E-Reserves in Transition: Exploring New Possibilities in E-Reserves Service Delivery

Nearly all academic libraries offer course reserves and most have long considered it a core library service. However, expanding use of course management systems in academia have opened new opportunities for libraries interested in exploring changes to electronic reserves services. Budget constraints and staffing shortages have also led several institutions to consider eliminating or modifying their e-reserves operations. Potentially difficult challenges, however, also accompany making significant changes to often well-established practices. This environmental scan of selected academic libraries across the United States discusses institutions which have maintained the status quo in e-reserves services, as well as those who have changed or discontinued these services. The article also provides insight on why some of the latter decided to make these changes

Nordic calibration comparison for radiotherapy dosemeters : Cylindrical and plane-parallel ionization chambers

Raportissa kuvataan pohjoismaisena yhteistyönä tehty mittausvertailu. Mittausvertailussa oli mukana viisi laboratoriota Pohjoismaista (Suomi, Ruotsi, Norja ja kaksi laboratoriota Tanskasta). Vertailussa käytettiin kahta erilaista sädehoidon annosmittauksissa käytettävää ionisaatiokammiota (sylinteri ja tasolevykammiot) sekä näihin liittyvää elektrometriä. Osallistuvat laboratoriota määrittivät kalibrointikertoimen veteen absorboituneelle annokselle näille ionisaatiokammioille Co-60 –säteilyllä. Lisäksi laboratoriot määrittivät joitakin ionisaatiokammioiden korjauskertoimia sekä elektrometrin herkkyyskorjauskertoimen, mikäli mittaukset oli mahdollista toteuttaa kyseissä laboratoriossa. Kaikki mittaustulokset ovat erittäin lähellä toisiaan epävarmuusarvioiden puitteissa ja ne tukevat hyvin kaikkien laboratorioiden mittauskykyä

Letter to editor

No abstract availabl

Impact of CD4 and CD8 dynamics and viral rebounds on loss of virological control in HIV controllers

Objective: HIV controllers (HICs) spontaneously maintain HIV viral replication at low level without antiretroviral therapy (ART), a small number of whom will eventually lose this ability to control HIV viremia. The objective was to identify factors associated with loss of virological control. Methods: HICs were identified in COHERE on the basis of \ue2\u89\ua55 consecutive viral loads (VL) \ue2\u89\ua4500 copies/mL over \ue2\u89\ua51 year whilst ART-naive, with the last VL \ue2\u89\ua4500 copies/mL measured \ue2\u89\ua55 years after HIV diagnosis. Loss of virological control was defined as 2 consecutive VL >2000 copies/mL. Duration of HIV control was described using cumulative incidence method, considering loss of virological control, ART initiation and death during virological control as competing outcomes. Factors associated with loss of virological control were identified using Cox models. CD4 and CD8 dynamics were described using mixed-effect linear models. Results: We identified 1067 HICs; 86 lost virological control, 293 initiated ART, and 13 died during virological control. Six years after confirmation of HIC status, the probability of losing virological control, initiating ART and dying were 13%, 37%, and 2%. Current lower CD4/CD8 ratio and a history of transient viral rebounds were associated with an increased risk of losing virological control. CD4 declined and CD8 increased before loss of virological control, and before viral rebounds. Discussion: Expansion of CD8 and decline of CD4 during HIV control may result from repeated low-level viremia. Our findings suggest that in addition to superinfection, other mechanisms, such as low grade viral replication, can lead to loss of virological control in HICs

COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study

Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41–0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02–1.04; HR = 1.79, 95% CI:1.04–3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated

The evolving landscape of COVID‐19 and post‐COVID condition in patients with chronic lymphocytic leukemia: A study by ERIC, the European research initiative on CLL

In this retrospective international multicenter study, we describe the clinical characteristics and outcomes of patients with chronic lymphocytic leukemia (CLL) and related disorders (small lymphocytic lymphoma and high-count monoclonal B lymphocytosis) infected by SARS-CoV-2, including the development of post-COVID condition. Data from 1540 patients with CLL infected by SARS-CoV-2 from January 2020 to May 2022 were included in the analysis and assigned to four phases based on cases disposition and SARS-CoV-2 variants emergence. Post-COVID condition was defined according to the WHO criteria. Patients infected during the most recent phases of the pandemic, though carrying a higher comorbidity burden, were less often hospitalized, rarely needed intensive care unit admission, or died compared to patients infected during the initial phases. The 4-month overall survival (OS) improved through the phases, from 68% to 83%, p = .0015. Age, comorbidity, CLL-directed treatment, but not vaccination status, emerged as risk factors for mortality. Among survivors, 6.65% patients had a reinfection, usually milder than the initial one, and 16.5% developed post-COVID condition. The latter was characterized by fatigue, dyspnea, lasting cough, and impaired concentration. Infection severity was the only risk factor for developing post-COVID. The median time to resolution of the post-COVID condition was 4.7 months. OS in patients with CLL improved during the different phases of the pandemic, likely due to the improvement of prophylactic and therapeutic measures against SARS-CoV-2 as well as the emergence of milder variants. However, mortality remained relevant and a significant number of patients developed post-COVID conditions, warranting further investigations

Copyright First Responders

Academic libraries grapple with copyright questions on a regular basis. As our work increasingly encompasses copyright-intensive programs and projects such as institutional repositories (IR), scholarly publishing, digital collections, open educational resources (OER), electronic reserves, streaming media, and MOOCs to name a few, the volume and complexity of copyright questions continues to expand. Although Orbis Cascade Alliance libraries are filled with copyright protected materials, most librarians and library need advanced copyright training as well as a peer support group to work through difficult, multifaceted copyright problems. This table talk will discuss an innovative copyright education and community of practice project known as CFRPNW – Copyright First Responders Pacific Northwest. Those who stop by the table will learn more about the project while engaging with CRFPNW Cohort 1 participants