689 research outputs found
An integrated numerical model for wave-soil-pipeline interactions
YesAn integrated Finite Element Method (FEM) model is proposed to investigate the dynamic seabed response for several specific pipeline layouts and to simulate the pipeline stability under waves loading. In the present model, the Reynolds-Averaged Navier-Stokes (RANS) equations are used to describe the wave motion in a fluid domain, while the seabed domain is described using the Biotâs poro-elastic theory. The interface between water and air is tracked by conservative Level Set method (LSM). The FEM and backward differentiation formula (BDF) are applied for spatial and temporal discretization respectively in the present model. One-way coupling is used to integrate flow and seabed models. The present model is firstly validated using several available laboratory experiments. It is then further extended to practical engineering applications, including the dynamic seabed response for the pipeline mounted on a flat seabed or inside a trench. The results show that the pipeline buried to a certain depth is better protected than that under partially buried in terms of transient liquefaction.Energy Technology Partnership (ETP), Wood Group Kenn
Full-length sequence analysis of a distinct isolate of Bidens mottle virus infecting sunflower in Taiwan
The full-length genome of a potyvirus, previously known as sunflower chlorotic spot virus isolate SF-1 (SCSV-SF-1) which causes novel symptoms on sunflowers (Helianthus annuus), was sequenced and analyzed. The genome of SCSV-SF-1 is 9,741 nucleotides long, encoding a polyprotein of 3,071 amino acids containing the consensus motifs of potyviruses. Sequence comparison revealed that the 3'-terminus of SCSV-SF-1 shared over 96% similarities with isolates of Bidens mottle virus (BiMoV). However, SCSV-SF-1 has a very narrow host range, excluding the diagnostic host species for BiMoV, Bidens pilosa and Zinnia elegans. Therefore, SCSV-SF-1 is a distinct isolate of BiMoV. This is the first report of the full-length nucleotide sequence of BiMoV infecting sunflower in Taiwan
Water vapor deposition from the inner gas coma onto the nucleus of Comet 67P/Churyumov-Gerasimenko
Rosetta has detected water ice existing on the surface of Comet 67P/Churyumov-Gerasimenko in various types of features. One of particular interest is the frost-like layer observed at the edge of receding shadows during the whole mission, interpreted as the recondensation of a thin layer of water ice. Two possible mechanisms, (1) subsurface ice sublimation and (2) gas coma deposition, have been proposed for producing this recondensation process and diurnal cycles of water ice. Previous studies have demonstrated both mechanisms based on simplified models. More precise and modern models are yet insufficient when addressing the gas-coma-deposition mechanism. We aim to study the recondensation from the inner water gas coma of the 67P/Churyumov-Gerasimenko with more physical constraints including the OSIRIS images, nucleus shape model, and insolation conditions. We compute, for the first time, the backflux distributions from the coma with various boundary conditions. Numerical simulations of this gas-coma-deposition process show that the equivalent water ice deposition can be up to several microns in an hour of accumulation time close to the perihelion passage, which is comparable with the simulation results of the other subsurface-ice sublimation mechanism
Innovative ligand-assisted synthesis of NIR-activated iron oxide for cancer theranostics
This work presents the development of a facile ligand-assisted hydrothermal reaction for the preparation of NIR-activated Fe3O4 nanostructures that can directly upgrade the iron oxide with MR contrast ability to be a MRI/photothermal theranostic agent
Structural optimisation of random discontinuous fibre composites: Part 1 â Methodology
This paper presents a finite element model to optimise the fibre architecture of components manufactured from discontinuous fibre composites. An optimality criterion method has been developed to maximise global component stiffness, by determining optimum distributions for local section thickness and preform areal mass. The model is demonstrated by optimising the bending performance of a flat plate with three holes. Results are presented from a sensitivity study to highlight the level of compromise in stiffness optimisation caused by manufacturing constraints associated with the fibre deposition method, such as the scale of component features relative to the fibre length
Discovery of New Natural Products by Intact-Cell Mass Spectrometry and LC-SPE-NMR: Malbranpyrroles, Novel Polyketides from Thermophilic Fungus Malbranchea sulfurea
Six photosensitive polyketides, malbranpyrroles A-F, were discovered from the thermophilic fungus Malbranchea sulfurea by using intact-cell desorption/ionization on silicon mass (ICD-MS) and LC-SPE-NMR. These two strategies facilitate the searching and structural determination of unstable natural products. The ICD-MS indicated that only brown hyphae of M. sulfurea can produce malbranpyrroles. The biosynthetic pathway of malbranpyrroles was evidenced by (13)C isotope precursors and amino acid feeding experiments. The cytotoxicity data revealed that the conformation of the conjugated system in malbranpyrroles does not affect cytotoxic potency against cancer cell lines. In addition, the chlorine atom was shown to be the pharmacophore for cytotoxicity
Mutations in the Salmonella enterica serovar Choleraesuis cAMP-receptor protein gene lead to functional defects in the SPI-1 Type III secretion system
Salmonella enterica serovar Choleraesuis (Salmonella Choleraesuis) causes a lethal systemic infection (salmonellosis) in swine. Live attenuated Salmonella Choleraesuis vaccines are effective in preventing the disease, and isolates of Salmonella Choleraesuis with mutations in the cAMP-receptor protein (CRP) gene (Salmonella Choleraesuis Delta crp) are the most widely used, although the basis of the attenuation remains unclear. The objective of this study was to determine if the attenuated phenotype of Salmonella Choleraesuis Delta crp was due to alterations in susceptibility to gastrointestinal factors such as pH and bile salts, ability to colonize or invade the intestine, or cytotoxicity for macrophages. Compared with the parental strain, the survival rate of Salmonella Choleraesuis Delta crp at low pH or in the presence of bile salts was higher, while the ability of the mutant to invade intestinal epithelia was significantly decreased. In examining the role of CRP on the secretory function of the Salmonella pathogenicity island 1 (SPI-1) encoded type III secretion system (T3SS), it was shown that Salmonella Choleraesuis Delta crp was unable to secrete the SPI-1 T3SS effector proteins, SopB and SipB, which play a role in Salmonella intestinal invasiveness and macrophage cytotoxicity, respectively. In addition, caspase-1 dependent cytotoxicity for macrophages was significantly reduced in Salmonella Choleraesuis Delta crp. Collectively, this study demonstrates that the CRP affects the secretory function of SPI-1 T3SS and the resulting ability to invade the host intestinal epithelium, which is a critical element in the pathogenesis of Salmonella Choleraesuis
Measurements of the observed cross sections for exclusive light hadrons containing at , 3.650 and 3.6648 GeV
By analyzing the data sets of 17.3, 6.5 and 1.0 pb taken,
respectively, at , 3.650 and 3.6648 GeV with the BES-II
detector at the BEPC collider, we measure the observed cross sections for
, , ,
and at the three energy
points. Based on these cross sections we set the upper limits on the observed
cross sections and the branching fractions for decay into these
final states at 90% C.L..Comment: 7 pages, 2 figure
Partial wave analysis of J/\psi \to \gamma \phi \phi
Using events collected in the BESII detector, the
radiative decay is
studied. The invariant mass distribution exhibits a near-threshold
enhancement that peaks around 2.24 GeV/.
A partial wave analysis shows that the structure is dominated by a
state () with a mass of
GeV/ and a width of GeV/. The
product branching fraction is: .Comment: 11 pages, 4 figures. corrected proof for journa
Direct Measurements of Absolute Branching Fractions for D0 and D+ Inclusive Semimuonic Decays
By analyzing about 33 data sample collected at and around 3.773
GeV with the BES-II detector at the BEPC collider, we directly measure the
branching fractions for the neutral and charged inclusive semimuonic decays
to be and , and determine the ratio of the two branching
fractions to be
- âŠ