Shuttle orbiter S-band quad antenna switching evaluation

Automatic switching of the shuttle orbiter S-band quad antennas by the orbiter on-board computers was evaluated. The development and use of an extensive computer program to determine antenna switch position states as a function of time for various orbital activities is described. The selection of the optimum quad antenna element at any given time is based on the look angle to the appropriate Tracking Data Relay Satellite (TDRS). It is shown that a 2.4 second period is required for updating the S-band quad antenna switch state based on a maximum roll rate of 2 deg per second. The possibility of a variable update period is suggested since the 2 deg per second attitude rate is seldom encountered and would, for example, dictate approximately 248,000 on-board computer calculations during Reference Mission 2. The average number of antenna switch state changes was found to be in the range of 1,300 for Reference Mission 2

Reliability Analysis of Complex NASA Systems with Model-Based Engineering

The emergence of model-based engineering, with Model- Based Systems Engineering (MBSE) leading the way, is transforming design and analysis methodologies. The recognized benefits to systems development include moving from document-centric information systems and document-centric project communication to a model-centric environment in which control of design changes in the life cycles is facilitated. In addition, a single source of truth about the system, that is up-to-date in all respects of the design, becomes the authoritative source of data and information about the system. This promotes consistency and efficiency in regard to integration of the system elements as the design emerges and thereby may further optimize the design. Therefore Reliability Engineers (REs) supporting NASA missions must be integrated into model-based engineering to ensure the outputs of their analyses are relevant and value-needed to the design, development, and operational processes for failure risks assessment and communication

Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness

Since its discovery nearly 40 years ago, p53 has ascended to the forefront of investigated genes and proteins across diverse research disciplines and is recognized most exclusively for its role in cancer as a tumor suppressor. Levine and Oren (2009) reviewed the evolution of p53 detailing the significant discoveries of each decade since its first report in 1979. In this review, we will highlight the emerging non-canonical functions and regulation of p53 in stem cells. We will focus on general themes shared among p53's functions in non-malignant stem cells and cancer stem-like cells (CSCs) and the influence of p53 on the microenvironment and CSC niche. We will also examine p53 gain of function (GOF) roles in stemness. Mutant p53 (mutp53) GOFs that lead to survival, drug resistance and colonization are reviewed in the context of the acquisition of advantageous transformation processes, such as differentiation and dedifferentiation, epithelial-to-mesenchymal transition (EMT) and stem cell senescence and quiescence. Finally, we will conclude with therapeutic strategies that restore wild-type p53 (wtp53) function in cancer and CSCs, including RING finger E3 ligases and CSC maintenance. The mechanisms by which wtp53 and mutp53 influence stemness in non-malignant stem cells and CSCs or tumor-initiating cells (TICs) are poorly understood thus far. Further elucidation of p53's effects on stemness could lead to novel therapeutic strategies in cancer research

Measurement of mutual inductance from frequency dependence of impedance of AC coupled circuit using digital dual-phase lock-in amplifier

We present a simple method to determine the mutual inductance $M$ between two coils in a coupled AC circuit by using a digital dual-phase lock-in amplifier. The frequency dependence of the real and imaginary parts is measured as the coupling constant is changed. The mutual inductance $M$ decreases as the distance $d$ between the centers of coils is increased. We show that the coupling constant is proportional to $d^{-n}$ with an exponent $n$ ($\approx$ 3). This coupling is similar to that of two magnetic moments coupled through a dipole-dipole interaction.Comment: 9 pages, 10 figures, Fig.1 is corrected, figures in png files, short version is published in Am. J. Phys. 76, (2008) 12

A simplified protocol for detecting two systemic bait markers (Rhodamine B and iophenoxic acid) in small mammals

We developed a method of quantifying levels of fluorescence in the whiskers of wild stoats (Mustela erminea) using fluorescence microscopy and Axiovision 3.0.6.1 software. The method allows for discrimination between natural fluorescence present in or on a whisker, and the fluorescence resulting from the ingestion of the systemic marker Rhodamine B (RB), although some visual judgement is still required. We also developed a new high performance liquid chromatography (HPLC) protocol for detecting the systemic marker iophenoxic acid (IPA) in the blood of laboratory rats (Rattus norvegicus) and wild stoats. With this method, the blood of an animal that has consumed IPA can be tested for the presence of the foreign IPA compound itself. This is a more reliable test than the previous method, which measured the raised level of natural blood protein-bound iodine correlated with IPA absorption. The quantity of blood required from animal subjects is very small (10 μl), so the testing is less intrusive and the method can be extended to smaller species. The extraction technique uses methanol, rather than acids and heavy metal salts, thereby simplifying the procedure. Recovery of IPA is quantitative, giving a highly reliable reading. In experiments on captive rats the IPA method proved successful. Of 12 positively marked carcasses, two that had not been frozen for the 24 h before blood samples were taken showed relatively lower IPA levels. The same IPA detection method, as well as the whisker analysis for RB, was applied successfully to a population of wild stoats to which both Rhodamine B and IPA were made available at bait stations. The presence of both bait markers was detectable in rats for at least 21 days and in stoats for at least 27 days

Fostering Global-Mindedness in Teacher Preparation

Teacher education programs require attention to the rapid changes in the world, in part because populations are becoming increasingly diverse. These rapidly changing classroom environments have prompted a need to train teachers who can communicate with and teach students from increasingly diverse backgrounds. In addition, they must have an understanding of cultural family values and practices which influence individual students among the various ethnic populations they teach. This paper will describe steps taken by one College of Education to create international partnerships and learning experiences in an effort to enhance their teacher training programs and develop an environment of global-mindedness

Pre-tenured Counselor Educators Engagement in Direct Counseling Service: Results of a National Survey

One hundred and fifty pre-tenured counselor education assistant professors participated in a survey regarding their engagement of direct counseling service (DCS). Both quantitative and qualitative data was analyzed. Participants reported significant restrictions on time and a lack of departmental support for DCS and a perception that DCS will not be valued within the tenure processes. However, the majority of pre-tenured faculty desired to engage in more DCS to maintain skills and enhance their teaching and scholarship. Data regarding the participation of DCS by pre-tenured faculty, and implications for counselor educators are shared

Climate adaptation by crop migration.

Many studies have estimated the adverse effects of climate change on crop yields, however, this literature almost universally assumes a constant geographic distribution of crops in the future. Movement of growing areas to limit exposure to adverse climate conditions has been discussed as a theoretical adaptive response but has not previously been quantified or demonstrated at a global scale. Here, we assess how changes in rainfed crop area have already mediated growing season temperature trends for rainfed maize, wheat, rice, and soybean using spatially-explicit climate and crop area data from 1973 to 2012. Our results suggest that the most damaging impacts of warming on rainfed maize, wheat, and rice have been substantially moderated by the migration of these crops over time and the expansion of irrigation. However, continued migration may incur substantial environmental costs and will depend on socio-economic and political factors in addition to land suitability and climate