Environmental Governance as a Development Strategy: The Case of Lucas do Rio Verde Legal

The goal of this dissertation is to describe and analyze one set of efforts to improve monitoring, licensing, accountability, and socio-environmental outcomes of industrial-scale farming in the Cerrado, located in Brazil's southern Amazon. These efforts are collectively called Lucas do Rio Verde Legal [Lucas Legal], an environmental licensing initiative which is the product of a multi-stakeholder partnership. This partnership includes an international environmental NGO, national and multi-national industrial agriculture firms, and local government agencies. Environmental issues in the Cerrado are frequently framed as economic, and, to a lesser extent, policy issues, due to the high profitability of industrial agriculture in the region and shortcomings on the part of the state to adequately monitor rural activities and enforce environmental laws. Lucas Legal is novel not only for its relative successes at improving the effectiveness of environmental licensing of rural properties locally and at the state level, but also for its role in increasing the interest of rural producers in addressing environmental issues and for calling attention to cultural, historical, institutional, and technical factors that contribute to agri-environmental problems in the Amazon. A multi-method approach, including archival research, ethnographic research, ongoing interviews with key informants, and a semi-structured survey of 20 farmers was used to explore the genesis and outcomes of Lucas Legal from many different angles, and to trace the history of the project and understand the unique history of the municipality (Lucas do Rio Verde) in which the project began. Analysis of the project drew on three distinct literatures - the literature on Environmental Governance; the literature on Environmentality, which is heavily based on Foucault's work on Governmentality; and the combined literatures on Advocacy and Discourse Coalitions. While none of these literatures was sufficient alone to explain the unique history and outcomes of Lucas Legal, the three literatures together offer useful insights into the contributions of different government, market, and civil society stakeholder groups. The grounded, ethnographic approach of this dissertation research helps fill an important gap in knowledge on this topic; few other studies of environmental governance in the Amazon have been in-depth enough to explore the settlement history of the region, the importance of inter-personal relationships and local politics to environmental and developmental outcomes, and to link these issues to outcomes of projects of environmental governance or local perceptions of environmental conservation. Understanding the diverse motivations of agricultural and non-agricultural actors in the Amazon is crucial to ensuring sustainable environmental outcomes as well as sustainable economic development

The Coffeeness of Costa Rica

The University of Kansas has long historical connections with Central America and the many Central Americans who have earned graduate degrees at KU. This work is part of the Central American Theses and Dissertations collection in KU ScholarWorks and is being made freely available with permission of the author through the efforts of Professor Emeritus Charles Stansifer of the History department and the staff of the Scholarly Communications program at the University of Kansas Libraries’ Center for Digital Scholarship.Costa Rica is a place that has come to be associated with coffee. The coffeeness of Costa Rica is possible due to a unique combination of physical and social elements, and elements of culture and meaning that have been pulled together in Costa Rica by the force of place. Costa Ricans and non-Costa Ricans have informed Costa Rica’s national identity as symbolized by coffee. Within Costa Rica, coffee and the development of the coffee industry have played a pivotal role in national identity formation. Costa Rica is participating in a world-system wherein capital wealth is exported from nation-states in the periphery to nation-states in the core. By exporting un-roasted coffee to the United States and Europe for roasting and sale, it is also exporting their culture “up” the commodity chain, by sending along images of coffee farmers and ideas of cooperative-based fair trade

Soil Salinity and Stomatal Conductance on Chaparral Plants

In our experiment we evaluated the soil salinity and corresponding stomatal conductance rates of Malosma laurina and Rhus integrifolia located near the coast and farther inland. Our prediction was that stomatal conductance would vary with the change in location of each species. Stomatal conductance was measured using a simple diffusion porometer and soil salinity was measured using a refractometer. We concluded that soil salinity caused a decline in stomatal conductance in both chaparral species. M. laurina was also found to be more sensitive to an increase in soil salinity, as its stomatal conductance rates declined more than that of R. integrifolia

Estimating the Potential for Conservation and Farming in the Amazon and Cerrado under Four Policy Scenarios

Since 2013, clearing rates have rapidly increased in the Amazon and Cerrado biomes. This acceleration has raised questions about the efficacy of current regional public and private conservation policies that seek to promote agricultural production while conserving remnants of natural vegetation. In this study, we assessed conservation and agricultural outcomes of four potential policy scenarios that represent perfect adherence to private sector, zero-deforestation commitments (i.e., the Amazon soy moratorium—ASM and the Amazon cattle agreements—CA) and to varying levels of implementation of the Brazilian Forest Code (FC). Under a zero-clearing scenario, we find that the extent of croplands as of 2017 within the two biomes (31 MHa) could double without further clearing if agriculture were to expand on all previously cleared land that is suitable for crops. Moreover, at least 47 MHa of land that is already cleared but unsuitable for crops would remain available for pasture. Under scenarios in which only legal clearing under the FC could occur, 51 MHa of additional natural vegetation could be cleared. This includes as many as 1 MHa of nonforest vegetation that could be cleared in the Amazon biome without triggering the ASM and CA monitoring systems. Two-thirds of the total vegetation vulnerable to legal clearing is located within the Cerrado biome, and 19 MHa of this land is suitable for cropland expansion. Legal clearing of all of these areas could reduce biodiversity persistence by 4% within the two biomes, when compared with the zero-clearing scenario, and release up to 9 PgCO2e, with the majority (75%) coming from the Cerrado biome. However, when we considered the potential outcomes of full implementation of the FC, we found that 22% (11 MHa) of the 51 MHa of vegetation subject to legal clearing could be protected through the environmental quotas market, while an additional 1 MHa should be replanted across the two biomes, predominantly in the Amazon biome (73% of the area subject to replanting). Together, quotas and replanting could prevent the release of 2 PgCO2e that would otherwise be emitted if all legal clearing occurred. Based on our results, we conclude that ongoing legal clearing could create additional space for cropland and cattle production beyond the substantial existing stocks of cleared areas but would significantly impair local carbon and biodiversity stocks.</jats:p

Macrophage phenotype in response to ECM bioscaffolds

Macrophage presence and phenotype are critical determinants of the healing response following injury. Downregulation of the pro-inflammatory macrophage phenotype has been associated with the therapeutic use of bioscaffolds composed of extracellular matrix (ECM), but phenotypic characterization of macrophages has typically been limited to small number of non-specific cell surface markers or expressed proteins. The present study determined the response of both primary murine bone marrow derived macrophages (BMDM) and a transformed human mononuclear cell line (THP-1 cells) to degradation products of two different, commonly used ECM bioscaffolds; urinary bladder matrix (UBM-ECM) and small intestinal submucosa (SIS-ECM). Quantified cell responses included gene expression, protein expression, commonly used cell surface markers, and functional assays. Results showed that the phenotype elicited by ECM exposure (MECM) is distinct from both the classically activated IFNγ + LPS phenotype and the alternatively activated IL-4 phenotype. Furthermore, the BMDM and THP-1 macrophages responded differently to identical stimuli, and UBM-ECM and SIS-ECM bioscaffolds induced similar, yet distinct phenotypic profiles. The results of this study not only characterized an MECM phenotype that has anti-inflammatory traits but also showed the risks and challenges of making conclusions about the role of macrophage mediated events without consideration of the source of macrophages and the limitations of individual cell markers

Criteria for effective zero-deforestation commitments

Zero-deforestation commitments are a type of voluntary sustainability initiative that companies adopt to signal their intention to reduce or eliminate deforestation associated with commodities that they produce, trade, and/or sell. Because each company defines its own zero-deforestation commitment goals and implementation mechanisms, commitment content varies widely. This creates challenges for the assessment of commitment implementation or effectiveness. Here, we develop criteria to assess the potential effectiveness of zero-deforestation commitments at reducing deforestation within a company supply chain, regionally, and globally. We apply these criteria to evaluate 52 zero-deforestation commitments made by companies identified by Forest 500 as having high deforestation risk. While our assessment indicates that existing commitments converge with several criteria for effectiveness, they fall short in a few key ways. First, they cover just a small share of the global market for deforestation-risk commodities, which means that their global impact is likely to be small. Second, biome-wide implementation is only achieved in the Brazilian Amazon. Outside this region, implementation occurs mainly through certification programs, which are not adopted by all producers and lack third-party near-real time deforestation monitoring. Additionally, around half of all commitments include zero-net deforestation targets and future implementation deadlines, both of which are design elements that may reduce effectiveness. Zero-net targets allow promises of future reforestation to compensate for current forest loss, while future implementation deadlines allow for preemptive clearing. To increase the likelihood that commitments will lead to reduced deforestation across all scales, more companies should adopt zero-gross deforestation targets with immediate implementation deadlines and clear sanction-based implementation mechanisms in biomes with high risk of forest to commodity conversion.ISSN:0959-3780ISSN:1872-949

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways

It is of considerable translational importance whether depression is a form or a consequence of sickness behavior. Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated by pro-inflammatory cytokines. It is an adaptive response that enhances recovery by conserving energy to combat acute inflammation. There are considerable phenomenological similarities between sickness behavior and depression, for example, behavioral inhibition, anorexia and weight loss, and melancholic (anhedonia), physio-somatic (fatigue, hyperalgesia, malaise), anxiety and neurocognitive symptoms. In clinical depression, however, a transition occurs to sensitization of immuno-inflammatory pathways, progressive damage by oxidative and nitrosative stress to lipids, proteins, and DNA, and autoimmune responses directed against self-epitopes. The latter mechanisms are the substrate of a neuroprogressive process, whereby multiple depressive episodes cause neural tissue damage and consequent functional and cognitive sequelae. Thus, shared immuno-inflammatory pathways underpin the physiology of sickness behavior and the pathophysiology of clinical depression explaining their partially overlapping phenomenology. Inflammation may provoke a Janus-faced response with a good, acute side, generating protective inflammation through sickness behavior and a bad, chronic side, for example, clinical depression, a lifelong disorder with positive feedback loops between (neuro)inflammation and (neuro)degenerative processes following less well defined triggers

The small molecule inhibitor BX-795 uncouples IL-2 production from inhibition of Th2 inflammation and induces CD4+ T cells resembling iTreg

BackgroundTreg cells have been shown to be an important part of immune-homeostasis and IL-2 which is produced upon T cell receptor (TCR)-dependent activation of T lymphocytes has been demonstrated to critically participate in Treg development.ObjectiveTo evaluate small molecule inhibitors (SMI) for the identification of novel IL-2/Treg enhancing compounds.Materials and methodsWe used TCR-dependent and allergen-specific cytokine secretion of human and mouse T cells, next generation messenger ribonucleic acid sequencing (RNA-Seq) and two different models of allergic airway inflammation to examine lead SMI-compounds.ResultsWe show here that the reported 3-phosphoinositide dependent kinase-1 (PDK1) SMI BX-795 increased IL-2 in culture supernatants of Jurkat E6-1 T cells, human peripheral blood mononuclear cells (hPBMC) and allergen-specific mouse T cells upon TCR-dependent and allergen-specific stimulation while concomitantly inhibiting Th2 cytokine secretion. RNA-Seq revealed that the presence of BX-795 during allergen-specific activation of T cells induces a bona fide Treg cell type highly similar to iTreg but lacking Foxp3 expression. When applied in mugwort pollen and house dust mite extract-based models of airway inflammation, BX-795 significantly inhibited Th2 inflammation including expression of Th2 signature transcription factors and cytokines and influx into the lungs of type 2-associated inflammatory cells such as eosinophils.ConclusionsBX-795 potently uncouples IL-2 production from Th2 inflammation and induces Th-IL-2 cells, which highly resemble induced (i)Tregs. Thus, BX-795 may be a useful new compound for the treatment of allergic diseases