My Intriguing Search for William J. Cleghorn

William Cleghorn was born in Savannah to Harriet Clark in 1822. A black man, skilled in the baking profession, was given his freedom, along with his wife and two children in 1846. Cornelia, his wife was a seamstress and Francis M. Stone was her guardian. In 1850, Mr. Cleghorn began to be noted in Savannah for his fine catering to social gatherings hosted by white society members. His reputation grew and more opportunities for his services were presented throughout his career.https://digitalcommons.georgiasouthern.edu/sav-bios-lane/1038/thumbnail.jp

Theme and Content of Delusions in Asian Indian Psychotic Patients: Correlation with Diagnosis

The aim of this study was to investigate the types of delusions present in Asian Indian psychotic patients and evaluate correlation with patient diagnosis. Delusional narratives were collected from 50 Indian patients with schizophrenia or an affective disorder. These narratives were judged for delusional theme and content and were correlated with DSM-III-R diagnoses. Using simple categorical analysis, delusional themes of grandiosity and guilt correlated with affective diagnoses. Delusional themes of reference and Schneiderian types were more often associated with schizophrenia. These findings support the concept that delusional themes can be used as valid diagnostic clues in the assessment of psychotic Indian patients

A course of study in the history of Salem, Massachusetts.

Thesis (M.A.)--Boston Universit

A study of the cooperative-training programs in retail selling in the high schools of California, Oregon, and Washington.

Thesis (M.A.)--Boston Universit

Assessment of Carbon Monoxide Levels in Four Vehicle Remarketing Facilities

At vehicle remarketing facilities, also known as auto auctions, unacceptable carbon monoxide levels are possible due to vehicles running in an enclosed building. This study assesses and compares the levels of carbon monoxide at four vehicle remarketing facilities. The facilities were separated by vehicle volume and designated as large, medium, small A, and small B facility. The carbon monoxide levels at the large dealer auction were lower than the levels at the medium and small facilities. The levels at the large auction were within health and safety guidelines while there was at least one breach of guidelines at the three public facilities. Several factors could have contributed to the variation such as differences in ventilation characteristics, the nature of the auction, and vehicle characteristics. The conclusion was that the levels of carbon monoxide at certain vehicle auctions were not within certain occupational and public health standards. Levels such as were recorded during sampling could pose health problems for sensitive population within the general population.Master of Science in Public Healt

Trigeminal neuralgia

Trigeminal neuralgia is a rare, episodic facial pain that is unilateral, electric shock-like, and provoked by light touch. At first, it is often mistaken as a tooth problem owing to its presentation in the two lower branches of the trigeminal nerve. Patients may undergo unnecessary—and sometimes irreversible—dental treatment before the condition isrecognised. Initially, a small dose of an antiepileptic drug (such as carbamazepine) rather than any analgesic drug can provide excellent pain relief. However, up to 10% of patients will not respond to antiepileptic drugs,1 and in rare instances trigeminal neuralgia can be secondary to a brain tumour, multiple sclerosis, or vascular anomalies, which will be identified only on neuroimaging.2 If quality of life becomes impaired and symptoms are uncontrolled with drug treatment, patientsshould be referred to a neurosurgeon for consideration of surgical management. Studies in Europe have shown that trigeminal neuralgia results in considerable interference with activities of daily living that is comparable to other neuropathic pain conditions,3 and could lead to suicide.4 This review aims to highlight the key features of trigeminal neuralgia and familiarise readers with both the medical and surgical management of this condition, which remains based on limited evidence and expert opinion

Trigeminal neuralgia

Trigeminal neuralgia is a rare, episodic facial pain that is unilateral, electric shock-like, and provoked by light touch. At first, it is often mistaken as a tooth problem owing to its presentation in the two lower branches of the trigeminal nerve. Patients may undergo unnecessary—and sometimes irreversible—dental treatment before the condition isrecognised. Initially, a small dose of an antiepileptic drug (such as carbamazepine) rather than any analgesic drug can provide excellent pain relief. However, up to 10% of patients will not respond to antiepileptic drugs,1 and in rare instances trigeminal neuralgia can be secondary to a brain tumour, multiple sclerosis, or vascular anomalies, which will be identified only on neuroimaging.2 If quality of life becomes impaired and symptoms are uncontrolled with drug treatment, patientsshould be referred to a neurosurgeon for consideration of surgical management. Studies in Europe have shown that trigeminal neuralgia results in considerable interference with activities of daily living that is comparable to other neuropathic pain conditions,3 and could lead to suicide.4 This review aims to highlight the key features of trigeminal neuralgia and familiarise readers with both the medical and surgical management of this condition, which remains based on limited evidence and expert opinion

The role of EGFR double minutes in modulating the response of malignant gliomas to radiotherapy.

EGFR amplification in cells having double minute chromosomes (DM) is commonly found in glioblastoma multiforme (GBM); however, how much it contributes to the current failure to treat GBM successfully is unknown. We studied two syngeneic primary cultures derived from a GBM with and without cells carrying DM, for their differential molecular and metabolic profiles, in vivo growth patterns, and responses to irradiation (IR). Each cell line has a distinct molecular profile consistent with an invasive "go" (with DM) or angiogenic "grow" phenotype (without DM) demonstrated in vitro and in intracranial xenograft models. Cells with DM were relatively radio-resistant and used higher glycolytic respiration and lower oxidative phosphorylation in comparison to cells without them. The DM-containing cell was able to restore tumor heterogeneity by mis-segregation of the DM-chromosomes, giving rise to cell subpopulations without them. As a response to IR, DM-containing cells switched their respiration from glycolic metabolism to oxidative phosphorylation and shifted molecular profiles towards that of cells without DM. Irradiated cells with DM showed the capacity to alter their extracellular microenvironment to not only promote invasiveness of the surrounding cells, regardless of DM status, but also to create a pro-angiogenic tumor microenvironment. IR of cells without DM was found primarily to increase extracellular MMP2 activity. Overall, our data suggest that the DM-containing cells of GBM are responsible for tumor recurrence due to their high invasiveness and radio-resistance and the mis-segregation of their DM chromosomes, to give rise to fast-growing cells lacking DM chromosomes