Crowdsourcing Design: A Synthesis of Literatures

Crowdsourcing is a phenomenon emerging in various sectors and industries that provides an opportunity for governments to collaborate with the public to generate information, deliver public services, or facilitate policy innovation. This review paper synthesizes prior research and practices on crowdsourcing from a variety of disciplines and focuses on the purpose, crowd, motivation, process design and outcomes. A process map for governments to design crowdsourcing is generated and three key actions are highlighted, namely incentive design, communication, and information aggregation

Cross-National Network Diffusion of Crowdsourcing Innovation Policy: Peer to Patent

This study examines network factors in the cross-national diffusion of a recent crowdsourcing innovation in the public sector, called Peer to Patent. Policy diffusion theory, as applied to informational network exchange, suggests that information about innovation will be communicated through social networks among policy decision makers. Building on case studies from five countries-”the United States, Australia, South Korea, Japan, and the United Kingdom-”that have adopted Peer to Patent, this study finds that the pattern of adoption is best explained by the underlying network structure of professional and institutional actors that allow policymakers to exchange ideas and learn from others. The informational network framework includes epistemic communities, international organizations, and globalized corporate entities and is affected by other mediating factors such as regulations, peer-to-peer relations, and technology. Policy transfer is thus a complex concept that includes multiple streams of transnational communication and exchange

Incorporated but Not IRS-Registered: Exploring the (Dark) Grey Fringes of the Nonprofit Universe

Listings of Internal Revenue Service (IRS)-registered and state-incorporated nonprofits for the same region may differ for a variety of reasons. Using Indiana as a case study, we first describe the distribution of nonprofits across these two listings. We then present findings from a small telephone survey of incorporated nonprofits that are not registered with the IRS for Indiana to explore whether they are excluded from the IRS-listing for statutory, technical, or compliance reasons. We consider several aspects of state incorporation status: date of incorporation and whether active status has been maintained or not. We conclude that researchers need to pay careful attention to the limitations of the IRS registration system when wishing to examine the dimensions of the nonprofit sector at local, state, or regional levels. Our finding, that some nonprofits fail to maintain active incorporation status, points to significant problems of nonprofit capacity

A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci

The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1. Here, we show that lysosomal membrane permeabilization (LMP) and cytosolic translocation of activated cathepsin D occur prior to activation of a mitochondrial pathway of macrophage apoptosis. Pharmacological inhibition or knockout of cathepsin D during pneumococcal infection blocked macrophage apoptosis. As a result of cathepsin D activation, Mcl-1 interacted with its ubiquitin ligase Mule and expression declined. Inhibition of cathepsin D had no effect on early bacterial killing but inhibited the late phase of apoptosis-associated killing of pneumococci in vitro. Mice bearing a cathepsin D-/- hematopoietic system demonstrated reduced macrophage apoptosis in vivo, with decreased clearance of pneumococci and enhanced recruitment of neutrophils to control pulmonary infection. These findings establish an unexpected role for a cathepsin D-mediated lysosomal pathway of apoptosis in pulmonary host defense and underscore the importance of apoptosis-associated microbial killing to macrophage function

Dual effect of thiol addition on fluorescent polymeric micelles: ON-to-OFF emissive switch and morphology transition

YesThe morphology transition from micelles to vesicles of a solution-state self-assembled block copolymer, containing a fluorescent dye at the core–shell interface, has been induced by an addition–elimination reaction using a thiol, and has been shown to be coupled to a simultaneous ON-to-OFF switch in particle fluorescence.EPSRC and the IAS at the University of Warwic