Why CREM Should be Implemented by the Office-Based Companies in Shanghai, China?

The purpose of this paper is to investigate why CREM should be carried out within the office based companies in Shanghai. Besides, the current CREM practices and performances in the office based companies in Shanghai are examined as well. Design/methodology/approach - The CREM added value creating model for office based corporations in Shanghai is constructed based on literature review. Then, according to the model, the proposition as to why CREM should be carried out within the office based companies in Shanghai is developed. Later, two case studies, which are composed of online questionnaire, structured interviews, and secondary documentary review, are investigated to test the proposition. Findings - Although the result from the two-case study does not provide direct evidence to support the proposition that alternative added values listed in the model is the driving force of CREM implementation for Shanghai office users, CREM, or Corporate Office Estate Management, does help them to promote marketing and corporate branding, staff retention, as well as efficiency and cost control. Research limitations/implications – The research is based on two case studies, the logic of which is replication. Thus, it is not possible to draw any strong generalization. Future studies are needed to validate or contradict the findings in the research. Practical implications – The research process and result provides inspirations for the office occupiers in Shanghai, China, on how Corporate Real Estate Management (CREM) can contribute to the core business, and what specific added values CREM can create. Besides, the CREM added value creating model for office based corporations in Shanghai provides framework for CREM managers on how CREM can be strategically carried out. Originality/value – Since CREM is a brand new discipline in China, the research is the first one digging into Corporate Office Estate Management practices in Shanghai, with the incorporation of the CREM added value creating model. Keywords – CREM, office property, added value, Shanghai Paper type – Master degree thesi

Aural attention training using computer software

Vecāki un skolotāji ikdienā saskaras ar nepietiekamām bērna koncentrēšanās spējām un uzmanības nenoturību, ko mūsdienās pedagogi uzskata par vienu no aktuālākajām problēmām skolās. Šī darba mērķis ir izstrādāt rīku-spēli, ko varētu izmantot uzmanības trenēšanai. Darbs izstrādāts sadarbībā ar Valdi Bernhofu, balstoties uz viņa topošā promocijas darba „Skaņaugstuma un ritma struktūrsistēma audiālās uzmanības treniņam” pētījuma praktisko daļu. Uzmanība ir katra kognitīva procesa priekšnoteikums un, kā rāda literatūras analīze, tieši skaņaugstumi un ritmi ir visbiežāk minētie parametri saistībā ar uzmanības spējām. Tāpēc Bernhofs pētījumā izstrādājis tieši skaņaugstumu un ritma struktūrsistēmu, kuras analīzei un realizācijai veltīts šis darbs. Darbs apraksta audiālās uzmanības trenēšanas rīka A.U.T. izstrādes ciklu no iepazīšanās ar doto sistēmu līdz tās izmantošanai uzmanības treniņam. Šis darbs ietver iepazīšanos ar Bernhofa struktūrsistēmas teorētisko pamatojumu, šīs sistēmas matemātisko un praktisko analīzi, pilota fāzes izstrādi un tās rezultātu, pielietojuma un tehnisko aspektu analīzi. Balstoties uz šo analīzi, ir veikta programmas gala versijas izstrāde un nobeigumā veikts kopējais programmas darbības pārskats, bet pētījuma gala rezultāti tiks publicēti Bernhofa disertācijā. Programma A.U.T. realizēta Javā, izmantojot modificētu datorpeli kā testu vadības rīku. Darba koncepcija, datorpgroammas izveides kritēriji un pilota fāzes rezultāti prezentēti un publicēti starptautiskajā konferencē „Cognitive and Behavioral Psychology (CBP) 2012”, gala versijas rezultāti aicināti publicēt „Global Science and Technology Forum: Journal of Law and Social Sciences”. Atslēgvārdi: audiālā uzmanība, mācību programma, MIDI, JavaAttention deficit disorder appears to be a common phenomenon among elementary school pupils and is recognized as one of the key problems in schools. This work aims to create a game/tool that would be used to train attention. This paper is written is collaboration with Valdis Bernhofs and addresses the practical part of his promotion paper "Pitch and Rhythm structural system for training aural attentiveness”. The hypothesis states that pitch and rhythm are the key music parameters to evoke a positive effect on aural attention system. Thus in his work Bernhofs develops a pitch and rhythm structural system for aural attentiveness training. This work covers the development cycle of aural attention training tool A.U.T. from introduction to the training system to the practical application of the developed learning tool. This paper includes brief summary of the theoretical background of Bernhofs’ paper, mathematical analysis of the system, pilot phase and both practical and technical analysis of its results, development of the final version and brief analysis of the final tests. The research is ongoing and the final results of the tests will be posted in Bernhofs’ dissertation. The program A.U.T. is developed in Java using modified mouse as a controller. The concept and results of the pilot phase were presented and published in the annual Cognitive and Behavioral Psychology (CBP) conference in Singapore, 2012. The results of the final paper have been asked to be published in “Global Science and Technology Forum: Journal of Law and Social Sciences”. Keywords: aural attentiveness, training program, Midi, Jav

Accurate Calculation of Iron Loss of High-Temperature and High-Speed Permanent Magnet Synchronous Generator under the Conditions of SVPWM Modulation

The high-temperature and high-speed permanent magnet synchronous generator (HTHSPMSG) is the core component ensuring the efficient and safe operation of the high-speed aircraft power supply system. At present, the existing iron loss model fails to meet the requirements for the precise calculation of the iron loss of HTHSPMSG under high-temperature and high-frequency conditions. In this paper, a 40 kW, 18,000 rpm HTHSPMSG is used to study the accurate calculation of iron loss at an ambient temperature of 350 °C. Considering the influence of high temperature and high frequency on the loss and performance of electromagnetic materials, a test platform for the loss performance of the magnetic core materials is established. Then, according to the loss performance of the electromagnetic material, the corresponding iron loss coefficient is fitted by the variable coefficient iron loss separation model. In addition, the digital twin field-circuit co-simulation method is proposed to guarantee the accuracy of the iron loss calculation. Then, the influence of carrier frequencies and modulation ratios on the iron loss characteristics of the HTHSPMSG under the conditions of SVPWM modulation is studied. Lastly, the effectiveness of the proposed method is verified by the experimental results, which provide a reference for the accurate analysis of iron loss of the same type of HTHSPMSG

A novel ferroptosis-related gene signature for overall survival prediction in patients with gastric cancer

Abstract The global diagnosis rate and mortality of gastric cancer (GC) are among the highest. Ferroptosis and iron-metabolism have a profound impact on tumor development and are closely linked to cancer treatment and patient’s prognosis. In this study, we identified six PRDEGs (prognostic ferroptosis- and iron metabolism-related differentially expressed genes) using LASSO-penalized Cox regression analysis. The TCGA cohort was used to establish a prognostic risk model, which allowed us to categorize GC patients into the high- and the low-risk groups based on the median value of the risk scores. Our study demonstrated that patients in the low-risk group had a higher probability of survival compared to those in the high-risk group. Furthermore, the low-risk group exhibited a higher tumor mutation burden (TMB) and a longer 5-year survival period when compared to the high-risk group. In summary, the prognostic risk model, based on the six genes associated with ferroptosis and iron-metabolism, performs well in predicting the prognosis of GC patients

DataSheet_1_Immune-related gene-based prognostic index for predicting survival and immunotherapy outcomes in colorectal carcinoma.docx

IntroductionColorectal cancer shows high incidence and mortality rates. Immune checkpoint blockade can be used to treat colorectal carcinoma (CRC); however, it shows limited effectiveness in most patients.MethodsTo identify patients who may benefit from immunotherapy using immune checkpoint inhibitors, we constructed an immune-related gene prognostic index (IRGPI) for predicting the efficacy of immunotherapy in patients with CRC. Transcriptome datasets and clinical information of patients with CRC were used to identify differential immune-related genes between tumor and para-carcinoma tissue. Using weighted correlation network analysis and Cox regression analysis, the IRGPI was constructed, and Kaplan–Meier analysis was used to evaluate its predictive ability. We also analyzed the molecular and immune characteristics between IRGPI high-and low-risk subgroups, performed sensitivity analysis of ICI treatment, and constructed overall survival-related receiver operating characteristic curves to validate the IRGPI. Finally, IRGPI genes and tumor immune cell infiltration in CRC model mice with orthotopic metastases were analyzed to verify the results.ResultsThe IRGPI was constructed based on the following 11 hub genes: ADIPOQ, CD36, CCL24, INHBE, UCN, IL1RL2, TRIM58, RBCK1, MC1R, PPARGC1A, and LGALS2. Patients with CRC in the high-risk subgroup showed longer overall survival than those in the low-risk subgroup, which was confirmed by GEO database. Clinicopathological features associated with cancer progression significantly differed between the high- and low-risk subgroups. Furthermore, Kaplan–Meier analysis of immune infiltration showed that the increased infiltration of naïve B cells, macrophages M1, and regulatory T cells and reduced infiltration of resting dendritic cells and mast cells led to a worse overall survival in patients with CRC. The ORC curves revealed that IRGPI predicted patient survival more sensitive than the published tumor immune dysfunction and rejection and tumor inflammatory signatureDiscussionThus, the low-risk subgroup is more likely to benefit from ICIs than the high-risk subgroup. CRC model mice showed higher proportions of Tregs, M1 macrophages, M2 macrophages and lower proportions of B cells, memory B cell immune cell infiltration, which is consistent with the IRGPI results. The IRGPI can predict the prognosis of patients with CRC, reflect the CRC immune microenvironment, and distinguish patients who are likely to benefit from ICI therapy.</p

Health Benefits and Costs of Clean Heating Renovation: An Integrated Assessment in a Major Chinese City

China has been promoting one of the world’s largest campaigns for clean heating renovation since 2017. Here, we present an integrated cost–benefit analysis in a major prefecture-level city by combining a large-scale household energy survey and PM2.5 exposure measurement, high-resolution chemical transport simulation, and health impact assessment. We find that the completed renovation decreases the share of solid fuels in the heating energy mix from 96 to 6% and achieves a concomitant reduction of cooking solid-fuel use by 70%. The completed renovation decreases the ambient PM2.5 concentration in Linfen by 0.5–5 μg m–3 (2.4 μg m–3 on average) and decreases the integrated PM2.5 exposure by 4.2 (3.5–5.0) μg m–3. The renovation is estimated to avoid 162 (125–225) and 328 (254–457) premature deaths annually based on two health impact assessment methods. The ratios of monetized health benefits to cost are 1.51 (0.73–2.59) and 3.06 (1.49–5.23) based on the above two methods. The benefit-to-cost ratio is projected to remain high if the renovation is further expanded. More polluted and less wealthy households enjoy larger health benefits but also experience a higher expense increase, suggesting that a more carefully designed subsidy policy is needed to protect low-income households

Cepharanthine Ameliorates Pulmonary Fibrosis by Inhibiting the NF-κB/NLRP3 Pathway, Fibroblast-to-Myofibroblast Transition and Inflammation

Pulmonary fibrosis (PF) is one of the sequelae of Corona Virus Disease 2019 (COVID-19), and currently, lung transplantation is the only viable treatment option. Hence, other effective treatments are urgently required. We investigated the therapeutic effects of an approved botanical drug, cepharanthine (CEP), in a cell culture model of transforming growth factor-β1 (TGF-β1) and bleomycin (BLM)-induced pulmonary fibrosis rat models both in vitro and in vivo. In this study, CEP and pirfenidone (PFD) suppressed BLM-induced lung tissue inflammation, proliferation of blue collagen fibers, and damage to lung structures in vivo. Furthermore, we also found increased collagen deposition marked by α-smooth muscle actin (α-SMA) and Collagen Type I Alpha 1 (COL1A1), which was significantly alleviated by the addition of PFD and CEP. Moreover, we elucidated the underlying mechanism of CEP against PF in vitro. Various assays confirmed that CEP reduced the viability and migration and promoted apoptosis of myofibroblasts. The expression levels of myofibroblast markers, including COL1A1, vimentin, α-SMA, and Matrix Metallopeptidase 2 (MMP2), were also suppressed by CEP. Simultaneously, CEP significantly suppressed the elevated Phospho-NF-κB p65 (p-p65)/NF-κB p65 (p65) ratio, NOD-like receptor thermal protein domain associated protein 3 (NLRP3) levels, and elevated inhibitor of NF-κB Alpha (IκBα) degradation and reversed the progression of PF. Hence, our study demonstrated that CEP prevented myofibroblast activation and treated BLM-induced pulmonary fibrosis in a dose-dependent manner by regulating nuclear factor kappa-B (NF-κB)/ NLRP3 signaling, thereby suggesting that CEP has potential clinical application in pulmonary fibrosis in the future

The effect of probiotics supplementation on cancer-treatment complications: a critical umbrella review of interventional meta-analyses

Cancer-related complications pose significant challenges in the management and treatment of patients with malignancies. Several meta-analyses have indicated improving effects of probiotics on cancer complications, while some studies have reported contentious findings. The purpose of the present study was to evaluate the efficacy of probiotics in addressing cancer complications, including diarrhea, mucositis, and infections, following chemotherapy, radiotherapy, and surgery. Relevant studies were searched in the PubMed, Scopus, Embase and Web of Science databases and Google Scholar up to September 2023. All meta-analyses addressing the effects of probiotics on all cancer treatments-induced complications including infection, diarrhea and oral mucositis were included. The pooled results were calculated using a random-effects model. Analyses of subgroups, sensitivity and publication bias were also conducted. The results revealed that the probiotics supplementation was effective on reduction of total cancer complications (OR:0.53; 95% CI: 0.44, 0.62, p < 0.001; I2=79.0%, p < 0.001), total infection rate (OR:0.47; 95%CI: 0.41, 0.52, p < 0.001; I2= 48.8%, p < 0.001); diarrhea (OR:0.50; 95%CI: 0.44, 0.57, p < 0.001; I2=44.4%, p = 0.023) and severe diarrhea (OR: 0.4; 95%CI: 0.27, 0.56, p < 0.001; I2=31.3%, p = 0.178), oral mucositis (OR: 0.76; 95%CI: 0.58, 0.94, p < 0.001; I2=95.5%, p < 0.001) and severe oral mucositis (OR:0.65, 95%CI: 0.58, 0.72 p < 0.001; I2=22.1%, p = 0.274). Multi strain probiotic (OR:0.49; 95%CI: 0.32, 0.65, p < 0.001; I2=90.7%, p < 0.001) were more efficacious than single strain (OR:0.73; 95%CI: 0.66, 0.81, p < 0.001; I2=0.00%, p = 0.786). The findings of the current umbrella meta-analysis provide strong evidence that probiotic supplementation can reduce cancer complications

Specific subsets of urothelial bladder carcinoma infiltrating T cells associated with poor prognosis

Abstract Comprehensive investigation of tumor-infiltrating lymphocytes in cancer is crucial to explore the effective immunotherapies, but the composition of infiltrating T cells in urothelial bladder carcinoma (UBC) remains elusive. Here, single-cell RNA sequencing (scRNA-seq) were performed on total 30,905 T cells derived from peripheral blood, adjacent normal and tumor tissues from two UBC patients. We identified 18 distinct T cell subsets based on molecular profiles and functional properties. Specifically, exhausted T (TEx) cells, exhausted NKT (NKTEx) cells, Ki67+ T cells and B cell-like T (B-T) cells were exclusively enriched in UBC. Additionally, the gene signatures of TEx, NKTEx, Ki67+ T and B-T cells were significantly associated with poor survival in patients with BC and various tumor types. Finally, IKZF3 and TRGC2 are the potential biomarkers of TEx cells. Overall, our study demonstrated an exhausted context of T cells in UBC, which layed a theoretical foundation for the development of effective tumor immunotherapies