The potential interaction between clopidogrel and proton pump inhibitors: a systematic review

<p>Abstract</p> <p>Background</p> <p>Recently, several publications have investigated a possible drug interaction between clopidogrel and proton pump inhibitors (PPIs), and regulatory agencies have issued warnings despite discordant study results. In an attempt to clarify the situation, we performed a systematic review with a critical analysis of study methodologies to determine whether varying study quality (that is, bias) could explain the discordant results.</p> <p>Methods</p> <p>A systematic review of all studies reporting clinical outcomes was performed using an electronic literature search of the MEDLINE and EMBASE databases, abstracts from the major cardiology conferences and a hand-search of bibliographies from identified articles. Each study was evaluated for its risk of bias according to a prespecified quality measure scale.</p> <p>Results</p> <p>A total of 18 studies were identified. Ten of 13 studies judged to be of low scientific quality reported a statistically positive interaction between clopidogrel and the general class of PPIs, and each concluded this was likely a clinically meaningful effect. None of the five studies judged to be of moderate or high quality reported a statistically significant association. Multiple sources of heterogeneity (that is, different populations, outcomes assessed, drug exposure methods and study quality) prevented a formal quantitative analysis of all studies. An increased risk of bias was observed in the positive studies, resulting in an inverse correlation between study quality and a reported statistically positive interaction (10/13 versus 0/5; <it>P </it>= p = 0.007). There was also no clinical evidence for a positive interaction according to specific PPIs.</p> <p>Conclusion</p> <p>The observed association between clopidogrel and PPIs is found uniquely in studies judged to be of low quality and with an increased risk of bias. High-quality evidence supporting a clinically significant clopidogrel/PPI interaction is presently lacking.</p

RobotAtFactory 4.0: a ROS framework for the SimTwo simulator

Robotics competitions encourage the development of solutions to new challenges that emerge in sync with the rise of Industry 4.0. In this context, robotic simulators are employed to facilitate the development of these solutions by disseminating knowledge in robotics, Education 4.0, and STEM. The RobotAtFactory 4.0 competition arises to promote improvements in industrial challenges related to autonomous robots. The official organization provides the simulation scene of the competition through the open-source SimTwo simulator. This paper aims to integrate the SiwTwo simulator with the Robot Operating System (ROS) middleware by developing a framework. This integration facilitates the design of robotic systems since ROS has a vast repository of packages that address common problems in robotics. Thus, competitors can use this framework to develop their solutions through ROS, allowing the simulated and real systems to be integrated.This work has been supported by FCT - Fundação para a Ciência e Tecnologia within the Project Scope: UIDB/05757/2020. The project that gave rise to these results received the support of a fellowship from ”la Caixa” Foundation (ID 100010434). The fellowship code is LCF/BQ/DI20/11780028.info:eu-repo/semantics/publishedVersio

Decolonizing-recolonizing curriculum in management and accounting

Objective: to reflexively understand how management and accounting decolonial academics in the Global South perceive and respond to the decolonizing curriculum agenda created in the Atlantic North within the hyper-contra-revolutionary context of the COVID-19 pandemic. Theoretical approach: we embrace a decolonizing-recolonizing perspective that challenges reaffirms theory/practice and North/South binarisms that we internalize. Method: we embrace action research based on self-criticism and reflexivity to address the experiences of privileged decolonial scholars. Results: our findings reveal important aspects related to decolonizing-recolonizing dynamics that are occurring in bodies, contexts, and academic spaces. Conclusions: our study reveals that decolonizing the management and accounting curriculum in the South is permeated by difficulties for theoretical delinking, which trigger tensions about the constitution of personal/collective being, the mobilization of intellectual/practical activism, the creation of forms of engagement internal/ external to the academy, transcending the competitive/solidaristic academic action model; the construction of knowledge in extractivist/non-extractivist forms; and the materialization of pluriversal knowledge in academic/nonacademic products. We hope to encourage everyday decolonizing-recolonizing management and accounting education that goes beyond the North/South binarism and curricular reforms led by the counter-revolutionary neoliberal university and its Eurocentric business schools

Boundaries, barriers, or bridges? Unraveling the integration of doctoral students in the accounting academic community

We aim to understand how the accounting academic community shapes and socializes doctoral students. From a critical-qualitative stance, the analyses found support in Étienne Wenger’s Social Learning Systems, focusing on the relationship between doctoral students’ socialization and the accounting academic community – understood as a Community of Practice (CoP). Our findings indicate that doctoral students, as Legitimate Peripheral Participants, do not become central members due to imposed communitarian limits. These limits work as an impediment to the relationship between the individual and the CoP. Some participants indicated a loss of meaning and episodes of epistemic violence that (re)produce community limits that define the ‘good accounting academic’, among other aspects, regarding boundaries and power dynamics. We contribute to expanding the discussion on Social Systems of Learning and CoPs by presenting empirical evidence of the barriers between CoPs and the professional socialization process

Effect of Time of Day on Performance, Hormonal and Metabolic Response during a 1000-M Cycling Time Trial

The aim of this study was to determine the effect of time of day on performance, pacing, and hormonal and metabolic responses during a 1000-m cycling time-trial. Nine male, recreational cyclists visited the laboratory four times. During the 1st visit the participants performed an incremental test and during the 2nd visit they performed a 1000-m cycling familiarization trial. On the 3rd and 4th visits, the participants performed a 1000-m TT at either 8 am or 6 pm, in randomized, repeated-measures, crossover design. the time to complete the time trial was lower in the evening than in the morning (88.2 +/- 8.7 versus 94.7 +/- 10.9 s, respectively, p<0.05), but there was no significant different in pacing. However, oxygen uptake and aerobic mechanical power output at 600 and 1000 m tended to be higher in the evening (p<0.07 and 0.09, respectively). There was also a main effect of time of day for insulin, cortisol, and total and free testosterone concentration, which were all higher in the morning (+60%, +26%, +31% and +22%, respectively, p<0.05). the growth hormone, was twofold higher in the evening (p<0.05). the plasma glucose was similar to 11% lower in the morning (p<0.05). Glucagon, norepinephrine, epinephrine and lactate were similar for the morning and evening trials (p<0.05), but the norepinephrine response to the exercise was increased in the morning (+46%, p<0.05), and it was accompanied by a 5-fold increase in the response of glucose. Muscle recruitment, as measured by electromyography, was similar between morning and evening trials (p<0.05). Our findings suggest that performance was improved in the evening, and it was accompanied by an improved hormonal and metabolic milieu.Alagoas Research Foundation (FAPEAL)Univ Fed Alagoas, Sports Sci Res Grp, Maceio, Alagoas, BrazilUniv Fed Pernambuco, CAV, Dept Phys Educ & Sports Sci, Vitoria de Santo Anta, PE, BrazilUniv São Paulo, Sch Phys Educ & Sport, Endurance Performance Res Grp, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med, Div Nephrol, São Paulo, BrazilVictoria Univ, Inst Sport Exercise & Act Living, Melbourne, Vic 8001, AustraliaUniversidade Federal de São Paulo, Dept Med, Div Nephrol, São Paulo, BrazilAlagoas Research Foundation (FAPEAL): 20110825-011-0025-0004Web of Scienc

Impacto da pandemia de COVID-19 na ocorrência de resistência bacteriana frente aos antimicrobianos - revisão integrativa: Impact of the COVID-19 pandemic on the occurrence of bacterial resistance to antimicrobials - integrative review

A pandemia de COVID-19 trouxe imensuráveis consequências para a sociedade, dentre elas o aumento da resistência bacteriana, um problema de saúde pública mundial. O objetivo dessa investigação foi analisar e descrever as evidências cientificas acerca da influência da COVID-19 sobre os índices de resistência bacteriana. Essa pesquisa consiste em uma revisão integrativa da literatura por meio das bases de dados National Library of Medicine National Institutes of Health (PubMed), Science Direct e Biblioteca Virtual em Saúde (BVS/MEDLINE), publicadas no período de 2020 e 2021. Um total de 3537 estudos foram identificados e 20 foram incluídos na análise final. As principais complicações associadas à ocorrência de resistência bacteriana em pacientes com COVID-19 destacadas foram o aumento da taxa de mortalidade seguida do aumento no número de coinfecções e hospitalização prolongada. Além disso, o Staphylococcus aureus foi o agente mais correlacionado com a resistência bacteriana. Por outro lado, a classe medicamentosa com maior índice de resistência associada citada foi a dos macrolídeos. O principal fator associado à pandemia que contribuiu para o advento da resistência bacteriana foi o uso indiscriminado de antimicrobianos. É preciso salientar a importância da implementação de boas práticas assistenciais como as medidas de bundles que incluam gestão e uso racional de antimicrobianos e a busca de evidências científicas para estabelecer condutas médicas mais assertivas, evitando a administração de antimicrobianos de forma inadequada. Dessa forma, será possível minimizar os efeitos da pandemia no que tange os aspectos de resistência bacteriana.A pandemia de COVID-19 trouxe imensuráveis consequências para a sociedade, dentre elas o aumento da resistência bacteriana, um problema de saúde pública mundial. O objetivo dessa investigação foi analisar e descrever as evidências cientificas acerca da influência da COVID-19 sobre os índices de resistência bacteriana. Essa pesquisa consiste em uma revisão integrativa da literatura por meio das bases de dados National Library of Medicine National Institutes of Health (PubMed), Science Direct e Biblioteca Virtual em Saúde (BVS/MEDLINE), publicadas no período de 2020 e 2021. Um total de 3537 estudos foram identificados e 20 foram incluídos na análise final. As principais complicações associadas à ocorrência de resistência bacteriana em pacientes com COVID-19 destacadas foram o aumento da taxa de mortalidade seguida do aumento no número de coinfecções e hospitalização prolongada. Além disso, o Staphylococcus aureus foi o agente mais correlacionado com a resistência bacteriana. Por outro lado, a classe medicamentosa com maior índice de resistência associada citada foi a dos macrolídeos. O principal fator associado à pandemia que contribuiu para o advento da resistência bacteriana foi o uso indiscriminado de antimicrobianos. É preciso salientar a importância da implementação de boas práticas assistenciais como as medidas de bundles que incluam gestão e uso racional de antimicrobianos e a busca de evidências científicas para estabelecer condutas médicas mais assertivas, evitando a administração de antimicrobianos de forma inadequada. Dessa forma, será possível minimizar os efeitos da pandemia no que tange os aspectos de resistência bacteriana