Therapeutic decision making in autoimmune and inflammatory disorders of the central nervous system in children.

ABSTRACT Autoimmune and inflammatory disorders of the central nervous system can result in significant morbidity and mortality. Through the recognition of syndromes using diagnostic biomarkers, the clinician is now able to use immune suppressive therapies to improve outcomes. However, the therapeutic decision-making process is complex. The clinician has to balance the risk of disease, with the risk of treatment side effects. To achieve this balance, it is important to understand the natural history of disease, the risk of residual disability, the risk of relapse, and risk of a fatal outcome. It is also important to have some understanding of the pathological processes, as some of the entities have more reversible processes, whereas others have destructive processes. This review will assess the dynamic nature of this decision-making process, and compare some of the more severe diseases such as neuromyelitis optica, anti-N-methyl-D-aspartate receptor encephalitis and opsoclonus myoclonus ataxia syndrome, with disorders with more favourable outcomes such as Sydenham chorea and post-infectious cerebellar ataxia

Therapeutic decision making in autoimmune and inflammatory disorders of the central nervous system in children.

ABSTRACT Autoimmune and inflammatory disorders of the central nervous system can result in significant morbidity and mortality. Through the recognition of syndromes using diagnostic biomarkers, the clinician is now able to use immune suppressive therapies to improve outcomes. However, the therapeutic decision-making process is complex. The clinician has to balance the risk of disease, with the risk of treatment side effects. To achieve this balance, it is important to understand the natural history of disease, the risk of residual disability, the risk of relapse, and risk of a fatal outcome. It is also important to have some understanding of the pathological processes, as some of the entities have more reversible processes, whereas others have destructive processes. This review will assess the dynamic nature of this decision-making process, and compare some of the more severe diseases such as neuromyelitis optica, anti-N-methyl-D-aspartate receptor encephalitis and opsoclonus myoclonus ataxia syndrome, with disorders with more favourable outcomes such as Sydenham chorea and post-infectious cerebellar ataxia

Estimation of energy and material use of sintering-based construction for a lunar outpost - with the example of SinterHab module design

In this paper, we would revisit the usability of microwave for lunar regolith sintering through an in-depth experiment, and examine the minimum materials and energy required for sintering based on the SinterHab design. This will include the minimum layers to print, estimated printing time, minimum energy required for the sintering process and the potential energy sources

Spatio-temporal variation of conversational utterances on Twitter

Conversations reflect the existing norms of a language. Previously, we found that utterance lengths in English fictional conversations in books and movies have shortened over a period of 200 years. In this work, we show that this shortening occurs even for a brief period of 3 years (September 2009-December 2012) using 229 million utterances from Twitter. Furthermore, the subset of geographically-tagged tweets from the United States show an inverse proportion between utterance lengths and the state-level percentage of the Black population. We argue that shortening of utterances can be explained by the increasing usage of jargon including coined words.Comment: 13 pages, 7 figures, published in PLoS On

Lorentz-Violating Vector Fields Slow the Universe Down

We consider the gravitational effects of a single, fixed-norm, Lorentz-violating timelike vector field. In a cosmological background, such a vector field acts to rescale the effective value of Newton's constant. The energy density of this vector field precisely tracks the energy density of the rest of the universe, but with the opposite sign, so that the universe experiences a slower rate of expansion for a given matter content. This vector field similarly rescales Newton's constant in the Newtonian limit, although by a different factor. We put constraints on the parameters of the theory using the predictions of primordial nucleosynthesis, demonstrating that the norm of the vector field should be less than the Planck scale by an order of magnitude or more.Comment: 15 pages, Revtex4, updated version. Added References. Minor Typos corrected. Older version published in PR

A variety of lepton number violating processes related to Majorana neutrino masses

A Majorana type of the neutrino mass matrix induces a class of lepton number violating processes. Cross sections of these reactions are given in terms of the neutrino mass matrix element, and a semi-realistic event rate is estimated. These processes provide mass and mixing parameters not directly accessible by the neutrino oscillation experiments. If these processes are discovered with a larger rate than given here, it would imply a new physics of the lepton number violation not directly related to the Majorana neutrino mass, such as R-parity violating operators in SUSY models.Comment: 15 pages, 1 figur

Kinetics and moving species during Co2Si formation by rapid thermal annealing

We have investigated the growth kinetics and identified the moving species during Co2Si formation by rapid thermal annealing (RTA). For the kinetics study, samples which consisted of a thin Co film on an evaporated Si substrate were used. To study which species moves, samples imbedded with two very thin Ta markers were employed. Upon RTA, only one silicide phase, Co2Si, was observed to grow before all Co was consumed. The square root of time dependence and the activation energy of about 2.1±0.2 eV were observed during the Co2Si formation up to 680 °C. The marker study indicated that Co is the dominant mobile species during Co2Si formation by RTA. We conclude that Co2Si grows by the same mechanisms during RTA and conventional thermal annealing