Social Work Advocacy: Professional Self-Interest and Social Justice

This study employed an analysis of the advocacy-related resources and materials available through the 50 NASW state chapter websites. Results revealed that a large number of states had no information about advocacy on their websites (42%). One third of the mission statements reviewed contained language indicating that advocacy was part of the chapter mission, while nearly as many included no content related to advocacy or social justice on their homepages. Nearly two thirds of the websites contained no resources, tools or links to help with advocacy practice, promotion or education. Thirteen advocacy themes emerged, which represented policy issues within the state advocacy agendas. Professional Self-Interest was the issue with the highest frequency (17%) across the 2010 state chapter agendas, but the 12 other social justice issues combined dominated the legislative agendas (83%). Professional selfinterest issues accounted for the highest rate of prevalence on state agendas, as it appeared on 86% of the chapter agendas analyzed

Evidence for Induction of Integron-Based Antibiotic Resistance by the SOS Response in a Clinical Setting

Bacterial resistance to β-lactams may rely on acquired β-lactamases encoded by class 1 integron-borne genes. Rearrangement of integron cassette arrays is mediated by the integrase IntI1. It has been previously established that integrase expression can be activated by the SOS response in vitro, leading to speculation that this is an important clinical mechanism of acquiring resistance. Here we report the first in vivo evidence of the impact of SOS response activated by the antibiotic treatment given to a patient and its output in terms of resistance development. We identified a new mechanism of modulation of antibiotic resistance in integrons, based on the insertion of a genetic element, the gcuF1 cassette, upstream of the integron-borne cassette blaOXA-28 encoding an extended spectrum β-lactamase. This insertion creates the fused protein GCUF1-OXA-28 and modulates the transcription, the translation, and the secretion of the β-lactamase in a Pseudomonas aeruginosa isolate (S-Pae) susceptible to the third generation cephalosporin ceftazidime. We found that the metronidazole, not an anti-pseudomonal antibiotic given to the first patient infected with S-Pae, triggered the SOS response that subsequently activated the integrase IntI1 expression. This resulted in the rearrangement of the integron gene cassette array, through excision of the gcuF1 cassette, and the full expression the β-lactamase in an isolate (R-Pae) highly resistant to ceftazidime, which further spread to other patients within our hospital. Our results demonstrate that in human hosts, the antibiotic-induced SOS response in pathogens could play a pivotal role in adaptation process of the bacteria

Employment of Unwed Mothers: The Role of Government and Social Support

Employment, Government support, Social support, Unwed mothers,