High-capacity wave energy conversion by multi-floats, multi-PTO, control and prediction: generalised state-space modelling with linear optimal control and arbitrary headings

Wave energy converters with capacity similar to, or greater than, wind turbines are desirable for the supply of electricity to the grid. It is shown that this may be provided by multiple floats in a hinged raft-type configuration with multimode forcing. The case analysed has 8 floats and 4 power take off (PTO) units. Analysis is based on linear diffraction-radiation modelling, validated in wave basin experiments with a smaller number of floats. Control is desirable to improve energy capture, mainly demonstrated for point absorbers, but this has not previously been applied to such a complex problem with many freedoms. The linear hydrodynamic model in a state-space form makes it possible to implement advanced control algorithms in real time. Linear non-causal optimal control (LNOC) is applied with wave force prediction from auto-regression. For the design case with zero heading, as the configuration heads naturally into the wave direction, energy capture is improved by between 21% and 83%. The energy capture is about 62% the maximum possible from idealised analyses. Off-design, non-zero headings are also analysed to indicate how energy capture can be reduced; this is again improved by control, by several times at 90 degrees heading

The cumulative effects of known susceptibility variants to predict primary biliary cirrhosis risk.

Multiple genetic variants influence the risk for development of primary biliary cirrhosis (PBC). To explore the cumulative effects of known susceptibility loci on risk, we utilized a weighted genetic risk score (wGRS) to evaluate whether genetic information can predict susceptibility. The wGRS was created using 26 known susceptibility loci and investigated in 1840 UK PBC and 5164 controls. Our data indicate that the wGRS was significantly different between PBC and controls (P=1.61E-142). Moreover, we assessed predictive performance of wGRS on disease status by calculating the area under the receiver operator characteristic curve. The area under curve for the purely genetic model was 0.72 and for gender plus genetic model was 0.82, with confidence limits substantially above random predictions. The risk of PBC using logistic regression was estimated after dividing individuals into quartiles. Individuals in the highest disclosed risk group demonstrated a substantially increased risk for PBC compared with the lowest risk group (odds ratio: 9.3, P=1.91E-084). Finally, we validated our findings in an analysis of an Italian PBC cohort. Our data suggested that the wGRS, utilizing genetic variants, was significantly associated with increased risk for PBC with consistent discriminant ability. Our study is a first step toward risk prediction for PBC

L-Monomethyl-arginine decreases apoptosis of chondrocytes by altering Bax and Bcl-2 expression in osteoarthritis of rabbit knee

Previous studies found that NG-monomethyl-L-arginine (L-NMMA) treatment inhibits progression of osteoarthritis. Here, we aimed to explore the effects of L-NMMA on chondrocyte apoptosis and Bax and Bcl-2 mRNA expression in rabbits with knee osteoarthritis. Knee osteoarthritis was induced in 24 healthy rabbits by Hulth method, and rabbits were randomly divided into control (n = 12) and experimental (n = 12) groups. Once weekly, knee joints of control rabbits were injected with saline solution, while knees of experimental rabbits were injected with L-NMMA. Knee joint samples were collected after 6 weeks of treatment. Apoptosis of chondrocytes was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL), and Bax and Bcl-2 mRNA expression by in situ hybridization. The results show that the mean rate of chondrocyte apoptosis in knees of the experimental rabbits was significantly lower than that of the control rabbits (P<0.05). Additionally, Bax expression decreased and Bcl-2 expression increased in the experimental group (P<0.05). In brief, LNMMA can inhibit apoptosis of joint chondrocytes through changes in the expression of apoptosisrelated genes. Thus, this molecule offers the potential for treating osteoarthritis.Key words: NG-Monomethyl-L-arginine, knee osteoarthritis, chondrocyte, apoptosis-related regulatory gene

Study on the application of a new multiepoxy reinforcement agent for sheep leather

Content: Leather is a kind of natural biomass composite material which is made of animal skin as material by a series of chemical and physical processing. Its main structure is Collagen fibers of three-dimensional network structure. As we all know sheep leather always exist a common problem with low strength, while the strength of leather depended on the woven degree of collagen fibers. Through the past decades, many methods have been tried to improve the properties of sheep leather. The most commonly used methods are retanning. However, the strength enhancement of sheep leather is extremely limited by retanning, although the fullness and softness may be improved. In this study, a new type of multi-epoxy reinforcement agent (IGE) and IGE with the synergistic effect of polyamine (IGE-PA) were used to enhance the strength of sheep leather in tanning and fatliquoring process. Comparing with chromium tanned leather, it was found that under the optimized conditions (dosage: 10%, pH: 8, Temperature: 35℃ for penetration and 45℃ for fixation, tanning time: 10 h) with IGE as the main tanning agent, the tearing strength was increased 56.8%. While when the polyamine as the synergetic agent for IGE, the tearing strength was significantly increased 87.9%. While IGE and IGE-PA were used in fatliquoring process, it has significant reinforcement effect for tetrakis hydroxymethyl phosphonium (THP) salt tanned leather. It was found that under the optimized conditions (Dosage: 2.5%, pH: 7-8, Temperature: 50℃, Time: 2h) with IGE in fatliquoring process, the tear strength was increased 50.24%, while the IGE-PA was used, the tear strength was increased 64.3%. Furthermore, TGA results showed that decomposition temperatures of IGE and IGE-PA enhanced leather were all higher than traditional chromium tanned leather. In addition, SEM results showed that IGE and IGE-PA enhanced leather obtained better opened-up fiber structure. Take-Away: 1. A new type of multi-epoxy tanning agent (IGE) has reinforcement effect for sheep leather especially in tear strength. 2. IGE with the synergistic effect of polyamine (IGE-PA) were used in tanning process, which has a significant enhancement for the sheep leather. 3. IGE and IGE-PA can be also used in fatliquoring process to enhance the strength of sheep leather