10,309 research outputs found
Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats.
The development of type 2 diabetes is accompanied by decreased immune function and the mechanisms are unclear. We hypothesize that oxidative damage and mitochondrial dysfunction may play an important role in the immune dysfunction in diabetes. In the present study, we investigated this hypothesis in diabetic Goto-Kakizaki rats by treatment with a combination of four mitochondrial-targeting nutrients, namely, R-alpha-lipoic acid, acetyl-L-carnitine, nicotinamide and biotin. We first studied the effects of the combination of these four nutrients on immune function by examining cell proliferation in immune organs (spleen and thymus) and immunomodulating factors in the plasma. We then examined, in the plasma and thymus, oxidative damage biomarkers, including lipid peroxidation, protein oxidation, reactive oxygen species, calcium and antioxidant defence systems, mitochondrial potential and apoptosis-inducing factors (caspase 3, p53 and p21). We found that immune dysfunction in these animals is associated with increased oxidative damage and mitochondrial dysfunction and that the nutrient treatment effectively elevated immune function, decreased oxidative damage, enhanced mitochondrial function and inhibited the elevation of apoptosis factors. These effects are comparable to, or greater than, those of the anti-diabetic drug pioglitazone. These data suggest that a rational combination of mitochondrial-targeting nutrients may be effective in improving immune function in type 2 diabetes through enhancement of mitochondrial function, decreased oxidative damage, and delayed cell death in the immune organs and blood
The classical nature of nuclear spin noise near clock transitions of Bi donors in silicon
Whether a quantum bath can be approximated as classical noise is a
fundamental issue in central spin decoherence and also of practical importance
in designing noise-resilient quantum control. Spin qubits based on bismuth
donors in silicon have tunable interactions with nuclear spin baths and are
first-order insensitive to magnetic noise at so-called clock-transitions (CTs).
This system is therefore ideal for studying the quantum/classical nature of
nuclear spin baths since the qubit-bath interaction strength determines the
back-action on the baths and hence the adequacy of a classical noise model. We
develop a Gaussian noise model with noise correlations determined by quantum
calculations and compare the classical noise approximation to the full quantum
bath theory. We experimentally test our model through dynamical decoupling
sequence of up to 128 pulses, finding good agreement with simulations and
measuring electron spin coherence times approaching one second - notably using
natural silicon. Our theoretical and experimental study demonstrates that the
noise from a nuclear spin bath is analogous to classical Gaussian noise if the
back-action of the qubit on the bath is small compared to the internal bath
dynamics, as is the case close to CTs. However, far from the CTs, the
back-action of the central spin on the bath is such that the quantum model is
required to accurately model spin decoherence.Comment: 5 pages, 3 figure
Regeneration towards suitability: A decision-making framework for determining urban regeneration mode and strategies
Dynamics of delay induced composite multi-scroll attractor and its application in encryption
This work was supported in part by NSFC (60804040, 61172070), Key Program of Nature Science Foundation of Shaanxi Province (2016ZDJC-01), Innovative Research Team of Shaanxi Province(2013KCT-04), Fok Ying Tong Education Foundation Young Teacher Foundation(111065), Chao Bai was supported by Excellent Ph.D. research fund (310-252071603) at XAUT.Peer reviewedPostprin
Uncovering many-body correlations in nanoscale nuclear spin baths by central spin decoherence
Many-body correlations can yield key insights into the nature of interacting
systems; however, detecting them is often very challenging in many-particle
physics, especially in nanoscale systems. Here, taking a phosphorus donor
electron spin in a natural-abundance 29Si nuclear spin bath as our model
system, we discover both theoretically and experimentally that many-body
correlations in nanoscale nuclear spin baths produce identifiable signatures in
the decoherence of the central spin under multiple-pulse dynamical decoupling
control. We find that when the number of decoupling -pulses is odd, central
spin decoherence is primarily driven by second-order nuclear spin correlations
(pairwise flip-flop processes). In contrast, when the number of -pulses is
even, fourth-order nuclear spin correlations (diagonal interaction renormalized
pairwise flip-flop processes) are principally responsible for the central spin
decoherence. Many-body correlations of different orders can thus be selectively
detected by central spin decoherence under different dynamical decoupling
controls, providing a useful approach to probing many-body processes in
nanoscale nuclear spin baths
RESEARCH ON MARKETING STRATEGY OF GEOGRAPHICAL INDICATION AGRICULTURAL PRODUCTS ENTERPRISES UNDER THE BACKGROUND OF CONSUMER PSYCHOLOGY
RESEARCH ON MARKETING STRATEGY OF GEOGRAPHICAL INDICATION AGRICULTURAL PRODUCTS ENTERPRISES UNDER THE BACKGROUND OF CONSUMER PSYCHOLOGY
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