Validation study of an approximate 2014 European power-flow model using PowerGAMA

This study presents a validation study of an approximated model of the European power system in 2014. A lightweight and open-source power-flow tool is used for this study. The tool and the model are publicly available and can be adapted to study future impact of large investments in the power system, specifically large-scale integration of renewable energy. The input dataset is based on a prior work, but it has been substantially updated for 2014. To maintain all aspects of the model open-source, only publicly available data was implemented. The modelling approach and simplifications are explained. Comparison of the simulation results with actual data on cross -border flows and energy mix for 2014 shows acceptable correlation. The model is able to capture main characteristics of the power system, such as reservoir handling, hydro pump pattern, and seasonal variation on cross -border flows.acceptedVersio

Isgur - Wise Functions for Confined Light Quarks in a Colour Electric Potential

We explore the influence on the Isgur-Wise function of the colour electric potential between heavy and light quarks in mesons. It is shown that in bag models, its inclusion tends to restore light quark flavour symmetry relative to the MIT bag predictions, and that relative to this model it flattens the Isgur-Wise function. Results compare very well with observations.Comment: 9 pages, 1 figure (available upon request), Latex, TPJU - 4/9

The ECOMA 2007 campaign: rocket observations and numerical modelling of aerosol particle charging and plasma depletion in a PMSE/NLC layer

The ECOMA series of rocket payloads use a set of aerosol particle, plasma, and optical instruments to study the properties of aerosol particles and their interaction with the ambient plasma environment in the polar mesopause region. In August 2007 the ECOMA-3 payload was launched into a region with Polar Mesosphere Summer Echoes (PMSE) and noctilucent clouds (NLC). An electron depletion was detected in a broad region between 83 and 88 km, coincident with enhanced density of negatively charged aerosol particles. We also find evidence for positive ion depletion in the same region. Charge neutrality requires that a population of positively charged particles smaller than 2 nm and with a density of at least 2×10<sup>8</sup> m<sup>−3</sup> must also have been present in the layer, undetected by the instruments. A numerical model for the charging of aerosol particles and their interaction with the ambient plasma is used to analyse the results, showing that high aerosol particle densities are required in order to explain the observed ion density depletion. The model also shows that a very high photoionisation rate is required for the particles smaller than 2 nm to become positively charged, indicating that these may have a lower work function than pure water ice

Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition

The development and implementation of Immune Checkpoint Inhibitors (ICI) in clinical oncology have significantly improved the survival of a subset of cancer patients with metastatic disease previously considered uniformly lethal. However, the low response rates and the low number of patients with durable clinical responses remain major concerns and underscore the limited understanding of mechanisms regulating anti-tumor immunity and tumor immune resistance. There is an urgent unmet need for novel approaches to enhance the efficacy of ICI in the clinic, and for predictive tools that can accurately predict ICI responders based on the composition of their tumor microenvironment. The receptor tyrosine kinase (RTK) AXL has been associated with poor prognosis in numerous malignancies and the emergence of therapy resistance. AXL is a member of the TYRO3-AXL-MERTK (TAM) kinase family. Upon binding to its ligand GAS6, AXL regulates cell signaling cascades and cellular communication between various components of the tumor microenvironment, including cancer cells, endothelial cells, and immune cells. Converging evidence points to AXL as an attractive molecular target to overcome therapy resistance and immunosuppression, supported by the potential of AXL inhibitors to improve ICI efficacy. Here, we review the current literature on the prominent role of AXL in regulating cancer progression, with particular attention to its effects on anti-tumor immune response and resistance to ICI. We discuss future directions with the aim to understand better the complex role of AXL and TAM receptors in cancer and the potential value of this knowledge and targeted inhibition for the benefit of cancer patients.publishedVersio

Links between magnetic fields and plasma flows in a coronal hole

We compare the small-scale features visible in the Ne viii Doppler-shift map of an equatorial coronal hole (CH) as observed by SUMER with the small-scale structures of the magnetic field as constructed from a simultaneous photospheric magnetogram by a potential magnetic-field extrapolation. The combined data set is analysed with respect to the small-scale flows of coronal matter, which means that the Ne viii Doppler-shift used as tracer of the plasma flow is investigated in close connection with the ambient magnetic field. Some small closed-field regions in this largely open CH are also found in the coronal volume considered. The Doppler-shift patterns are found to be clearly linked with the field topology.Comment: 4 pages, 3 figure

Ion Temperatures in the Low Solar Corona: Polar Coronal Holes at Solar Minimum

In the present work we use a deep-exposure spectrum taken by the SUMER spectrometer in a polar coronal hole in 1996 to measure the ion temperatures of a large number of ions at many different heights above the limb between 0.03 and 0.17 solar radii. We find that the measured ion temperatures are almost always larger than the electron temperatures and exhibit a non-monotonic dependence on the charge-to-mass ratio. We use these measurements to provide empirical constraints to a theoretical model of ion heating and acceleration based on gradually replenished ion-cyclotron waves. We compare the wave power required to heat the ions to the observed levels to a prediction based on a model of anisotropic magnetohydrodynamic turbulence. We find that the empirical heating model and the turbulent cascade model agree with one another, and explain the measured ion temperatures, for charge-to-mass ratios smaller than about 0.25. However, ions with charge-to-mass ratios exceeding 0.25 disagree with the model; the wave power they require to be heated to the measured ion temperatures shows an increase with charge-to-mass ratio (i.e., with increasing frequency) that cannot be explained by a traditional cascade model. We discuss possible additional processes that might be responsible for the inferred surplus of wave power.Comment: 11 pages (emulateapj style), 10 figures, ApJ, in press (v. 691, January 20, 2009

Rocket measurements of positive ions during polar mesosphere winter echo conditions

On 18 January 2005, two small, instrumented rockets were launched from Andøya Rocket Range (69.3° N, 16° E) during conditions with Polar Mesosphere Winter Echoes (PMWE). Each of the rockets was equipped with a Positive Ion Probe (PIP) and a Faraday rotation/differential absorption experiment, and was launched as part of a salvo of meteorological rockets measuring temperature and wind using falling spheres and chaff. Layers of PMWE were detected between 55 and 77 km by the 53.5 MHz ALWIN radar. The rockets were launched during a solar proton event, and measured extremely high ion densities, of order 1010 m−3, in the region where PMWE were observed. The density measurements were analyzed with the wavelet transform technique. At large length scales, ~103 m, the power spectral density can be fitted with a k−3 wave number dependence, consistent with saturated gravity waves. Outside the PMWE layers the k−3 spectrum extends down to approximately 102 m where the fluctuations are quickly damped and disappear into the instrumental noise. Inside the PMWE layers the spectrum at smaller length scales is well fitted with a k−5/3 dependence over two decades of scales. The PMWE are therefore clearly indicative of turbulence, and the data are consistent with the turbulent dissipation of breaking gravity waves. We estimate a lower limit for the turbulent energy dissipation rate of about 10−2 W/kg in the upper (72 km) layer

Isgur-Wise Functions from the Mit Bag Model

The Isgur-Wise functions for the ground state to ground state semileptonic decays involving $b \rightarrow c$ transitions are calculated from the (modified) MIT bag model. It is checked that the results for the decays $\overline{B} \rightarrow D l \overline\nu$ and $\overline{B} \rightarrow D^* l \overline\nu$ agree well with experiment. Predictions for the decays $\Lambda_b \rightarrow \Lambda_c l \overline\nu$, $\overline{B}_s \rightarrow D_s l \overline\nu$ and $\overline{B}_s \rightarrow D^*_s l \overline\nu$ are given and discussed.Comment: 12 pages (3 figures available upon request), LaTeX, TPJU - 9/9

The ECOMA 2007 campaign: Rocket observations and numerical modelling of aerosol particle charging and plasma depletion in a PMSE/NLC layer

The ECOMA series of rocket payloads use a set of aerosol particle, plasma, and optical instruments to study the properties of aerosol particles and their interaction with the ambient plasma environment in the polar mesopause region. In August 2007 the ECOMA-3 payload was launched into a region with Polar Mesosphere Summer Echoes (PMSE) and noctilucent clouds (NLC). An electron depletion was detected in a broad region between 83 and 88 km, coincident with enhanced density of negatively charged aerosol particles. We also find evidence for positive ion depletion in the same region. Charge neutrality requires that a population of positively charged particles smaller than 2 nm and with a density of at least 2×108 m−3 must also have been present in the layer, undetected by the instruments. A numerical model for the charging of aerosol particles and their interaction with the ambient plasma is used to analyse the results, showing that high aerosol particle densities are required in order to explain the observed ion density depletion. The model also shows that a very high photoionisation rate is required for the particles smaller than 2 nm to become positively charged, indicating that these may have a lower work function than pure water ice