1,094 research outputs found
MelHuBERT: A simplified HuBERT on Mel spectrograms
Self-supervised models have had great success in learning speech
representations that can generalize to various downstream tasks. However, most
self-supervised models require a large amount of compute and multiple GPUs to
train, significantly hampering the development of self-supervised learning. In
an attempt to reduce the computation of training, we revisit the training of
HuBERT, a highly successful self-supervised model. We improve and simplify
several key components, including the loss function, input representation, and
training in multiple stages. Our model, MelHuBERT, is able to achieve favorable
performance on phone recognition, speaker identification, and automatic speech
recognition against HuBERT, while saving 31.2% of the pre-training time, or
equivalently 33.5% MACs per one second speech. The code and pre-trained models
are available in https://github.com/nervjack2/MelHuBERT.Comment: ASRU 202
Predicting the epidemic threshold of the susceptible-infected-recovered model
Researchers have developed several theoretical methods for predicting
epidemic thresholds, including the mean-field like (MFL) method, the quenched
mean-field (QMF) method, and the dynamical message passing (DMP) method. When
these methods are applied to predict epidemic threshold they often produce
differing results and their relative levels of accuracy are still unknown. We
systematically analyze these two issues---relationships among differing results
and levels of accuracy---by studying the susceptible-infected-recovered (SIR)
model on uncorrelated configuration networks and a group of 56 real-world
networks. In uncorrelated configuration networks the MFL and DMP methods yield
identical predictions that are larger and more accurate than the prediction
generated by the QMF method. When compared to the 56 real-world networks, the
epidemic threshold obtained by the DMP method is closer to the actual epidemic
threshold because it incorporates full network topology information and some
dynamical correlations. We find that in some scenarios---such as networks with
positive degree-degree correlations, with an eigenvector localized on the high
-core nodes, or with a high level of clustering---the epidemic threshold
predicted by the MFL method, which uses the degree distribution as the only
input parameter, performs better than the other two methods. We also find that
the performances of the three predictions are irregular versus modularity
Application of the indirect fluorescent antibody assay in the study of malaria infection in the Yangtze River Three Gorges Reservoir, China
<p>Abstract</p> <p>Background</p> <p>China Yangtze Three Gorges Project (TGP) is one of the biggest construction projects in the world. The areas around the Three Gorge Dam has a history of tertian malaria and subtertian malaria epidemic, but there are no overall data about malaria epidemics before the completion of the project. The objective of this study was to get a reliable baseline on malaria infection in the Yangtze River Three Gorges reservoir area and to provide reference data for future studies about the impact of the project on malaria epidemics.</p> <p>Methods</p> <p>Two surveys of malaria infection were carried out in area, at six-month intervals in May and October 2008. About 3,600 dual specimens blood film samples for parasite diagnosis and filter paper blood spots for serology (using the immunofluorescence antibody test) were collected from the general population, including school populations, whenever possible.</p> <p>Results</p> <p>The overall percentage of positive response of the same population during post-transmission periods was about twice (1.40/0.72) of that in pre-transmission. Positive individuals under 15 years of age were detected in all the localities.</p> <p>Conclusion</p> <p>A certain extent of malaria infection existed in this area. Additional studies are needed to determine the length of malaria experience, and chemotherapeutic intervention as well as the distribution of main vectors for transmission in this area.</p
INFLUENCE OF TRANSGLUTAMINASE-INDUCED CROSS-LINKING ON IN VITRO DIGESTIBILITY OF SOY PROTEIN ISOLATE
ABSTRAC
ReLLa: Retrieval-enhanced Large Language Models for Lifelong Sequential Behavior Comprehension in Recommendation
With large language models (LLMs) achieving remarkable breakthroughs in
natural language processing (NLP) domains, LLM-enhanced recommender systems
have received much attention and have been actively explored currently. In this
paper, we focus on adapting and empowering a pure large language model for
zero-shot and few-shot recommendation tasks. First and foremost, we identify
and formulate the lifelong sequential behavior incomprehension problem for LLMs
in recommendation domains, i.e., LLMs fail to extract useful information from a
textual context of long user behavior sequence, even if the length of context
is far from reaching the context limitation of LLMs. To address such an issue
and improve the recommendation performance of LLMs, we propose a novel
framework, namely Retrieval-enhanced Large Language models (ReLLa) for
recommendation tasks in both zero-shot and few-shot settings. For zero-shot
recommendation, we perform semantic user behavior retrieval (SUBR) to improve
the data quality of testing samples, which greatly reduces the difficulty for
LLMs to extract the essential knowledge from user behavior sequences. As for
few-shot recommendation, we further design retrieval-enhanced instruction
tuning (ReiT) by adopting SUBR as a data augmentation technique for training
samples. Specifically, we develop a mixed training dataset consisting of both
the original data samples and their retrieval-enhanced counterparts. We conduct
extensive experiments on a real-world public dataset (i.e., MovieLens-1M) to
demonstrate the superiority of ReLLa compared with existing baseline models, as
well as its capability for lifelong sequential behavior comprehension.Comment: Under Revie
Effects of maternal enflurane exposure on NR2B expression in the hippocampus of their offspring
Este trabalho objetiva o estudo da patogênese de deficiência no aprendizado e memória de prole de ratos resultante da anestesia maternal por enflurano, por meio da expressão da subunidade 2B do receptor do ácidoN-metil-D-aspártico (NR2B) no hipocampo dos filhotes. Dividiram-se, aleatoriamente, 30 fêmeas de ratos Sprague-Dawley em três grupos: controle (grupo C), exposição ao enflurano por 4 h (grupo E1) e por 8 h (grupo E2). De oito a 10 dias após o início da gravidez, os ratos dos grupos E1 e E2 inalaram enflurano 1,7% em 2 L/min de oxigênio, por 4 h e 8 h, respectivamente. Ratos do grupo C inalaram apenas 2 L/min de oxigênio. O labirinto de água de Morris foi empregado para analisar as funções de aprendizado e memória da cria em 20 e 30 dias após o nascimento. Utilizaram-se ensaios de RT-PCR e de imuno-histoquímica para medir os níveis de mRNA e expressão da proteína do NR2B, respectivamente. Em comparação com os ratos controle do grupo C, aqueles dos grupos E1 e E2 exibiram latências de escape mais longas, menor número de travessias na plataforma e menos tempo gasto no quadrante alvo no teste de exploração espacial (P ; 0.05) in terms of mRNA levels and protein expression of NR2B. The cognitive function of the offspring is impaired when maternal rats are exposed to enflurane during early pregnancy. A possible mechanism of this effect is related to the down-regulation of NR2B expression
Cyclic tensile stretch modulates osteogenic differentiation of adipose-derived stem cells via the BMP-2 pathway
Protein detection using hydrogel-based molecularly imprinted polymers integrated with dual polarisation interferometry
A polyacrylamide-based molecularly imprinted polymer (MIP) was prepared for bovine haemoglobin (BHb). A 3 mg/ml solution of BHb was injected over a dual polarisation interferometer (DPI) sensor to form a physisorbed layer typically of 3.5 ± 0.5 nm thickness. Onto the pre-adsorbed protein layer, MIP and NIP (non-imprinted polymer) were separately injected to monitor the interaction of BHb MIP or NIP particles under different loading conditions with the pre-adsorbed protein layer. In the case of NIP flowing of the protein layer, there was negligible surface stripping of the pre-adsorbed protein. When a protein-eluted sample of MIP particles was flowed over a pre-adsorbed protein layer on the sensor chip, the sensor detected significant decreases in both layer thickness and mass, suggestive that protein was being selectively bound to MIP after being stripped-off from the sensor surface. We also integrated thin-film MIPS for BHb and BSA onto the DPI sensor surface and were able to show that whereas BHb bound selectively and strongly to the BHb MIP thin film (resulting in a sustained increase in thickness and mass), the BHb protein only demonstrated transient and reversible binding on the BSA MIP. MIPs were also tested after biofouling with plasma or serum at various dilutions. We found that serum at 1/100 dilution allowed the MIP to still function selectively. This is the first demonstration of MIPs being integrated with DPI in the development of synthetic receptor-based optical protein sensors. © 2012 Elsevier B.V. All rights reserved
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