60 research outputs found
Efficacy of an autogenous vaccine against highly virulent "Staphylococcus aureus" infection in rabbits
[EN] The efficacy of an autogenous vaccine consisting of a whole cell suspension of formalin killed bacteria in sterile buffered saline against Staphylococcus aureus infections was determined, using a well-established rabbit skin infection model. Thirteen eight-week-old rabbits were vaccinated twice subcutaneously with a two-week interval while ten rabbits were injected twice with sterile buffered saline. Two weeks after the last injection, ten vaccinated and all PBS-injected rabbits were inoculated intradermally with 108 cfu of a S. aureus strain which had been shown to be highly virulent for rabbits. Three vaccinated animals served as negative controls and were intradermally injected with sterile buffered saline. All rabbits were examined daily for the development of skin lesions until fourteen days after the experimental infection when all rabbits were euthanised. All animals experimentally infected with S. aureus developed skin abscesses within 24 hours post-inoculation, but in the vaccinated group the maximum abscess diameter was significantly lower than in the non-vaccinated group (P=0.048). The difference between the autovaccinated and non-vaccinated group increased over time (P<0.001). These results indicate that vaccination with an inactivated whole cell bacterin may be useful for control of staphylococcosis in rabbits but does not prevent abscess formation in animals inoculated with a high dose of a highly virulent S. aureus strain.Meulemans, G.; Haesebrouck, F.; Lipinska, U.; Duchateau, L.; Hermans, K. (2011). Efficacy of an autogenous vaccine against highly virulent "Staphylococcus aureus" infection in rabbits. World Rabbit Science. 19(1):1-9. https://doi.org/10.4995/wrs.2011.8121919
Molecular evolution of candidate male reproductive genes in the brown algal model Ectocarpus
Сетевая система контроля технологического процесса выращивания полупроводниковых кристаллов и тонких пленок
Экспериментальное моделирование аппаратно-программного обеспечения показало достаточную надежность работы системы и значительное уменьшение трудоемкости контроля и управления параметрами технологического процесса
Retrospective study on the occurrence of <em>Staphylococcus aureus</em> clonal complex 398 among porcine isolates from the 1970s
Characterization of a Novel Panton-Valentine Leukocidin (PVL)-Encoding Staphylococcal Phage and Its Naturally PVL-Lacking Variant
Ab-Initio Guided Design of Twinning Induced Plasticity and Weight Reduced Austenitic Steels
Identification of the Escherichia coli sohB gene, a multicopy suppressor of the HtrA (DegP) null phenotype
The Yersinia enterocolitica GsrA stress protein, involved in intracellular survival, is induced by macrophage phagocytosis
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