BIOMECHANICAL MEASUREMENT AND EVALUATION FOR WUSU COMPULSORY PROGRAM

INTRODUCTION: The Wusu compulsory program is a new form of competition. It differs from the Wusu optional program in that all the athletes must execute the same compulsory program. Following this, judges asses the level of expertise of athletes, by scores gained, based on their performance. The comparability and objectivity in grading a compulsory program is better than in an optional program. So it is feasible to analyze technique of the Wusu compulsory program using a biomechanical measuring method. The compulsory exercise described as, “the turn about for flying kick on the right“, was measured and analyzed quantitatively in this paper. With the calculations from this study, a new evaluation factor and advanced development of competitive Wusu wasdeveloped

The Application of Stereo Anti-eccentrically Teaching Methods in Traditional Chinese Qigong Course

目的 探讨立体带功防偏模式在中医气功教学中的应用。方法 从气功偏差的严重后果及目前的教学现状、立体带功防偏气功教学法的目标和意义、立体带功防偏气功教学法的具体步骤等方面进行了详细的介绍。结果 2012-2013年医学气功学课程11个班级723个学生中，出现不适感的人数仅占1.8%，在一周内不适感消失的占61.5%，两周内不适感消失者达100%，没有一例严重偏差的出现，达到了安全教学的目的。结论 立体带功防偏气功教学法可以及时发现学生出现偏差的苗头并及时纠正，提高了教学的安全性，因此值得推广。Objective: To explore the use of stereo anti-eccentrically Chinese qigong teaching mode. Method: To introduce the concrete steps of Qigong teaching methods from Qigong serious consequences，deeviation and the present teaching situation, the goal and significance of stereo anti-eccentrically qigong teaching methods etc. Result: In 2013, 6 classes and 498 students, only 23（4.61%）students appeared discomfort. Within a week the improvement of discomfort students is 16（69.56%）,disappearance of discomfort students is 5（21.73%）, two weeks later,disappeared discomfort students achieve 100%, have no  emergence of severe deviation, reached the safety of teaching purpose. Conclusion: Stereo anti-eccentrically Qigong teaching method can find the first hint of deviation and correct them in time, can improve the security of teaching. so it is worth spreading

Cavernous Transformation of the Portal Vein Might Increase the Risk of Liver Abscess

Cavernous transformation of the portal vein (CTPV) is not quite common in adults, and cases with CTPV and acute liver abscess are lacking. We report a patient with CTPV inducing extrahepatic and intrahepatic obstruction, finally leading to acute liver abscess due to bile duct infection. We aim to find out the possible relationship between CTPV and acute liver abscess. A 45-year-old female patient was admitted to our hospital for recurrent upper abdominal pain and distension for one year, aggravated with fever for three years. A diagnosis of CTPV and liver abscess was made by 16-slice computed tomography. Effective antibiotics and drainage were used for this patients, and she was eventually cured. When treating patients with CTPV, extrahepatic and intrahepatic obstruction, one should be aware of the presence of acute liver abscess, and empirical antibiotics might be valuable

Comparison of lignocellulose composition in four major species of Miscanthus

Miscanthus is a perennial grass rich in lignocellulose that has attracted interest as a non-food crop for renewable bioenergy with major environmental and economic benefits for China. The lignocellulose composition of whole stems of four major species of Miscanthus was assessed. The average values of total moisture content (TMC) (61.90%) and hemicelluloses (34.86%) were the highest while cellulose (32.71%) and acid detergent lignin (ADL) (8.90%) were the lowest in Miscanthus floridulus. On the contrary, the contents of cellulose (42.11%) and ADL (13.64%) were the highest and total ash (TA) (2.89%) was the lowest in Miscanthus lutarioriparius. The Shannon–Weaver diversity indices of components for the four species showed that hemicellulose content (H’= 2.00±0.11) was the most variable trait followed by cellulose (H’= 1.84±0.07), then ADL (H’= 1.84±0.07). The variational range of each component was relatively higher in Miscanthus sacchariflorus. In M. lutarioriparius, the diversity indices of each component were moderate. The diversity of cellulose was the highest and hemicellulose, ADL, TA and TMC were low in Miscanthus sinensis. By correlation analysis, neutral detergent fiber (NDF) significantly and positively correlated with ADF, cellulose and ADL at P<0.01 as well as the relationship of cellulose and ADL in the four species. Hemicellulose showed significant (P<0.01) but negative correlation with cellulose and ADL in M. floridulus, M. lutarioriparius and M. sacchariflorus. By principal component analysis (PCA), the components ADF and cellulose were the PC1 that were considered the foremost for the evaluation and selection of resource in the four species. The conclusions show that lignocellulose composition contents of Miscanthus culms were different. M. floridulus was more fit to ethanol fermentation. Though the components contents in M. sinensis and M. sacchariflorus were moderate, the range of choice was large. It provided a possible means to screen the appropriate materials according to different utilization. M. lutarioriparius had more superiorities relatively. So the four species of Miscanthus were appropriate for extension as excellent herbaceous energy plants, though, reasonable species choice should be employed according to the conversion approach and the growth characteristics, productivity levels and biomass quality characteristics of these tall grasses.Keywords: Miscanthus, bioenergy, lignocellulose compositions, detergent fiber, diversity analysis, PC

Dynamic Image for 3D MRI Image Alzheimer's Disease Classification

We propose to apply a 2D CNN architecture to 3D MRI image Alzheimer's disease classification. Training a 3D convolutional neural network (CNN) is time-consuming and computationally expensive. We make use of approximate rank pooling to transform the 3D MRI image volume into a 2D image to use as input to a 2D CNN. We show our proposed CNN model achieves $9.5\%$ better Alzheimer's disease classification accuracy than the baseline 3D models. We also show that our method allows for efficient training, requiring only 20% of the training time compared to 3D CNN models. The code is available online: https://github.com/UkyVision/alzheimer-project.Comment: Accepted to ECCV2020 Workshop on BioImage Computin

Early-Warning Method of Train Running Safety of a High-Speed Railway Bridge Based on Transverse Vibration Monitoring

Making use of long-term transverse vibration monitoring data of DaShengGuan Bridge, the early-warning method of train running safety of the high-speed railway bridge is established by adopting principal component analysis (PCA) method. Firstly, the root mean square (RMS) of the transverse acceleration of the main girder is used as the monitoring parameter for the train running safety. The correlation model between the RMS values measured from different positions is further adopted as the evaluating model for the train running safety. Finally, the effects of the environmental changes on the evaluating model are eliminated using the PCA method and the warning index for the train running safety is further constructed. The analysis results show that the correlation between the RMS values of the accelerations from different measuring positions on the main girder can be analyzed by a quadratic polynomial fitting model. The PCA method can effectively remove the environmental effects on the quadratic polynomial fitting model. The proposed warning method provides a good capability for detecting the abnormal changes of the measured transverse accelerations and hence it is suitable for early-warning of the train running safety

The Association between Individual SNPs or Haplotypes of Matrix Metalloproteinase 1 and Gastric Cancer Susceptibility, Progression and Prognosis

BACKGROUND: The single nucleotide polymorphisms (SNPs) in matrix metalloproteinase 1(MMP-1) play important roles in some cancers. This study examined the associations between individual SNPs or haplotypes in MMP-1 and susceptibility, clinicopathological parameters and prognosis of gastric cancer in a large sample of the Han population in northern China. METHODS: In this case-controlled study, there were 404 patients with gastric cancer and 404 healthy controls. Seven SNPs were genotyped using the MALDI-TOF MS system. Then, SPSS software, Haploview 4.2 software, Haplo.states software and THEsias software were used to estimate the association between individual SNPs or haplotypes of MMP-1 and gastric cancer susceptibility, progression and prognosis. RESULTS: Among seven SNPs, there were no individual SNPs correlated to gastric cancer risk. Moreover, only the rs470206 genotype had a correlation with histologic grades, and the patients with GA/AA had well cell differentiation compared to the patients with genotype GG (OR=0.573; 95%CI: 0.353-0.929; P=0.023). Then, we constructed a four-marker haplotype block that contained 4 common haplotypes: TCCG, GCCG, TTCG and TTTA. However, all four common haplotypes had no correlation with gastric cancer risk and we did not find any relationship between these haplotypes and clinicopathological parameters in gastric cancer. Furthermore, neither individual SNPs nor haplotypes had an association with the survival of patients with gastric cancer. CONCLUSIONS: This study evaluated polymorphisms of the MMP-1 gene in gastric cancer with a MALDI-TOF MS method in a large northern Chinese case-controlled cohort. Our results indicated that these seven SNPs of MMP-1 might not be useful as significant markers to predict gastric cancer susceptibility, progression or prognosis, at least in the Han population in northern China

Hypoxia-mimetic agents inhibit proliferation and alter the morphology of human umbilical cord-derived mesenchymal stem cells

<p>Abstract</p> <p>Background</p> <p>The therapeutic efficacy of human mesenchymal stem cells (hMSCs) for the treatment of hypoxic-ischemic diseases is closely related to level of hypoxia in the damaged tissues. To elucidate the potential therapeutic applications and limitations of hMSCs derived from human umbilical cords, the effects of hypoxia on the morphology and proliferation of hMSCs were analyzed.</p> <p>Results</p> <p>After treatment with DFO and CoCl₂, hMSCs were elongated, and adjacent cells were no longer in close contact. In addition, vacuole-like structures were observed within the cytoplasm; the rough endoplasmic reticulum expanded, and expanded ridges were observed in mitochondria. In addition, DFO and CoCl₂treatments for 48 h significantly inhibited hMSCs proliferation in a concentration-dependent manner (<it>P </it>< 0.05). This treatment also increased the number of cells in G0/G1 phase and decreased those in G2/S/M phase.</p> <p>Conclusions</p> <p>The hypoxia-mimetic agents, DFO and CoCl₂, alter umbilical cord-derived hMSCs morphology and inhibit their proliferation through influencing the cell cycle.</p

Pharmacokinetics of diltiazem hydrochloride delay-onset sustained-release pellet capsules in healthy volunteers

Embora a farmacocinética (PK) do cloridrato de diltiazem nas formas de comprimidos de liberação imediata e cápsulas de liberação modificada em ensaios clínicos já tenha sido relatada, a pesquisa da PK do cloridrato de diltiazem na forma de cápsulas com peletes de liberação retardada e sustentada ainda é muito importante. Neste trabalho, propusemos avaliar a farmacocinética do cloridrato de diltiazem administrado através desta nova forma farmacêutica em voluntários chineses sadios, assim como a influência da ingestão de alimentos neste perfil farmacocinético. Foi realizado um ensaio clínico aberto, randomizado e paralelo em 36 voluntários, que receberam dose oral única de 90 mg, 180 mg ou 270 mg e dose múltiplas (90 mg/d × 6 d) pela mesma via de administração. Para avaliar o efeito da ingestão de alimentos sobre a PK do diltiazem foi realizada a administração de dose única (360 mg) em 24 voluntários chineses sadios. A concentração plasmática do diltiazem foi determinada por Cromatografia Liquida de Alta Eficiência em fase reversa (CLAE-FR) e os principais parâmetros farmacocinéticos foram analisados através do emprego do software PKSolver (Ver 2.0). O ensaio de farmacocinética clínica foi conduzido na clínica Pharmacological Center (No.JDX1999064) do Hospital de Xiangya, Central South University, China. Os parâmetros PK obtidos indicaram que a nova formulação de cápsulas de liberação retardada e sustentada de cloridrato de diltiazem possue marcantes características de liberação retardada e controlada do fármaco.The pharmacokinetics (PK) of ordinary tablets and sustained release capsules of diltiazem hydrochloride in human clinical trials had been studied. The PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules, a new dosage form, has not been reported, although it is very important to clinical use. In this paper, we investigated the PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules and the food influence in Chinese healthy volunteers. The PK parameters indicated that the diltiazem hydrochloride delay-onset sustained-release pellet capsules appeared marked characteristics of delayed and controlled release. An opened-label, randomized and parallel clinical trial was conducted in 36 Chinese healthy volunteers with single oral dose (90 mg, 180 mg or 270 mg) and a multiple oral dose (90 mg d-1×6 d) administration. The effect of food on the PK of one single oral dose (360 mg) was investigated in 24 healthy Chinese volunteers. Plasma diltiazem concentration was determined by reversed-phase high-performance liquid chromatography (RP-HPLC) and the main pharmacokinetic parameters were analyzed by PKSolver (Ver 2.0). All clinical studies were conducted in the Clinical Pharmacological Center (No. JDX1999064) of Xiangya Hospital Affiliated Central South University, China. The PK parameters suggested that the new formulation had marked characteristics of delayed and controlled release of diltiazem, and food intake did not alter significantly diltiazem pharmacokinetic parameters

SDSS J013127.34−-032100.1: A newly discovered radio-loud quasar at z=5.18z=5.18 with extremely high luminosity

Only very few z>5 quasars discovered to date are radio-loud, with a radio-to-optical flux ratio (radio-loudness parameter) higher than 10. Here we report the discovery of an optically luminous radio-loud quasar, SDSS J013127.34-032100.1 (J0131-0321 in short), at z=5.18+-0.01 using the Lijiang 2.4m and Magellan telescopes. J0131-0321 has a spectral energy distribution consistent with that of radio-loud quasars. With an i-band magnitude of 18.47 and radio flux density of 33 mJy, its radio-loudness parameter is ~100. The optical and near-infrared spectra taken by Magellan enable us to estimate its bolometric luminosity to be L_bol ~ 1.1E48 erg/s, approximately 4.5 times greater than that of the most distant quasar known to date. The black hole mass of J0131-0321 is estimated to be 2.7E9 solar masses, with an uncertainty up to 0.4 dex. Detailed physical properties of this high-redshift, radio-loud, potentially super-Eddington quasar can be probed in the future with more dedicated and intensive follow-up observations using multi-wavelength facilities.Comment: 5 pages, 3 figures, accepted to ApJ