Balltracking: an highly efficient method for tracking flow fields

We present a method for tracking solar photospheric flows that is highly efficient, and demonstrate it using high resolution MDI continuum images. The method involves making a surface from the photospheric granulation data, and allowing many small floating tracers or balls to be moved around by the evolving granulation pattern. The results are tested against synthesised granulation with known flow fields and compared to the results produced by Local Correlation tracking (LCT). The results from this new method have similar accuracy to those produced by LCT. We also investigate the maximum spatial and temporal resolution of the velocity field that it is possible to extract, based on the statistical properties of the granulation data. We conclude that both methods produce results that are close to the maximum resolution possible from granulation data. The code runs very significantly faster than our similarly optimised LCT code, making real time applications on large data sets possible. The tracking method is not limited to photospheric flows, and will also work on any velocity field where there are visible moving features of known scale length

Lie discrete symmetries of lattice equations

We extend two of the methods previously introduced to find discrete symmetries of differential equations to the case of difference and differential-difference equations. As an example of the application of the methods, we construct the discrete symmetries of the discrete Painlev\'e I equation and of the Toda lattice equation

Lubiprostone ameliorates the cystic fibrosis mouse intestinal phenotype

<p>Abstract</p> <p>Background</p> <p>Cystic fibrosis (CF) is caused by mutations in the <it>CFTR </it>gene that impair the function of CFTR, a cAMP-regulated anion channel. In the small intestine loss of CFTR function creates a dehydrated, acidic luminal environment which is believed to cause an accumulation of mucus, a phenotype characteristic of CF. CF mice have small intestinal bacterial overgrowth, an altered innate immune response, and impaired intestinal transit. We investigated whether lubiprostone, which can activate the CLC2 Cl^-channel, would improve the intestinal phenotype in CF mice.</p> <p>Methods</p> <p><it>Cftr^tm1UNC</it>(CF) and wildtype (WT) littermate mice on the C57BL/6J background were used. Lubiprostone (10 μg/kg-day) was administered by gavage for two weeks. Mucus accumulation was estimated from crypt lumen widths in periodic acid-Schiff base, Alcian blue stained sections. Luminal bacterial load was measured by qPCR for the bacterial 16<it>S </it>gene. Gastric emptying and small intestinal transit in fasted mice were assessed using gavaged rhodamine dextran. Gene expression was evaluated by Affymetrix Mouse430 2.0 microarray and qRT-PCR.</p> <p>Results</p> <p>Crypt width in control CF mice was 700% that of WT mice (<it>P </it>< 0.001). Lubiprostone did not affect WT crypt width but, unexpectedly, increased CF crypt width 22% (<it>P </it>= 0.001). Lubiprostone increased bacterial load in WT mice to 490% of WT control levels (<it>P </it>= 0.008). Conversely, lubiprostone decreased bacterial overgrowth in CF mice by 60% (<it>P </it>= 0.005). Lubiprostone increased gastric emptying at 20 min postgavage in both WT (<it>P </it>< 0.001) and CF mice (<it>P </it>< 0.001). Lubiprostone enhanced small intestinal transit in WT mice (<it>P </it>= 0.024) but not in CF mice (<it>P </it>= 0.377). Among other innate immune markers, expression of mast cell genes was elevated 4-to 40-fold in the CF intestine as compared to WT, and lubiprostone treatment of CF mice decreased expression to WT control levels.</p> <p>Conclusions</p> <p>These results indicate that lubiprostone has some benefits for the CF intestinal phenotype, especially on bacterial overgrowth and the innate immune response. The unexpected observation of increased mucus accumulation in the crypts of lubiprostone-treated CF mice suggests the possibility that lubiprostone increases mucus secretion.</p

Penrose Diagram for a Transient Black Hole

A Penrose diagram is constructed for a spatially coherent black hole that smoothly begins an accretion, then excretes symmetrically as measured by a distant observer, with the initial and final states described by a metric of Minkowski form. Coordinate curves on the diagram are computationally derived. Causal relationships between space-time regions are briefly discussed. The life cycle of the black hole demonstrably leaves asymptotic observers in an unaltered Minkowski space-time of uniform conformal scale.Comment: 14 pages, 9 figures, spelling correction

Caerulein-induced acute pancreatitis in mice that constitutively overexpress Reg/PAP genes

BACKGROUND: The cystic fibrosis (CF) mouse pancreas has constitutively elevated expression of the Reg/PAP cell stress genes (60-fold greater Reg3α, and 10-fold greater PAP/Reg3β and Reg3γ). These genes are suggested to be involved in protection or recovery from pancreatic injury. METHODS: To test this idea the supramaximal caerulein model was used to induce acute pancreatitis in wild type and CF mice. Serum amylase, pancreatic water content (as a measure of edema), pancreatic myeloperoxidase activity, and Reg/PAP expression were quantified. RESULTS: In both wild type and CF mice caerulein induced similar elevations in serum amylase (maximal at 12 h), pancreatic edema (maximal at 7 h), and pancreatic myeloperoxidase activity (MPO, a marker of neutrophil infiltration; maximal at 7 h). By immunohistochemistry, Reg3α was strongly expressed in the untreated CF pancreas but not in wild type. During pancreatitis, Reg3α was intensely expressed in foci of inflamed tissue in both wild type and CF. CONCLUSION: These data demonstrate that the severity of caerulein-induced pancreatitis is not ameliorated in the CF mouse even though the Reg/PAP stress genes are already highly upregulated. While Reg/PAP may be protective they may also have a negative effect during pancreatitis due to their anti-apoptotic activity, which has been shown to increase the severity of pancreatitis

Lotic-SIPCO2: Adaptation of an open-source CO2 sensor system and examination of associated emission uncertainties across a range of stream sizes and land uses

River networks play a crucial role in the global carbon cycle, as relevant sources of carbon dioxide (CO2) to the atmosphere. Advancements in high-frequency monitoring in aquatic environments have enabled measurement of dissolved CO2 concentration at temporal resolutions essential for studying carbon variability and evasion from these dynamic ecosystems. Here, we describe the adaptation, deployment, and validation of an open-source and relatively low-cost in situ pCO2 sensor system for lotic ecosystems, the lotic-SIPCO2. We tested the lotic-SIPCO2 in 10 streams that spanned a range of land cover and basin size. Key system adaptations for lotic environments included prevention of biofouling, configuration for variable stage height, and reduction of headspace equilibration time. We then examined which input parameters contribute the most to uncertainty in estimating CO2 emission rates and found scaling factors related to the gas exchange velocity were the most influential when CO2 concentration was significantly above saturation. Near saturation, sensor measurement of pCO2 contributed most to uncertainty in estimating CO2 emissions. We also found high-frequency measurements of pCO2 were not necessary to accurately estimate median emission rates given the CO2 regimes of our streams, but daily to weekly sampling was sufficient. High-frequency measurements of pCO2 remain valuable for exploring in-stream metabolic variability, source partitioning, and storm event dynamics. Our adaptations to the SIPCO2 offer a relatively affordable and robust means of monitoring dissolved CO2 in lotic ecosystems. Our findings demonstrate priorities and related considerations in the design of monitoring projects of dissolved CO2 and CO2 evasion dynamics more broadly

Damage of woven composite under tensile and shear stress using infrared thermography and micrographic cuts

Infrared thermography was used to study damage developing in woven fabrics. Two different experiments were performed, a ±45° tensile test and a rail shear test. These two different types of tests show different damage scenarios, even if the shear stress/strain curves are similar. The ±45° tension test shows matrix hardening and matrix cracking whereas the rail shear test shows only matrix hardening. The infrared thermography was used to perform an energy balance, which enabled the visualization of the portion of dissipated energy caused by matrix cracking. The results showed that when the resin is subjected to pure shear, a larger amount of energy is stored by the material, whereas when the resin is subjected to hydrostatic pressure, the main part of mechanical energy is dissipated as heat

Winding number order in the Haldane model with interactions

We study the Haldane model with nearest–neighbor interactions. This model is physically motivated by the associated implementation with ultracold atoms. We show that the topological phase of the interacting model can be characterized by a physically observable winding number. The robustness of this number extends well beyond the topological insulator phase towards attractive and repulsive interactions that are comparable to the kinetic energy scale of the model. We identify and characterize the relevant phases of the model as a function of the interaction strength

Small scale energy release driven by supergranular flows on the quiet Sun

In this article we present data and modelling for the quiet Sun that strongly suggest a ubiquitous small-scale atmospheric heating mechanism that is driven solely by converging supergranular flows. A possible energy source for such events is the power transfer to the plasma via the work done on the magnetic field by photospheric convective flows, which exert drag of the footpoints of magnetic structures. In this paper we present evidence of small scale energy release events driven directly by the hydrodynamic forces that act on the magnetic elements in the photosphere, as a result of supergranular scale flows. We show strong spatial and temporal correlation between quiet Sun soft X-ray emission (from &lt;i&gt;Yohkoh&lt;/i&gt; and &lt;i&gt;SOHO&lt;/i&gt; MDI-derived flux removal events driven by deduced photospheric flows. We also present a simple model of heating generated by flux submergence, based on particle acceleration by converging magnetic mirrors. In the near future, high resolution soft X-ray images from XRT on the &lt;i&gt;Hinode&lt;/i&gt; satellite will allow definitive, quantitative verification of our results