Экспериментальное моделирование аппаратно-программного обеспечения показало достаточную надежность работы системы и значительное уменьшение трудоемкости контроля и управления параметрами технологического процесса

A Abendroth

A Halenius

A Hill

A Jons

A Kenneson

A Kienast

A Kodan

AD Hislop

AD Kwong

AD Lipinska

AJ Davison

AJ Eisfeld

Andrew J. Davison

B Galocha

B Glaunsinger

B Park

B Sadasivan

BB Finlay

Bryan D. Griffin

C Liang

CJ Powers

CL Perria

D Alzhanova

D Beinert

D Horst

D Koppers-Lalic

D Nachmani

Daniëlle Horst

DJ McGeoch

DR Peaper

E Procko

EA Armandola

EA Reits

EJ Wiertz

Emmanuel J. H. J. Wiertz

EO Long

EW Hewitt

F Momburg

F Seyffer

GW Wilkinson

H de la Salle

H Hengel

H Ziegler

HT Moins-Teisserenc

IA York

J Geng

J Kim

J Koch

J Lin

J Rudolph

J Yuan

J Zuo

JA Campbell

JE Bigger

JH Cox

JM Boname

JM Middeldorp

JO Koopmann

JS Burgos

K Ahn

K Fruh

K Goldsmith

K Grauwet

Kasturi Haldar

L Coscoy

L Lybarger

L Neumann

L Saveanu

LL Quinn

M Byun

M Chen

M Hohl

M Nijenhuis

M Raghavan

M Rowe

M Vasireddi

MA Epstein

Maaike E. Ressing

Marieke C. Verweij

MC Verweij

ME Ressing

MF Princiotta

MJ Androlewicz

ML Fenwick

N Grossmann

Технология и конструирование в электронной аппаратуре

PubMed

Herpesviruses are large DNA viruses that are highly abundant within their host populations. Even in the presence of a healthy immune system, these viruses manage to cause lifelong infections. This persistence is partially mediated by the virus entering latency, a phase of infection characterized by limited viral protein expression. Moreover, herpesviruses have devoted a significant part of their coding capacity to immune evasion strategies. It is believed that the close coexistence of herpesviruses and their hosts has resulted in the evolution of viral proteins that specifically attack multiple arms of the host immune system. Cytotoxic T lymphocytes (CTLs) play an important role in antiviral immunity. CTLs recognize their target through viral peptides presented in the context of MHC molecules at the cell surface. Every herpesvirus studied to date encodes multiple immune evasion molecules that effectively interfere with specific steps of the MHC class I antigen presentation pathway. The transporter associated with antigen processing (TAP) plays a key role in the loading of viral peptides onto MHC class I molecules. This is reflected by the numerous ways herpesviruses have developed to block TAP function. In this review, we describe the characteristics and mechanisms of action of all known virus-encoded TAP inhibitors. Orthologs of these proteins encoded by related viruses are identified, and the conservation of TAP inhibition is discussed. A phylogenetic analysis of members of the family Herpesviridae is included to study the origin of these molecules. In addition, we discuss the characteristics of the first TAP inhibitor identified outside the herpesvirus family, namely, in cowpox virus. The strategies of TAP inhibition employed by viruses are very distinct and are likely to have been acquired independently during evolution. These findings and the recent discovery of a non-herpesvirus TAP inhibitor represent a striking example of functional convergent evolution

Marieke C Verweij

Bryan D Griffin

Rutger D Luteijn

Andrew J Davison

Maaike E Ressing

Emmanuel J H J Wiertz

Directory of Open Access Journals

PLoS Pathogens

Viral inhibition of the transporter associated with antigen processing (TAP): a striking example of functional convergent evolution.

Rutger D. Luteijn

Crossref

Viral Inhibition of the Transporter Associated with Antigen Processing (TAP): A Striking Example of Functional Convergent Evolution

Verweij, Marieke C.

Horst, Daniëlle

Griffin, Bryan D.

Luteijn, Rutger D.

Davison, Andrew J.

Ressing, Maaike E.

Wiertz, EJHJ

NARCIS 

Viral Inhibition of the Transporter Associated with Antigen Processing (TAP) : A Striking Example of Functional Convergent Evolution

Wiertz, Emmanuel J.H.J.

Enlighten

English

Viral inhibition of the transporter associated with antigen processing (TAP): a striking example of functional convergent evolution

Enlighten: Publications

Utrecht University Repository

http://eprints.gla.ac.uk/107667/1/107667.pdf