World Press Photo 2012: the discursive construction of the Arab Spring

O presente artigo pretende analisar a forma como o fenómeno da Primavera Árabe foi retratado nas fotografias vencedoras do concurso World Press Photo em 2012. As fotografias jornalísticas, embora se apresentem como índices do real, condicionam frequentemente a percepção dos indivíduos e influenciam as suas práticas sociais. Também as fotografias vencedoras do World Press Photo, um dos concursos mais prestigiados de fotojornalismo, em 2012 não fogem ao construtivismo discursivo que molda a representação e a percepção dos acontecimentos. A partir da análise crítica do discurso, nomeadamente dos instrumentos teóricos da semiótica barthesiana e da semiótica social de Gunther Kress e Theo van Leeuwen, procurámos interpretar as 38 fotografias vencedoras do World Press Photo 2012, a fim de reflectirmos sobre o modo como contribuíram para a compreensão da Revolta Árabe e como despertaram o nosso interesse e a nossa imaginação para o desenrolar do conflito.ABSTRACT:This article aims to analyze how the Arab Spring phenomenon was represented in the award-winning photographs of the World Press Photo contest in 2012. Although news photographs are usually seen as indexes of the real, they often limit the perception of individuals and influence their social practices. Also the winning photographs in 2012 of the World Press Photo, one of the most prestigious photojournalism contests, do not escape the discursive constructivism that shapes the representation and perception of events. Drawing from critical discourse analysis, namely from the theoretical tools of barthesian semiotics and Gunther Kress’s and Theo van Leeuwen’s social semiotics, we sought to interpret the 38 award-winning photographs of the World Press Photo contest in 2012, in order to reflect on the way they have contributed to our understanding of the Arab Revolt and aroused our interest and imagination to the unfolding of the conflict.info:eu-repo/semantics/publishedVersio

Correlations of perceived post-editing effort with measurements of actual effort

Human rating of predicted post-editing effort is a common activity and has been used to train confidence estimation models. However, the correlation between human ratings and actual post-editing effort is under-measured. Moreover, the impact of presenting effort indicators in a post-editing user interface on actual post-editing effort has hardly been researched. In this study, ratings of perceived post-editing effort are tested for correlations with actual temporal, technical and cognitive post-editing effort. In addition, the impact on post-editing effort of the presentation of post-editing effort indicators in the user interface is also tested. The language pair involved in this study is English-Brazilian Portuguese. Our findings, based on a small sample, suggest that there is little agreement between raters for predicted post-editing effort and that the correlations between actual post-editing effort and predicted effort are only moderate, and thus an inefficient basis for MT confidence estimation. Moreover, the presentation of post-editing effort indicators in the user interface appears not to impact on actual post-editing effort

Pioglitazone Treatment Increases Survival and Prevents Body Weight Loss in Tumor-Bearing Animals: Possible Anti-Cachectic Effect

Cachexia is a multifactorial syndrome characterized by profound involuntary weight loss, fat depletion, skeletal muscle wasting, and asthenia; all symptoms are not entirely attributable to inadequate nutritional intake. Adipose tissue and skeletal muscle loss during cancer cachexia development has been described systematically. the former was proposed to precede and be more rapid than the latter, which presents a means for the early detection of cachexia in cancer patients. Recently, pioglitazone (PGZ) was proposed to exhibit anticancer properties, including a reduction in insulin resistance and adipose tissue loss; nevertheless, few studies have evaluated its effect on survival. for greater insight into a potential anti-cachectic effect due to PGZ, 8-week-old male Wistar rats were subcutaneously inoculated with 1 mL (2x10(7)) of Walker 256 tumor cells. the animals were randomly assigned to two experimental groups: TC (tumor + saline-control) and TP5 (tumor + PGZ/5 mg). Body weight, food ingestion and tumor growth were measured at baseline and after removal of tumor on days 7, 14 and 26. Samples from different visceral adipose tissue (AT) depots were collected on days 7 and 14 and stored at -80oC (5 to 7 animals per day/group). the PGZ treatment showed an increase in the survival average of 27.3%(P<0.01) when compared to TC. It was also associated with enhanced body mass preservation (40.7 and 56.3%, p<0.01) on day 14 and 26 compared with the TC group. the treatment also reduced the final tumor mass (53.4%, p<0.05) and anorexia compared with the TC group during late-stage cachexia. the retroperitoneal AT (RPAT) mass was preserved on day 7 compared with the TC group during the same experimental period. Such effect also demonstrates inverse relationship with tumor growth, on day 14. Gene expression of PPAR-gamma, adiponectin, LPL and C/EBP-alpha from cachectic rats was upregulated after PGZ. Glucose uptake from adipocyte cells (RPAT) was entirely re-established due to PGZ treatment. Taken together, the results demonstrate beneficial effects of PGZ treatment at both the early and final stages of cachexia.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Mogi das Cruzes, Integrated Grp Biotechnol, Lab Adipose Tissue Biol, Mogi Das Cruzes, BrazilUniv São Paulo, Inst Biomed Sci, Canc Metab Res Grp, São Paulo, BrazilUniv São Paulo, Inst Biomed Sci, Physiol Lab, São Paulo, BrazilUniv Estadual Maringa, Dept Physiol Sci, Maringa, Parana, BrazilUniversidade Federal de São Paulo, Dept Biomed Engn, Sao Jose Dos Campos, BrazilBoston Sch Med, Dept Biochem, Boston, MA USAUniversidade Federal de São Paulo, Dept Biomed Engn, Sao Jose Dos Campos, BrazilFAPESP: 2010/51078-1FAPESP: 2008/54091-9FAPESP: 2012/51094-1Web of Scienc

C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate ragulator assembly

Ragulator is a pentamer composed of p18, MP1, p14, C7orf59, and hepatitis B virus X-interacting protein (HBXIP; LAMTOR 1-5) which acts as a lysosomal scaffold of the Rag GTPases in the amino acid sensitive branch of TORC1 signaling. Here, we present the crystal structure of human HBXIP-C7orf59 dimer (LAMTOR 4/5) at 2.9 angstrom and identify a phosphorylation site on C7orf59 which modulates its interaction with p18. Additionally, we demonstrate the requirement of HBXIP-C7orf59 to stabilize p18 and allow further binding of MP1-p14. The structure of the dimer revealed an unfolded N terminus in C7orf59 (residues 1-15) which was shown to be essential for p18 binding. Full-length p18 does not interact stably with MP1-p14 in the absence of HBXIP-C7orf59, but deletion of p18 residues 108-161 rescues MP1-p14 binding. C7orf59 was phosphorylated by protein kinase A (PKA) in vitro and mutation of the conserved Ser67 residue to aspartate prevented phosphorylation and negatively affected the C7orf59 interaction with p18 both in cell culture and in vitro. C7orf59 Ser67 was phosphorylated in human embryonic kidney 293T cells. PKA activation with forskolin induced dissociation of p18 from C7orf59, which was prevented by the PKA inhibitor H-89. Our results highlight the essential role of HBXIP-C7orf59 dimer as a nucleator of pentameric Ragulator and support a sequential model of Ragulator assembly in which HBXIP-C7orf59 binds and stabilizes p18 which allows subsequent binding of MP1-p149915891602CNPQ - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPESP – Fundação de Amparo à Pesquisa Do Estado De São Paulo2014/12445-0; 2017/21455-7; 2014/17264-3190174/2012-

Eyetracking and Applied Linguistics

Eyetracking has become a powerful tool in scientific research and has finally found its way into disciplines such as applied linguistics and translation studies, paving the way for new insights and challenges in these fields. The aim of the first International Conference on Eyetracking and Applied Linguistics (ICEAL) was to bring together researchers who use eyetracking to empirically answer their research questions. It was intended to bridge the gaps between applied linguistics, translation studies, cognitive science and computational linguistics on the one hand and to further encourage innovative research methodologies and data triangulation on the other hand. These challenges are also addressed in this proceedings volume: While the studies described in the volume deal with a wide range of topics, they all agree on eyetracking as an appropriate methodology in empirical research

Eyetracking and Applied Linguistics

Eyetracking has become a powerful tool in scientific research and has finally found its way into disciplines such as applied linguistics and translation studies, paving the way for new insights and challenges in these fields. The aim of the first International Conference on Eyetracking and Applied Linguistics (ICEAL) was to bring together researchers who use eyetracking to empirically answer their research questions. It was intended to bridge the gaps between applied linguistics, translation studies, cognitive science and computational linguistics on the one hand and to further encourage innovative research methodologies and data triangulation on the other hand. These challenges are also addressed in this proceedings volume: While the studies described in the volume deal with a wide range of topics, they all agree on eyetracking as an appropriate methodology in empirical research

Eyetracking and Applied Linguistics

Eyetracking has become a powerful tool in scientific research and has finally found its way into disciplines such as applied linguistics and translation studies, paving the way for new insights and challenges in these fields. The aim of the first International Conference on Eyetracking and Applied Linguistics (ICEAL) was to bring together researchers who use eyetracking to empirically answer their research questions. It was intended to bridge the gaps between applied linguistics, translation studies, cognitive science and computational linguistics on the one hand and to further encourage innovative research methodologies and data triangulation on the other hand. These challenges are also addressed in this proceedings volume: While the studies described in the volume deal with a wide range of topics, they all agree on eyetracking as an appropriate methodology in empirical research

Eyetracking and Applied Linguistics

Eyetracking has become a powerful tool in scientific research and has finally found its way into disciplines such as applied linguistics and translation studies, paving the way for new insights and challenges in these fields. The aim of the first International Conference on Eyetracking and Applied Linguistics (ICEAL) was to bring together researchers who use eyetracking to empirically answer their research questions. It was intended to bridge the gaps between applied linguistics, translation studies, cognitive science and computational linguistics on the one hand and to further encourage innovative research methodologies and data triangulation on the other hand. These challenges are also addressed in this proceedings volume: While the studies described in the volume deal with a wide range of topics, they all agree on eyetracking as an appropriate methodology in empirical research

Eyetracking and Applied Linguistics

Eyetracking has become a powerful tool in scientific research and has finally found its way into disciplines such as applied linguistics and translation studies, paving the way for new insights and challenges in these fields. The aim of the first International Conference on Eyetracking and Applied Linguistics (ICEAL) was to bring together researchers who use eyetracking to empirically answer their research questions. It was intended to bridge the gaps between applied linguistics, translation studies, cognitive science and computational linguistics on the one hand and to further encourage innovative research methodologies and data triangulation on the other hand. These challenges are also addressed in this proceedings volume: While the studies described in the volume deal with a wide range of topics, they all agree on eyetracking as an appropriate methodology in empirical research