New Results on Stability Analysis of Uncertain Neutral-Type Lur'e Systems Derived from a Modified Lyapunov-Krasovskii Functional

This paper is concerned with the problem of the absolute and robustly absolute stability for the uncertain neutral-type Lur’e system with time-varying delays. By introducing a modified Lyapunov-Krasovskii functional (LKF) related to a delay-product-type function and two delay-dependent matrices, some new delay-dependent robustly absolute stability criteria are proposed, which can be expressed as convex linear matrix inequality (LMI) framework. The criteria proposed in this paper are less conservative than some recent previous ones. Finally, some numerical examples are presented to show the effectiveness of the proposed approach

Transcription factors NF-YB involved in embryogenesis and hormones responses in Dimocarpus Longan Lour

IntroductionNF-YB transcription factor is an important regulatory factor in plant embryonic development.ResultsIn this study, 15 longan NF-YB (DlNF-YB) family genes were systematically identified in the whole genome of longan, and a comprehensive bioinformatics analysis of DlNF-YB family was performed. Comparative transcriptome analysis of DlNF-YBs expression in different tissues, early somatic embryogenesis (SE), and under different light and temperature treatments revealed its specific expression profiles and potential biological functions in longan SE. The qRT-PCR results implied that the expression patterns of DlNF-YBs were different during SE and the zygotic embryo development of longan. Supplementary 2,4-D, NPA, and PP333 in longan EC notably inhibited the expression of DlNF-YBs; ABA, IAA, and GA3 suppressed the expressions of DlNF-YB6 and DlNF-YB9, but IAA and GA3 induced the other DlNF-YBs. Subcellular localization indicated that DlNF-YB6 and DlNF-YB9 were located in the nucleus. Furthermore, verification by the modified 5'RNA Ligase Mediated Rapid Amplification of cDNA Ends (5' RLM-RACE) method demonstrated that DlNF-YB6 was targeted by dlo-miR2118e, and dlo-miR2118e regulated longan somatic embryogenesis (SE) by targeting DlNF-YB6. Compared with CaMV35S- actuated GUS expression, DlNF-YB6 and DlNF-YB9 promoters significantly drove GUS expression. Meanwhile, promoter activities were induced to the highest by GA3 but suppressed by IAA. ABA induced the activities of the promoter of DlNF-YB9, whereas it inhibited the promoter of DlNF-YB6.DiscussionHence, DlNF-YB might play a prominent role in longan somatic and zygotic embryo development, and it is involved in complex plant hormones signaling pathways

SIRT1 Activation by a c-MYC Oncogenic Network Promotes the Maintenance and Drug Resistance of Human FLT3-ITD Acute Myeloid Leukemia Stem Cells

SummaryThe FLT3-ITD mutation is frequently observed in acute myeloid leukemia (AML) and is associated with poor prognosis. In such patients, FLT3 tyrosine kinase inhibitors (TKIs) are only partially effective and do not eliminate the leukemia stem cells (LSCs) that are assumed to be the source of treatment failure. Here, we show that the NAD-dependent SIRT1 deacetylase is selectively overexpressed in primary human FLT3-ITD AML LSCs. This SIRT1 overexpression is related to enhanced expression of the USP22 deubiquitinase induced by c-MYC, leading to reduced SIRT1 ubiquitination and enhanced stability. Inhibition of SIRT1 expression or activity reduced the growth of FLT3-ITD AML LSCs and significantly enhanced TKI-mediated killing of the cells. Therefore, these results identify a c-MYC-related network that enhances SIRT1 protein expression in human FLT3-ITD AML LSCs and contributes to their maintenance. Inhibition of this oncogenic network could be an attractive approach for targeting FLT3-ITD AML LSCs to improve treatment outcomes

Existence of Positive Solutions in Generalized Boundary Value Problem for p-Laplacian Dynamic Equations on Time Scales

We analytically establish the conditions for the existence of at least two or three positive solutions in the generalized m-point boundary value problem for the p-Laplacian dynamic equations on time scales by means of the Avery-Henderson fixed point theorem and the five functionals fixed point theorem. Furthermore, we illustrate the possible application of our analytical results with a concrete and nontrivial dynamic equation on specific time scales

Existence of Positive Solutions in Generalized Boundary Value Problem for <inline-formula><graphic file="1687-1847-2009-848191-i1.gif"/></inline-formula>-Laplacian Dynamic Equations on Time Scales

<p/> <p>We analytically establish the conditions for the existence of at least two or three positive solutions in the generalized <inline-formula><graphic file="1687-1847-2009-848191-i2.gif"/></inline-formula>-point boundary value problem for the <inline-formula><graphic file="1687-1847-2009-848191-i3.gif"/></inline-formula>-Laplacian dynamic equations on time scales by means of the Avery-Henderson fixed point theorem and the five functionals fixed point theorem. Furthermore, we illustrate the possible application of our analytical results with a concrete and nontrivial dynamic equation on specific time scales.</p

CO2 splitting by H2O to CO and O2 under UV light in TiMCM-41 silicate sieve

The 266 nm light-induced reaction of CO{sub 2} and H{sub 2}O gas mixtures (including isotopic modifications {sup 13}CO{sub 2}, C{sup 18}O{sub 2}, and D{sub 2}O) in framework TiMCM-41 silicate sieve was monitored by in-situ FT-IR spectroscopy at room temperature. Carbon monoxide gas was observed as the sole product by infrared, and the growth was found to depend linearly on the photolysis laser power. H{sub 2}O was confirmed as stoichiometric electron donor. The work establishes CO as the single photon, 2-electron transfer product of CO{sub 2} photoreduction by H{sub 2}O at framework Ti centers for the first time. O{sub 2} was detected as co-product by mass spectrometric analysis of the photolysis gas mixture. These results are explained by single UV photon-induced splitting of CO{sub 2} by H{sub 2}O to CO and surface OH radical

CO2 splitting by H2O to CO and O2 under UV light in TiMCM-41silicate sieve

The 266 nm light-induced reaction of CO{sub 2} and H{sub 2}O gas mixtures (including isotopic modifications {sup 13}CO{sub 2}, C{sup 18}O{sub 2}, and D{sub 2}O) in framework TiMCM-41 silicate sieve was monitored by in-situ FT-IR spectroscopy at room temperature. Carbon monoxide gas was observed as the sole product by infrared, and the growth was found to depend linearly on the photolysis laser power. H{sub 2}O was confirmed as stoichiometric electron donor. The work establishes CO as the single photon, 2-electron transfer product of CO{sub 2} photoreduction by H{sub 2}O at framework Ti centers for the first time. O{sub 2} was detected as co-product by mass spectrometric analysis of the photolysis gas mixture. These results are explained by single UV photon-induced splitting of CO{sub 2} by H{sub 2}O to CO and surface OH radical