Square-planar vs. Trigonal bipyramidal geometry in Pt(II) complexes containing triazole-based glucose ligands as potential anticancer agents

This article describes the synthesis, characterization, and biological activity of novel square-planar cationic platinum(II) complexes containing glucoconjugated triazole ligands and a comparison with the results obtained from the corresponding five-coordinate complexes bearing the same triazole ligands. Stability in solution, reactivity with DNA and small molecules of the new compounds were evaluated by NMR, fluorescence, and UV–vis absorption spectroscopy, together with their cytotoxic action against pairs of immortalized and tumorigenic cell lines. The results show that the square-planar species exhibit greater stability than the corresponding five-coordinate ones. Furthermore, although the square-planar complexes are less cytotoxic than the latter ones, they exhibit a certain selectivity. These results simultaneously demonstrate that overall stability is a fundamental prerequisite for preserving the performance of the agents and that coordinative saturation constitutes a point in favor of their biological action

Compact relaxations for polynomial programming problems

Reduced RLT constraints are a special class of Reformulation- Linearization Technique (RLT) constraints. They apply to nonconvex (both continuous and mixed-integer) quadratic programming problems subject to systems of linear equality constraints. We present an extension to the general case of polynomial programming problems and discuss the derived convex relaxation. We then show how to perform rRLT constraint generation so as to reduce the number of inequality constraints in the relaxation, thereby making it more compact and faster to solve. We present some computational results validating our approach

Nuclear halo and the coherent nuclear interaction

The unusual structure of Li11, the first halo nucleus found, is analyzed by the Preparata model of nuclear structure. By applying Coherent Nucleus Theory, we obtain an interaction potential for the halo-neutrons that rightly reproduces the fundamental state of the system.Comment: 9 pages Submitted to International Journal of Modern Physics E (IJMPE

Ageing test of the ATLAS RPCs at X5-GIF

An ageing test of three ATLAS production RPC stations is in course at X5-GIF, the CERN irradiation facility. The chamber efficiencies are monitored using cosmic rays triggered by a scintillator hodoscope. Higher statistics measurements are made when the X5 muon beam is available. We report here the measurements of the efficiency versus operating voltage at different source intensities, up to a maximum counting rate of about 700Hz/cm^2. We describe the performance of the chambers during the test up to an overall ageing of 4 ATLAS equivalent years corresponding to an integrated charge of 0.12C/cm^2, including a safety factor of 5.Comment: 4 pages. Presented at the VII Workshop on Resistive Plate Chambers and Related Detectors; Clermont-Ferrand October 20th-22nd, 200

Channel estimation method with improved performance for the UMTS-TDD mode

Channel estimation is an essential building block for UTRA-TDD high performance receivers. Once the performance of the channel estimator algorithm proposed by 3GPP is highly dependent on the time spreading between consecutive multi-path components, a Successive Multi-path channel Estimation Technique (SMET) that improves the time resolution is proposed in this paper. A SMET based maximum likelihood approach for vectorial channel estimation, to include the estimation of the direction-of-arrival, is also proposed. This algorithm solves efficiently the complex problem of DOA estimation of multiple users in a multi path propagation environment even when the number of required DOA's exceeds the number of antenna array elements. Another property of the proposed algorithm is its ability to resolve signals from different users arriving from the same direction. This is due to processing in both time and space dimensions. The performance of these algorithms is assessed by resorting to simulations in multi-path environments using the UMTS-TDD specifications, and also by comparing the rms estimation errors against the Crámer-Rao Bound. The effect of imperfect channel estimation on the performance of RAKE and Hard-Decision Parallel Interference Canceller receivers is also analysed. The results show that a good performance can be achieved with SMET, from low to high values of Eb/n0

Wax: A benign hydrogen-storage material that rapidly releases H2-rich gases through microwave-assisted catalytic decomposition

Hydrogen is often described as the fuel of the future, especially for application in hydrogen powered fuel-cell vehicles (HFCV’s). However, its widespread implementation in this role has been thwarted by the lack of a lightweight, safe, on-board hydrogen storage material. Here we show that benign, readily-available hydrocarbon wax is capable of rapidly releasing large amounts of hydrogen through microwave-assisted catalytic decomposition. This discovery offers a new material and system for safe and efficient hydrogen storage and could facilitate its application in a HFCV. Importantly, hydrogen storage materials made of wax can be manufactured through completely sustainable processes utilizing biomass or other renewable feedstocks

Entanglement in Many-Body Systems

The recent interest in aspects common to quantum information and condensed matter has prompted a prosperous activity at the border of these disciplines that were far distant until few years ago. Numerous interesting questions have been addressed so far. Here we review an important part of this field, the properties of the entanglement in many-body systems. We discuss the zero and finite temperature properties of entanglement in interacting spin, fermionic and bosonic model systems. Both bipartite and multipartite entanglement will be considered. At equilibrium we emphasize on how entanglement is connected to the phase diagram of the underlying model. The behavior of entanglement can be related, via certain witnesses, to thermodynamic quantities thus offering interesting possibilities for an experimental test. Out of equilibrium we discuss how to generate and manipulate entangled states by means of many-body Hamiltonians.Comment: 61 pages, 29 figure

Nonlinear Integer Programming

Research efforts of the past fifty years have led to a development of linear integer programming as a mature discipline of mathematical optimization. Such a level of maturity has not been reached when one considers nonlinear systems subject to integrality requirements for the variables. This chapter is dedicated to this topic. The primary goal is a study of a simple version of general nonlinear integer problems, where all constraints are still linear. Our focus is on the computational complexity of the problem, which varies significantly with the type of nonlinear objective function in combination with the underlying combinatorial structure. Numerous boundary cases of complexity emerge, which sometimes surprisingly lead even to polynomial time algorithms. We also cover recent successful approaches for more general classes of problems. Though no positive theoretical efficiency results are available, nor are they likely to ever be available, these seem to be the currently most successful and interesting approaches for solving practical problems. It is our belief that the study of algorithms motivated by theoretical considerations and those motivated by our desire to solve practical instances should and do inform one another. So it is with this viewpoint that we present the subject, and it is in this direction that we hope to spark further research.Comment: 57 pages. To appear in: M. J\"unger, T. Liebling, D. Naddef, G. Nemhauser, W. Pulleyblank, G. Reinelt, G. Rinaldi, and L. Wolsey (eds.), 50 Years of Integer Programming 1958--2008: The Early Years and State-of-the-Art Surveys, Springer-Verlag, 2009, ISBN 354068274