Pharmacotherapy Safety and Efficacy in Adolescent Smoking Cessation

OBJECTIVE: To determine whether or not pharmacotherapy is a safe and effective treatment option for smoking cessation in adolescent

How do Millennial retail shopping habits for animal feed differ from that of other generations?

Master of AgribusinessDepartment of Agricultural EconomicsAleksan ShanoyanCompetition in the retail animal feed business can be challenging. Millennials are emerging as an increasingly important consumer group. Companies want to attract Millennials as new customers while at the same time retaining current customers of Baby Boomers and Gen X generations. Consequently, an important question is how do Millennial retail shopping habits for animal feed differ from that of other generations. To help answer this question the thesis research utilizes customer survey data obtained, from the Kent Nutrition Group. The data was collected through an online survey which was conducted with customers from Company W’s customer list. The total sample consists of 1068 customers. The data is analyzed using exploratory data analysis to gain insights on key differences and important attributes related to marketing and selling to customers from different generation groups. The results indicate that word of mouth serves as the largest initial source of awareness for all customers. Not surprisingly, the results show higher tendency to shop online and a preference for social media as a source of information by Millennials compared to Baby Boomers and Gen X customers. Knowledgeable staff and a positive in-store shopping experience continue to be a high priority for all customers. In general, e-mail or a mailed newsletter were identified as important communication methods by respondents of all generations. The results also show high preference by customers of all generations for receiving sales circulars and tips for animal and pet care. Sales circulars, direct mailers and newspaper ads are the core communication channels that customers view advertising from Company W. Three quarters of Company W’s customers expressed some level of interest in shopping online through Company W if the option were available. This implies that offering online shopping options will not only enhance the current customers’ experience but also attract new customers. The gained insights will be used by Company W to adapt and enhance their marketing and sales strategies to a) effectively engage and attract more Millennial customers and b) improve retention and service for customers of Baby Boomers and Gen X generations. The researcher will use the insights gained from this study to improve marketing efforts for the Kent Nutrition Group

Simultaneous Laser-induced Fluorescence of Nitric Oxide and Atomic Oxygen in the Hypersonic Materials Environment Test System Arcjet Facility

Simultaneous nitric oxide (NO) and atomic oxygen (O) laser induced fluorescence (LIF) experiments were performed in the Hypersonic Materials Environmental Test System (HYMETS) facility at the NASA Langley Research Center. The data serves as an experimental database for validation for chemical and thermal nonequilibrium models used in hypersonic flows. Measurements were taken over a wide range of stagnation enthalpies (6.7 - 18.5 MJ/kg) using an Earth atmosphere simulant with a composition of 75% N2, 20% O2, and 5% Ar (by volume). These are the first simultaneous measurements of NO and O LIF to be reported in literature for the HYMETS facility. The maximum O LIF mean signal intensity was observed at a stagnation enthalpy of approximately 12 MJ/kg while the maximum NO LIF mean signal intensity was observed at a stagnation enthalpy of 6.7 MJ/kg. Experimental results were compared to simple fluorescence model that assumes equilibrium conditions in the plenum and frozen chemistry in the isentropic nozzle expansion (Mach 5). The equilibrium calculations were performed using CANTERA v2.1.1 with 16 species. The fluorescence model captured the correlation in mean O and NO LIF signal intensities over the entire range of stagnation enthalpies tested. Very weak correlations between single-shot O and NO LIF intensities were observed in the experiments at all of the stagnation enthalpy conditions

A review of fatal accident incidence rate trends in fishing

Background: Injury prevention in fishing is one of the most important occupational health challenges.Aim: The aim was to describe and compare internationally the trends of the fatal injury incidence rates and to discuss the impact of the implemented safety programs.Materials and methods: The review is based on journal articles and reports from the maritime authorities in Poland, United Kingdom, Norway, Iceland, Denmark, United States and Alaska and Canada. The original incidence rates were recalculated as per 1,000 person-years for international comparison of the trends.Results: The risk of fatal accidents in fishing in the northern countries has been reduced by around 50% to an average of about 1 per 1,000 person-years. Norway and Canada keep the lowest rates with around 0.5 and 0.25 per 1,000 person-years. About half of the fatal injuries are related to vessel disasters and drowning. The safety programs seem to have good effects, but the risk is still about 25 to 50 times higher than for onshore workers.Conclusions: The overall fatal injury rates in the European and North American studies decreased by around 50% most probably as result of the implemented safety programs. However the high risk in fishing compared to onshore workers calls for continued and intensified safety programs

The Resurgence of the Adora2b Receptor as an Immunotherapeutic Target in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense desmoplastic stroma that impedes drug delivery, reduces parenchymal blood flow, and suppresses the anti-tumor immune response. The extracellular matrix and abundance of stromal cells result in severe hypoxia within the tumor microenvironment (TME), and emerging publications evaluating PDAC tumorigenesis have shown the adenosine signaling pathway promotes an immunosuppressive TME and contributes to the overall low survival rate. Hypoxia increases many elements of the adenosine signaling pathway, resulting in higher adenosine levels in the TME, further contributing to immune suppression. Extracellular adenosine signals through 4 adenosine receptors (Adora1, Adora2a, Adora2b, Adora3). Of the 4 receptors, Adora2b has the lowest affinity for adenosine and thus, has important consequences when stimulated by adenosine binding in the hypoxic TME. We and others have shown that Adora2b is present in normal pancreas tissue, and in injured or diseased pancreatic tissue, Adora2b levels are significantly elevated. The Adora2b receptor is present on many immune cells, including macrophages, dendritic cells, natural killer cells, natural killer T cells, γδ T cells, B cells, T cells, CD

The experience of family carers attending a joint reminiscence group with people with dementia: A thematic analysis

Reminiscence therapy has the potential to improve quality of life for people with dementia. In recent years reminiscence groups have extended to include family members, but carers' experience of attending joint sessions is undocumented. This qualitative study explored the experience of 18 family carers attending 'Remembering Yesterday Caring Today' groups. Semi-structured interviews were transcribed and subjected to thematic analysis. Five themes were identified: experiencing carer support; shared experience; expectations (met and unmet), carer perspectives of the person with dementia's experience; and learning and comparing. Family carers' experiences varied, with some experiencing the intervention as entirely positive whereas others had more mixed feelings. Negative aspects included the lack of respite from their relative, the lack of emphasis on their own needs, and experiencing additional stress and guilt through not being able to implement newly acquired skills. These findings may explain the failure of a recent trial of joint reminiscence groups to replicate previous findings of positive benefit. More targeted research within subgroups of carers is required to justify the continued use of joint reminiscence groups in dementia care

Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants.

A locus on human chromosome 11q23 tagged by marker rs3802842 was associated with colorectal cancer (CRC) in a genome-wide association study; this finding has been replicated in case-control studies worldwide. In order to identify biologic factors at this locus that are related to the etiopathology of CRC, we used microarray-based target selection methods, coupled to next-generation sequencing, to study 103 kb at the 11q23 locus. We genotyped 369 putative variants from 1,030 patients with CRC (cases) and 1,061 individuals without CRC (controls) from the Ontario Familial Colorectal Cancer Registry. Two previously uncharacterized genes, COLCA1 and COLCA2, were found to be co-regulated genes that are transcribed from opposite strands. Expression levels of COLCA1 and COLCA2 transcripts correlate with rs3802842 genotypes. In colon tissues, COLCA1 co-localizes with crystalloid granules of eosinophils and granular organelles of mast cells, neutrophils, macrophages, dendritic cells and differentiated myeloid-derived cell lines. COLCA2 is present in the cytoplasm of normal epithelial, immune and other cell lineages, as well as tumor cells. Tissue microarray analysis demonstrates the association of rs3802842 with lymphocyte density in the lamina propria (p = 0.014) and levels of COLCA1 in the lamina propria (p = 0.00016) and COLCA2 (tumor cells, p = 0.0041 and lamina propria, p = 6 × 10(-5)). In conclusion, genetic, expression and immunohistochemical data implicate COLCA1 and COLCA2 in the pathogenesis of colon cancer. Histologic analyses indicate the involvement of immune pathways

CD73-Generated Extracellular Adenosine Promotes Resolution of Neutrophil-Mediated Tissue Injury and Restrains Metaplasia in Pancreatitis

Pancreatitis is currently the leading cause of gastrointestinal hospitalizations in the US. This condition occurs in response to abdominal injury, gallstones, chronic alcohol consumption or, less frequently, the cause remains idiopathic. CD73 is a cell surface ecto-5\u27-nucleotidase that generates extracellular adenosine, which can contribute to resolution of inflammation by binding adenosine receptors on infiltrating immune cells. We hypothesized genetic deletion of CD73 would result in more severe pancreatitis due to decreased generation of extracellular adenosine. CD73 knockout (CD7

Results of a UK-wide vignette study with occupational therapists to explore cognitive screening post-stroke

Background. There is a paucity of evidence in the UK regarding occupational therapy (OT) cognitive screening, and whether, and how, cognitive impairments are identified and assessed. AimsTo identify current OT practice for the assessment of cognitive problems in patients following stroke.MethodsOTs were invited to complete an online vignette study. Participants were asked to identify any presenting cognitive problems, decide whether to complete cognitive assessments and list any assessments they would use. Data were analysed using descriptive analysis.Findings Fifty-three OTs from across the UK participated. OTs identified key cognitive issues but some problems, such as apraxia and attention, were overlooked. A large number of potential assessments were suggested: the most common were the Montreal Cognitive Assessment and Oxford Cognitive Screen. Conclusion The variation found in OTs’ recognition and assessment of cognitive problems has potential to impact on management and rehabilitation in stroke services, survivor outcomes, education and research