3,671 research outputs found
Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals.
We explored the possible augmenting effect of traumatic brain injury (TBI) history on HIV (human immunodeficiency virus) associated neurocognitive complications. HIV-infected participants with self-reported history of definite TBI were compared to HIV patients without TBI history. Groups were equated for relevant demographic and HIV-associated characteristics. The TBI group evidenced significantly greater deficits in executive functioning and working memory. N-acetylaspartate, a putative marker of neuronal integrity, was significantly lower in the frontal gray matter and basal ganglia brain regions of the TBI group. Together, these results suggest an additional brain impact of TBI over that from HIV alone. One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms
The Doppler Shadow of WASP-3b: A tomographic analysis of Rossiter-McLaughlin observations
Hot-Jupiter planets must form at large separations from their host stars
where the temperatures are cool enough for their cores to condense. They then
migrate inwards to their current observed orbital separations. Different
theories of how this migration occurs lead to varying distributions of orbital
eccentricity and the alignment between the rotation axis of the star and the
orbital axis of the planet. The spin-orbit alignment of a transiting system is
revealed via the Rossiter-McLaughlin effect, which is the anomaly present in
the radial velocity measurements of the rotating star during transit due to the
planet blocking some of the starlight. In this paper we aim to measure the
spin-orbit alignment of the WASP-3 system via a new way of analysing the
Rossiter-McLaughlin observations. We apply a new tomographic method for
analysing the time variable asymmetry of stellar line profiles caused by the
Rossiter-McLaughlin effect. This new method eliminates the systematic error
inherent in previous methods used to analyse the effect. We find a value for
the projected stellar spin rate of v sin i = 13.9 \pm 0.03 km/s which is in
agreement with previous measurements but has a much higher precision. The
system is found to be well aligned which favours an evolutionary history for
WASP-3b involving migration through tidal interactions with a protoplanetary
disc. Using gyrochronology we estimate the age of the star to be ~300 Myr with
an upper limit of 2 Gyr from comparison with isochrones.Comment: Accepted for publication in A&A, 8 pages, 4 figures, 2 table
Theory of commensurable magnetic structures in holmium
The tendency for the period of the helically ordered moments in holmium to
lock into values which are commensurable with the lattice is studied
theoretically as a function of temperature and magnetic field. The
commensurable effects are derived in the mean-field approximation from
numerical calculations of the free energy of various commensurable structures,
and the results are compared with the extensive experimental evidence collected
during the last ten years on the magnetic structures in holmium. In general the
stability of the different commensurable structures is found to be in accord
with the experiments, except for the tau=5/18 structure observed a few degrees
below T_N in a b-axis field. The trigonal coupling recently detected in holmium
is found to be the interaction required to explain the increased stability of
the tau=1/5 structure around 42 K, and of the tau=1/4 structure around 96 K,
when a field is applied along the c-axis.Comment: REVTEX, 31 pages, 7 postscript figure
The Kepler Light Curve of V344 Lyrae: Constraining the Thermal-Viscous Limit Cycle Instability
We present time dependent modeling based on the accretion disk limit cycle
model for a 270 d light curve of the short period SU UMa-type dwarf nova V344
Lyr taken by Kepler. The unprecedented precision and cadence (1 minute) far
surpass that generally available for long term light curves. The data encompass
two superoutbursts and 17 normal (i.e., short) outbursts. The main decay of the
superoutbursts is nearly perfectly exponential, decaying at a rate ~12 d/mag,
while the much more rapid decays of the normal outbursts exhibit a
faster-than-exponential shape. Our modeling using the basic accretion disk
limit cycle can produce the main features of the V344 Lyr light curve,
including the peak outburst brightness. Nevertheless there are obvious
deficiencies in our model light curves: (1) The rise times we calculate, both
for the normal and superoutbursts, are too fast. (2) The superoutbursts are too
short. (3) The shoulders on the rise to superoutburst have more structure than
the shoulder in the observed superoutburst and are too slow, comprising about a
third to half of the total viscous plateau, rather than the ~10% observed.
However, one of the alpha_{cold} -> alpha_{hot} interpolation schemes we
investigate (one that is physically motivated) does yield longer superoutbursts
with suitably short, less structured shoulders.Comment: 39 pages, 9 figures, accepted in the Astrophysical Journa
Risk factors for exacerbations and pneumonia in patients with chronic obstructive pulmonary disease: a pooled analysis.
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) are at risk of exacerbations and pneumonia; how the risk factors interact is unclear. METHODS: This post-hoc, pooled analysis included studies of COPD patients treated with inhaled corticosteroid (ICS)/long-acting β2 agonist (LABA) combinations and comparator arms of ICS, LABA, and/or placebo. Backward elimination via Cox's proportional hazards regression modelling evaluated which combination of risk factors best predicts time to first (a) pneumonia, and (b) moderate/severe COPD exacerbation. RESULTS: Five studies contributed: NCT01009463, NCT01017952, NCT00144911, NCT00115492, and NCT00268216. Low body mass index (BMI), exacerbation history, worsening lung function (Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage), and ICS treatment were identified as factors increasing pneumonia risk. BMI was the only pneumonia risk factor influenced by ICS treatment, with ICS further increasing risk for those with BMI <25 kg/m2. The modelled probability of pneumonia varied between 3 and 12% during the first year. Higher exacerbation risk was associated with a history of exacerbations, poorer lung function (GOLD stage), female sex and absence of ICS treatment. The influence of the other exacerbation risk factors was not modified by ICS treatment. Modelled probabilities of an exacerbation varied between 31 and 82% during the first year. CONCLUSIONS: The probability of an exacerbation was considerably higher than for pneumonia. ICS reduced exacerbations but did not influence the effect of risks associated with prior exacerbation history, GOLD stage, or female sex. The only identified risk factor for ICS-induced pneumonia was BMI <25 kg/m2. Analyses of this type may help the development of COPD risk equations
Luteolin Decreases EGFR-Mediated Cell Proliferation and Induces Apoptosis in Glioblastoma Cell Lines.
Glioblastomas are a subtype of gliomas, which are the most aggressive and deadly form of brain tumours. The epidermal growth factor receptor (EGFR) is over-expressed and amplified in glioblastomas. Luteolin is a common bioflavonoid found in a variety of fruits and vegetables. The aim of the present study was to explore the molecular and biological effects of luteolin on EGF-induced cell proliferation and the potential of luteolin to induce apoptosis in glioblastoma cells. In vitro cell viability assays demonstrated that luteolin decreased cell proliferation in the presence or absence of EGF. Immunoblots revealed that luteolin decreased the protein expression levels of phosphorylated Akt, mTOR, p70S6K, and MAPK in the presence of EGF. Furthermore, our results revealed the ability of luteolin to induce caspase and PARP cleavages in glioblastoma cells in addition to promoting cell cycle arrest. Our results demonstrated that luteolin has an inhibitory effect on downstream signalling molecules activated by EGFR, particularly the Akt and MAPK signalling pathways, and provided a rationale for further clinical investigation into the use of luteolin as a therapeutic molecule in the management of glioblastoma. This article is protected by copyright. All rights reserved
Rossiter-McLaughlin Effect Measurements for WASP-16, WASP-25 and WASP-31
We present new measurements of the Rossiter-McLaughlin (RM) effect for three
WASP planetary systems, WASP-16, WASP-25 and WASP-31, from a combined analysis
of their complete sets of photometric and spectroscopic data. We find a low
amplitude RM effect for WASP-16 (Teff = 5700 \pm 150K), suggesting that the
star is a slow rotator and thus of an advanced age, and obtain a projected
alignment angle of lambda = -4.2 degrees +11.0 -13.9. For WASP-25 (Teff =
5750\pm100K) we detect a projected spin-orbit angle of lambda = 14.6 degrees
\pm6.7. WASP-31 (Teff = 6300\pm100K) is found to be well-aligned, with a
projected spin-orbit angle of lambda = 2.8degrees \pm3.1. A circular orbit is
consistent with the data for all three systems, in agreement with their
respective discovery papers. We consider the results for these systems in the
context of the ensemble of RM measurements made to date. We find that whilst
WASP-16 fits the hypothesis of Winn et al. (2010) that 'cool' stars (Teff <
6250K) are preferentially aligned, WASP-31 has little impact on the proposed
trend. We bring the total distribution of the true spin-orbit alignment angle,
psi, up to date, noting that recent results have improved the agreement with
the theory of Fabrycky & Tremaine (2007) at mid-range angles. We also suggest a
new test for judging misalignment using the Bayesian Information Criterion,
according to which WASP-25 b's orbit should be considered to be aligned.Comment: 20 pages, 14 tables, 10 figures. Accepted to MNRA
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