57,309 research outputs found
FreezeOut: Accelerate Training by Progressively Freezing Layers
The early layers of a deep neural net have the fewest parameters, but take up
the most computation. In this extended abstract, we propose to only train the
hidden layers for a set portion of the training run, freezing them out
one-by-one and excluding them from the backward pass. Through experiments on
CIFAR, we empirically demonstrate that FreezeOut yields savings of up to 20%
wall-clock time during training with 3% loss in accuracy for DenseNets, a 20%
speedup without loss of accuracy for ResNets, and no improvement for VGG
networks. Our code is publicly available at
https://github.com/ajbrock/FreezeOutComment: Extended Abstrac
Self-organizing, two-temperature Ising model describing human segregation
A two-temperature Ising-Schelling model is introduced and studied for
describing human segregation. The self-organized Ising model with Glauber
kinetics simulated by M\"uller et al. exhibits a phase transition between
segregated and mixed phases mimicking the change of tolerance (local
temperature) of individuals. The effect of external noise is considered here as
a second temperature added to the decision of individuals who consider change
of accommodation. A numerical evidence is presented for a discontinuous phase
transition of the magnetization.Comment: 5 pages, 4 page
SMASH: One-Shot Model Architecture Search through HyperNetworks
Designing architectures for deep neural networks requires expert knowledge
and substantial computation time. We propose a technique to accelerate
architecture selection by learning an auxiliary HyperNet that generates the
weights of a main model conditioned on that model's architecture. By comparing
the relative validation performance of networks with HyperNet-generated
weights, we can effectively search over a wide range of architectures at the
cost of a single training run. To facilitate this search, we develop a flexible
mechanism based on memory read-writes that allows us to define a wide range of
network connectivity patterns, with ResNet, DenseNet, and FractalNet blocks as
special cases. We validate our method (SMASH) on CIFAR-10 and CIFAR-100,
STL-10, ModelNet10, and Imagenet32x32, achieving competitive performance with
similarly-sized hand-designed networks. Our code is available at
https://github.com/ajbrock/SMAS
Generative and Discriminative Voxel Modeling with Convolutional Neural Networks
When working with three-dimensional data, choice of representation is key. We
explore voxel-based models, and present evidence for the viability of
voxellated representations in applications including shape modeling and object
classification. Our key contributions are methods for training voxel-based
variational autoencoders, a user interface for exploring the latent space
learned by the autoencoder, and a deep convolutional neural network
architecture for object classification. We address challenges unique to
voxel-based representations, and empirically evaluate our models on the
ModelNet benchmark, where we demonstrate a 51.5% relative improvement in the
state of the art for object classification.Comment: 9 pages, 5 figures, 2 table
Free Form Lensing Implications for the Collision of Dark Matter and Gas in the Frontier Fields Cluster MACSJ0416.1-2403
We present a free form mass reconstruction of the massive lensing cluster
MACSJ0416.1-2403 using the latest Hubble Frontier Fields data. Our model
independent method finds that the extended lensing pattern is generated by two
elongated, closely projected clusters of similar mass. Our lens model
identifies new lensed images with which we improve the accuracy of the dark
matter distribution. We find that the bimodal mass distribution is nearly
coincident with the bimodal X-ray emission, but with the two dark matter peaks
lying closer together than the centroids of the X-ray emisison. We show this
can be achieved if the collision has occurred close to the plane and such that
the cores are deflected around each other. The projected mass profiles of both
clusters are well constrained because of the many interior lensed images,
leading to surprisingly flat mass profiles of both components in the region
15-100 kpc. We discuss the extent to which this may be generated by tidal
forces in our dynamical model which are large during an encounter of this type
as the cores "graze" each other. The relative velocity between the two cores is
estimated to be about 1200 km/s and mostly along the line of sight so that our
model is consistent with the relative redshift difference between the two cD
galaxies (dz = 0.04).Comment: 22 pages, 18 figures, 2 table
The clinical effectiveness and cost-effectiveness of inhaler devices used in the routine management of chronic asthma in older children: a systematic review and economic evaluation
Background:
This review examines the clinical effectiveness and
cost-effectiveness of hand-held inhalers to deliver
medication for the routine management of chronic
asthma in children aged between 5 and 15 years.
Asthma is a common disease of the airways, with a
prevalence of treated asthma in 5–15-year-olds of
around 12% and an actual prevalence in the community
as high as 23%. Treatment for the condition
is predominantly by inhalation of medication. There
are three main types of inhaler device, pressurised
metered dose, breath actuated, and dry powder, with
the option of the attachment of a spacer to the first
two devices under some prescribed circumstances.
Two recent reviews have examined the clinical and
cost-effectiveness evidence on inhaler devices, but
one was for children aged under 5 years and the
comparison in the second was made between pressurised
metered dose inhalers and other types only.
Objectives:
This review examines the clinical effectiveness and
cost-effectiveness of manual pressurised metered
dose inhalers, breath-actuated metered dose
inhalers, and breath-actuated dry powder inhalers,
with and without spacers as appropriate, to deliver
medication for the routine management of chronic
asthma in children aged between 5 and 15 years.
Methods:
Two previous HTA reviews have compared the
effectiveness of inhaler devices, one focusing on
asthma in children aged under 5 years and the
other on asthma and chronic obstructive airways
disease in all age groups. For the current review, a
literature search was carried out to identify all
evidence relating to the use of inhalers in older
children with chronic asthma. A search of in-vitro
studies undertaken for one of the previous reviews
was also updated.
The data sources used were: 15 electronic bibliographic
databases; the reference lists of one of the
previous HTA reports and other relevant articles;
health services research-related internet resources;
and all sponsor submissions.
Studies were selected according to strict inclusion
and exclusion criteria, and relevant information
concerning effectiveness and patient compliance
and preference was extracted directly on to an
extraction/evidence table. Quality assurance
was monitored.
Economic evaluation was undertaken by reviewing
existing cost-effective evidence. Further economic
modelling was carried out, and tables constructed
to determine device cost-minimisation and
incremental quality-adjusted life-year (QALY)
thresholds between devices.
Results:
Number and quality of studies, and
direction of evidence:
Fourteen randomised controlled studies were
identified relating to the clinical effectiveness of
inhaler devices for delivering β2-agonists. A further
five were on devices delivering corticosteroids and
one concerned the delivery of cromoglicate.
Overall, there were no differences in clinical
efficacy between inhaler devices, but a pressurised
metered dose inhaler with a spacer would appear
to be more effective than one without. These
findings endorse those of a previous HTA review
but extend them to other inhaler devices.
Seven randomised controlled trials examined the
impact on clinical effectiveness of using a nonchlorofluorocarbon
(CFC) propellant in place of
a CFC propellant in metered dose inhalers, both
pressurised and breath activated, although only one
study considered the latter type. No differences were
found between inhalers containing either propellant.
A further 30 studies of varying quality, from 12 randomised
controlled trials to non-controlled studies,
were identified that concerned the impact of use
by, and preference for, inhaler type, and treatment
adherence in children. Differences between the
studies, and limitations in comparative data between
various inhaler device types, make it difficult to draw
any firm conclusions from this evidence.
Summary of benefits:
No obvious benefits for one inhaler device type
over another for use in children aged 5–15 years
were identified.
Costs and cost per quality-adjusted
life-year:
Two approaches have been taken: cost-minimisation
and QALY threshold. In the QALY threshold
approach, additional QALYs that each device must
produce compared with a cheaper device to achieve
an acceptable cost per QALY were calculated. Using
the cheapest and most expensive devices for delivering
200 μg of beclometasone per day, assuming no
cost offset for any device, and a threshold of £5000,
the largest QALY needed was 0.00807. With such
a small QALY increase, no intervention can be
categorically rejected as not cost-effective.
Conclusions:
Generalisability of findings:
On the available evidence there are no obvious
benefits for one inhaler device over another
when used by children aged 5–15 years with
chronic asthma. However, the evidence, in the
majority of cases, was compiled on children
with mild to moderate asthma and restricted
to a limited number of drugs. Therefore the
findings may not be generalisable to those at
the more severe end of the spectrum of the
disease or to inhaler devices delivering some
of the drugs used in the management of asthma.
Need for further research:
Many of the previous studies are likely to
have been underpowered. Further clinical
trials with a robust methodology, sufficient
power and qualitative components are needed
to demonstrate any differences in clinical
resource use and patients’ asthma symptoms.
Further studies should also include the
behavioural aspects of patients towards their
medication and its delivery mechanisms.
It is acknowledged that sufficient power may
prove impractical owing to the large numbers
of patients required
Millimeter and hard x ray/gamma ray observations of solar flares during the June 1991 GRO campaign
We have carried out high-spatial-resolution millimeter observations of solar flares using the Berkeley-Illinois-Maryland Array (BIMA). At the present time, BIMA consists of only three elements, which is not adequate for mapping highly variable solar phenomena, but is excellent for studies of the temporal structure of flares at millimeter wavelengths at several different spatial scales. We present BIMA observations made during the Gamma Ray Observatories (GRO)/Solar Max 1991 campaign in Jun. 1991 when solar activity was unusually high. Our observations covered the period 8-9 Jun. 1991; this period overlapped the period 4-15 Jun. when the Compton Telescope made the Sun a target of opportunity because of the high level of solar activity
Optimal Estimates for the Electric Field in Two-Dimensions
The purpose of this paper is to set out optimal gradient estimates for
solutions to the isotropic conductivity problem in the presence of adjacent
conductivity inclusions as the distance between the inclusions goes to zero and
their conductivities degenerate. This difficult question arises in the study of
composite media. Frequently in composites, the inclusions are very closely
spaced and may even touch. It is quite important from a practical point of view
to know whether the electric field (the gradient of the potential) can be
arbitrarily large as the inclusions get closer to each other or to the boundary
of the background medium.
In this paper, we establish both upper and lower bounds on the electric field
in the case where two circular conductivity inclusions are very close but not
touching. We also obtain such bounds when a circular inclusion is very close to
the boundary of a circular domain which contains the inclusion. The novelty of
these estimates, which improve and make complete our earlier results published
in Math. Ann., is that they give an optimal information about the blow-up of
the electric field as the conductivities of the inclusions degenerate.Comment: 26 page
Reconfigurable self-sufficient traps for ultracold atoms based on a superconducting square
We report on the trapping of ultracold atoms in the magnetic field formed
entirely by persistent supercurrents induced in a thin film type-II
superconducting square. The supercurrents are carried by vortices induced in
the 2D structure by applying two magnetic field pulses of varying amplitude
perpendicular to its surface. This results in a self-sufficient quadrupole trap
that does not require any externally applied fields. We investigate the
trapping parameters for different supercurrent distributions. Furthermore, to
demonstrate possible applications of these types of supercurrent traps we show
how a central quadrupole trap can be split into four traps by the use of a bias
field.Comment: 5 pages, 7 figure
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