Microwave Spectroscopy

Contains reports on three research projects.United States Army Signal Corps (Contract DA36-039-sc-87376

Being in Sync: Practicing Creative Nature Connection with Youth

This article and companion video detail the Creative Nature Connection program, its theory and application, in five place based learning classrooms. Opening the senses, repeated practice, using simple materials, making encounters personally meaningful, following the principles of contemplative practice and supporting improvisational free play all support the shift to being in- sync with nature building a love of nature, creative confidence and environmental knowledge. Themes of resilience, well-being, trust, calm, creative confidence, focus, self-change, alternative ways to know, belonging and connection to self, others and nature, are briefly shared using student\u27s and teacher\u27s words. The companion video shares short student interviews and work samples, and shares one afternoon of drawing and painting with a dragonfly. The video can be viewed here: https://vimeo.com/19926081

Microwave Spectroscopy

Contains reports on five research projects.United States Army Signal Corps (Contract DA36-039-sc-87376

Ectrodactyly and lethal pulmonary acinar dysplasia associated with homozygous FGFR2 mutations identified by exome sequencing

First published: 11 July 2016Abstract not availableChristopher P. Barnett, Nathalie J. Nataren, Manuela Klingler-Hoffmann, Quenten Schwarz, Chan-Eng Chong, Young K. Lee, Damien L. Bruno, Jill Lipsett, Andrew J. McPhee, Andreas W. Schreiber, Jinghua Feng, Christopher N. Hahn, and Hamish S. Scot

Laser/optics techniques Second interim summary report

Transmit beam offset and coarse acquisition subsystems for laser/optics technique breadboard and acquisition and track simulatio

Laser/optics techniques Interim summary report

Laboratory prototype laser telescope package for deep space communication

Laser/optics techniques Summary report

Gas laser and telescope techniques for deep space optical communication syste

Primary and malignant cholangiocytes undergo CD40 mediated Fas dependent Apoptosis, but are insensitive to direct activation with exogenous fas ligand

Introduction Cholangiocarcinoma is a rare malignancy of the biliary tract, the incidence of which is rising, but the pathogenesis of which remains uncertain. No common genetic defects have been described but it is accepted that chronic inflammation is an important contributing factor. We have shown that primary human cholangiocyte and hepatocyte survival is tightly regulated via co-operative interactions between two tumour necrosis family (TNF) receptor family members; CD40 and Fas (CD95). Functional deficiency of CD154, the ligand for CD40, leads to a failure of clearance of biliary tract infections and a predisposition to cholangiocarcinoma implying a direct link between TNF receptor-mediated apoptosis and the development of cholangiocarcinoma. Aims To determine whether malignant cholangiocytes display defects in CD40 mediated apoptosis. By comparing CD40 and Fas-mediated apoptosis and intracellular signalling in primary human cholangiocytes and three cholangiocyte cell lines. Results Primary cholangiocytes and cholangiocyte cell lines were relatively insensitive to direct Fas-mediated killing with exogenous FasL when compared with Jurkat cells, which readily underwent Fas-mediated apoptosis, but were extremely sensitive to CD154 stimulation. The sensitivity of cells to CD40 activation was similar in magnitude in both primary and malignant cells and was STAT-3 and AP-1 dependent in both. Conclusions 1) Both primary and malignant cholangiocytes are relatively resistant to Fas–mediated killing but show exquisite sensitivity to CD154, suggesting that the CD40 pathway is intact and fully functional in both primary and malignant cholangiocytes 2) The relative insensitivity of cholangiocytes to Fas activation demonstrates the importance of CD40 augmentation of Fas dependent death in these cells. Agonistic therapies which target CD40 and associated intracellular signalling pathways may be effective in promoting apoptosis of malignant cholangiocytes