Common Premotor Regions for the Perception and Production of Prosody and Correlations with Empathy and Prosodic Ability

Background: Prosody, the melody and intonation of speech, involves the rhythm, rate, pitch and voice quality to relay linguistic and emotional information from one individual to another. A significant component of human social communication depends upon interpreting and responding to another person’s prosodic tone as well as one’s own ability to produce prosodic speech. However there has been little work on whether the perception and production of prosody share common neural processes, and if so, how these might correlate with individual differences in social ability. Methods: The aim of the present study was to determine the degree to which perception and production of prosody rely on shared neural systems. Using fMRI, neural activity during perception and production of a meaningless phrase in different prosodic intonations was measured. Regions of overlap for production and perception of prosody were found in premotor regions, in particular the left inferior frontal gyrus (IFG). Activity in these regions was further found to correlate with how high an individual scored on two different measures of affective empathy as well as a measure on prosodic production ability. Conclusions: These data indicate, for the first time, that areas that are important for prosody production may also be utilized for prosody perception, as well as other aspects of social communication and social understanding, such as aspect

Evidence of Carbon Uptake Associated with Vegetation Greening Trends in Eastern China

Persistent and widespread increase of vegetation cover, identified as greening, has been observed in areas of the planet over late 20th century and early 21st century by satellite-derived vegetation indices. It is difficult to verify whether these regions are net carbon sinks or sources by studying vegetation indices alone. In this study, we investigate greening trends in Eastern China (EC) and corresponding trends in atmospheric CO₂ concentrations. We used multiple vegetation indices including NDVI and EVI to characterize changes in vegetation activity over EC from 2003 to 2016. Gap-filled time series of column-averaged CO₂ dry air mole fraction (XCO₂) from January 2003 to May 2016, based on observations from SCIAMACHY, GOSAT, and OCO-2 satellites, were used to calculate XCO₂ changes during growing season for 13 years. We derived a relationship between XCO₂ and surface net CO₂ fluxes from two inversion model simulations, CarbonTracker and Monitoring Atmospheric Composition and Climate (MACC), and used those relationships to estimate the biospheric CO₂ flux enhancement based on satellite observed XCO₂ changes. We observed significant growing period (GP) greening trends in NDVI and EVI related to cropland intensification and forest growth in the region. After removing the influence of large urban center CO₂ emissions, we estimated an enhanced XCO₂ drawdown during the GP of −0.070 to −0.084 ppm yr⁻¹. Increased carbon uptake during the GP was estimated to be 28.41 to 46.04 Tg C, mainly from land management, which could offset about 2–3% of EC’s annual fossil fuel emissions. These results show the potential of using multi-satellite observed XCO₂ to estimate carbon fluxes from the regional biosphere, which could be used to verify natural sinks included as national contributions of greenhouse gas emissions reduction in international climate change agreements like the UNFCC Paris Accord

Association of index finger palpatory assessment of pubovisceral muscle body integrity with MRIâ documented tear

AimsPubovisceral (PV) muscle tears are associated with pelvic floor disorders. The goal of this study was to determine whether index finger palpatory assessment of PV muscle body integrity through the lateral vaginal wall is a reliable indicator of PV muscle tear severity diagnosed by magnetic resonance imaging (MRI).MethodsWe studied 85 women, 7 weeks after vaginal birth. All had at least one risk factor for obstetricâ related PV muscle tear. The ordinal outcome measure of MRIâ documented PV muscle tear was defined as: none, less than 50% unilateral tear, 50% or greater unilateral tear or less than 50% bilateral tear, and 50% or greater bilateral tear. PV muscle body integrity by palpatory assessment was scored on a matrix, with each side scored independently and classified as PV muscle body â presentâ (assuredly felt), â equivocalâ (not sure if felt), or â absentâ (assuredly not felt). Proportional odds models were constructed to estimate the relationship between PV muscle body integrity palpatory assessment and MRIâ documented PV muscle tears.ResultsThirtyâ five percent of study participants exhibited varying degrees of MRIâ documented PV muscle tears. Using palpatory assessment, we identified â PV muscle body present bilaterallyâ in 20%, â equivocal unilaterally or present contralaterallyâ in 8%, â equivocal or absent unilaterallyâ or â equivocal bilaterallyâ in 62%, and â absent bilaterallyâ in 9%. The odds ratio for estimating MRI results from palpatory assessment was 3.62 (95% confidence intervalâ =â 1.70â 7.73, Pâ =â 0.001).ConclusionsA rapid and inexpensive palpatory assessment in the clinic was highly associated with the risk of MRIâ documented PV muscle tear and is a useful component of a clinical assessment.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149233/1/nau23967_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149233/2/nau23967.pd

2013-2014 Mostly Music: Eastern European/USA Connection

https://spiral.lynn.edu/conservatory_mostlymusic/1020/thumbnail.jp

2018-2019 Mostly Music: Franz Schubert

https://spiral.lynn.edu/conservatory_mostlymusic/1033/thumbnail.jp

Proteins associated with pancreatic cancer survival in patients with resectable pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with a dismal prognosis. However, while most patients die within the first year of diagnosis, very rarely, a few patients can survive for >10 years. Better understanding the molecular characteristics of the pancreatic adenocarcinomas from these very-long-term survivors (VLTS) may provide clues for personalized medicine and improve current pancreatic cancer treatment. To extend our previous investigation, we examined the proteomes of individual pancreas tumor tissues from a group of VLTS patients (survival ≥10 years) and short-term survival patients (STS, survival <14 months). With a given analytical sensitivity, the protein profile of each pancreatic tumor tissue was compared to reveal the proteome alterations that may be associated with pancreatic cancer survival. Pathway analysis of the differential proteins identified suggested that MYC, IGF1R and p53 were the top three upstream regulators for the STS-associated proteins, and VEGFA, APOE and TGFβ-1 were the top three upstream regulators for the VLTS-associated proteins. Immunohistochemistry analysis using an independent cohort of 145 PDAC confirmed that the higher abundance of ribosomal protein S8 (RPS8) and prolargin (PRELP) were correlated with STS and VLTS, respectively. Multivariate Cox analysis indicated that 'High-RPS8 and Low-PRELP' was significantly associated with shorter survival time (HR=2.69, 95% CI 1.46-4.92, P=0.001). In addition, galectin-1, a previously identified protein with its abundance aversely associated with pancreatic cancer survival, was further evaluated for its significance in cancer-associated fibroblasts. Knockdown of galectin-1 in pancreatic cancer-associated fibroblasts dramatically reduced cell migration and invasion. The results from our study suggested that PRELP, LGALS1 and RPS8 might be significant prognostic factors, and RPS8 and LGALS1 could be potential therapeutic targets to improve pancreatic cancer survival if further validated

Prime-Boost Vaccine Regimen for SjTPl and SjC23 Schistosome Vaccines, Increases Efficacy in Water Buffalo in a Field Trial in China

Schistosomiasis remains a serious zoonotic disease in China and the Philippines. Water buffalo and cattle account for the majority of transmission. Vaccination of water buffalo is considered a key strategy to reduce disease prevalence. Previously, we showed that vaccination of water buffalo with SjC23 or SjCTPI plasmid DNA vaccines, induced 50% efficacy to challenge infection. Here, we evaluated several parameters to determine if we can develop a two dose vaccine that maintains the efficacy of the three dose vaccine. We performed four trials evaluating: (1) lab produced vs. GLP grade vaccines, (2) varying the time between prime and boost, (3) the influence of an IL-12 adjuvant, and (4) a two dose heterologous (DNA-protein) prime-boost. We found the source of the DNA vaccines did not matter, nor did increasing the interval between prime and boost. Elimination of the IL-12 plasmid lowered homologous DNA-DNA vaccine efficacy. A major finding was that the heterologous prime boost improved vaccine efficacy, with the prime-boost regimen incorporating both antigens providing a 55% reduction in adult worms and 53% reduction in liver eggs. Vaccinated buffalo produced vaccine-specific antibody responses. These trials suggest that highly effective vaccination against schistosomes can be achieved using a two dose regimen. No adjuvants were used with the protein boost, and the potential that addition of adjuvant to the protein boost to further increase efficacy should be evaluated. These results suggest that use of these two schistosome vaccines can be part of an integrated control strategy to reduce transmission of schistosomiasis in Asia

Crystallographic preferred orientations of ice deformed in direct-shear experiments at low temperatures

Synthetic polycrystalline ice was sheared at temperatures of-5,-20 and-30 °C, to different shear strains, up to γ = 2.6, equivalent to a maximum stretch of 2.94 (final line length is 2.94 times the original length). Cryo-electron backscatter diffraction (EBSD) analysis shows that basal intracrystalline slip planes become preferentially oriented parallel to the shear plane in all experiments, with a primary cluster of crystal c axes (the c axis is perpendicular to the basal plane) perpendicular to the shear plane. In all except the two highest-strain experiments at-30 °C, a secondary cluster of c axes is observed, at an angle to the primary cluster. With increasing strain, the primary c-axis cluster strengthens. With increasing temperature, both clusters strengthen. In the-5 °C experiments, the angle between the two clusters reduces with strain. The c-axis clusters are elongated perpendicular to the shear direction. This elongation increases with increasing shear strain and with decreasing temperature. Highly curved grain boundaries are more prevalent in samples sheared at higher temperatures. At each temperature, the proportion of curved boundaries decreases with increasing shear strain. Subgrains are observed in all samples. Microstructural interpretations and comparisons of the data from experimentally sheared samples with numerical models suggest that the observed crystallographic orientation patterns result from a balance of the rates of lattice rotation (during dislocation creep) and growth of grains by strain-induced grain boundary migration (GBM). GBM is faster at higher temperatures and becomes less important as shear strain increases. These observations and interpretations provide a hypothesis to be tested in further experiments and using numerical models, with the ultimate goal of aiding the interpretation of crystallographic preferred orientations in naturally deformed ice

Field Testing Integrated Interventions for Schistosomiasis Elimination in the People's Republic of China: Outcomes of a Multifactorial Cluster-Randomized Controlled Trial

Despite significant progress, China faces the challenge of re-emerging schistosomiasis transmission in currently controlled areas due, in part, to the presence of a range of animal reservoirs, notably water buffalo and cattle, which can harbor Schistosoma japonicum infections. Environmental, ecological and social-demographic changes in China, shown to affect the distribution of oncomelanid snails, can also impact future schistosomiasis transmission. In light of their importance in the S. japonicum, lifecycle, vaccination has been proposed as a means to reduce the excretion of egg from cattle and buffalo, thereby interrupting transmission from these reservoir hosts to snails. A DNA-based vaccine (SjCTPI) our team developed showed encouraging efficacy against S. japonicum in Chinese water buffaloes. Here we report the results of a double-blind cluster randomized trial aimed at determining the impact of a combination of the SjCTPI bovine vaccine (given as a prime-boost regimen), human mass chemotherapy and snail control on the transmission of S. japonicum in 12 selected administrative villages around the Dongting Lake in Hunan province. The trial confirmed human praziquantel treatment is an effective intervention at the population level. Further, mollusciciding had an indirect ~50% efficacy in reducing human infection rates. Serology showed that the SjCTPI vaccine produced an effective antibody response in vaccinated bovines, resulting in a negative correlation with bovine egg counts observed at all post-vaccination time points. Despite these encouraging outcomes, the effect of the vaccine in preventing human infection was inconclusive. This was likely due to activities undertaken by the China National Schistosomiasis Control Program, notably the treatment, sacrifice or removal of bovines from trial villages, over which we had no control; as a result, the trial design was compromised, reducing power and contaminating outcome measures. This highlights the difficulties in undertaking field trials of this nature and magnitude, particularly over a long period, and emphasizes the importance of mathematical modeling in predicting the potential impact of control intervention measures. A transmission blocking vaccine targeting bovines for the prevention of S. japonicum with the required protective efficacy would be invaluable in tandem with other preventive intervention measures if the goal of eliminating schistosomiasis from China is to become a reality.DM is a NHMRC Senior Principal Research Fellow. DG is a NHMRC Career Development Fello