administración de operaciones, diseño y organización, para lo cual desarrollo la mejora continua, el six sigma (DMAIC), benchmarking y el justo a tiempo. La investigación tiene un nivel de tipo correlacional y por su temporalidad transversal, de diseño no experimental porque solo se recogerán opiniones o se usara la percepción sin manipular. El trabajo de investigación uso como técnica la encuesta y como instrumento el cuestionario, el mismo que ha pasado el proceso de fiabilidad con el juicio de expertos y la prueba de confiabilidad usando SPSS como herramienta. La investigación luego de obtener los datos concluyo que existe relación entre la variable Gestión de almacén y Administración de la Calidad total en un Depósito Aduanero del Callao. De igual forma se determinó la relación positiva con cada una de las dimensiones para cada variable

Variable levels of drift in tunicate cardiopharyngeal gene regulatory elements.

Background: Mutations in gene regulatory networks often lead to genetic divergence without impacting gene expression or developmental patterning. The rules governing this process of developmental systems drift, including the variable impact of selective constraints on different nodes in a gene regulatory network, remain poorly delineated. Results: Here we examine developmental systems drift within the cardiopharyngeal gene regulatory networks of two tunicate species, Corella inflata and Ciona robusta. Cross-species analysis of regulatory elements suggests that trans-regulatory architecture is largely conserved between these highly divergent species. In contrast, cis-regulatory elements within this network exhibit distinct levels of conservation. In particular, while most of the regulatory elements we analyzed showed extensive rearrangements of functional binding sites, the enhancer for the cardiopharyngeal transcription factor FoxF is remarkably well-conserved. Even minor alterations in spacing between binding sites lead to loss of FoxF enhancer function, suggesting that bound trans-factors form position-dependent complexes. Conclusions: Our findings reveal heterogeneous levels of divergence across cardiopharyngeal cis-regulatory elements. These distinct levels of divergence presumably reflect constraints that are not clearly associated with gene function or position within the regulatory network. Thus, levels of cis-regulatory divergence or drift appear to be governed by distinct structural constraints that will be difficult to predict based on network architectur

Variable Levels Of Drift In Tunicate Cardiopharyngeal Gene Regulatory Elements

Background: Mutations in gene regulatory networks often lead to genetic divergence without impacting gene expression or developmental patterning. The rules governing this process of developmental systems drift, including the variable impact of selective constraints on different nodes in a gene regulatory network, remain poorly delineated. Results: Here we examine developmental systems drift within the cardiopharyngeal gene regulatory networks of two tunicate species, Corella inflata and Ciona robusta. Cross-species analysis of regulatory elements suggests that trans-regulatory architecture is largely conserved between these highly divergent species. In contrast, cis-regulatory elements within this network exhibit distinct levels of conservation. In particular, while most of the regulatory elements we analyzed showed extensive rearrangements of functional binding sites, the enhancer for the cardiopharyngeal transcription factor FoxF is remarkably well-conserved. Even minor alterations in spacing between binding sites lead to loss of FoxF enhancer function, suggesting that bound trans-factors form position-dependent complexes. Conclusions: Our findings reveal heterogeneous levels of divergence across cardiopharyngeal cis-regulatory elements. These distinct levels of divergence presumably reflect constraints that are not clearly associated with gene function or position within the regulatory network. Thus, levels of cis-regulatory divergence or drift appear to be governed by distinct structural constraints that will be difficult to predict based on network architecture

A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction

Background: Carbohydrates play a major role in cell signaling in many biological processes. We have developed a set of glycomimetic drugs that mimic the structure of carbohydrates and represent a novel source of therapeutics for endothelial dysfunction, a key initiating factor in cardiovascular complications. Purpose: Our objective was to determine the protective effects of small molecule glycomimetics against free fatty acid­induced endothelial dysfunction, focusing on nitric oxide (NO) and oxidative stress pathways. Methods: Four glycomimetics were synthesized by the stepwise transformation of 2,5­dihydroxybenzoic acid to a range of 2,5­substituted benzoic acid derivatives, incorporating the key sulfate groups to mimic the interactions of heparan sulfate. Endothelial function was assessed using acetylcholine­induced, endotheliumdependent relaxation in mouse thoracic aortic rings using wire myography. Human umbilical vein endothelial cell (HUVEC) behavior was evaluated in the presence or absence of the free fatty acid, palmitate, with or without glycomimetics (1µM). DAF­2 and H2DCF­DA assays were used to determine nitric oxide (NO) and reactive oxygen species (ROS) production, respectively. Lipid peroxidation colorimetric and antioxidant enzyme activity assays were also carried out. RT­PCR and western blotting were utilized to measure Akt, eNOS, Nrf­2, NQO­1 and HO­1 expression. Results: Ex vivo endothelium­dependent relaxation was significantly improved by the glycomimetics under palmitate­induced oxidative stress. In vitro studies showed that the glycomimetics protected HUVECs against the palmitate­induced oxidative stress and enhanced NO production. We demonstrate that the protective effects of pre­incubation with glycomimetics occurred via upregulation of Akt/eNOS signaling, activation of the Nrf2/ARE pathway, and suppression of ROS­induced lipid peroxidation. Conclusion: We have developed a novel set of small molecule glycomimetics that protect against free fatty acidinduced endothelial dysfunction and thus, represent a new category of therapeutic drugs to target endothelial damage, the first line of defense against cardiovascular disease

Sitios de Interés Geológico de la República Argentina

Fil: González, María Alejandra. Ministerio de Planificación Federal, Inversión Pública y Servicios. Secretaría de Minería. Servicio Geológico Minero Argentino (SEGEMAR); Argentina.Fil: Hernández Llosa, María Isabel. Instituto de Arqueología, Facultad de Filosofía y Letras, Universidad de Buenos Aires – CONICET; Argentina.La Quebrada de Humahuaca, que une a la Puna con los valles de la provincia de Jujuy, fue declarada por la UNESCO Patrimonio Cultural y Natural de la Humanidad en el año 2003. El río Grande la recorre de norte a sur y en su descenso se aprecian cambios en el clima, la vegetación y el paisaje. La actual configuración de la quebrada es el resultado de procesos geológicos muy diversos que se iniciaron en el Precámbrico. La gran variedad de rocas -incluyendo algunas de las más antiguas del país- le otorgan un extraordinario colorido al paisaje. Entre numerosos puntos de interés merecen mencionarse los cerros de Siete Colores y La Pollera de la Colla, el Pucará y el abanico aluvial de Tilcara, la Garganta del Diablo, el Angosto de Perchel, las dunas trepadoras, el flujo de Volcán, la sierra de Aguilar y el abra de Zenta. La Quebrada de Humahuaca, que fue escenario de numerosos sucesos históricos, atesora una gran riqueza cultural que abarca expresiones pictóricas, musicales, arquitectónicas y religiosas, entre las más destacadas

More than the Motifs: the archaeological analysis of rock art in arid regions of the Southern Hemisphere

Three regional rock art studies undertaken in the southern hemisphere (northwest central Queensland in Australia, Lluta Valley in northern Chile and Quebrada de Humahuaca in Northwest Argentina) are analysed. Based on the relationships between rock art and other aspects of the physical, social and chronological context of its production, we show the articulation between the production of rock art and past social strategies. The three examples demonstrate many consistencies in the way rock art has been utilised in arid environments while also identifying regionally distinct variations in technique and function. In each of the arid regions, competition arose for limited and valued resources. In each example, the production of rock art was used as a powerful tool to negotiate newly arising circumstances in order to ensure predictable and desirable economic and social outcomes for the artists' group. The methods and form used to achieve these outcomes varied in each case study, because of the availability of materials for art production, the topography and environmental conditions in each specific area, particular cultural preferences and the ways in which people utilised art. In northwest central Queensland the rock art assemblage was employed for the negotiation of group identity at several levéis. In the Lluta Valley, the geoglyphs embody social, political and economical aspirations, being produced as a means of legitimating the access of lama caravans to the coast and its resources. In the Quebrada de Humahuaca increased competition for resources led to the production of different rock art assemblages; the herders produced panels that played roles such as marking grazing territories, commemorating past events and most significantly, as part of the ritual life of the herders

Synthesis and incorporation of nanosized pinning centers for YBa2Cu3O7-x superconductors

The solution processing of YBa2Cu3O7-x (YBCO) coated conductors has been extensively studied, however the dependence of Jc on the magnitude and the orientation of the magnetic field still poses problems for practical applications in high magnetic fields. This can be circumvented by the incorporation of inert metal oxide nanoparticles in the YBCO coating. In-situ created nanostructures present in the YBCO layer have proven their effectiveness. In these nanocomposites the nanostructures tend to attain random orientation with respect to the epitaxial YBCO, generating incoherent interfaces within the epitaxial YBCO matrix that causes localized nanostrained regions, that has been correlated with a strong enhancement of vortex pinning.[1] However, the size, morphology and distribution of in-situ created nanostructures an thus the associated nanostrain cannot be controlled in the layer. The less established ex-situ approach, in which first nanoparticles are synthesized by wet chemical methods and are afterwards added to the YBCO precursor solution, offer the promise of a better control over particle growth, size, size distribution and shape and thus also over the introduced nanostrain. This research is devoted to the processing of ZrO2 and HfO2 nanocrystals (NCs), useful for ex-situ pinning in YBCO. We explored a microwave-assisted solvothermal and a heating-up synthesis method for the preparation of the NCs.[2] Both synthesis methods give rise to small NCs (3 – 10 nm in diameter) and narrow size distributions, characterized by means of XRD, DLS and TEM analyses. The two methods lead to NCs with different surface chemistry, yet in both cases the NCs are capped with organic ligands to prevent agglomeration, ensuring colloidal stability in apolar solvents.[3] However, as the YBCO precursor typically provides a more polar environment, e.g. methanol, an important aspect of this research involves finding the appropriate stabilizing molecule and studying the particle stability in the polar YBCO precursor solution. After ensured particle stability in the YBCO precursor solution, the YBCO-NCs suspension were deposited on a La2Zr2O7 substrate through spin coating to study the influence of the NCs in the YBCO coating. The effect of different concentrations of APCs in YBCO were investigated, bringing us closer to the effective incorporation of high-temperature superconductors in high and alternating magnetic field applications, relevant in alternative energy generation. References [1] X. Obradors, T. Puig, A. Palau, et al. (2011) Comprehensive Nanoscience and Technology 303-349 [2] J. De Roo, K. De Keukeleere, J. Feys et al. (2013) Journal of Nanoparticle Research 15:1778 [3] J. De Roo, F. Van den Broeck, K. De Keukeleere, et al. (2014) JACS 9650-965

Manejo de glucómetros: detección de errores e intervención farmacéutica

INTRODUCCIÓN La técnica de automonitorización de la glucemia en sangre capilar (AMG) es una parte esencial en el control de la diabetes y de sus complicaciones. OBJETIVOS Registrar y evaluar los errores cometidos por los pacientes diabéticos en la técnica de AMG y comprobar la mejora obtenida tras una intervención farmacéutica. MATERIAL Y MÉTODOS Se realizó un estudio cuasiexperimental pretest-postest utilizando una encuesta previamente consensuada. Se estudiaron 78 pacientes de un total de siete farmacias. El periodo de estudio fue del 1 de marzo al 30 de junio de 2009. El farmacéutico observó y registró los errores cometidos por el paciente diabético al realizar la técnica de AMG y le instruyó de manera individualizada en el procedimiento correcto. Tras un periodo de 30 días se le citó de nuevo y se le pidió que realizase un nuevo autoanálisis, y así comprobar la efectividad de la intervención farmacéutica. Los errores se clasificaron según su influencia en el resultado de la medición de la glucemia