18 research outputs found
Primary spinal cord tumors of childhood: effects of clinical presentation, radiographic features, and pathology on survival
To determine the relationship between clinical presentation, radiographic features, pathology, and treatment on overall survival of newly diagnosed pediatric primary spinal cord tumors (PSCT). Retrospective analysis of all previously healthy children with newly diagnosed PSCT at a single institution from 1995 to present was performed. Twenty-five pediatric patients (15 boys, average 7.9Â years) were diagnosed with PSCT. Presenting symptoms ranged from 0.25 to 60Â months (average 7.8Â months). Symptom duration was significantly shorter for high grade tumors (average 1.65Â months) than low grade tumors (average 11.2Â months) (PÂ =Â 0.05). MRI revealed tumor (8 cervical, 17 thoracic, 7 lumbar, 7 sacral) volumes of 98â94,080Â mm3 (average 19,474Â mm3). Homogeneous gadolinium enhancement on MRI correlated with lower grade pathology (PÂ =Â 0.003). There was no correlation between tumor grade and volume (PÂ =Â 0.63) or edema (PÂ =Â 0.36) by MRI analysis. Median survival was 53Â months and was dependent on tumor grade (PÂ =Â 0.05) and gross total resection (PÂ =Â 0.01) but not on gender (PÂ =Â 0.49), age of presentation (PÂ =Â 0.82), duration of presenting symptoms (PÂ =Â 0.33), or adjuvant therapies (PÂ =Â 0.17). Stratified KaplanâMeier analysis confirmed the association between degree of resection and survival after controlling for tumor grade (PÂ =Â 0.01). MRI homogeneous gadolinium enhancement patterns may be helpful in distinguishing low grade from high grade spinal cord malignancies. While tumor grade and gross total resection rather than duration of symptoms correlated with survival in our series, greater than one-third of patients had reported symptoms greater than 6Â months duration prior to diagnosis
Retrospective analysis of 104 histologically proven adult brainstem gliomas: clinical symptoms, therapeutic approaches and prognostic factors
Childhood glioblastoma multiforme of the spinal cord
Article first published online: 20 JUL 2006Astrocytoma accounts for more than 50% of all central nervous system tumours diagnosed, with particular prevalence in the 15- to 34-year-old age bracket, rarely arising in younger children. In 1995, a 7-year-old boy presented in Emergency with a 3-day history of severe radicular back pain and associated muscle spasms, exacerbated by lying on his back. Both bone scan and plain X-rays were unremarkable; however, MRI showed a 3-cm space-occupying lesion at the level of T5-T6. The patient proceeded to biopsy and partial excision of the tumour through laminectomy, histology confirming an anaplastic astrocytoma (glioblastoma multiforme), St Anne Mayo grade 4. Treatment consisted of a radical course of radiotherapy alone, delivering a total dose of 44.8 Gy at 1.6 Gy per fraction. The treatment comprised of three phases using two oblique wedged fields on a 6 MV linear accelerator. The patient remains disease free 7 years post treatment, with the only effect noted being a slight kyphoscoliosis at the site of the laminectomy and radiation. This report highlights the efficacy of combined surgery and radiation therapy in the management of spinal cord glioblastoma multiforme in preventing tumour recurrence, with acceptable morbidity. Further evaluation of the treatment efficacy would be difficult because of the scarcity of such cases.C Oake, MF Borg, A Hanieh and RW Byar