64 research outputs found
Potential of denufosol as an early intervention in CF lung disease: efficacy in patients with minimal pharmacotherapy in a US phase 3 clinical trial
Low Mach number effect in simulation of high Mach number flow
In this note, we relate the two well-known difficulties of Godunov schemes:
the carbuncle phenomena in simulating high Mach number flow, and the inaccurate
pressure profile in simulating low Mach number flow. We introduced two simple
low-Mach-number modifications for the classical Roe flux to decrease the
difference between the acoustic and advection contributions of the numerical
dissipation. While the first modification increases the local numerical
dissipation, the second decreases it. The numerical tests on the double-Mach
reflection problem show that both modifications eliminate the kinked Mach stem
suffered by the original flux. These results suggest that, other than
insufficient numerical dissipation near the shock front, the carbuncle
phenomena is strongly relevant to the non-comparable acoustic and advection
contributions of the numerical dissipation produced by Godunov schemes due to
the low Mach number effect.Comment: 9 pages, 1 figur
MidA is a putative methyltransferase that is required for mitochondrial complex I function
10 páginas, 6 figuras.-- et al.Dictyostelium and human MidA are homologous proteins that belong to a family of proteins of unknown function called DUF185. Using yeast two-hybrid screening and pull-down experiments, we showed that both proteins interact with the mitochondrial complex I subunit NDUFS2. Consistent with this, Dictyostelium cells lacking MidA showed a specific defect in complex I activity, and knockdown of human MidA in HEK293T cells resulted in reduced levels of assembled complex I. These results indicate a role for MidA in complex I assembly or stability. A structural bioinformatics analysis suggested the presence of a methyltransferase domain; this was further supported by site-directed mutagenesis of specific residues from the putative catalytic site. Interestingly, this complex I deficiency in a Dictyostelium midA- mutant causes a complex phenotypic outcome, which includes phototaxis and thermotaxis defects. We found that these aspects of the phenotype are mediated by a chronic activation of AMPK, revealing a possible role of AMPK signaling in complex I cytopathology.This work was supported by grants BMC2006-00394 and BMC2009-09050 to R.E. from the Spanish Ministerio de Ciencia e Innovación; to P.R.F. from the Thyne Reid Memorial Trusts and the Australian Research Council; to A.V. and O.G. from the Spanish National Bioinformatics Institute (www.inab.org), a platform of Genome Spain; to R.G. from the Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, Spain (PI070167) and from the Comunidad de Madrid (GEN-0269/2006). S.C. is supported by a research contract from ConsejerÃa de Educación de la Comunidad de Madrid y del Fondo Social Europeo (FSE).Peer Reviewe
Four years of Ulysses dust data: 1996 to 1999
The Ulysses spacecraft is orbiting the Sun on a highly inclined ellipse (, perihelion distance 1.3 AU, aphelion distance 5.4 AU). Between
January 1996 and December 1999 the spacecraft was beyond 3 AU from the Sun and
crossed the ecliptic plane at aphelion in May 1998. In this four-year period
218 dust impacts were recorded with the dust detector on board. We publish and
analyse the complete data set of both raw and reduced data for particles with
masses to g. Together with 1477 dust impacts
recorded between launch of Ulysses and the end of 1995 published earlier
\cite{gruen1995c,krueger1999b}, a data set of 1695 dust impacts detected with
the Ulysses sensor between October 1990 and December 1999 is now available. The
impact rate measured between 1996 and 1999 was relatively constant with about
0.2 impacts per day. The impact direction of the majority of the impacts is
compatible with particles of interstellar origin, the rest are most likely
interplanetary particles. The observed impact rate is compared with a model for
the flux of interstellar dust particles. The flux of particles several
micrometers in size is compared with the measurements of the dust instruments
on board Pioneer 10 and Pioneer 11 beyond 3 AU (Humes 1980, JGR, 85,
5841--5852, 1980). Between 3 and 5 AU, Pioneer results predict that Ulysses
should have seen five times more ( sized) particles than
actually detected.Comment: accepted by Planetary and Space Science, 22 pages, 8 figures (1
colour figure
Formulation of Kinetic Energy Preserving Conservative Schemes for Gas Dynamics and Direct Numerical Simulation of One-Dimensional Viscous Compressible Flow in a Shock Tube Using Entropy and Kinetic Energy Preserving Schemes
The Construction of Discretely Conservative Finite Volume Schemes that Also Globally Conserve Energy or Entropy
Relaxation time of the order parameter in a high-temperature superconductor
We present femtosecond time-resolved measurements on the high-Tc superconductor Tl2Ba2Ca2Cu3O10. At temperatures below Tc, we observe a relaxation process which is distinct from the equilibration of hot carriers in the normal state. Our results demonstrate an increasing relaxation rate as the superconducting gap opens. This is consistent with the behavior of conventional metallic superconductors
An implementation of the robust inviscid wall boundary condition in high-speed flow calculations
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