Do we need to rethink guidance on repeated interviews?

Within the legal system, children are frequently interviewed about their experiences more than once, with different information elicited in different interviews. The presumed positive and negative effects of multiple interviewing have generated debate and controversy within the legal system and among researchers. Some commentators emphasise that repeated interviews foster inaccurate recall and are inherently suggestive, whereas others emphasise the benefits of allowing witnesses more than one opportunity to recall information. In this article we briefly review the literature on repeated interviewing before presenting a series of cases highlighting what happens when children are interviewed more than once for various reasons. We conclude that, when interviewers follow internationally recognised best-practice guidelines emphasising open-questions and free memory recall, alleged victims of abuse should be interviewed more than once to ensure that more complete accounts are obtained. Implications for current legal guidelines concerning repeated interviewing are discussed

Physically founded phonon dispersions of few-layer materials, and the case of borophene

An increasing number of theoretical calculations on few-layer materials have been reporting a non-zero sound velocity for all three acoustic phonon modes. In contrast with these reports, here we show that the lowest phonon dispersion branch of atomistically described few-layer materials should be quadratic, and this can have dramatic consequencies on calculated properties, such as the thermal conductivity. By reformulating the interatomic force constants (IFC) in terms of internal coordinates, we find that a delicate balance between the IFCs is responsible for this quadraticity. This balance is hard to obtain in ab-initio calculations even if all the symmetries are numerically enforced a posteriori, but it arises naturally in our approach. We demonstrate the phenomenon in the case of borophene, where a very subtle correction to the ab-initio IFCs yields the physically correct quadratic dispersion, while leaving the rest of the spectrum virtually unmodified. Such quadraticity nevertheless has a major effect on the computed lattice thermal conductivity, which in the case of borophene changes by more than a factor 2, and reverses its anisotropy, when the subtle IFC correction is put in place

Research and assessment methods for leadership development in practice

While the field of leadership education continues to grow in terms of number of programs, students, and associated professional educators, our rigorous understanding of the impact of these programs has continued to lag behind such growth. Many postsecondary leadership educators work on campuses and have graduated from masters-level preparatory programs that do not focus extensively on rigorous research/assessment methods and may, therefore, lack the background necessary for high-level work (Brachle et al., 2021; Rosch et al., 2017; Teig, 2018). As a result, researchers and program assessment staff often recognize the need to take their methodological development “into their own hands” to increase their knowledge and maintain the high standards of rigor required in well-developed fields. Advancements in leadership education have afforded the opportunity to facilitate leadership learning better today than 20 years ago or even 10 years ago. For example, advancements in leadership education have taught us the critical importance of undergirding leader/leadership development (LD) programs in leadership theory and research that match learner needs (Avolio et al., 2009; Day & Liu, 2019) – this is what separates leadership education from expensive leadership development consultations that lack depth and involve programs based on popular fads. Advancements in leadership education have taught us that leadership is an active and dynamic process, where leadership is not singularly about the leader (Day et al., 2014; Komives et al., 2013). Those who are not in formal leadership roles are not passive recipients of whatever the leader does, but rather have important voice and are an active and essential part of the leadership process. Thus, we are learning that LD programs must be multi-level (Day et al., 2014; DeRue & Myers, 2014; O’Connell, 2014) – LD cannot focus on individual leader development and expect the team to get better, but rather team leadership capacity must also be enhanced

Ascorbic Acid for the Treatment of Rasburicase induced Methemoglobinemia in the Setting of Acute Renal Failure

Purpose A case of apparent rasburicase-induced methemoglobinemia and acute kidney injury treated with i.v. ascorbic acid because of suspected glucose-6-phosphate dehydrogenase (G6PD) deficiency is reported. Summary A 46-year-old African-American man with a recent diagnosis of multiple myeloma and renal insufficiency was admitted to the hospital with a cough, hemoptysis, and fatigue. His medical history included hypertrophic cardiomyopathy, ventricular tachycardia, attention deficit/hyperactivity disorder, and pleural effusion. No treatments for multiple myeloma were started before hospital admission. Levofloxacin 750 mg orally daily for possible pneumonia, lenalidomide 10 mg orally daily, and dexamethasone 20 mg orally weekly were administered. Plasmapheresis was also initiated. Laboratory test results revealed sustained hyperuricemia, which was believed to be due in part to tumor lysis, and a single dose of rasburicase 6 mg i.v. was administered. Subsequently, the patient experienced a decrease in oxygen saturation. Methemoglobinemia was suspected, and the patient’s methemoglobin fraction was found to be 14.5%. The patient developed worsening shortness of breath and a drop in hemoglobin concentration, consistent with methemoglobinemia and hemolysis. Ascorbic acid 5 g i.v. every 6 hours was initiated for a total of six doses. Because the patient was assumed to have G6PD deficiency, which was later confirmed, methylene blue was avoided. Within 24 hours, the patient’s oxygen saturation values and symptoms improved. Conclusion A patient with apparent rasburicase-induced methemoglobinemia and acute kidney injury was treated with i.v. ascorbic acid (5 g every six hours for six doses) because of the possibility, later proved, that he had G6PD deficiency. The methemoglobinemia resolved without worsening of renal function

Infiltration and short-term movement of nitrogen in a silt-loam soil typical of rice cultivation in Arkansas

Rice production in Arkansas is one of the top three crop commodities in terms of cash receipts. Researchers and farmers report that nitrogen (N) needs to be managed according to a variety of factors with two important ones being soil and fertilizer type. The objectives of this experiment were to determine: 1) the degree to which floodwater-incorporated N applied as urea or as ammonium sulfate infiltrates intact cores (7.2-cm dia., 10-cm depth) containing DeWitt siltloam soil, and 2) the distribution of N during 12 h of ponding. Inorganic-N concentrations were analyzed at 2-cm depth intervals in cores following removal of the flood. Nitrogen from applied fertilizer was recovered as ammonium. Ammonium sulfate-N remained in the top 4 cm of soil with concentrations of 375 µg N g-1 in the surface 2 cm and 300 µg N g-1 at the 2 - 4 cm depth after 12 hr of ponding. At all depth intervals below 4 cm, ammonium sulfate-N remained below 30 µg N g-1. In contrast, after 12 h of ponding, N in soil receiving urea was 105 µg N g-1 in the top 2 cm and 173 µg N g-1 at 2-4 cm. At 4-6, 6-8, and 8-10 cm, N was 109, 108, and 35 µg N g-1, respectively, after 12 h of ponding. These results demonstrate immediate and deeper movement of ammonium into silt loam soil receiving urea as compared to ammonium sulfate, demonstrating how the form of N in fertilizer affects its movement into the soil profile

Book reviews

Teaching/Communication/Extension/Profession,

A quantitative empirical directing group scale for selectivity in iridium-catalysed hydrogen isotope exchange reactions

A palette of commonly used directing groups, including various pharmaceutically relevant nitrogen-containing heterocycles, are quantitatively ranked based on the results of intermolecular hydrogen isotope exchange competition reactions using two iridium complexes: [Ir(COD)(IMes)(PPh3)][BArF24] and [IrCl(COD)(IMes)]. The directing group power scales that have been constructed from these data reveal a wide range of reactivity covering four orders of magnitude. Intramolecular competition experiments have demonstrated that the obtained reactivity scale provides accurate predictions of regioselectivity within molecules with multiple competing directing groups. This work contributes to our understanding and control of regioselectivity in metal-catalysed C-H activation reactions

Quantitative prediction of selectivity in iridium-catalysed hydrogen isotope exchange reactions

A pallette of commonly used directing groups, including various pharmaceutically relevant nitrogen-containing heterocycles, are quantitatively ranked based on the results of intermolecular hydrogen isotope exchange competition reactions using two iridium complexes: [Ir(COD)(IMes)(PPh3)][BArF24] and [IrCl(COD)(IMes)]. The directing group power scales that have been constructred from these data reveal a wide range of reactivity covering four orders of magnitude. Intramolecular competition experiments have demonstrated that the obtained reactivity scale provides accurate predictions of regioselectivity within molecules with multiple competing directing groups. This work contributes to our understanding and control of regioselectivity in metal-catalysed C-H activation reactions

Analyzing point of care tools through faculty, resident, and stakeholder buy-in: a cautionary tale

Purpose: Costs for Preston Medical Library’s primary point-of-care (POC) clinical tool have increased to half of the acquisitions budget, while user affiliation data have not been provided to facilitate cost sharing. In response, user preferences for POC tools were analyzed to determine a viable, less expensive alternative to the current subscription. Setting/Participants/Resources: Faculty and residents at the University of Tennessee Graduate School of Medicine (GSM), and other clinical staff at the University of Tennessee Medical Center (UTMC), a 685-bed teaching hospital. Methodology: At the direction of school leadership, a working group of library staff, resident physicians, and medical faculty members was appointed, and data were gathered through individual user surveys of clinical support tools. Three POC tool options were considered. Select clinicians evaluated the tools using a series of questions individually chosen as typical to their disciplines. Additionally, feedback was sought from other AAHSL institutions regarding subscriptions to the tool in question and funding schemes. At the same time, the Dean communicated to the medical campus community that cost increases for the product had become prohibitive, requiring consideration of alternatives. Results/Outcomes: Survey responses revealed a strong preference for the incumbent tool, rating PubMed as the second preferred source, but not substitutable. Working group members preferred the current product at POC, judging one of the candidate tools as “adequate” but less user friendly and more time consuming to access. Hospital leadership also received responses from clinical staff. As a result, a cost sharing agreement with the school was forged. Discussion/Conclusion: A deliberative approach to assessing POC clinical tools was used, resulting in continued access to the preferred product. Enhanced data gathering on a go-forward basis will help to ascertain use patterns by academic and hospital users. The library and the other stakeholders will monitor development of alternative POC tools and costs for future decision making

Vancomycin minimum inhibitory concentration is not a substitute for clinical judgment: Response to healthcare-associated ventriculitis and meningitis

To the Editor—We read with interest the new clinical practice guideline for healthcare-associated ventriculitis and meningitis published in Clinical Infectious Diseases [1]. The guideline recommends consideration of alternative therapies for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis and ventriculitis for isolates with a vancomycin minimum in-hibitory concentration (MIC) ≥1μg/mL. We believe this recommendation places inappropriate emphasis on a single determinant of antimicrobial therapy that has uncertain clinical relevance and variable accuracy depending on the antimicrobial susceptibility testing (AST) method used. This may lead clinicians to use less well-evidenced strategies in cases likely to respond to vancomycin