44 research outputs found
Exile Vol. XXVI No. 1
Photo: Untitled by Jamie Bailey 3
Poem: Hi, My Name Is by Kathy Andrews 4
Poem: Untitled by Willi Haworth 5
Photo: Stratified Snow by Jim Lundy 6
Poem: Untitled by A. Pence 7
Poem: Akua\u27ba by Tona Dickerson 8
Photo: Untitled by Jim Lundy 9
Story: The Dogcatchers of Portimao by Debora Papierski 10-13
Photo: Untitled by Holly Hall 14
Poem: Tocopold Bloom: A Working Class Hero by Mary Ladky 15
Photo: Untitled by Cory Easter 16
Poem: A Mortal Wound by Peter Fish 17
Poem: Let Me Sleep by R. G. Trub 18-19
Photo: Modified Cube by Jim Lundy 20
Story: Untitled by Kathy Desmond 21-23
Photo: Untitled by Holly Hall 24
Poem: Untitled by Sharon McCartney 25
Photo: Untitled by Him Lundy 26
Poem: Every Morning I Wake by Peter Fish 27
Photo: Untitled by Rof Smith 28
Poem: For Mark Some Words by Bonny Lowe 29
Photo: Untitled by Jim Lundy 30
Poem: A Flash of Crooked Light by Lisa Minacci 31
Photo: Untitled by Jim Lundy 32
Poem: Paper Hearts by W. Dulles 33
Drawing: Untitled by Roger Weisman 34
Story: Untitled by Dane Lavin 35-42
Photo: Untitled by Jim Lundy 43
Special Thanks To Laurie Howard -
Exile Vol. XXVII No. 1
ANDY ACKER: Four Lane Breakfast 30
MIKE AUGUSTA: The Store 25-27
J. L. FREEMAN: Bobbie 22
Poem 33
JENNIFER E. GARDNER: Photo 3
Deeds Field 9
Photo 21
Photo 23
Photo 24
LAURA GILBERT: Photo 13
Photo 28
Photo 29
Photo 31
Photo 36
KATE GLAZER: Drawing 14
MICHAEL HEINLIN: Reflections 19
DAVE HOGSHIRE: The Life And Times Of General Worm 29
CHAD HUSSEY: Waiting for Anne Sexton 13
JOHN WHITWORTH KROPF: Friends in the Park 30
DANE LAVIN: Story 4-8
LISA LAWRENCE: Poem 17
The Man With The Red Hat 15
JAMES LUNDY: Bonds 10
Photo 30
Photo 34
Twisted Ulna 11
LISA MEAD: Resistance 9
LISA MINACCI: The Drop 33
A. PENCE: The Minstrels 1
Mussels 33
PENELOPE A. RISEBOROUGH: Poem 2
Regent Street Mannequins 2
RICK RORICK: Photo 18
A. K. SESSIONS Nervious Tension 10
SUZIE SNYDER: Photo 16
L. S. VIOLA: Trash Can
JOHN ZARCHEN: In Autumn 20
ANONYMOUS: Untitled Article 32
Sandymount Strand 35
Cover drawing by Kate Glaze
Role of CD44 in clear cell renal cell carcinoma invasiveness after antiangiogenic treatment
Treballs Finals de Grau de Farmàcia, Facultat de Farmàcia, Universitat de Barcelona, 2017. Tutor/a: Joan Carles Rodríguez Rubio.[eng] During last century, big effort to understand the biochemical basis of cancer was carried
out. One of the principal branches of these cancer investigations used drugs to prevent
the formation of new blood vessels –process called angiogenesis– responsible for the
nutrients supply of the tumour. These drugs are generally called antiangiogenics.
It was discovered that some types of tumour have or develop resistance to these drugs
when treatment was long enough. For that reason, mechanisms of resistance,
aggressiveness, invasion and/or metastasis after the treatment are nowadays relevant
to study. Recently, a protein that could be involved in the increased invasiveness of
tumour cells after the antiangiogenic treatment appeared.
This project collects some evidence that indicates that this protein, called CD44, might
play a role in the increased invasion after antiangiogenic treatment in mouse models of
renal carcinoma.[cat] Durant l’últim segle, s’ha fet un gran esforç per aprofundir en la basant bioquímica de la
investigació contra el càncer. Una de les branques principals d’aquesta investigació
utilitza fàrmacs que prevenen la formació de nous vasos sanguinis –procés anomenat
angiogènesis- encarregats de nodrir el tumor. Aquests fàrmacs es diuen generalment
antiangiogènics. S’ha descobert que alguns tipus de tumor tenen o desenvolupen
resistència a aquests fàrmacs quan el tractament és prou llarg. Per aquesta raó,
actualment s’està investigant profundament quins són els mecanismes pels quals
apareix aquesta resistència, així com també perquè els tumors es tornen més agressius,
invasius i/o metastàtics després del tractament. Recentment s’ha descobert una
proteïna que podria estar involucrada en l’augment de la invasivitat de les cèl·lules
tumorals després del tractament antiangiogènic.
Aquest treball recull algunes de les evidències que apunten cap al paper de la proteïna
CD44 en l’increment de la invasió tumoral post-tractament amb fàrmacs antiangiogènics
en models ratolins de càncer renal
Chikungunya Virus Neutralization Antigens and Direct Cell-to-Cell Transmission Are Revealed by Human Antibody-Escape Mutants
Chikungunya virus (CHIKV) is an alphavirus responsible for numerous epidemics throughout Africa and Asia, causing infectious arthritis and reportedly linked with fatal infections in newborns and elderly. Previous studies in animal models indicate that humoral immunity can protect against CHIKV infection, but despite the potential efficacy of B-cell-driven intervention strategies, there are no virus-specific vaccines or therapies currently available. In addition, CHIKV has been reported to elicit long-lasting virus-specific IgM in humans, and to establish long-term persistence in non-human primates, suggesting that the virus might evade immune defenses to establish chronic infections in man. However, the mechanisms of immune evasion potentially employed by CHIKV remain uncharacterized. We previously described two human monoclonal antibodies that potently neutralize CHIKV infection. In the current report, we have characterized CHIKV mutants that escape antibody-dependent neutralization to identify the CHIKV E2 domain B and fusion loop “groove” as the primary determinants of CHIKV interaction with these antibodies. Furthermore, for the first time, we have also demonstrated direct CHIKV cell-to-cell transmission, as a mechanism that involves the E2 domain A and that is associated with viral resistance to antibody-dependent neutralization. Identification of CHIKV sub-domains that are associated with human protective immunity, will pave the way for the development of CHIKV-specific sub-domain vaccination strategies. Moreover, the clear demonstration of CHIKV cell-to-cell transmission and its possible role in the establishment of CHIKV persistence, will also inform the development of future anti-viral interventions. These data shed new light on CHIKV-host interactions that will help to combat human CHIKV infection and inform future studies of CHIKV pathogenesis
CT Scan Effective Radiation Dose Reduction in Pediatric Trauma Patients
This project attempts to address the problem of excessive radiation exposure via CT imaging for pediatric patients presenting at adult regional trauma centers.
To answer this question, we utilized the pediatric trauma registry to conduct a retrospective chart review of consisting of all patients under 14 years of age that received trauma related CT imaging and that were transferred from an adult trauma center to Dayton Children’s Hospital in the time period of January 2019 to December 2019.Cases of unnecessary imaging will be determined by subject matter expert review, based on ACS and Image Gently guidelines. Cases of overexposure to radiation were determined via DLP and effective radiation dose, in conjunction with subject matter expert review.
Results showed that 48 pediatrics patients were transferred to Dayton Children’s Hospital from 12 different adult trauma, from January to December 2019. In total, 118 scans were performed on these 48 patients. Of these, 41 scans were identified as an opportunity for improvement. The most common opportunity for improvement was a reduction in unnecessary cervical spine scans.
From a patient safety perspective, this project emphasizes the need for increased knowledge of pediatric imaging guidelines at adult trauma centers. Such knowledge includes knowing when a scan can be reformatted from an existing image, as well as an understanding of weight-based pediatric imaging. A follow up project could be to assess for change after implementation of guidelines at the adult trauma centers
Shelley Weinstock, \u2776, Lisa Pence, \u2775, and Deborah Bornstein-Gichan, \u2776 (BardCorps)
Shelley Weinstock, Lisa Pence, and Deborah Bornstein-Gichan, \u2776, \u2775, and \u2776 respectively, were at Bard at a time when the Feminist Movement was just beginning to gain momentum: I remember it being a very new idea. Feminism was a big, new idea and it was wonderful. Shelley found acceptance and encouragement as a woman in science, while Lisa and Deborah describe their experiences in the literature and dance departments. Together, the three speak of their reasons for attending Bard; what the college provided for them then and since in their lives and careers; and how much their friendships with each other and their classmates has meant through it all. Forty years on, an initial rebuff from a guy friend is now remembered with laughter and huge affection: I\u27d go out with you, but I\u27m social climbing. I\u27m only dating seniors.https://digitalcommons.bard.edu/oral_hist/1077/thumbnail.jp