Studies of Adrenal Androgens

Imperial Users onl

Description of inclusive scattering of 4.045 GeV electrons from D

We exploit a relationship between the Structure Functions of nucleons, the physical deuteron and of a deuteron, composed of point-nucleons to compute angular distributions of inclusive cross sections of 4.05 GeV electrons. We report general agreement with data and interpret the remaining discrepancies. We discuss the potential of the data for information on neutron structure functions $F_k^n(x,Q^2)$ and the static form factor $G_M^n(Q^2)$.Comment: 9 pages,1 Fig., PS fil

Studies in pianistic sonority, nuance and expression: French performance practices in the piano works of Maurice Ravel

This thesis traces the development of Maurice Ravel’s pianism in relation to sonority, nuance and expression by addressing four main areas of research that have remained largely unexplored within Ravel scholarship: the origins of Ravel’s pianism and influences to which he was exposed during his formative training; his exploration of innovative pianistic techniques with particular reference to thumb deployment; his activities as performer and teacher, and role in defining a performance tradition for his piano works; his place in the French pianistic canon. Identifying the main research questions addressed in this study, an Introduction outlines the dissertation content, explains the criteria and objectives for the performance component (Public Recital) and concludes with a literature review. Chapter 1 explores the pianistic techniques Ravel acquired during his formative training, and considers how his study of specific works from the nineteenth-century piano repertory shaped and influenced his compositional style and pianism. Chapter 2 discusses Ravel’s implementation of his idiosyncratic ‘strangler’ thumbs as articulators of melodic, harmonic, rhythmic and textural material in selected piano works. Ravel’s role in defining a performance tradition for his piano works as disseminated to succeeding generations of pianists is addressed in Chapter 3, while Chapters 4 and 5 evaluate Ravel’s impact upon twentieth-century French pianism through considering how leading French piano pedagogues and performers responded to his trailblazing piano techniques. It will be shown that through his activities as teacher and performer, as well as composer, Ravel took control of every detail pertaining to his piano works with his meticulously notated scores, piano roll recordings and interpretive guidance imparted to other pianists, thus catalysing performance practices that promulgated a distinctively French twentieth-century pianistic tradition

The aspirations and expectations of young people attending a Welsh-medium and an English-medium school in the South Wales Valley

This qualitative study explores the aspirations and expectations of fifty-two young people attending a Welsh-medium and an English-medium school in the South Wales Valleys (an area which has undergone significant and economic changes as a result of deindustrialisation). These young people were first interviewed at the start of Year 11 when they were considering their futures after compulsory education. Some of these young people were interviewed again approximately a year after to explore whether they were able to achieve their aspirations and to examine whether their long-term aspirations had changed. This study illustrates how wider trends such as the contraction of the youth labour market and increasing participation rates in further and higher education as well as transformations in the local labour market have changed the way in which young people understand their educational and employment prospects. Different to some of the young people in Brown’s (1987) Schooling Ordinary Kids study, all of the young people in this study aspired to stay in some form of education and training after Year 11. This study also identifies three types of students – The Academic Inheritors, the Academic Strivers and Vocational students – which differ in terms of their orientations to education and occupational futures. There are also variations between these types of students in terms of their social background, educational experiences and the character and usage of their social networks. The different types of students highlight the limitations of accounts which present Rational Choice Theory (associated with the work of Boudon (1974) and Goldthorpe (1998)) and Bourdieu’s Cultural Reproduction Theory as opposing/competing explanatory theories. This study also compared and contrasted the aspirations and expectations of young people who attended a Welsh-medium and an English-medium school. This study shows how school choice has an impact on the social composition of Welsh-medium and English-medium schools in South East Wales, with Welsh-medium schools on average having lower proportions of students from poorer households compared to English-medium schools. School choice provides some explanation for the differences between the aspirations of young people attending the Welsh-medium and the English-medium school in this study. This study offers a new analysis of the aspirations and expectations of young people finishing compulsory education, in a context of significant social and economic change. It also makes an original contribution by exploring the aspirations of young people who attend a Welsh-medium and an English-medium school – something which has not been explored in depth before by researchers. In addition, this study contributes towards debates regarding the extent that Rational Choice Theory and Bourdieu’s Cultural Reproduction Theory are able to explain young people’s aspirations and expectations. In attempting to explain differences in student orientations, it also shows that it is extremely difficult to empirically test the relative merits of these theories and as such contributes to existing discussions of educational opportunities and inequalities. This study also has policy implications regarding how key actors such as policymakers and schools can provide support to young people to fulfil and achieve their aspirations

Toxigenic Clostridium difficile colonization among hospitalised adults; risk factors and impact on survival

Objectives: To establish risk factors for Clostridium difficile colonization among hospitalized patients in England. Methods: Patients admitted to elderly medicine wards at three acute hospitals in England were recruited to a prospective observational study. Participants were asked to provide a stool sample as soon as possible after enrolment and then weekly during their hospital stay. Samples were cultured for C. difficile before ribotyping and toxin detection by PCR. A multivariable logistic regression model of risk factors for C. difficile colonization was fitted from univariable risk factors significant at the p < 0.05 level. Results: 410/727 participants submitted ≥1 stool sample and 40 (9.8%) carried toxigenic C. difficile in the first sample taken. Ribotype 106 was identified three times and seven other ribotypes twice. No ribotype 027 strains were identified. Independent predictors of colonization were previous C. difficile infection (OR 4.53 (95% C.I. 1.33–15.48) and malnutrition (MUST score ≥2) (OR 3.29 (95% C.I. 1.47–7.35)). Although C. difficile colonised patients experienced higher 90-day mortality, colonization was not an independent risk for death. Conclusions: In a non-epidemic setting patients who have previously had CDI and have a MUST score of ≥2 are at increased risk of C. difficile colonization and could be targeted for active surveillance to prevent C. difficile transmission

Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study

Objective Sepsis mortality is reported to be high worldwide, however recently the attributable fraction of mortality due to sepsis (AFsepsis) has been questioned. If improvements in treatment options are to be evaluated, it is important to know what proportion of deaths are potentially preventable or modifiable after a sepsis episode. The aim of the study was to establish the fraction of deaths directly related to the sepsis episode on the general wards and emergency departments. Results 839 patients were recruited over the two 24-h periods in 2016 and 2017. 521 patients fulfilled SEPSIS-3 criteria. 166 patients (32.4%) with sepsis and 56 patients (17.6%) without sepsis died within 90 days. Out of the 166 sepsis deaths 12 (7.2%) could have been directly related to sepsis, 28 (16.9%) possibly related and 96 (57.8%) were not related to sepsis. Overall AFsepsis was 24.1%. Upon analysis of the 40 deaths likely to be attributable to sepsis, we found that 31 patients (77.5%) had the Clinical Frailty Score ≥ 6, 28 (70%) had existing DNA-CPR order and 17 had limitations of care orders (42.5%)