Higher-order Topological and Nodal Superconductors MS (M = Nb and Ta) Transition-metal Sulfides

Intrinsic topological superconducting materials are exotic and vital to develop the next-generation topological superconducting devices, topological quantum calculations, and quantum information technologies. Here, we predict the topological and nodal superconductivity of MS (M = Nb and Ta) transition-metal sulfides by using the density functional theory for superconductors combining with the symmetry indicators. We reveal their higher-order topology nature with an index of Z4 = 2. These materials have a higher Tc than the Nb or Ta metal superconductors due to their flat-band and strong electron-phonon coupling nature. Electron doping and lighter isotopes can effectively enhance the Tc. Our findings show that the MS (M = Nb and Ta) systems can be new platforms to study exotic physics in the higher-order topological superconductors, and provide a theoretical support to utilize them as the topological superconducting devices in the field of advanced topological quantum calculations and information technologies.Comment: 5 pages, 3 figure

Using datamining approaches to selectacupoints in acupuncture and Moxibustion for knee osteoarthritis

Background: Acupuncture and moxibustion are traditional Chinese medicine therapies commonly used to treat knee osteoarthritis (KOA). Although acupoint selection affects the effectiveness of acupuncture and moxibustion, the basic rules of acupoint selection are little understood and there is a lack of guidelines regarding prescription. In this study, we used data mining approaches to investigate the principles of acupoint selection and provide a framework for formulation prescription in acupuncture and moxibustion for clinical treatment of KOA.Materials and Methods: PubMed, Cochrane Library, Science Citation Index, Wanfang database, VIP database, and China National Knowledge Infrastructure were searched for randomized controlled clinical trials published in English or Chinese from January 1, 2009 to October 1, 2015 evaluating the effect of acupuncture and moxibustion on KOA. Databases were established. Frequency statistics and association rule were used to extract and analyze the data.Results: A total of 876 acupuncture prescriptions and 122 acupoints were included in the analysis. Acupoints were concentrated in acupoints of fourteen meridians. The most frequently used acupoints were Dubi (ST35), Neixiyan (EX-LE4), Yanglingquan (GB34), Xuehai (SP10), Liangqiu (ST34), Zusanli (ST36), Yinlingquan (SP9), and Ashi point. The most frequently used meridian was Stomach Meridian of Foot-Yangming. Acupoints were concentrated mainly in the lower limbs. 42 acupoint pairs occurred frequently, and the top acupoint pairing was Dubi (ST35) and Neixiyan (EX-LE4).Conclusion: Acupoint selection and formulation prescription should focus on locally affected areas, and follow the theory of meridians, which helps establish guidelines for acupuncture and moxibustion in KOA patients.Key words: acupuncture and moxibustion, knee osteoarthritis, acupoint, data mining technolog

USING DATA MINING APPROACHES TO SELECT ACUPOINTS IN ACUPUNCTURE AND MOXIBUSTION FOR KNEE OSTEOARTHRITIS

Background: Acupuncture and moxibustion are traditional Chinese medicine therapies commonly used to treat knee osteoarthritis (KOA). Although acupoint selection affects the effectiveness of acupuncture and moxibustion, the basic rules of acupoint selection are little understood and there is a lack of guidelines regarding prescription. In this study, we used data mining approaches to investigate the principles of acupoint selection and provide a framework for formulation prescription in acupuncture and moxibustion for clinical treatment of KOA. Materials and Methods: PubMed, Cochrane Library, Science Citation Index, Wanfang database, VIP database, and China National Knowledge Infrastructure were searched for randomized controlled clinical trials published in English or Chinese from January 1, 2009 to October 1, 2015 evaluating the effect of acupuncture and moxibustion on KOA. Databases were established. Frequency statistics and association rule were used to extract and analyze the data. Results: A total of 876 acupuncture prescriptions and 122 acupoints were included in the analysis. Acupoints were concentrated in acupoints of fourteen meridians. The most frequently used acupoints were Dubi (ST35), Neixiyan (EX-LE4), Yanglingquan (GB34), Xuehai (SP10), Liangqiu (ST34), Zusanli (ST36), Yinlingquan (SP9), and Ashi point. The most frequently used meridian was Stomach Meridian of Foot-Yangming. Acupoints were concentrated mainly in the lower limbs. 42 acupoint pairs occurred frequently, and the top acupoint pairing was Dubi (ST35) and Neixiyan (EX-LE4). Conclusion: Acupoint selection and formulation prescription should focus on locally affected areas, and follow the theory of meridians, which helps establish guidelines for acupuncture and moxibustion in KOA patients

Causal relationships between COVID-19 and osteoporosis: a two-sample Mendelian randomization study in European population

IntroductionThe causal relationship between Coronavirus disease 2019 (COVID-19) and osteoporosis (OP) remains uncertain. We aimed to assess the effect of COVID-19 severity (severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, COVID-19 hospitalization, and severe COVID-19) on OP by a two-sample Mendelian randomization (MR) study.MethodsWe conducted a two-sample MR analysis using publicly available genome-wide association study (GWAS) data. Inverse variance weighting (IVW) was used as the main analysis method. Four complementary methods were used for our MR analysis, which included the MR–Egger regression method, the weighted median method, the simple mode method, and the weighted mode method. We utilized the MR-Egger intercept test and MR pleiotropy residual sum and outlier (MR-PRESSO) global test to identify the presence of horizontal pleiotropy. Cochran’s Q statistics were employed to assess the existence of instrument heterogeneity. We conducted a sensitivity analysis using the leave-one-out method.ResultsThe primary results of IVW showed that COVID-19 severity was not statistically related to OP (SARS-CoV-2 infection: OR (95% CI) = 0.998 (0.995 ~ 1.001), p = 0.201403; COVID-19 hospitalization: OR (95% CI) =1.001 (0.999 ~ 1.003), p = 0.504735; severe COVID-19: OR (95% CI) = 1.000 (0.998 ~ 1.001), p = 0.965383). In addition, the MR-Egger regression, weighted median, simple mode and weighted mode methods showed consistent results. The results were robust under all sensitivity analyses.ConclusionThe results of the MR analysis provide preliminary evidence that a genetic causal link between the severity of COVID-19 and OP may be absent

Synchronous post-acceleration of laser-driven protons in helical coil targets by controlling the current dispersion

Post-acceleration of protons in helical coil targets driven by intense, ultrashort laser pulses can enhance ion energy by utilizing the transient current from the targets’ self-discharge. The acceleration length of protons can exceed a few millimeters, and the acceleration gradient is of the order of GeV/m. How to ensure the synchronization between the accelerating electric field and the protons is a crucial problem for efficient post-acceleration. In this paper, we study how the electric field mismatch induced by current dispersion affects the synchronous acceleration of protons. We propose a scheme using a two-stage helical coil to control the current dispersion. With optimized parameters, the energy gain of protons is increased by four times. Proton energy is expected to reach 45 MeV using a hundreds-of-terawatts laser, or more than 100 MeV using a petawatt laser, by controlling the current dispersion

Um programa de ginástica para coronariopatas Coletânea de Exercícios Sugeridos

The acceleration of super-heavy ions (SHIs) from plasmas driven by ultrashort (tens of femtoseconds) laser pulses is a challenging topic waiting for breakthrough. The detecting and controlling of the ionization process, and the adoption of the optimal acceleration scheme are crucial for the generation of highly energetic SHIs. Here, we report the experimental results on the generation of deeply ionized super-heavy ions (Au) with unprecedented energy of 1.2 GeV utilizing ultrashort laser pulses (22 fs) at the intensity of 10^22 W/cm2. A novel self-calibrated diagnostic method was developed to acquire the absolute energy spectra and charge state distributions of Au ions abundant at the charge state of 51+ and reaching up to 61+. The measured charge state distributions supported by 2D particle-in-cell simulations serves as an additional tool to inspect the ionization dynamics associated with SHI acceleration, revealing that the laser intensity is the crucial parameter for the acceleration of Au ions over the pulse duration. The use of double-layer targets results in a prolongation of the acceleration time without sacrificing the strength of acceleration field, which is highly favorable for the generation of high-energy super heavy ions

A cross-scale ‘material-component-system’ framework for transition towards zero-carbon buildings and districts with low, medium and high-temperature phase change materials

Transition towards a carbon-neutral district energy community calls for carbon elimination and offsetting strategies, and phase change materials (PCMs) with substantial potential latent energy density can contribute significantly to carbon neutrality through both carbon-positive (like PCM-based thermal control in solar PVs) and carbon-negative strategies (like waste-to-energy recovery). However, roadmap for PCMs’ application in carbon-neutral transition is ambiguous in the current academia, and a state-of-the-art overview on latent thermal storage is necessary. In this study, a comprehensive review was conducted on cutting-edge technologies for carbon-neutral transition with latent thermal storages. Both carbon-positive and carbon-negative strategies in the operational stage are reviewed. Carbon-positive solution mainly focuses on energy-efficient buildings, through a series of passive, active, and smart control strategies with artificial intelligence. Passive strategies, to enhance thermal inertia and thermal storage of building envelopes, mainly include free cooling, solar chimney, solar façade, and Trombe walls. Active strategies mainly include mechanical ventilations, active water pipe-embedded radiative cooling, and geothermal system integration. The ultimate target is to minimise building energy demands, with improved utilisation efficiency on natural heating (e.g., concentrated solar thermal energy, geothermal heating, and solar-driven ventilative heating) and cooling resources (e.g., ventilative cooling, geothermal cooling, and sky radiative cooling). As one of the most critical solutions to offset the released carbon emission, carbon-negative strategies with PCMs mainly include cleaner power production and waste heat recovery. Main functions of PCMs include energy efficiency enhancement on cleaner power production, steady steam production, steady heat flux via the latent storage capacity, and pre-heat purpose on waste heat recovery. A thermal energy interaction network with transportation is formulated with PCMs’ recovering heat from internal combustion engines and spatiotemporal energy sharing, to provide frontier research guidelines. Future studies are recommended to spotlight standard testing procedure and database, benchmarks for suitable PCMs selection, seasonal cascaded energy storage, nanofluid-based heat transfer enhancement in PCMs, anti-corrosion, compatibility, thermochemical stability, and economic feasibility of PCMs. This study provides a clear roadmap on developing PCMs for transition towards a carbon-neutral district energy community, together with applications, prospects, and challenges, paving the path for combined efforts from chemical materials synthesis and applications.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Design & Construction Managemen

An inter-city energy migration framework for regional energy balance through daily commuting fuel-cell vehicles

Spatiotemporal energy interaction and sharing are promising solutions to penetrate renewable energy, enhance grid power stability, and improve regional energy flexibility. However, the current literature is restrained in a small-scale neighborhood level, without considering inter-city energy migration through spatiotemporal complementarity between renewable-abundant regions (like suburb or countryside areas) and demand-shortage regions (like city centers). In this study, the energy interaction boundary is extended from a neighborhood scale to an inter-city scale, to maximize the renewable energy penetration, demand coverage, and reduce regional energy imbalance. This study firstly proposes a holistic framework on inter-city transportation-based energy migration, consisting of a residential community with rooftop photovoltaic systems and electrical batteries, an office building, hydrogen vehicles (HVs), a hydrogen (H2) station, and local power grids, for the energy transmission between building groups in spatially different regions through the daily commuting of HVs. Optimal grid-regulation strategies are thereafter proposed and adopted to stabilize the grid power and reduce energy costs. Parametric analysis on energy trading strategies and prices has been conducted, to improve the participation motivations of different stakeholders. Results indicate that, compared to the reference case with isolated buildings and vehicles, the transportation-based energy migration framework covers 23.2 % of the office energy demand and elevates the community's renewable self-use ratio from 72.7 % to 98.6 %. Meanwhile, the maximum grid-export power in the renewable-abundant region (suburb residential community) and the annual grid-import power in the demand-shortage region (city-center office) are reduced by up to 86.9 % (from 155.7 to 20.4 kW) and 29.4 % (from 49.0 to 34.6 kW), respectively. Moreover, even considering the fuel cell degradation cost of HVs, the transportation-based energy migration framework reduces the operating costs of the office building and HVs (the H2 cost and the fuel cell degradation cost) by 16.4 % (from $52791.3 to$44154.7) and 1.7 % (from $27172.5 to$26707.4), respectively. Afterward, compared to the reference case, the peak-shaving and load-shaping grid-regulation strategies can decrease the peak grid-export power of the community by about 71.6 % (from 155.7 to 44.2 kW), and the maximum grid-import power of the office by 23.7 % (from 49.0 to 37.4 kW), respectively. Furthermore, the transportation-based energy migration framework is economically feasible, only when the renewable export price for H2 production is 0.07 $/kWh, the onsite-renewable-generated H2 lower than 6.5$/kg for the HV owners, and the vehicle-to-building electricity lower than 0.3 $/kWh for the office building. This study provides a novel inter-city energy migration framework with hydrogen networks to enhance district energy sharing, improve regional energy balance and reduce carbon emission, together with frontier guidelines on energy trading prices to promote participation motivations from different stakeholders.</p