Transforming the Entrepreneurial Landscape: Emergent Innovative Behaviors in Internet Firms

Implications for opportunity identification, alliance formation, and strategic orientation of Internet entrepreneurs are presented as preliminary steps toward a new netpreneurship model of business formation

The Status of Women\u27s Entrepreneurship: Pathways to Future Entrepreneurship Development and Education

This article examines major areas of inquiry related to entrepreneurial capabilities, motivations, and the acquisition of resources to launch and grow women-owned businesses

Discrete Choices, Trade‐offs, and Advantages: Modeling Social Venture Opportunities and Intentions

[Excerpt] Our study is motivated by the fundamental question of whether social entrepreneurs differ from \u27traditional\u27 entrepreneurs. More concretely, is the way that aspiring entrepreneurs view social entrepreneurial opportunities different from the way they view more traditional (defined as primarily economic) entrepreneurial opportunities? Answering this question is critical to the advancement of the study of social entrepreneurship, and represents a powerful vehicle for demonstrating how the study of social entrepreneurship also advances our knowledge of traditional entrepreneurship

NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus

The PIDDosome (PIDD–RAIDD–caspase-2 complex) is considered to be the primary signaling platform for caspase-2 activation in response to genotoxic stress. Yet studies of PIDD-deficient mice show that caspase-2 activation can proceed in the absence of PIDD. Here we show that DNA damage induces the assembly of at least two distinct activation platforms for caspase-2: a cytoplasmic platform that is RAIDD dependent but PIDD independent, and a nucleolar platform that requires both PIDD and RAIDD. Furthermore, the nucleolar phosphoprotein nucleophosmin (NPM1) acts as a scaffold for PIDD and is essential for PIDDosome assembly in the nucleolus after DNA damage. Inhibition of NPM1 impairs caspase-2 processing, apoptosis, and caspase-2–dependent inhibition of cell growth, demonstrating that the NPM1-dependent nucleolar PIDDosome is a key initiator of the caspase-2 activation cascade. Thus we have identified the nucleolus as a novel site for caspase-2 activation and function

Women-owned family businesses in transitional economies: key influences on firm innovativeness and sustainability

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. It was originally published in the Journal of Innovation and Entrepreneurship 2014, 3:8.This research presents an examination of familial influence on strategic entrepreneurial behaviors within a transitional economic context. Utilizing a large sample of women-led family businesses, the study investigates the relationships between risk-taking propensity, entrepreneurial intensity, and opportunity recognition of the entrepreneur and the innovative orientation of the firm and sustainability. A model of the influences on innovativeness and sustainability in family firms is developed, and the potential contribution of the present study is the identification of constructs that facilitate these strategic outcomes and behaviors that drive growth. The degree to which family firms can create new products, services, and processes that add value to their marketplace can strongly influence their sustainability, especially in an emerging economy