Investigating Role-play Implementation: A Multiple Case Study on Chinese EFL Teachers Using Role-play in Their Secondary Classrooms

This study explored role-play implementation in secondary school EFL classrooms in China with a main research question: How can Chinese EFL teachers make effective use of role-play in their classroom teaching? To explore this question, the author reviewed relevant literature and proposed a theoretical framework for the use of role-play that incorporates three lenses: particular research background in Chinese EFL education context (including a proposed CRCTL approach to meet learner\u27s cultural needs), theoretical ground for positioning role-play in EFL education, and introduction of particular role-play literature (concept, strength and weakness, tutor roles and tasks, previous research studies). A multiple case study on seven Chinese EFL teachers using role-play in their classes is the overall methodology and data were obtained from individual/focus group interviews, direct classroom observations, and questionnaires. The findings not only reflected the benefits of role-play as a language teaching strategy; the strength of CRCLT in particular cultural contexts, but also responded to a complex question of the needs of teachers and students doing role-play in EFL classrooms in China and to the question of a series of issues that need to be considered in order to meet their needs. Based on the findings, recommendations to classroom teachers, teacher educators and educational administrators have been made followed by a sample role-play project \u27Christmas\u27 which integrates various levels of role-play in different EFL classes. Supported by detailed information from classrooms, this study intends to facilitate more in-depth discussions from researchers and practitioners regarding role-play implementation in EFL classrooms. This study is expected not only to be helpful for EFL teachers and students in China but also for those in other countries

Use of Antihypertensive Agents and Association With Risk of Adverse Outcomes in Chronic Kidney Disease: Focus on Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers.

Background Our objective was to determine patterns of antihypertensive agent use by stage of chronic kidney disease (CKD) and to evaluate the association between different classes of antihypertensive agents with nonrenal outcomes, especially in advanced CKD . Methods and Results We studied 3939 participants of the CRIC (Chronic Renal Insufficiency Cohort) study. Predictors were time-dependent angiotensin-converting enzyme inhibitor or angiotensin receptor blocker , β-blocker, and calcium channel blocker use (versus nonuse of agents in each class). Outcomes were adjudicated heart failure events or death. Adjusted Cox models were used to determine the association between predictors and outcomes. We also examined whether the associations differed based on the severity of CKD (early [stage 2-3 CKD ] versus advanced disease [stage 4-5 CKD ]). During median follow-up of 7.5 years, renin-angiotensin-aldosterone system inhibitor use plateaued during CKD stage 3 (75%) and declined to 37% by stage 5, while β-blocker, calcium channel blocker, and diuretic use increased steadily with advancing CKD . Renin-angiotensin-aldosterone system inhibitor use was associated with lower risk of heart failure (hazard ratio, 0.79; 95% confidence interval, 0.67-0.97) and death (hazard ratio, 0.78; 95% confidence interval, 0.67-0.90), regardless of severity of CKD . Calcium channel blocker use was not associated with risk of heart failure or death, regardless of the severity of CKD . β-Blocker use was associated with higher risk of heart failure (hazard ratio, 1.62; 95% confidence interval, 1.29-2.04) and death (hazard ratio, 1.22; 95% confidence interval, 1.03-1.43), especially during early CKD ( P<0.05 for interaction). Conclusions Angiotensin-converting enzyme inhibitor and angiotensin receptor blocker use decreased, while use of other agents increased with advancing CKD . Use of agents besides angiotensin-converting enzyme inhibitors or angiotensin receptor blockers may be associated with suboptimal outcomes in patients with CKD

MPC for MPC: Secure Computation on a Massively Parallel Computing Architecture

Massively Parallel Computation (MPC) is a model of computation widely believed to best capture realistic parallel computing architectures such as large-scale MapReduce and Hadoop clusters. Motivated by the fact that many data analytics tasks performed on these platforms involve sensitive user data, we initiate the theoretical exploration of how to leverage MPC architectures to enable efficient, privacy-preserving computation over massive data. Clearly if a computation task does not lend itself to an efficient implementation on MPC even without security, then we cannot hope to compute it efficiently on MPC with security. We show, on the other hand, that any task that can be efficiently computed on MPC can also be securely computed with comparable efficiency. Specifically, we show the following results: - any MPC algorithm can be compiled to a communication-oblivious counterpart while asymptotically preserving its round and space complexity, where communication-obliviousness ensures that any network intermediary observing the communication patterns learn no information about the secret inputs; - assuming the existence of Fully Homomorphic Encryption with a suitable notion of compactness and other standard cryptographic assumptions, any MPC algorithm can be compiled to a secure counterpart that defends against an adversary who controls not only intermediate network routers but additionally up to 1/3 - ? fraction of machines (for an arbitrarily small constant ?) - moreover, this compilation preserves the round complexity tightly, and preserves the space complexity upto a multiplicative security parameter related blowup. As an initial exploration of this important direction, our work suggests new definitions and proposes novel protocols that blend algorithmic and cryptographic techniques

Effect of Blood Pressure Control on Long-Term Risk of End-Stage Renal Disease and Death Among Subgroups of Patients With Chronic Kidney Disease.

Background Our objective was to explore the effect of intensive blood pressure (BP) control on kidney and death outcomes among subgroups of patients with chronic kidney disease divided by baseline proteinuria, glomerular filtration rate, age, and body mass index. Methods and Results We included 840 MDRD (Modification of Diet in Renal Disease) trial and 1067 AASK (African American Study of Kidney Disease and Hypertension) participants. We used Cox models to examine whether the association between intensive BP control and risk of end-stage renal disease (ESRD) or death is modified by baseline proteinuria (≥0.44 versus <0.44 g/g), glomerular filtration rate (≥30 versus <30 mL/min per 1.73 m2), age (≥40 versus <40 years), or body mass index (≥30 versus <30 kg/m2). The median follow-up was 14.9 years. Strict (versus usual) BP control was protective against ESRD (hazard ratio [HR]ESRD, 0.77; 95% CI, 0.64-0.92) among those with proteinuria ≥0.44 g/g but not proteinuria <0.44 g/g. Strict (versus usual) BP control was protective against death (HRdeath, 0.73; 95% CI, 0.59-0.92) among those with glomerular filtration rate <30 mL/min per 1.73 m2 but not glomerular filtration rate ≥30 mL/min per 1.73 m2 (HRdeath, 0.98; 95% CI, 0.84-1.15). Strict (versus usual) BP control was protective against ESRD among those ≥40 years (HRESRD, 0.82; 95% CI, 0.71-0.94) but not <40 years. Strict (versus usual) BP control was also protective against ESRD among those with body mass index ≥30 kg/m2 (HRESRD, 0.75; 95% CI, 0.61-0.92) but not body mass index <30 kg/m2. Conclusions The ESRD and all-cause mortality benefits of intensive BP lowering may not be uniform across all subgroups of patients with chronic kidney disease. But intensive BP lowering was not associated with increased risk of ESRD or death among any subgroups that we examined

EFFECT OF ISOTHERMAL AGING ON SAC305 HARMONIC VIBRATION DURABILITY

The effect of isothermal aging on the harmonic vibration durability of Sn3.0Ag0.5Cu solder interconnects is examined. Printed wiring assemblies with daisy-chained leadless chip resistors (LCRs) are aged at 125°C for 0, 100, and 500 hours. These assemblies are instrumented with accelerometers and strain gages to maintain the same harmonic vibration profile in-test, and to characterize PWB behavior. The tested assemblies are excited at their first natural frequencies until LCRs show a resistance increase of 20%. Dynamic finite element models are employed to generate strain transfer functions, which relate board strain levels observed in-test to respective solder strain levels. The transfer functions are based on locally averaged values of strains in critical regions of the solder and in appropriate regions of the PWB. The vibration test data and the solder strains from FEA are used to estimate lower-bound material fatigue curves for SAC305 solder materials, as a function of isothermal pre-aging

Computer simulations of block copolymer tethered nanoparticle self-assembly

We perform molecular simulations to study the self-assembly of block copolymer tethered cubic nanoparticles. Minimal models of the tethered nanoscale building blocks (NBBs) are utilized to explore the structures arising from self-assembly. We demonstrate that attaching a rigid nanocube to a diblock copolymer affects the typical equilibrium morphologies exhibited by the pure copolymer. Lamellar and cylindrical phases are observed in both systems but not at the corresponding relative copolymer tether block fractions. The effect of nanoparticle geometry on phase behavior is investigated by comparing the self-assembled structures formed by the tethered NBBs with those of their linear ABCABC triblock copolymer counterparts. The tethered nanocubes exhibit the conventional triblock copolymer lamellar and cylindrical phases when the repulsive interactions between different blocks are symmetric. The rigid and bulky nature of the cube induces interfacial curvature in the tethered NBB phases compared to their linear ABCABC triblock copolymer counterparts. We compare our results with those structures obtained from ABCABC diblock copolymer tethered nanospheres to further elucidate the role of cubic nanoparticle geometry on self-assembly.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87871/2/064905_1.pd

The regulatory function of sphingosine-1-phosphate signaling axis on regulatory T cells in colorectal cancer

In tumors associated with inflammation such as inflammatory bowel disease (IBD) and colorectal cancer (CRC), high numbers of regulatory T cells (Tregs) are associated with both favorable and poor prognoses. The functions of Tregs in CRC remain elusive and have yet to be clearly defined. With new evidence supporting many subsets of Tregs, the research on the development and functions of these cells has begun to come to fruition. The sphingosine 1 phosphate (S1P) pathway was recently reported to regulate the development and function of regulatory T cells. This pathway may shine new light into the pleiotropic nature of these cells in cancer. In this review, we will examine current literature on the many functions of Tregs in CRC and highlight the significance of the S1P signaling pathway in Treg development/function with the implication of novel therapeutic strategies in treatment of CRC patients