7 research outputs found
Enhancement of Immune Response Against Bordetella spp. by Disrupting Immunomodulation
- Author
- Publication venue
- The Research Repository @ WVU
- Publication date
- 01/01/2019
- Field of study
Well-adapted pathogens must evade clearance by the host immune system and the study of how they do this has revealed myriad complex strategies and mechanisms. Classical bordetellae are very closely related subspecies that are known to modulate adaptive immunity in a variety of ways, permitting them to either persist for life or repeatedly infect the same host. Exploring the hypothesis that exposure to immune cells would cause bordetellae to induce expression of important immunomodulatory mechanisms, we identified a putative regulator of an immunomodulatory pathway. The deletion of btrS in B. bronchiseptica did not affect colonization or initial growth in the respiratory tract of mice, its natural host, but did increase activation of the inflammasome pathway, and recruitment of inflammatory cells. The mutant lacking btrS recruited many more B and T cells into the lungs, where they rapidly formed highly organized and distinctive Bronchial Associated Lymphoid Tissue (BALT) not induced by any wild type Bordetella species, and a much more rapid and strong antibody response than observed with any of these species. Immunity induced by the mutant was measurably more robust in all respiratory organs, providing completely sterilizing immunity that protected against challenge infections for many months. Moreover, the mutant induced sterilizing immunity against infection with other classical bordetellae, including B. pertussis and B. parapertussis, something the current vaccines do not provide. These findings reveal profound immunomodulation by bordetellae and demonstrate that by disrupting it much more robust protective immunity can be generated, providing a pathway to greatly improve vaccines and preventive treatments against these important pathogens
Autoantibodies against type I IFNs in patients with critical influenza pneumonia
- Author
- 3c-dijon Study
- Abad Arranz Maria
- Abel Laurent
- Abel Laurent
- Abelenda Alonso Gabriela
- Abou Tayoun Ahmad
- Aguilar Guisado Manuela
- Aiuti Alessandro
- Al-muhsen Saleh
- Al-mulla Fahd
- Anderson Mark S.
- Andreakos Evangelos
- Andreakos Evangelos
- Argaud Laurent
- Arias Andrés A.
- Aydillo Teresa
- Balsera-manzanero MarĂa
- Baris Feldman Hagit
- Bastard Paul
- Belot Alexandre
- Belot Alexandre
- Biggs Catherine M.
- Bizien Lucy
- Boeuf Benoit
- Bogunovic Dusan
- Bolze Alexandre
- Bondarenko Anastasiia
- Bonneaudeau Brigitte
- Bousfiha Ahmed A.
- Briones Marisa
- Brodin Petter
- Bryceson Yenan
- Bustamante Carlos D.
- Butte Manish J.
- Cannet Dorothée
- Carratala Jordi
- Casalegno Jean Sebastien
- Casanova Jean Laurent
- Casanova Jean Laurent
- Casari Giorgio
- Castagnoli Riccardo
- Cerba Healthcare Group
- Christodoulou John
- Cobat Aurélie
- Coeuret Pellicer Mireille
- Cognasse Fabrice
- Colomb Benoit
- Condino-neto Antonio
- Constances Cohort
- Constantinescu Stefan N.
- Cooper Megan A.
- Cordero Elisa
- Covid Human Genetic Effort
- Cupic Anastasija
- Dalgard Clifton L.
- Darmon Michael
- Debette Stéphanie
- Debette Stéphanie
- Del Mar Muñoz Garcia Maria
- Desai Murkesh
- Dominguez Pinilla Nerea
- Drolet Beth A.
- Dufouil Carole
- El Baghdadi Jamila
- Escoresca Ortega Ana
- Espinosa Padilla Sara
- Etablissement Français Du Sang Study Group
- Etzioni Amos
- Fellay Jacques
- Ferreres José
- Ferres Marcela
- Feys Simon
- Fievet Nathalie
- Flaig Amandine
- Flores Carlos
- Fournet Thomas
- Fragkou Paraskevi C.
- Franco José Luis
- Froidure Antoine
- Galani Ioanna Evdokia
- Gallardo RĂos Rafaela
- Gallian Pierre
- GarcĂa Salum Tamara
- GarcĂa Sastre Adolfo
- Gervais Adrian
- Goavec Kelian
- Goldberg Marcel
- Gonzalez Granado Luis L.
- Gregersen Peter K.
- Grimbacher Bodo
- Haerynck Filomeen
- Haerynck Filomeen
- Hagin David
- Halwani Rabih
- Hammarström Lennart
- Hamzeh Cognasse Hind
- Hanna Suhair
- Heath James R.
- Henny Joseph
- Henrickson Sarah E.
- Hernu Romain
- Hsieh Elena W.Y.
- Husebye Eystein
- Imai Kohsuke
- Itan Yuval
- Jarvis Erich D.
- Javouhey Etienne
- Jeanne Michel
- Jouanguy Emmanuelle
- Karamitros Timokratis
- Kisand Kai
- Kisand Kai
- Koltsida Ourania
- Ku Cheng-lung
- Ku Cheng-lung
- Kuo Chen-yen
- Lachaize Morgane
- Lau Yu-lung
- Laurent Emilie
- Le Corre Nicole
- Le Got Stéphane
- Le Voyer Tom
- Lei Wei-te
- Lemonnier Sylvie
- Lina Bruno
- Ling Yun
- Lucas Carrie L.
- Lyon Antigrippe Working Group
- Maniatis Tom
- Manry Jeremy
- Mansouri Davood
- Martin Fernando
- MarĂłdi LĂĄszlĂł
- Medina Rafael A.
- Mehlal Sedkaoui Souad
- Merino DĂaz Laura
- Meyts Isabelle
- Meyts Isabelle
- Milner Joshua D.
- Miorin Lisa
- Mironska Kristina
- Mogensen Trine H.
- Morand Patrice
- Morel Pascal
- Morio Tomohiro
- Nadif Rachel
- Navarrete NicolĂĄs
- Ng Lisa F.P.
- NiubĂł Jordi
- Notarangelo Luigi D.
- Notarangelo Luigi D.
- Novelli Antonio
- Novelli Giuseppe
- O'farrelly Cliona
- Okada Satoshi
- Okamoto Keisuke
- Ozcelik Tayfun
- Ozguler Anna
- Padey Blandine
- Palomo Virginia
- Pan-hammarström Qiang
- Pape Jean W.
- Patural Hugues
- Peigue Lafeuille Helene
- Perez De Diego Rebeca
- Perlin David S.
- Perroquin Magali
- Pesole Graziano
- Philippot Quentin
- Pizzorno Andrés
- Planas Anna M.
- Pothier Pierre
- Pozzetto Bruno
- Prando Carolina
- Puel Anne
- Pujol Aurora
- Quenot Jean Pierre
- Queromes Gregory
- Quintana Murci Lluis
- Ramaswamy Sathishkumar
- RamĂrez Duque Nieves
- Rapti Vasiliki
- Reipi Inf Working Group
- Renia Laurent
- Resnick Igor
- Retamar Gentil Pilar
- Richard Pascale
- RodrĂguez De Castro Felipe
- RodrĂguez Gallego Carlos
- RodrĂguez-gallego Carlos
- Rombauts Alexander
- Romero Oraa Laura
- Romero VĂĄzquez Gloria MarĂa
- Rosa Calatrava Manuel
- Rosain Jérémie
- Rovina Nikoletta
- Ruiz Hernandez José Juan
- Saker Kahina
- Salamanca Rivera Celia
- Sallette JĂ©rĂŽme
- Sancho Shimizu Vanessa
- Schwebel Carole
- Sediva Anna
- SeppÀnen Mikko R.J.
- Shahrooei Mohammed
- Shcherbina Anna
- Slaby Ondrej
- Snow Andrew L.
- Soler PalacĂn Pere
- Solé Violån Jordi
- Soumaré Aïcha
- Souweine Bertrand
- Spaan AndrĂĄs N.
- Su Helen C.
- SĂĄnchez Cordero Maria Jose
- SĂĄnchez CĂ©spedes Javier
- SĂ€rekannu Karita
- Tal Galit
- Tancevski Ivan
- Tangye Stuart G.
- Temel Ćehime GĂŒlsĂŒn
- Tiberghien Pierre
- Tiberghien Pierre
- Triantafyllia Vasiliki
- Trouillet Assant Sophie
- Tsiodras Sotirios
- Turvey Stuart E.
- Tzourio Christophe
- Uddin K.m. Furkan
- Uddin Mohammed J.
- Valiente AdoraciĂłn
- Van De Beek Diederik
- Vanderbeke Lore
- Vanker Martti
- Vinh Donald C.
- Von Bernuth Horst
- Wauters Joost
- Wauters Joost
- Wroblewski Isabelle
- Zatz Mayana
- Zawadzki Pawel
- Zhang Qian
- Zins Marie
- Zins Marie
- Publication venue
- 'Rockefeller University Press'
- Publication date
- 01/01/2022
- Field of study
In an international cohort of 279 patients with hypoxemic influenza pneumonia, we identified 13 patients (4.6%) with autoantibodies neutralizing IFN-alpha and/or -omega, which were previously reported to underlie 15% cases of life-threatening COVID-19 pneumonia and one third of severe adverse reactions to live-attenuated yellow fever vaccine. Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-alpha 2 alone (five patients) or with IFN-omega (eight patients) from a cohort of 279 patients (4.7%) aged 6-73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-alpha 2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-omega. The patients' autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients 70 yr of age (3.1 vs. 4.4%, P = 0.68). The risk of critical influenza was highest in patients with antibodies neutralizing high concentrations of both IFN-alpha 2 and IFN-omega (OR = 11.7, P = 1.3 x 10(-5)), especially those <70 yr old (OR = 139.9, P = 3.1 x 10(-10)). We also identified 10 patients in additional influenza patient cohorts. Autoantibodies neutralizing type I IFNs account for similar to 5% of cases of life-threatening influenza pneumonia in patients <70 yr old
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
- Author
- Abe-jones Yumiko
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abolhassani Hassan
- Abou Tayoun Ahmad
- Achille Cristian
- Ailioaie Oana
- Aiuti Alessandro
- Al-muhsen Saleh
- Al-mulla Fahd
- Aliberti Anna
- Allavena Clotilde
- Allende Luis M.
- Altamirano Luz Torres
- Anderson Mark S.
- Anderson Mark S.
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Angelini Micol
- Angoulvant François
- AntolĂ Arnau
- Arias Andrés A.
- Arroyo-sĂĄnchez Daniel
- Asthana Saurabh
- Aytekin Gokhan
- Azoulay Cecile
- Bachelet Delphine
- Bair Rebecca
- Bal Antonin
- Baldanti Fausto
- Bartoli Marie
- Basmaci Romain
- Bastard Paul
- Behilill Sylvie
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bergami Federica
- Bezzi Michela
- Bhavsar Krishna
- Bhide Sharvari
- Biggs Catherine M.
- Bitker Laurent
- Bizien Lucy
- Bogunovic Dusan
- Bolze Alexandre
- Bompoil Thierry
- Bondarenko Anastasia
- Bondarenko Anastasiia
- Borghesi Alessandro
- Bouadma Lila
- Bouscambert Maude
- Bousfiha Ahmed A.
- Boutboul David
- Boyarchuk Oksana
- Brodin Petter
- Bryceson Yenan
- Burrel Sonia
- Bustamante Carlos D.
- Butte Manish J.
- Calfee Carolyn S.
- Carrillo Sidney A.
- Casanova Jean-laurent
- Casari Giorgio
- Cassaniti Irene
- Catherinot Emilie
- Cervantes-gonzalez Minerva
- Chair Anissa
- Chak Suzanna
- Chirouze Catherine
- Christodoulou John
- Clément Bénédicte
- Cobat Aurélie
- Coelho Alexandra
- Collins Zachary
- Comet Consortium
- Condino-neto Antonio
- Constantinescu Stefan N.
- Conti Francesca
- Cooper Megan A.
- Cordel Hugues
- Couffignal Camille
- Couffin-cadiergues Sandrine
- Covid Hge Consortium
- Dalgard Clifton L.
- Danielson Jeffrey
- De Diego Rebeca Perez
- De Montmollin Etienne
- Debard Alexa
- Debray Marie-pierre
- Delaunay Clarisse
- Deplanque Dominique
- Derisi Joseph L.
- Desai Murkesh
- Descamps Diane
- Desvallée Mathilde
- Diallo Alpha
- Diehl Jean-luc
- Diouf Alphonsine
- Dorgham Karim
- Dorival CĂ©line
- Drolet Beth A.
- Dubos François
- Duval Xavier
- Duvlis Sotirija
- Dâortenzio Eric
- El Baghdadi Jamila
- Eloy Philippine
- Enouf Vincent
- Epaulard Olivier
- Ergun Dilek
- Ergun Recai
- Erle David J.
- Esperou HĂ©lĂšne
- Espinosa-padilla Sara
- Esposito-farese Marina
- Etienne Manuel
- Fekkar Arnaud
- Feldman Hagit Baris
- Fellay Jacques
- Flores Carlos
- Fragiadakis Gabriela K.
- Franco José Luis
- French Covid Study Group
- Froidure Antoine
- Gagro Alenka
- Garot Denis
- Garzaro Margaux
- Garçon Pierre
- Gault Nathalie
- Gaymard Alexandre
- Gervais Adrian
- Ghale Rajani
- Ghirardello Stefano
- Ghosn Jade
- Gigante Tristan
- Gilg Morgane
- Goehringer François
- Gorochov Guy
- Gregersen Peter K.
- Grimbacher Bodo
- Guedj Jérémie
- Haerynck Filomeen
- Hagin David
- Halwani Rabih
- Halwani Rabih
- Hammarström Lennart
- Hatipoglu Nevin
- Heath James R.
- Hendrickson Carolyn M.
- Henrickson Sarah E.
- Hernu Romain
- Hoctin Alexandre
- Hoffmann Isabelle
- Houas Ikram
- Hsieh Elena W.y.
- Hulot Jean-sébastien
- Husebye Eystein
- Imai Kohsuke
- Imberti Luisa
- Itan Yuval
- Jaafoura Salma
- Jarvis Erich D.
- Jauregui Alejandra
- Jeziorski Eric
- Jouanguy Emmanuelle
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabrina
- Kanat Fikret
- Kangelaris Kirsten N.
- Karamitros Timokratis
- Keles Sevgi
- Keles Sevgi
- Kenney Heather
- Kerroumi Younes
- Khalil Antoine
- Khan Coralie
- Kimmoun Antoine
- Kisand Kai
- Kopcha Vasyl
- Korda Mykhaylo
- Krummel Matthew F.
- Ku Cheng-lung
- Laine Fabrice
- Langelier Charles R.
- Laouenan CĂ©dric
- Laouénan Cédric
- Laribi Samira
- Lau Yu-lung
- Laurie Matthew T.
- Le Bris Cyril
- Le Gac Sylvie
- Le Hingrat Quentin
- Le Mestre Soizic
- Le Nagard Hervé
- Le Turnier Paul
- Le Voyer Tom
- Le Minh
- Lea Tasha
- Lee Deanna
- Leligdowicz Aleksandra
- Lemaignen Adrien
- Lemee VĂ©ronique
- Leroux Carolyn
- Lescure François-xavier
- Letrou Sophie
- Levy Yves
- Lhuillier Marine
- Lina Bruno
- Ling Yun
- Lingas Guillaume
- Liu Jamin
- Lota Raphael
- Lucas Carrie L.
- Lucet Jean Christophe
- Machado MoĂŻse
- Mahevas Matthieu
- Malvy Denis
- Mambert Marina
- Maniatis Tom
- Manry Jérémy
- Mansouri Davood
- Manuel Aldric
- Martinez-picado Javier
- MarĂłdi LĂĄszlĂł
- Matthay Michael
- Mentré France
- Meyts Isabelle
- Meziane Amina
- Milner Joshua D.
- Mironska Kristina
- Mitchell Anthea M.
- Mogensen Trine H.
- Mojoli Francesco
- Monneret Guillaume
- Morandeira Francisco
- Morbieu Caroline
- Morio Tomohiro
- Mouquet Hugo
- Mullaert Jimmy
- Nagl Laurenz
- Neant NadĂšge
- Neuville Mathilde
- Neven Bénédicte
- Ng Lisa F. P.
- Ng Lisa F.p.
- Nguyen Duc
- Nguyen Viet
- Noret Marion
- Notarangelo Luigi D.
- Notarangelo Luigi D.
- Novelli Antonio
- Novelli Antonio
- Novelli Giuseppe
- Novelli Giuseppe
- O'farrelly Cliona
- Okada Satoshi
- Okamoto Keisuke
- Ozcelik Tayfun
- Ozcelik Tayfun
- Pagani Michele
- Pan-hammarström Qiang
- Pan-hammarström Qiang
- Papadopoulos Aurélie
- Pape Jean W.
- Patel Ravi
- Paul Christelle
- Paz Artal Estela
- Paz Pauline Caraux
- Peiffer-smadja Nathan
- Peigne Vincent
- Perani Cristiano
- Perlin David S.
- Pesole Graziano
- Pession Andrea
- Petrov-sanchez Ventzislava
- Peytavin Gilles
- Pham Huong
- Philippot Quentin
- Picone Olivier
- Pierce Logan
- Piquard Valentine
- Piralla Antonio
- Planas Anna M.
- Poissy Julien
- Poulakou Garyphallia
- Prando Carolina
- Prasad Priya
- Puel Anne
- Pujol Aurora
- Pujol Aurora
- Puéchal Oriane
- Quaresima Virginia
- Quintana-murci Lluis
- Raffi François
- Ramaswamy Sathishkumar
- Rao Arjun Arkal
- Rashid Ahmad
- Renia Laurent
- Renia Laurent
- Resnick Igor
- Reyes Luis Felipe
- Rigo-bonnin RaĂșl
- Rocamora-blanch Gemma
- Rodriguez Nicklaus
- RodrĂguez-gallego Carlos
- RodrĂguez-gallego Carlos
- Rosa-calatrava Manuel
- Rosain Jérémie
- Rossignol Bénédicte
- Rossignol Patrick
- Roussel Lucie
- Roy Carine
- Rubio Luis
- Sahanic Sabina
- Saker Kahina
- Salagianni Maria
- Samad Bushra
- Sancho-shimizu Vanessa
- Schneider Marion
- Sediva Anna
- SeppÀnen Mikko R.j.
- Shahrooei Mohammed
- Sharif-askari Narjes Saheb
- Shaw Cole
- Shcherbina Anna
- Sigman Austin
- Siouti Eleni
- Slaby Ondrej
- Snow Andrew L.
- Solanich Xavier
- Soler-palacĂn Pere
- Sottini Alessandra
- Spaan AndrĂĄs N.
- Stepanovskyy Yurii
- Su Richa
- Tancevski Ivan
- Tancevski Ivan
- Tandjaoui-lambiotte Yacine
- Tang Kevin
- Tangye Stuart G.
- Tardivon Coralie
- Teixeira Carla
- Tellier Marie-capucine
- Terrier Olivier
- Thompson Leslie M.
- Timsit Jean-françois
- Trouillet-assant Sophie
- Troya Jesus
- Tual Christelle
- Tubiana Sarah
- Tulek Baykal
- Turvey Stuart E.
- Téoulé François
- Uddin K M Furkan
- Uddin Mohammed
- Van Der Werf Sylvie
- Vanel Noémie
- Vazquez Sara
- Veislinger Aurélie
- Venet Fabienne
- Vinh Donald C.
- Visseaux Benoit
- Volokha Alla
- Wang Chung Yu
- Ward Alyssa
- Weiss GĂŒnter
- Wiedemann Aurélie
- Willmore Andrew
- Willmore Andrew
- Wilson Michael
- Wilson Michael R
- Woodruff Prescott G.
- Yazdanpanah Yazdan
- Ye Chun Jimmie
- Zamecnik Colin
- Zhang Qian
- Zhang Shen-ying
- Zhang Yu
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 13/04/2023
- Field of study
Life-threatening `breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS- CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals ( age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto- Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-a2 and IFN-., while two neutralized IFN-omega only. No patient neutralized IFN-ss. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population
An Empirical Study on Antecedents and Consequences of Export Market Orientation and Performance in Export Firms
- Author
- Anderson Paul F
- Autio Erkko
- Aviv Shoham
- Avlonitis George J
- Baker William Edward
- Baker William Edward
- Barney Jay
- Bentler Peter M
- Bentler Peter M
- Bettis Richard A
- Cadogan John W
- Cadogan John W
- Cadogan John W
- Calantone Roger J
- Cavusgil S. Tamer
- Cavusgil S. Tamer
- Cavusgil S. Tamer
- Cooper Robert G
- Daft Richard L
- Davis Duane
- Day George S
- Day George S
- Deshpande Rohit
- Dess Gregory G
- Diamantopoulos Adamantios
- Dickson Peter R
- Eisenhardt Kathleen M
- Eriksson Kent
- Farrell Mark Anthony
- Farrell Mark Anthony
- Glejser Herbert
- Grant Robert M
- Gripsrud Geir
- Hult G
- Hult G
- Hunt Shelby D
- Hurley Robert F
- Jacobson Robert
- Jaworski Bernard J
- Jolly Vijay K
- Kaplan David
- Kasper Hans
- Kaynak Erdener
- Kirpalani V
- Knight Gary A
- Kohli Ajay K
- Kohli Ajay K
- Kropp Fredric
- Li Tiger
- Lusch Robert F
- Madsen Tage Koed
- McNaughton Rod B
- Miesenbock Kurt J
- Moen Ăystein
- Narver John C
- Oviatt Benjamin M
- Rialp Alex
- Roberts Edward B
- Schlegelmilch Bodo B
- Sinkula James Michael
- Sinkula James Michael
- Slater Stanley F
- Slater Stanley F
- Souchon Adamantios
- Utterback James M
- Woo Caronyn Y
- Yli-Renko Helena
- Zahra Shaker A
- Zahra Shaker A
- Zhou Kevin Z
- Zhou Lina
- Zou Shaoming
- Publication venue
- 'Korean Academy of Commodity Science & Technology'
- Publication date
- Field of study
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
- Author
- Abe-Jones Yumiko
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abolhassani Hassan
- Abou Tayoun Ahmad
- Achille Cristian
- Ailioaie Oana
- Aiuti Alessandro
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Aliberti Anna
- Allavena Clotilde
- Allende Luis, M
- Altamirano Luz, Torres
- Anderson Mark, S
- Anderson Mark, S
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Angelini Micol
- Angoulvant François
- AntolĂ Arnau
- Arias Andrés, A
- Arroyo-SĂĄnchez Daniel
- Asthana Saurabh
- Aytekin Gokhan
- Azoulay Cecile
- Bachelet Delphine
- Bair Rebecca
- Bal Antonin
- Baldanti Fausto
- Bartoli Marie
- Basmaci Romain
- Bastard Paul
- Behilill Sylvie
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bergami Federica
- Bezzi Michela
- Bhavsar Krishna
- Bhide Sharvari
- Biggs Catherine, M
- Bitker Laurent
- Bizien Lucy
- Bogunovic Dusan
- Bolze Alexandre
- Bompoil Thierry
- Bondarenko Anastasia
- Bondarenko Anastasiia
- Borghesi Alessandro
- Bouadma Lila
- Bouscambert Maude
- Bousfiha Ahmed, A
- Boutboul David
- Boyarchuk Oksana
- Brodin Petter
- Bryceson Yenan
- Burrel Sonia
- Bustamante Carlos, D
- Butte Manish, J
- Calfee Carolyn, S
- Carrillo Sidney, A
- Casanova Jean-Laurent
- Casari Giorgio
- Cassaniti Irene
- Catherinot Emilie
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chak Suzanna
- Chirouze Catherine
- Christodoulou John
- Clément Bénédicte
- Cobat Aurélie
- Coelho Alexandra
- Collins Zachary
- Condino-Neto Antonio
- Constantinescu Stefan, N
- Conti Francesca
- Cooper Megan, A
- Cordel Hugues
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Dalgard Clifton, L
- Danielson Jeffrey
- de Diego Rebeca, Perez
- de Montmollin Etienne
- Debard Alexa
- Debray Marie-Pierre
- Delaunay Clarisse
- Deplanque Dominique
- Derisi Joseph, L
- Desai Murkesh
- Descamps Diane
- Desvallée Mathilde
- Diallo Alpha
- Diehl Jean-Luc
- Diouf Alphonsine
- Dorgham Karim
- Dorival CĂ©line
- Drolet Beth, A
- Dubos François
- Duval Xavier
- Duvlis Sotirija
- Dâortenzio Eric
- El Baghdadi Jamila
- Eloy Philippine
- Enouf Vincent
- Epaulard Olivier
- Ergun Dilek
- Ergun Recai
- Erle David, J
- Esperou HĂ©lĂšne
- Espinosa-Padilla Sara
- Esposito-Farese Marina
- Etienne Manuel
- Fekkar Arnaud
- Feldman Hagit, Baris
- Fellay Jacques
- Flores Carlos
- Fragiadakis Gabriela, K
- Franco José, Luis
- Froidure Antoine
- Gagro Alenka
- Garot Denis
- Garzaro Margaux
- Garçon Pierre
- Gault Nathalie
- Gaymard Alexandre
- Gervais Adrian
- Ghale Rajani
- Ghirardello Stefano
- Ghosn Jade
- Gigante Tristan
- Gilg Morgane
- Goehringer François
- Gorochov Guy
- Gregersen Peter, K
- Grimbacher Bodo
- Guedj Jérémie
- Haerynck Filomeen
- Hagin David
- Halwani Rabih
- Halwani Rabih
- Hammarström Lennart
- Hatipoglu Nevin
- Heath James, R
- Hendrickson Carolyn, M
- Henrickson Sarah, E
- Hernu Romain
- Hoctin Alexandre
- Hoffmann Isabelle
- Houas Ikram
- Hsieh Elena, W Y
- Hulot Jean-SĂ©bastien
- Husebye Eystein
- Imai Kohsuke
- Imberti Luisa
- Itan Yuval
- Jaafoura Salma
- Jarvis Erich, D
- Jauregui Alejandra
- Jeziorski Eric
- Jouanguy Emmanuelle
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabrina
- Kanat Fikret
- Kangelaris Kirsten, N
- Karamitros Timokratis
- Keles Sevgi
- Keles Sevgi
- Kenney Heather
- Kerroumi Younes
- Khalil Antoine
- Khan Coralie
- Kimmoun Antoine
- Kisand Kai
- Kopcha Vasyl
- Korda Mykhaylo
- Krummel Matthew, F
- Ku Cheng-Lung
- Laine Fabrice
- Langelier Charles, R
- Laouenan CĂ©dric
- Laouénan Cédric
- Laribi Samira
- Lau Yu-Lung
- Laurie Matthew, T
- Le Bris Cyril
- Le Gac Sylvie
- Le Hingrat Quentin
- Le Mestre Soizic
- Le Nagard Hervé
- Le Turnier Paul
- Le Voyer Tom
- Le Minh
- Lea Tasha
- Lee Deanna
- Leligdowicz Aleksandra
- Lemaignen Adrien
- Lemee VĂ©ronique
- Leroux Carolyn
- Lescure François-Xavier
- Letrou Sophie
- Levy Yves
- Lhuillier Marine
- Lina Bruno
- Ling Yun
- Lingas Guillaume
- Liu Jamin
- Lota Raphael
- Lucas Carrie, L
- Lucet Jean, Christophe
- Machado MoĂŻse
- Mahevas Matthieu
- Malvy Denis
- Mambert Marina
- Maniatis Tom
- Manry Jérémy
- Mansouri Davood
- Manuel Aldric
- Martinez-Picado Javier
- MarĂłdi LĂĄszlĂł
- Matthay Michael
- Mentré France
- Meyts Isabelle
- Meziane Amina
- Milner Joshua, D
- Mironska Kristina
- Mitchell Anthea, M
- Mogensen Trine, H
- Mojoli Francesco
- Monneret Guillaume
- Morandeira Francisco
- Morbieu Caroline
- Morio Tomohiro
- Mouquet Hugo
- Mullaert Jimmy
- Nagl Laurenz
- Neant NadĂšge
- Neuville Mathilde
- Neven Bénédicte
- Ng Lisa, F P
- Ng Lisa, F P
- Nguyen Duc
- Nguyen Viet
- Noret Marion
- Notarangelo Luigi, D
- Notarangelo Luigi, D
- Novelli Antonio
- Novelli Antonio
- Novelli Giuseppe
- Novelli Giuseppe
- O'Farrelly Cliona
- Okada Satoshi
- Okamoto Keisuke
- Ozcelik Tayfun
- Ozcelik Tayfun
- Pagani Michele
- Pan-Hammarström Qiang
- Pan-Hammarström Qiang
- Papadopoulos Aurélie
- Pape Jean, W
- Patel Ravi
- Paul Christelle
- Paz Artal Estela
- Paz Pauline, Caraux
- Peiffer-Smadja Nathan
- Peigne Vincent
- Perani Cristiano
- Perlin David, S
- Pesole Graziano
- Pession Andrea
- Petrov-Sanchez Ventzislava
- Peytavin Gilles
- Pham Huong
- Philippot Quentin
- Picone Olivier
- Pierce Logan
- Piquard Valentine
- Piralla Antonio
- Planas Anna, M
- Poissy Julien
- Poulakou Garyphallia
- Prando Carolina
- Prasad Priya
- Puel Anne
- Pujol Aurora
- Pujol Aurora
- Puéchal Oriane
- Quaresima Virginia
- Quintana-Murci Lluis
- Raffi François
- Ramaswamy Sathishkumar
- Rao Arjun, Arkal
- Rashid Ahmad
- Renia Laurent
- Renia Laurent
- Resnick Igor
- Reyes Luis, Felipe
- Rigo-Bonnin RaĂșl
- Rocamora-Blanch Gemma
- Rodriguez Nicklaus
- RodrĂguez-Gallego Carlos
- RodrĂguez-Gallego Carlos
- Rosa-Calatrava Manuel
- Rosain Jérémie
- Rossignol Bénédicte
- Rossignol Patrick
- Roussel Lucie
- Roy Carine
- Rubio Luis
- Sahanic Sabina
- Saker Kahina
- Salagianni Maria
- Samad Bushra
- Sancho-Shimizu Vanessa
- Schneider Marion
- Sediva Anna
- SeppÀnen Mikko, R J
- Shahrooei Mohammed
- Sharif-Askari Narjes, Saheb
- Shaw Cole
- Shcherbina Anna
- Sigman Austin
- Siouti Eleni
- Slaby Ondrej
- Snow Andrew, L
- Solanich Xavier
- Soler-PalacĂn Pere
- Sottini Alessandra
- Spaan AndrĂĄs, N
- Stepanovskyy Yurii
- Su Richa
- Tancevski Ivan
- Tancevski Ivan
- Tandjaoui-Lambiotte Yacine
- Tang Kevin
- Tangye Stuart, G
- Tardivon Coralie
- Teixeira Carla
- Tellier Marie-Capucine
- Terrier Olivier
- Thompson Leslie, M
- Timsit Jean-François
- Trouillet-Assant Sophie
- Troya Jesus
- Tual Christelle
- Tubiana Sarah
- Tulek Baykal
- Turvey Stuart, E
- Téoulé François
- Uddin K, M Furkan
- Uddin Mohammed
- van der Werf Sylvie
- Vanel Noémie
- Vazquez Sara
- Veislinger Aurélie
- Venet Fabienne
- Vinh Donald, C
- Visseaux Benoit
- Volokha Alla
- Wang Chung, Yu
- Ward Alyssa
- Weiss GĂŒnter
- Wiedemann Aurélie
- Willmore Andrew
- Willmore Andrew
- Wilson Michael, R
- Wilson Michael, R
- Woodruff Prescott, G
- Yazdanpanah Yazdan
- Ye Chun, Jimmie
- Zamecnik Colin
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Publication venue
- American Association for the Advancement of Science (AAAS)
- Publication date
- 14/06/2022
- Field of study
International audienceLife-threatening âbreakthroughâ cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS-CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals (age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto-Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-α2 and IFN-Ï, while two neutralized IFN-Ï only. No patient neutralized IFN-ÎČ. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cåceres
- Aguilera-Albesa Sergio
- AguilĂł-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Ăzge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- AntolĂ Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz MarĂa JesĂșs
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart MĂ©lodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
- Azot Axelle
- Azoulay Cecile
- Bachelet Delphine
- Bahram Seiamak
- Bajolle Fanny
- Baldanti Fausto
- Baldolli Aurélie
- Ballester Maite
- Baris-Feldman Hagit
- Barreiros Lucila
- Barrou Benoit
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Batten Isabella
- Bauters Fré
- Bax Diane
- Bayhan Gulsum Iclal
- Behillil Sylvie
- Behillill Sylvie
- Bellani Giacomo
- Belot Alexandre
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Beretta Ilaria
- Bergin Colm
- Bertholon Frédérique
- Bettini Laura Rachele
- Beudel Martijn
- Bezrodnik Liliana
- Bhavsar Krishna
- Biggs Catherine
- Biggs Catherine
- Bilbao Agurtzane
- Bilguvar Kaya
- Biondi Andrea
- Bitker Laurent
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanco Ignacio
- BlandiniĂšres Adeline
- Bleibtreu Alexandre
- Bloomfield Marketa
- BlĂĄzquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boisson Bertrand
- Bolivar-Prados Mireia
- Bolze Alexandre
- Bomers Marije
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bonfanti Paolo
- Bonneaudeau Brigitte
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels CĂ©dric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botta Michela
- Bouadma Lila
- Bouadma Lila
- Boucherit Soraya
- Boudhabhay Idris
- Bouiller KĂ©vin
- Boulanger CĂ©cile
- Bourgeois Fleur Le
- Bourgeon Marilou
- Bourke Nollaig
- Bourke Nollaig
- Bourke Nollaig
- Bouscambert-Duchamp Maude
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousquet Aurore
- Bousso Philippe
- Boutolleau David
- Bouvattier Claire
- Boyarchuk Oksana
- Boyarchuk Oksana
- Bozdemir Ćefika Elmas
- Bravais Juliette
- Briones M. Luisa
- Briseño-Roa Luis
- Brodin Petter
- Brodin Petter
- Brouwer Matthijs
- Bruhns Pierre
- Bruneau LĂ©a
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bueno Maria Rita P.
- Bugiani Marianna
- Buis David
- Bukhari Huda
- Bulle Esther
- Burdet Charles
- Burdet Charles
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- Bustamante Jacinta
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- Celik Jale Bengi
- Cerf-Bensussan Nadine
- Cervantes-Gonzalez Minerva
- Ceschi Alessandro
- Chahine Abir
- Chair Anissa
- Chakravorty Samya
- Chalumeau Martin
- Charbit Bruno
- Charpentier Charlotte
- Chauvineau-Grenier Angélique
- Chen Jie
- Cheng Matthew
- Chirouze Catherine
- Chirouze Catherine
- Chouchane Osoul
- Chrabieh Maya
- Christodoulou John
- Ciceri Fabio
- Citerio Giuseppe
- Clavé Pere
- Clercq Jozefien De
- Cloherty Alex
- Clotet Bonaventura
- Cobat Aurélie
- Codina Anna
- Coelho Alexandra
- Coeuret-Pellicer Mireille
- Cognasse Fabrice
- Cognasse Fabrice
- Cohen Yves
- Colobran Roger
- Colobran Roger
- Comarmond Cloé
- Combes Alain
- Comoli Patrizia
- Condino-Neto Antonio
- Condino-Neto Antonio
- Conlon Niall
- Connolly Emma
- Constantinescu Stefan
- Conti Francesca
- Contro Ernesto
- Cooper Megan
- Cordel Hugues
- Correales Luisa Paola Duarte
- Corsico Angelo
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Couffin-Cadiergues Sandrine
- Coulongeat Matthieu
- CoĆkuner Taner
- Cruz InĂ©s MarĂn
- Cuadros Esmeralda Nuñez
- Cumano Ana
- Cvetkovski Aleksandar
- Cyrus Cyril
- Daganou Maria
- Dalgard Clifton
- Dalgard Clifton
- Dalmau David
- Dalmau David
- Danielson Jeffrey
- Danion François
- Darazam Ilad Alavi
- Darley David Ross
- Das Vincent
- Dauby Nicolas
- Dauger Stéphane
- de Brabander Justin
- de Bree Godelieve
- de Bruin Sanne
- de Chambrun Marc Pineton
- de Diego Rebeca Perez
- de Jong Menno
- de la Chapelle Aliénor
- de Lamballerie Xavier
- de Montmollin Etienne
- de Munter Paul
- de Pontual Loic
- de Prost Nicolas
- de Rotte Maurits
- de Vera MartĂn Castillo
- de Vries Heder
- Debard Alexa
- Debette Stéphanie
- Debette Stéphanie
- Debray Marie-Pierre
- Dechanet Aline
- Dehban Amin
- Delmonte Ottavia
- Delplancq Geoffroy
- Demar Magalie
- Demirkol Yasemin Kendir
- Demoule Alexandre
- Deplanque Dominique
- Deplanque Dominique
- Deriano Ludovic
- Desai Murkesh
- Descamps Diane
- Descamps Diane
- Desguerre Isabelle
- Desille-Dugast Mireille
- Desmarets Maxime
- Desvallée Mathilde
- Di Sabatino Antonio
- Di Santo James
- Diallo Alpha
- Diego Rebeca PĂ©rez De
- Diehl Jean-Luc
- Diehl Jean-Luc
- Dijkstra Mirjam
- Dillies Marie-AgnĂšs
- Ding Li
- Dinh Khoa Manh
- Diouf Alphonsine
- Djossou FĂ©lix
- Dobbelaere Stephanie
- Dobbs Kerry
- Dominguez-Garrido Elena
- DomĂnguez-Garrido Elena
- Dongelmans Dave
- Dorgham Karim
- Dorival CĂ©line
- Drolet Beth
- Dromer Françoise
- Dubos François
- Dubost Clément
- Duffy Darragh
- Duffy Darragh
- Dufouil Carole
- Dujardin Romein
- Dunne Jean
- Dupont Annabelle
- Duval Xavier
- Duval Xavier
- Duvlis Sotirija
- Dyer Adam
- Dâangio Mariella
- Dâenfert Christophe
- Dâortenzio Eric
- Eberl GĂ©rard
- Ecobichon Jean-Luc
- Ekwall Olov
- El Baghdadi Jamila
- El Bakkouri Jalila
- Elbers Paul
- Elnagdy Marwa
- Eloy Philippine
- Emiroglu Melike
- Endo Akifumi
- Enninga Jost
- Enouf Vincent
- Enouf Vincent
- Epaulard Olivier
- Erdeniz Emine Hafize
- Erikstrup Christian
- Erikstrup Christian
- Esperou HĂ©lĂšne
- Espinosa-Padilla Sara
- Esposito-Farase Marina
- Espérou HélÚne
- Etienne Manuel
- Eto Shohei
- Euvrard Romain
- Fabio Giovanna
- Faivre Laurence
- Falck Antonin
- Fallon Aoife
- Fartoukh Muriel
- Faure Morgane
- Fekkar Arnaud
- Feldman Hagit Baris
- Feldman Hagit Baris
- Fellay Jacques
- Fellay Jacques
- Fellay Jacques
- Ferrer Ricard
- Ferreres Jose
- Fievet Nathalie
- Flaig Amandine
- Fleuren Lucas
- Flores Carlos
- Flores Carlos
- Florkin Benoit
- Fontes Magnus
- Foti Giuseppe
- Fouchard Julie
- Franco José Luis
- Franco José Luis
- Francois Bruno
- Frezouls Wahiba
- Froidure Antoine
- FumadĂł Victoria
- Fung Kitty
- Fusco Francesca
- Gagneux-Brunon Amandine
- Gagro Alenka
- Gallian Pierre
- Garcia-Prat Marina
- GarcĂa Paula Andrea Gaviria
- Garot Denis
- Garçon Pierre
- Gatineau Audrey Giraud
- Gaudet Alexandre
- Gault Nathalie
- Gaussem Pascale
- Gaymard Alexandre
- Gayretli Zeynep
- Geerlings Suzanne
- Geijtenbeek Theo
- Gentile Stéphanie
- Gervais Adrian
- Ghirardello Stefano
- Ghosn Jade
- Gigante Tristan
- Gil-Herrera Juana
- Gilardin Laurent
- Gilardin Laurent
- Gilg Morgane
- Girbes Armand
- Girona-AlarcĂłn MĂČnica
- Gissot Valérie
- GodĂnez Karen Alejandra Cifuentes
- Goehringer François
- Goffard Jean-Christophe
- Goldberg Marcel
- Gomperts-Boneca Ivo
- Gonzales Nacho
- Gonzalez-Granado Luis
- GonzĂĄlez-Montelongo Rafaela
- Goorhuis Bram
- Gorochov Guy
- Got Stéphane Le
- Gregersen Peter
- Gregersen Peter
- Gribouval Olivier
- Grimbacher Bodo
- Grobusch Martin
- Guaqueta Jeser Santiago Grass
- Guedj Jérémie
- Guerder Antoine
- Gumucio Victor Daniel
- Gunst Jan
- Gut Marta
- Gålvez-Romero José Luis
- GĂ©rardin Patrick
- GĂłmez Oscar
- GĂŒlhan Belgin
- Hadjadj JĂ©rĂŽme
- Haerynck Filomeen
- Haerynck Filomeen
- Haerynck Filomeen
- Hafkamp Florianne
- Hagens Laura
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- Hagin David
- HaljasmÀgi Liis
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- Halwani Rabih
- Halwani Rabih
- Hamann Jorg
- Hammarström Lennart
- Hammarström Lennart
- Hammarström Lennart
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- Heath James
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- Heunks Leo
- Ho Po-Ki
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- Hoffmann Hans-Heinrich
- Hoffmann Isabelle
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- Okamoto Keisuke
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- Tancevski Ivan
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- Tandjaoui-Lambiotte Yacine
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- Tubiana Sarah
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- Uddin K.
- Uddin Mohammed
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- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Vabres Pierre
- Valencia-Ramos Juan
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt MichĂšle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel SĂ©bastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain CĂ©dric
- Villar-GarcĂa Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- VĂ©lez VerĂłnica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- YahĆi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- YĂŒkselmiĆ Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Ăñigo-Campos Antonio
- Ăz Ćadiye KĂŒbra TĂŒter
- Ăzkan Esra AkyĂŒz
- Ăzçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cåceres
- Aguilera-Albesa Sergio
- AguilĂł-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Ăzge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- AntolĂ Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz MarĂa JesĂșs
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart MĂ©lodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
- Azot Axelle
- Azoulay Cecile
- Bachelet Delphine
- Bahram Seiamak
- Bajolle Fanny
- Baldanti Fausto
- Baldolli Aurélie
- Ballester Maite
- Baris-Feldman Hagit
- Barreiros Lucila
- Barrou Benoit
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Batten Isabella
- Bauters Fré
- Bax Diane
- Bayhan Gulsum Iclal
- Behillil Sylvie
- Behillill Sylvie
- Bellani Giacomo
- Belot Alexandre
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Beretta Ilaria
- Bergin Colm
- Bertholon Frédérique
- Bettini Laura Rachele
- Beudel Martijn
- Bezrodnik Liliana
- Bhavsar Krishna
- Biggs Catherine
- Biggs Catherine
- Bilbao Agurtzane
- Bilguvar Kaya
- Biondi Andrea
- Bitker Laurent
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanco Ignacio
- BlandiniĂšres Adeline
- Bleibtreu Alexandre
- Bloomfield Marketa
- BlĂĄzquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boisson Bertrand
- Bolivar-Prados Mireia
- Bolze Alexandre
- Bomers Marije
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bonfanti Paolo
- Bonneaudeau Brigitte
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels CĂ©dric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botta Michela
- Bouadma Lila
- Bouadma Lila
- Boucherit Soraya
- Boudhabhay Idris
- Bouiller KĂ©vin
- Boulanger CĂ©cile
- Bourgeois Fleur Le
- Bourgeon Marilou
- Bourke Nollaig
- Bourke Nollaig
- Bourke Nollaig
- Bouscambert-Duchamp Maude
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousquet Aurore
- Bousso Philippe
- Boutolleau David
- Bouvattier Claire
- Boyarchuk Oksana
- Boyarchuk Oksana
- Bozdemir Ćefika Elmas
- Bravais Juliette
- Briones M. Luisa
- Briseño-Roa Luis
- Brodin Petter
- Brodin Petter
- Brouwer Matthijs
- Bruhns Pierre
- Bruneau LĂ©a
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bueno Maria Rita P.
- Bugiani Marianna
- Buis David
- Bukhari Huda
- Bulle Esther
- Burdet Charles
- Burdet Charles
- Burrel Sonia
- Bustamante Carlos
- Bustamante Jacinta
- Butte Manish
- BĂ©ziat Vivien
- Cannet Dorothée
- Capra Ruggero
- Carapito Raphael
- Carrabba Maria
- Carrillo Jorge
- Casanova Jean-Laurent
- Casanova Jean-Laurent
- Casari Giorgio
- Casari Giorgio
- Casari Giorgio
- Casasnovas Carlos
- Caseris Marion
- Cassaniti Irene
- Castagnoli Riccardo
- Castelle Martin
- Castelli Francesco
- Castro Mateus
- Catherinot Emilie
- Cazzaniga Marina
- Celik Jale Bengi
- Cerf-Bensussan Nadine
- Cervantes-Gonzalez Minerva
- Ceschi Alessandro
- Chahine Abir
- Chair Anissa
- Chakravorty Samya
- Chalumeau Martin
- Charbit Bruno
- Charpentier Charlotte
- Chauvineau-Grenier Angélique
- Chen Jie
- Cheng Matthew
- Chirouze Catherine
- Chirouze Catherine
- Chouchane Osoul
- Chrabieh Maya
- Christodoulou John
- Ciceri Fabio
- Citerio Giuseppe
- Clavé Pere
- Clercq Jozefien De
- Cloherty Alex
- Clotet Bonaventura
- Cobat Aurélie
- Codina Anna
- Coelho Alexandra
- Coeuret-Pellicer Mireille
- Cognasse Fabrice
- Cognasse Fabrice
- Cohen Yves
- Colobran Roger
- Colobran Roger
- Comarmond Cloé
- Combes Alain
- Comoli Patrizia
- Condino-Neto Antonio
- Condino-Neto Antonio
- Conlon Niall
- Connolly Emma
- Constantinescu Stefan
- Conti Francesca
- Contro Ernesto
- Cooper Megan
- Cordel Hugues
- Correales Luisa Paola Duarte
- Corsico Angelo
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Couffin-Cadiergues Sandrine
- Coulongeat Matthieu
- CoĆkuner Taner
- Cruz InĂ©s MarĂn
- Cuadros Esmeralda Nuñez
- Cumano Ana
- Cvetkovski Aleksandar
- Cyrus Cyril
- Daganou Maria
- Dalgard Clifton
- Dalgard Clifton
- Dalmau David
- Dalmau David
- Danielson Jeffrey
- Danion François
- Darazam Ilad Alavi
- Darley David Ross
- Das Vincent
- Dauby Nicolas
- Dauger Stéphane
- de Brabander Justin
- de Bree Godelieve
- de Bruin Sanne
- de Chambrun Marc Pineton
- de Diego Rebeca Perez
- de Jong Menno
- de la Chapelle Aliénor
- de Lamballerie Xavier
- de Montmollin Etienne
- de Munter Paul
- de Pontual Loic
- de Prost Nicolas
- de Rotte Maurits
- de Vera MartĂn Castillo
- de Vries Heder
- Debard Alexa
- Debette Stéphanie
- Debette Stéphanie
- Debray Marie-Pierre
- Dechanet Aline
- Dehban Amin
- Delmonte Ottavia
- Delplancq Geoffroy
- Demar Magalie
- Demirkol Yasemin Kendir
- Demoule Alexandre
- Deplanque Dominique
- Deplanque Dominique
- Deriano Ludovic
- Desai Murkesh
- Descamps Diane
- Descamps Diane
- Desguerre Isabelle
- Desille-Dugast Mireille
- Desmarets Maxime
- Desvallée Mathilde
- Di Sabatino Antonio
- Di Santo James
- Diallo Alpha
- Diego Rebeca PĂ©rez De
- Diehl Jean-Luc
- Diehl Jean-Luc
- Dijkstra Mirjam
- Dillies Marie-AgnĂšs
- Ding Li
- Dinh Khoa Manh
- Diouf Alphonsine
- Djossou FĂ©lix
- Dobbelaere Stephanie
- Dobbs Kerry
- Dominguez-Garrido Elena
- DomĂnguez-Garrido Elena
- Dongelmans Dave
- Dorgham Karim
- Dorival CĂ©line
- Drolet Beth
- Dromer Françoise
- Dubos François
- Dubost Clément
- Duffy Darragh
- Duffy Darragh
- Dufouil Carole
- Dujardin Romein
- Dunne Jean
- Dupont Annabelle
- Duval Xavier
- Duval Xavier
- Duvlis Sotirija
- Dyer Adam
- Dâangio Mariella
- Dâenfert Christophe
- Dâortenzio Eric
- Eberl GĂ©rard
- Ecobichon Jean-Luc
- Ekwall Olov
- El Baghdadi Jamila
- El Bakkouri Jalila
- Elbers Paul
- Elnagdy Marwa
- Eloy Philippine
- Emiroglu Melike
- Endo Akifumi
- Enninga Jost
- Enouf Vincent
- Enouf Vincent
- Epaulard Olivier
- Erdeniz Emine Hafize
- Erikstrup Christian
- Erikstrup Christian
- Esperou HĂ©lĂšne
- Espinosa-Padilla Sara
- Esposito-Farase Marina
- Espérou HélÚne
- Etienne Manuel
- Eto Shohei
- Euvrard Romain
- Fabio Giovanna
- Faivre Laurence
- Falck Antonin
- Fallon Aoife
- Fartoukh Muriel
- Faure Morgane
- Fekkar Arnaud
- Feldman Hagit Baris
- Feldman Hagit Baris
- Fellay Jacques
- Fellay Jacques
- Fellay Jacques
- Ferrer Ricard
- Ferreres Jose
- Fievet Nathalie
- Flaig Amandine
- Fleuren Lucas
- Flores Carlos
- Flores Carlos
- Florkin Benoit
- Fontes Magnus
- Foti Giuseppe
- Fouchard Julie
- Franco José Luis
- Franco José Luis
- Francois Bruno
- Frezouls Wahiba
- Froidure Antoine
- FumadĂł Victoria
- Fung Kitty
- Fusco Francesca
- Gagneux-Brunon Amandine
- Gagro Alenka
- Gallian Pierre
- Garcia-Prat Marina
- GarcĂa Paula Andrea Gaviria
- Garot Denis
- Garçon Pierre
- Gatineau Audrey Giraud
- Gaudet Alexandre
- Gault Nathalie
- Gaussem Pascale
- Gaymard Alexandre
- Gayretli Zeynep
- Geerlings Suzanne
- Geijtenbeek Theo
- Gentile Stéphanie
- Gervais Adrian
- Ghirardello Stefano
- Ghosn Jade
- Gigante Tristan
- Gil-Herrera Juana
- Gilardin Laurent
- Gilardin Laurent
- Gilg Morgane
- Girbes Armand
- Girona-AlarcĂłn MĂČnica
- Gissot Valérie
- GodĂnez Karen Alejandra Cifuentes
- Goehringer François
- Goffard Jean-Christophe
- Goldberg Marcel
- Gomperts-Boneca Ivo
- Gonzales Nacho
- Gonzalez-Granado Luis
- GonzĂĄlez-Montelongo Rafaela
- Goorhuis Bram
- Gorochov Guy
- Got Stéphane Le
- Gregersen Peter
- Gregersen Peter
- Gribouval Olivier
- Grimbacher Bodo
- Grobusch Martin
- Guaqueta Jeser Santiago Grass
- Guedj Jérémie
- Guerder Antoine
- Gumucio Victor Daniel
- Gunst Jan
- Gut Marta
- Gålvez-Romero José Luis
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- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
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- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt MichĂšle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel SĂ©bastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain CĂ©dric
- Villar-GarcĂa Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- VĂ©lez VerĂłnica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- YahĆi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- YĂŒkselmiĆ Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Ăñigo-Campos Antonio
- Ăz Ćadiye KĂŒbra TĂŒter
- Ăzkan Esra AkyĂŒz
- Ăzçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population