Solar Cycle Variations In The Electron Heat Flux: Ulysses Observations

Solar wind observations by the Ulysses spacecraft now include nearly ten years of continuous ion and electron measurements. In this study, we report detailed measurements of the electron heat flux in the solar wind. In particular, we examine the heat flux measurements for long-term correlations with wave activity and solar wind speed. We find that the average heat flux, when scaled by R2,9to account for variations due to distance from the Sun, is constant and independent of heliographic latitude or solar cycle. We find that during both solar maximum and solar minimum, there is no significant correlation between the magnitude of the electron heat flux and the solar wind speed. Comparison of the electron heat flux data with wave activity indicates that the whistler heat flux instability does not play an important role in limiting the solar wind heat flux

ULF waves in the Io torus: ULYSSES observations

International audienceThroughout the Io torus, Ulysses has observed intense ultralow frequency (ULF) wave activity in both electric and magnetic components. Such ULF waves have been previously suggested as the source of ion precipitation leading to Jovian aurorae. The peaks of the wave spectra are closely related to the ion cyclotron frequencies, which is evidence of the waves being ion cyclotron waves (ICWs). Analysis of the dispersion relation using a multicomponent density model shows that at high latitudes (approximately 30 deg), peak frequencies of the waves fall into L mode branches of guided or unguided ICWs. Near the equator, in addition to the ICWs below fcO(2+), there are strong signals at approximately 10 Hz which require an unexpectedly large energetic ion temperature anistropy to be explained by the excitation of either convective or nonconvective ion cyclotron instabilities. Their generation mechanism remains open for the future study. Evaluation of the Poynting vector and the dispersion relation analysis suggest that the waves near the equator had a small wave angle relative to the magnetic field, while those observed at high latitudes were more oblique. The polarization of the waves below fcH(+) is more random than that of the whistler mode waves, but left-hand-polarized components of the waves can still be seen. The intensity of the ICWs both near the equator and at high latitudes are strong enough to meet the requirement for producing strong pitch angle scattering of energetic ions

Image_2_Preparation, biological characterization and preliminary human imaging studies of 68Ga-DOTA-IBA.tif

PurposeIn this study, DOTA-IBA was radiolabeled with 68Ga and we determined the optimum labelling conditions and assessed the biological properties of 68Ga-DOTA-IBA. We investigated the biodistribution of 68Ga-DOTA-IBA in normal animals and undertook PET/CT imaging in humans. Finally, we explored the feasibility 68Ga-DOTA-IBA as a bone imaging agent and demonstrated its potential for the therapeutic release of 177Lu/225Ac-DOTA-IBA.MethodsThe controlled variables method was used to assess the impact of variables on the radiochemical purity of 68Ga-DOTA-IBA. The biological properties of 68Ga-DOTA-IBA were investigated.68Ga-DOTA-IBA micro-PET/CT imaging was performed on animals. Volunteers were recruited for 68Ga-DOTA-IBA imaging and data were compared to 99mTc-MDP imaging studies to calculate the target to non-target ratio (T/NT) of the lesions.ResultsThe prepared 68Ga-DOTA-IBA had a radiochemical purity of >97% and demonstrated good biological properties with a good safety profile in normal mice. PET/CT imaging of the animals showed rapid blood clearance with high contrast between the bone and stroma. Human imaging showed that 68Ga-DOTA-IBA could detect more lesions compared to 99mTc-MDP and had a higher targeted to untargeted ratio.Conclusions68Ga-DOTA-IBA is an osteophilic radiopharmaceutical that can be synthesized using a simple labelling method. 68Ga-DOTA-IBA has high radiochemical purity and is stable in vitro stability. It is rapidly cleared from the blood, has low toxicity and has strong targeting to the bone with long retention times. We also found that it is rapidly cleared in non-target tissues and has high contrast on whole-body bone imaging. 68Ga-DOTA-IBA PET/CT has potential as a novel bone imaging bone modality in patients with metastatic disease.</p

Image_1_Preparation, biological characterization and preliminary human imaging studies of 68Ga-DOTA-IBA.tif

PurposeIn this study, DOTA-IBA was radiolabeled with 68Ga and we determined the optimum labelling conditions and assessed the biological properties of 68Ga-DOTA-IBA. We investigated the biodistribution of 68Ga-DOTA-IBA in normal animals and undertook PET/CT imaging in humans. Finally, we explored the feasibility 68Ga-DOTA-IBA as a bone imaging agent and demonstrated its potential for the therapeutic release of 177Lu/225Ac-DOTA-IBA.MethodsThe controlled variables method was used to assess the impact of variables on the radiochemical purity of 68Ga-DOTA-IBA. The biological properties of 68Ga-DOTA-IBA were investigated.68Ga-DOTA-IBA micro-PET/CT imaging was performed on animals. Volunteers were recruited for 68Ga-DOTA-IBA imaging and data were compared to 99mTc-MDP imaging studies to calculate the target to non-target ratio (T/NT) of the lesions.ResultsThe prepared 68Ga-DOTA-IBA had a radiochemical purity of >97% and demonstrated good biological properties with a good safety profile in normal mice. PET/CT imaging of the animals showed rapid blood clearance with high contrast between the bone and stroma. Human imaging showed that 68Ga-DOTA-IBA could detect more lesions compared to 99mTc-MDP and had a higher targeted to untargeted ratio.Conclusions68Ga-DOTA-IBA is an osteophilic radiopharmaceutical that can be synthesized using a simple labelling method. 68Ga-DOTA-IBA has high radiochemical purity and is stable in vitro stability. It is rapidly cleared from the blood, has low toxicity and has strong targeting to the bone with long retention times. We also found that it is rapidly cleared in non-target tissues and has high contrast on whole-body bone imaging. 68Ga-DOTA-IBA PET/CT has potential as a novel bone imaging bone modality in patients with metastatic disease.</p