Transdermal β-Blocker Therapy in Essential Hypertension

Transdermal drug delivery has been applied to various agents in an effort to decrease the frequency of drug administration and increase the patients compliance. In our study, we demonstrated that transdermal application of a ß-blocker (20 mg mepindolol) in patients with essential hypertension led to effective blood pressure lowering effect within 1 week (160.1 ±6.1 mm Hg/95.8 ± 8.3 mm Hg vs 136.8 ± 7.2 mm Hg/84.3 ± 5.0 mm Hg; Ρ < 0.05). A controlled study of transdermal versus oral ß-blocker administration in hypertensives is necessary before this new therapeutic system is introduced in antihypertensive treatment. Am J Hypertens 1988; 1:199S-200

The Early Royal Society and Visual Culture

Recent studies have fruitfully examined the intersection between early modern science and visual culture by elucidating the functions of images in shaping and disseminating scientific knowledge. Given its rich archival sources, it is possible to extend this line of research in the case of the Royal Society to an examination of attitudes towards images as artefacts –manufactured objects worth commissioning, collecting and studying. Drawing on existing scholarship and material from the Royal Society Archives, I discuss Fellows’ interests in prints, drawings, varnishes, colorants, images made out of unusual materials, and methods of identifying the painter from a painting. Knowledge of production processes of images was important to members of the Royal Society, not only as connoisseurs and collectors, but also as those interested in a Baconian mastery of material processes, including a “history of trades”. Their antiquarian interests led to discussion of painters’ styles, and they gradually developed a visual memorial to an institution through portraits and other visual records.AH/M001938/1 (AHRC

Patient-derived xenograft (PDX) models in basic and translational breast cancer research

Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly supplanting long-established traditional cell lines as preferred models for conducting basic and translational preclinical research. In breast cancer, to complement the now curated collection of approximately 45 long-established human breast cancer cell lines, a newly formed consortium of academic laboratories, currently from Europe, Australia, and North America, herein summarizes data on over 500 stably transplantable PDX models representing all three clinical subtypes of breast cancer (ER+, HER2+, and "Triple-negative" (TNBC)). Many of these models are well-characterized with respect to genomic, transcriptomic, and proteomic features, metastatic behavior, and treatment response to a variety of standard-of-care and experimental therapeutics. These stably transplantable PDX lines are generally available for dissemination to laboratories conducting translational research, and contact information for each collection is provided. This review summarizes current experiences related to PDX generation across participating groups, efforts to develop data standards for annotation and dissemination of patient clinical information that does not compromise patient privacy, efforts to develop complementary data standards for annotation of PDX characteristics and biology, and progress toward "credentialing" of PDX models as surrogates to represent individual patients for use in preclinical and co-clinical translational research. In addition, this review highlights important unresolved questions, as well as current limitations, that have hampered more efficient generation of PDX lines and more rapid adoption of PDX use in translational breast cancer research

Global nachhaltige materielle Wohlstandsniveaus : Analyse und Veranschaulichung global nachhaltiger materieller Versorgungspfade auf der Ebene von Haushalten

Im Rahmen des Forschungsprojektes wurde auf der Ebene von privaten Haushalten untersucht, in welchem Ausmaß eine Bedürfnisbefriedigung mit materiellen Gütern innerhalb der Randbedingungen von globaler Gerechtigkeit, einer nachhaltigen Rohstoffnutzung und einer umweltverträglichen Gesellschaft möglich ist. Zur Bestimmung des Rohstoffbedarfs langlebiger Haushaltsgüter wurden das methodische Konzept der Verfügungskorridore entwickelt und empirisch fundiert sowie global tragfähige Ausstattungen für verschiedene Haushalte prototypisch dargestellt. Das im Rahmen des Projekts entwickelte Webtool veranschaulicht wesentliche Ergebnisse des Forschungsvorhabens. Vor dem Hintergrund ihrer eigenen Haushaltsausstattungen wird den Nutzer/-innen des Webtools das Forschungsthema "Rohstoffverbrauch und Nachhaltigkeit" exemplarisch veranschaulicht, wodurch eine konkrete Reflexion des eigenen Konsumverhaltens ermöglicht wird