2-(Furan-2-yl)-3-hy­droxy-4H-chromen-4-one

In the crystal structure of the title compound, C13H8O4, the inversely oriented mol­ecules form inversion dimers through pairs of O—H⋯O hydrogen-bonding inter­actions. An intramolecular O—H⋯O hydrogen bond occurs. In the packing of the mol­ecules, the nearly planar 2-(furan-2-yl)-4H-chromene units [dihedral angle between the chromene and furan rings = 3.8 (1)°] are either parallel or inclined at an angle of 80.7 (1)°

TOT and TVT as surgical methods of treatment of stress urinary incontinence in women - meta-analysis

Introduction: Urinary incontinence can affect up to 50% of women in the world. The most common is stress incontinence, which consists in involuntary, uncontrolled urination when the pressure in the abdominal cavity increases. Among the most commonly used methods of treating stress urinary incontinence there are treatments using a synthetic tape - TOT and TVT. In this work, both methods were compared in terms of e.g. their effectiveness, the presence of complications, the safety of both procedures and the method of performing both procedures. Material and methods: The work was based on the articles published in PubMed, medical books and websites. Results: Both TOT and TVT in the treatment of stress urinary incontinence are highly effective. Both short-term and long-term treatment results of both methods are very good and very similar. In the case of TOT, the subjective cure <1 year is 62-98%, where with TVT - 71-97%. Subjective long-term cure (>5 years) was 43-92% with TOT and 51-88% with TVT. The incidence of complications after TOT is significantly lower, but there is a higher probability of having to perform a repeat procedure to treat stress urinary incontinence. TVT has a lower risk of reoperation in >5 years (1.1%) but has a higher risk of chronic perineal pain. Conclusions: The placement of a tension-free TVT or TOT tape should be the surgery of choice for women with simple stress urinary incontinence. However, there is a higher risk of chronic perineal pain 12 months after having a tape placed behind the symphysis. The technique of passing the tapes through the obturator holes is associated with a lower risk of bladder injury and less discomfort during bladder emptying compared to the TVT technique. After TOT surgery both pain in the inner thighs and inguinal area and vaginal damage are more common than after TVT

Novel Mode of Trisiloxane Application Reduces Spider Mite and Aphid Infestation of Fruiting Shrub and Tree Crops

Application of pesticides leads to contamination of the natural environment, which entails the necessity to seek solutions that use substances which do not pose ecological hazards. The presented investigations tested the efficacy of a preparation containing organomodified trisiloxane and a cross-linking agent (Siltac EC) to limit the number of two-spotted spider mite (Tetranychus urticae) on the leaves of raspberry (Rubus idaeus) and blackcurrant (Ribes nigrum), as well as the numbers of green apple aphid (Aphis pomi) on apple trees (Malus domestica). The high effectiveness (more than 90%) of Siltac against spider mite on raspberry and blackcurrant leaves was rapid and persisted at least by two- three weeks after spraying. There was observed an inhibition of pest developing (i.e. significant decrease of eggs and larvae). Similar effect occurred per an apple tree shoot and the number of living apple aphids was reduced by more than 93% in comparison to untreated trees. In all experiments, the effectiveness of Siltac was similar and usually longer lasting than control pesticides. Moreover, no phytotoxicity of the tested preparation was observed during the investigations. In conclusion, on the basis of the presented results it was found that Siltac EC could be a good alternative to the currently used plant protection chemicals

"Employment in Poland 2011 - Poverty and jobs"

This edition is devoted to the issue of poverty. Growth of prosperity is not distributed evenly among the Polish citizens, and some of them still cannot satisfy even basic needs. The improvement of an overall economic situation reduces risk of poverty in general. However, in case the risk occurs, efficient and effective support measures should be provided. First part of the report defines poverty, and explains the extent of the connection with such phenomena as economic deprivation or social exclusion. It is vital, as the exact criterion of poverty is ambiguous. Having discussed these issues, we elaborate on the characteristics of poverty in Poland as compared to those observed in other Member States of the European Union, as well as their regional and local dimensions. The key element of this part is to determine the causes of poverty, i.e. to what extent poverty results from the features of national and regional economy, and to what extent from individual characteristics of people. The topics introduced in this part form background for subsequent parts of the report. The second part is devoted to the poverty of certain social groups such as elderly, children, unemployed and rural. Conducted analyses allow to dispel some of the myths in this matter, as well as to bring out the characteristics that are particularly important from the perspective of creating the support instruments for groups that are at risk of poverty. The issue of poverty among children is scrutinised from the intergenerational perspective, and its determinants and possible measures of preventing the phenomenon are discussed. The third part focuses on relations between income inequalities and situation on the labour market. In this part changes in distribution of wages in Poland are confronted with the poverty dynamics. They are supplemented with a reflection on the impact on poverty exerted by changes in the Polish society, including (but not limited to) those concerning household structure or economic activity of women. The phenomenon of so called working poor is also scrutinised here. We determine, inter alia, whether the characteristics of household or of work performed are more important causes of in-work poverty. We also elaborate on the question if situation of poor households is persistent or low-paid employment enables them to get out of poverty. The fourth part discusses available tools and instruments to fight the poverty. The state of affairs described in first three parts allows to take a closer look on efficiency and effectiveness of social policy measures applied in Poland, both tax and benefit based. Special attention is drawn to the issue of financial support of families with children as an element of social and demographic policy. The key features of this part are simulations of the impact of hypothetical changes in currently functioning system on rate of poverty in Poland. The recommendations for public policy constitute the summary of the report

Utilisation of methylcellulose as a shaping agent in the fabrication of Ba_{0.95}Ca_{0.05}Ce_{0.9}Y_{0.1}O_3 proton-conducting ceramic membranes via the gelcasting method

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Zinc(II) Complexes with Amino Acids for Potential Use in Dermatology: Synthesis, Crystal Structures, and Antibacterial Activity

The multifunctional profile of Zn2+ has influenced its great popularity in various pharmaceutical, food, and cosmetic products. Despite the use of different inorganic and organic zinc derivatives, the search for new zinc-containing compounds with a safer skin profile still remains an open issue. The present paper describes the synthesis, structural characterization, and antibacterial activity of zinc(II) complexes with proteinogenic amino acids as potential candidates for dermatological treatments. The obtained complexes are of the general formula [Zn(AA)2], where AA represents an amino acid (L-Glu, Gly, L-His, L-Pro, L-Met, and L-Trp). Their synthesis was designed in such a way that the final bis(aminoacidate) zinc(II) complexes did not contain any counter-ions such as Cl−, NO3 −, or SO4 2− that can cause some skin irritations. The chemical structure and composition of the compounds were identified by 1H NMR spectroscopy and elemental analysis, and four were also characterized by single-crystal X-ray diffraction. The Hirshfeld surface analysis for the Zn2+ metallic center helped to determine its coordination number and geometry for each complex. Finally, the antibacterial properties of the complexes were determined with respect to three Gram-positive strains, viz. Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, and Streptococcus pyogenes ATCC 19615, and two Gram-negative bacteria, viz. Escherichia coli ATCC 25992 and Pseudomonas aeruginosa ATCC 27853, and were compared with the activity of zinc 2-pirrolidone 5-carboxylate (ZnPCA), commonly applied in dermatology. It was found that the Zn(II) complexes with methionine and glycine exhibited a higher antibacterial activity than the tested standard, and the antimicrobial properties of complex with Trp were satisfactory. The results of the antimicrobial activity examination allow us to postulate that the obtained zinc complexes might become new active substances for use in dermatological products

Gene transfer into the central nervous system using Herpes Simplex Virus-1 vectors

Manipulation of gene expression in developing or in mature central nervous systems (CNS) holds a promise for the resolution of many compelling neurobiological questions, including the feasibility of gene therapy to treat diseases of the brain. In this context, a number of viral vectors has been used in recent years to introduce and express genes into the CNS. This article discusses a gene transfer system based on the Herpes Simplex Virus-1 (HSV-1). We describe here the use of non-replicating, non-toxic HSV-1 vector, 8117/43, in a series of studies carried in our joint program. This vector proves further the utility of HSV-1 as a delivery vehicle to a number of distinct sites within the CNS

Preliminary evaluation of application of a 3-dimensional network structure of siloxanes Dergall preparation on chick embryo development and microbiological status of eggshells

The spatial network structure of Dergall is based on substances nontoxic to humans and the environment which, when applied on solid surfaces, creates a coating that reduces bacterial cell adhesion. The bacteriostatic properties of siloxanes are based on a purely physical action mechanism which excludes development of drug-resistant microorganisms. The aims of the present study were to 1) evaluate a Dergall layer formed on the eggshell surface regarding the potential harmful effects on the chick embryo; 2) evaluate antimicrobial activity and estimate the prolongation time of Dergall's potential antimicrobial activity. Dergall at a concentration of 0.6% formed a layer on the eggshell surface. In vitro testing of the potential harmful effects of Dergall by means of a hen embryo test of the chorioallantoic membrane showed no irritation reaction at a concentration of 3% and lower. The hatchability of the groups sprayed with a Dergall water solution with a concentration of 0 to 5% was 89.1 to 93.8% for fertilized eggs (P > 0.05) but decreased to 63.7% (P < 0.05) in the group sprayed with a 6% concentration of the solution. This phenomenon was caused by embryo mortality in the first week of incubation. At the concentration of 0.6%, Dergall exhibited strong antibacterial properties against bacteria such as Staphylococcus aureus, Escherichia coli, Shigella dysenteriae, Shigella flexneri, and Salmonella typhimurium. For Streptococcus pyogenes, the highest antibacterial activity of Dergall was reported in the concentrations of 100 and 50%. For Pseudomonas aeruginosa, no antibacterial activity of Dergall was generally observed, but in vivo testing showed a strong decrease of all gram-negative bacteria growth. Moreover, a prolonged antimicrobial effect lasting until 3 D after disinfection was observed, which makes Dergall a safe and efficient disinfectant

The role of stress hyperglycemia and hyperlactatemia in non-diabetic patients with myocardial infarction treated with percutaneous coronary intervention

Background: Stress hyperglycemia and lactates have been used separately as markers of a severe clinical condition and poor outcomes in patients with myocardial infarction (MI). However, the interplay between glucose and lactate metabolism in patients with MI have not been sufficiently studied. The aim in the present study was to examine the relationship of glycemia on admission (AG) and lactate levels and their impact on the outcome in non-diabetic MI patients treated with percutaneous coronary intervention (PCI).  Methods: A total of 405 consecutive, non-diabetic, MI patients were enrolled in this retrospective, observational, single-center study. Clinical characteristic including glucose and lactate levels on admission and at 30-day mortality were assessed. Results: Patients with stress hyperglycemia (AG ≥ 7.8 mmol/L, n = 103) had higher GRACE score (median [interquartile range]: 143.4 (115.4–178.9) vs. 129.4 (105.7–154.5), p = 0.002) than normoglycemic patients (AG level &lt; 7.8 mmol/L, n = 302). A positive correlation of AG with lactate level (R = 0.520, p &lt; 0.001) was observed. The coexistence of both hyperglycemia and hyperlactatemia (lactate level ≥ 2.0 mmol/L) was associated with lower survival rate in the Kaplan-Meier estimates (p &lt; 0.001). In multivariable analysis both hyperglycemia and hyperlactatemia were related to a higher risk of death at 30-day follow-up (hazard ratio [HR] 3.21, 95%, confidence interval [CI] 1.04–9.93; p = 0.043 and HR 7.08; 95% CI 1.44-34.93; p = 0.016, respectively) Conclusions: There is a relationship between hyperglycemia and hyperlactatemia in non-diabetic MI patients treated with PCI. The coexistence of both hyperglycemia and hyperlactatemia is associated with lower survival rate and are independent predictors of 30-day mortality in MI patients and these markers should be evaluated simultaneously