Pengaruh Modal Intelektual Dan Modal Sosial Terhadap Kinerja Perusahaan Dengan Karakteristik Dewan Komisaris Sebagai Variabel Moderasi

Penelitian ini bertujuan untuk menganalisis pengaruh modal intelektual dan modal sosial terhadap kinerja perusahaan dan menguji peran karakteristik dewan komisaris sebagai variabel moderasi. Penelitian ini menggunakan sampel perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia mulai tadi 2012-2016 dengan total 41 perusahaan. Pemilihan sampel dilakukan berdasarkan metode purposive sampling dengan tujuan untuk mendapatkan sampel yang sesuai dengan tujuan penelitian. Berdasarkan kriteria tertentu yang telah ditetapkan, didapatkan pooling data dengan unit analisis 130. Teknik analisis yang digunakan adalah analisis regresi moderasi. Hasil penelitian menunjukkan bahwa modal intelektual dan modal sosial berpengaruh positif terhadap kinerja perusahaan. Berikutnya, variabel karakteristik dewan komisaris yang diukur dengan menggunakan indikator jumlah dewan komisaris, presentase dewan komisaris independen dan kualifikasi dewan komisaris terbukti bukan merupakan variabel moderasi. Kinerja perusahaan dapat meningkat apabila informasi mengenai modal intelektual dan modal sosial disajikan bagi pengguna laporan keuangan, sehingga informasi ini dapat meningkatkan kepercayaan pemangku kepentingan terhadap perusahaan dan menjadi bahan pertimbangan bagi pemegang saham dalam mengambil keputusan berinvestasi di dalam perusahaan, dan pada akhirnya kepercayaan dan dana investasi yang diberikan pada perusahaan dapat mendorong meningkatnya kegiatan operasional perusahaan yang mengarah pada peningkatan kinerja perusahaan. Hal ini sesuai dengan teori pemangku kepentingan (stakeholder theory)

The host response to the probiotic Escherichia coli strain Nissle 1917: Specific up-regulation of the proinflammatory chemokine MCP-1

BACKGROUND: The use of live microorganisms to influence positively the course of intestinal disorders such as infectious diarrhea or chronic inflammatory conditions has recently gained increasing interest as a therapeutic alternative. In vitro and in vivo investigations have demonstrated that probiotic-host eukaryotic cell interactions evoke a large number of responses potentially responsible for the effects of probiotics. The aim of this study was to improve our understanding of the E. coli Nissle 1917-host interaction by analyzing the gene expression pattern initiated by this probiotic in human intestinal epithelial cells. METHODS: Gene expression profiles of Caco-2 cells treated with E. coli Nissle 1917 were analyzed with microarrays. A second human intestinal cell line and also pieces of small intestine from BALB/c mice were used to confirm regulatory data of selected genes by real-time RT-PCR and cytometric bead array (CBA) to detect secretion of corresponding proteins. RESULTS: Whole genome expression analysis revealed 126 genes specifically regulated after treatment of confluent Caco-2 cells with E. coli Nissle 1917. Among others, expression of genes encoding the proinflammatory molecules monocyte chemoattractant protein-1 ligand 2 (MCP-1), macrophage inflammatory protein-2 alpha (MIP-2α) and macrophage inflammatory protein-2 beta (MIP-2β) was increased up to 10 fold. Caco-2 cells cocultured with E. coli Nissle 1917 also secreted high amounts of MCP-1 protein. Elevated levels of MCP-1 and MIP-2α mRNA could be confirmed with Lovo cells. MCP-1 gene expression was also up-regulated in mouse intestinal tissue. CONCLUSION: Thus, probiotic E. coli Nissle 1917 specifically upregulates expression of proinflammatory genes and proteins in human and mouse intestinal epithelial cells

69th Issue Info Kampus UiTM Sarawak Buletin : Januari 2015 / Professor Dato Dr. Jamil Hj Hamali... [et al.]

A very happy 2015 to UITM staff and students. I would like to express my deepest appreciation to the Chief Minister of Sarawak, Yang Amat Berhormat Dato Patinggi Tan Sri (Dr) Haji Adenan bin Haji Satem and the Vice - Chancellor of UITM,Yang Berbahagia Tan Sri Dato' Sri Professor Ir. Dr. Sahol Hamid Abu Bakar, FASc for the continues support given to UITM Sarawak.To the staff, i thank you all for your cooperation and dedication which have contributed to the tremendous development made by UITM Sarawak.In addition, i also encourage UITM Sarawak student to work hard and excel in their studies

Unravelling polar lipids dynamics during embryonic development of two sympatric brachyuran crabs (Carcinus maenas and Necora puber) using lipidomics

Embryogenesis is an important stage of marine invertebrates with bi-phasic life cycles, as it conditions their larval and adult life. Throughout embryogenesis, phospholipids (PL) play a key role as an energy source, as well as constituents of biological membranes. However, the dynamics of PL during embryogenesis in marine invertebrates is still poorly studied. The present work used a lipidomic approach to determine how polar lipid profiles shift during embryogenesis in two sympatric estuarine crabs, Carcinus maenas and Necora puber. The combination of thin layer chromatography, liquid chromatography – mass spectrometry and gas chromatography – mass spectrometry allowed us to achieve an unprecedented resolution on PL classes and molecular species present on newly extruded embryos (stage 1) and those near hatching (stage 3). Embryogenesis proved to be a dynamic process, with four PL classes being recorded in stage 1 embryos (68 molecular species in total) and seven PL classes at stage 3 embryos (98 molecular species in total). The low interspecific difference recorded in the lipidomic profiles of stage 1 embryos appears to indicate the existence of similar maternal investment. The same pattern was recorded for stage 3 embryos revealing a similar catabolism of embryonic resources during incubation for both crab species

Genetics of asthma: a molecular biologist perspective

Asthma belongs to the category of classical allergic diseases which generally arise due to IgE mediated hypersensitivity to environmental triggers. Since its prevalence is very high in developed or urbanized societies it is also referred to as "disease of civilizations". Due to its increased prevalence among related individuals, it was understood quite long back that it is a genetic disorder. Well designed epidemiological studies reinforced these views. The advent of modern biological technology saw further refinements in our understanding of genetics of asthma and led to the realization that asthma is not a disorder with simple Mendelian mode of inheritance but a multifactorial disorder of the airways brought about by complex interaction between genetic and environmental factors. Current asthma research has witnessed evidences that are compelling researchers to redefine asthma altogether. Although no consensus exists among workers regarding its definition, it seems obvious that several pathologies, all affecting the airways, have been clubbed into one common category called asthma. Needless to say, genetic studies have led from the front in bringing about these transformations. Genomics, molecular biology, immunology and other interrelated disciplines have unearthed data that has changed the way we think about asthma now. In this review, we center our discussions on genetic basis of asthma; the molecular mechanisms involved in its pathogenesis. Taking cue from the existing data we would briefly ponder over the future directions that should improve our understanding of asthma pathogenesis

Prospect of vasoactive intestinal peptide therapy for COPD/PAH and asthma: a review

There is mounting evidence that pulmonary arterial hypertension (PAH), asthma and chronic obstructive pulmonary disease (COPD) share important pathological features, including inflammation, smooth muscle contraction and remodeling. No existing drug provides the combined potential advantages of reducing vascular- and bronchial-constriction, and anti-inflammation. Vasoactive intestinal peptide (VIP) is widely expressed throughout the cardiopulmonary system and exerts a variety of biological actions, including potent vascular and airway dilatory actions, potent anti-inflammatory actions, improving blood circulation to the heart and lung, and modulation of airway secretions. VIP has emerged as a promising drug candidate for the treatment of cardiopulmonary disorders such as PAH, asthma, and COPD. Clinical application of VIP has been limited in the past for a number of reasons, including its short plasma half-life and difficulty in administration routes. The development of long-acting VIP analogues, in combination with appropriate drug delivery systems, may provide clinically useful agents for the treatment of PAH, asthma, and COPD. This article reviews the physiological significance of VIP in cardiopulmonary system and the therapeutic potential of VIP-based agents in the treatment of pulmonary diseases