Disability Severity, Professional Isolation Perceptions, and Career Outcomes: When Does Leader–Member Exchange Quality Matter?

Employees with disability-related communication impairment often experience isolation from professional connections that can negatively affect their careers. Management research suggests that having lower quality leader relationships can be an obstacle to the development of professional connections for employees with disabilities. However, in this paper we suggest that lower quality leader–member exchange (LMX) relationships may not be a uniform hurdle for the professional isolation of employees with disability-related communication impairment. Drawing on psychological disengagement theory, we predict that employees with more severe, rather than less severe, communication impairment develop resilience to challenges in lower quality LMX relationships by psychologically disengaging from professional connections and, in turn, bear fewer negative consequences of professional isolation on career outcomes. In two studies of deaf and hard of hearing employees, we find that in lower quality LMX relationships employees with more severe communication impairment perceive being less isolated than employees with less severe communication impairment, and, in turn, report better career outcomes. Overall, our findings suggest that employees with more severe communication impairment may develop effective coping strategies to manage challenges of perceived professional isolation for career outcomes when in lower quality LMX relationships

Observations of Persistent Leonid Meteor Trails. 1. Advection of the Diamond Ring

From a single image of a persistent trail left by a -1.5 magnitude Leonid meteor on November 17, 1998, the relative winds between 92.5 and 98 km altitude are derived, where the altitudes are determined by a sodium lidar. These are converted to true winds 82 sec after the appearance of the meteor by fixing the winds at 98 km to match the results of following the trail with the lidar for twelve minutes. The image and winds reveal a fine example of the effects of a gravity wave having a vertical wavelenth of 5.50 ± 0.02 km, a horizontal wavelength of 2650 ± 60 kin, an intrinsic period of 19.5 ± 0.4 hours, and an observed period of 8.6 ± 0.1 hours. Effects of the gravity wave are still present in the wind field 70 rain later

Meteor Trail Advection Observed During the 1998 Leonid Shower

Sodium resonance lidar observations of meteor trails are reported from the 1998 Leonid shower experimental at the Starfire Optical Range Kirtland Air Force Base, NM (35.0º N, 106.5º W ). The lidar was operating in a spatially scanning mode that allowed tracking for up to one half-hour. Three trails are presented here whose motion allowed inference of radial as well as vector wind components and apparent diffusivities. The winds are derived independently using the narrow linewidth sodium (Na) resonance Doppler lidar technique and are compared with the tracking results

Observations of persistent Leonid meteor trails 3. The ‘‘Glowworm’’

A spectacular, well-observed Leonid meteor of visual magnitude -14.3 appeared on 17 November 1998 and left a lingering trail, dubbed the Glowworm, that was well studied. From a location on Kirtland Air Force Base, near Albuquerque, New Mexico, we obtained CCD images of the trail from 94 to 203 s after the meteor and recorded a video with an intensified camera for even longer. From information obtained with a sodium lidar half an hour after the meteor, we have determined that a gravity wave with a vertical wavelength of 2.4 km was responsible for the right-angled appearance of the trail. The trail ended abruptly at 85 km, and its uppermost altitude may have been no greater than 91 km. We designate the Glowworm a Type I trail: one that is wide (1 km), cloudy in appearance, has high diffusion rates (800m2 s-1), high total line emission rates (1.5 x 1018 photons m-1 s-1), and is optically thicker than Type II trails. The lower parts of the Diamond Ring, another Leonid lingering trail that appeared 38 min earlier than the Glowworm, define the Type II trails, which appear as narrow, optically thinner parallel trails, with low diffusion rates (12 m2 s-1) and total line emission rates (1–3 x 1016 photons m1 s-1). No explanation is offered for the two orders of magnitude difference in these quantities. The Glowworm meteor produced infrasound [ReVelle and Whitaker, 1999], from which a meteoroid mass estimate of 522 g was made. We compare our photometry to a detailed numerical modeling of the shape of the trail and emission from the Glowworm made by Zinn et al. [1999], who find that the largest contributors to emission recorded by our CCD and video cameras are atmospheric O2 vibrational bands. Compared to our measurements, their calculated emission is too high by two orders of magnitude, but since most of O2 emission may be absorbed by atmospheric O2 before it reaches the ground, this may indeed be the primary contributor to the observed flux. Although the calculations of Zinn et al. lead to a hollow cylinder appearance which may be appropriate for the Glowworm, it is not pronounced enough to account for the complete darkness between the parallel structures seen in Type II trails. An upper limit to backscattering from dust of 3.7 x 10-5 of the expected return was found from directing a 180 W copper vapor laser at the Glowworm

A Randomized Controlled Trial of a Faith-Placed, Lay Health Advisor Delivered Smoking Cessation Intervention for Rural Residents

Introduction. Rural US residents smoke at higher rates than urban or suburban residents. We report results from a community-based smoking cessation intervention in Appalachian Kentucky. Study design. Single-blind, group-randomized trial with outcome measurements at baseline, 17 weeks and 43 weeks. Setting/participants. This faith-placed CBPR project was located in six counties of rural Appalachian Kentucky. A total of 590 individual participants clustered in 28 churches were enrolled in the study. Intervention. Local lay health advisors delivered the 12-week Cooper/Clayton Method to Stop Smoking program, leveraging sociocultural factors to improve the cultural salience of the program for Appalachian smokers. Participants met with an interventionist for one 90 min group session once per week incorporating didactic information, group discussion, and nicotine replacement therapy. Main outcome measures. The primary outcome was self-reported smoking status. Secondary outcomes included Fagerström nicotine dependence, self-efficacy, and decisional balance. Results. With post-intervention data from 92% of participants, those in intervention group churches (N = 383) had 13.6 times higher odds of reporting quitting smoking one month post-intervention than participants in attention control group churches (N = 154, p \u3c 0.0001). In addition, although only 3.2% of attention control group participants reported quitting during the control period, 15.4% of attention control participants reported quitting smoking after receiving the intervention. A significant dose effect of the 12-session Cooper/Clayton Method was detected: for each additional session completed, the odds of quitting smoking increased by 26%. Conclusions. The Cooper/Clayton Method, delivered in rural Appalachian churches by lay health advisors, has strong potential to reduce smoking rates and improve individuals\u27 health

Cryptococcus neoformans Dual GDP-mannose transporters and their role in biology and virulence

Cryptococcus neoformans is an opportunistic yeast responsible for lethal meningoencephalitis in humans. This pathogen elaborates a polysaccharide capsule, which is its major virulence factor. Mannose constitutes over one-half of the capsule mass and is also extensively utilized in cell wall synthesis and in glycosylation of proteins and lipids. The activated mannose donor for most biosynthetic reactions, GDP-mannose, is made in the cytosol, although it is primarily consumed in secretory organelles. This compartmentalization necessitates specific transmembrane transporters to make the donor available for glycan synthesis. We previously identified two cryptococcal GDP-mannose transporters, Gmt1 and Gmt2. Biochemical studies of each protein expressed in Saccharomyces cerevisiae showed that both are functional, with similar kinetics and substrate specificities in vitro. We have now examined these proteins in vivo and demonstrate that cells lacking Gmt1 show significant phenotypic differences from those lacking Gmt2 in terms of growth, colony morphology, protein glycosylation, and capsule phenotypes. Some of these observations may be explained by differential expression of the two genes, but others suggest that the two proteins play overlapping but nonidentical roles in cryptococcal biology. Furthermore, gmt1 gmt2 double mutant cells, which are unexpectedly viable, exhibit severe defects in capsule synthesis and protein glycosylation and are avirulent in mouse models of cryptococcosis

PHANGS CO kinematics: disk orientations and rotation curves at 150 pc resolution

We present kinematic orientations and high resolution (150 pc) rotation curves for 67 main sequence star-forming galaxies surveyed in CO (2-1) emission by PHANGS-ALMA. Our measurements are based on the application of a new fitting method tailored to CO velocity fields. Our approach identifies an optimal global orientation as a way to reduce the impact of non-axisymmetric (bar and spiral) features and the uneven spatial sampling characteristic of CO emission in the inner regions of nearby galaxies. The method performs especially well when applied to the large number of independent lines-of-sight contained in the PHANGS CO velocity fields mapped at 1'' resolution. The high resolution rotation curves fitted to these data are sensitive probes of mass distribution in the inner regions of these galaxies. We use the inner slope as well as the amplitude of our fitted rotation curves to demonstrate that CO is a reliable global dynamical mass tracer. From the consistency between photometric orientations from the literature and kinematic orientations determined with our method, we infer that the shapes of stellar disks in the mass range of log($\rm M_{\star}(M_{\odot})$)=9.0-10.9 probed by our sample are very close to circular and have uniform thickness.Comment: 19 figures, 36 pages, accepted for publication in ApJ. Table of PHANGS rotation curves available from http://phangs.org/dat

The Cysteine-Rich Domain of Human Adam 12 Supports Cell Adhesion through Syndecans and Triggers Signaling Events That Lead to β1 Integrin–Dependent Cell Spreading

The ADAMs (a disintegrin and metalloprotease) family of proteins is involved in a variety of cellular interactions, including cell adhesion and ecto- domain shedding. Here we show that ADAM 12 binds to cell surface syndecans. Three forms of recombinant ADAM 12 were used in these experiments: the cys-teine-rich domain made in Escherichia coli (rADAM 12-cys), the disintegrin-like and cysteine-rich domain made in insect cells (rADAM 12-DC), and full-length human ADAM 12-S tagged with green fluorescent protein made in mammalian cells (rADAM 12-GFP). Mesenchymal cells specifically and in a dose-dependent manner attach to ADAM 12 via members of the syndecan family. After binding to syndecans, mesenchymal cells spread and form focal adhesions and actin stress fibers. Integrin β1 was responsible for cell spreading because function-blocking monoclonal antibodies completely inhibited cell spreading, and chondroblasts lacking β1 integrin attached but did not spread. These data suggest that mesenchymal cells use syndecans as the initial receptor for the ADAM 12 cysteine-rich domain–mediated cell adhesion, and then the β1 integrin to induce cell spreading. Interestingly, carcinoma cells attached but did not spread on ADAM 12. However, spreading could be efficiently induced by the addition of either 1 mM Mn2+ or the β1 integrin–activating monoclonal antibody 12G10, suggesting that in these carcinoma cells, the ADAM 12–syndecan complex fails to modulate the function of β1 integrin

Profiling Transboundary Aerosols over Taiwan and Assessing Their Radiative Effects

A synergistic process was developed to study the vertical distributions of aerosol optical properties and their effects on solar heating using data retrieved from ground-based radiation measurements and radiative transfer simulations. Continuous MPLNET and AERONET observations were made at a rural site in northern Taiwan from 2005 to 2007. The aerosol vertical extinction profiles retrieved from ground-based lidar measurements were categorized into near-surface, mixed, and two-layer transport types, representing 76% of all cases. Fine-mode (Angstrom exponent, alpha, approx.1.4) and moderate-absorbing aerosols (columnar single-scattering albedo approx.0.93, asymmetry factor approx.0.73 at 440 nm wavelength) dominated in this region. The column-integrated aerosol optical thickness at 500 nm (tau(sub 500nm)) ranges from 0.1 to 0.6 for the near-surface transport type, but can be doubled in the presence of upper-layer aerosol transport. We utilize aerosol radiative efficiency (ARE; the impact on solar radiation per unit change of tau(sub 500nm)) to quantify the radiative effects due to different vertical distributions of aerosols. Our results show that the ARE at the top-of-atmosphere (-23 W/ sq m) is weakly sensitive to aerosol vertical distributions confined in the lower troposphere. On the other hand, values of the ARE at the surface are -44.3, -40.6 and -39.7 W/sq m 38 for near-surface, mixed, and two-layer transport types, respectively. Further analyses show that the impact of aerosols on the vertical profile of solar heating is larger for the near-surface transport type than that of two-layer transport type. The impacts of aerosol on the surface radiation and the solar heating profiles have implications for the stability and convection in the lower troposphere