PLASMA HEATING INSIDE INTERPLANETARY CORONAL MASS EJECTIONS BY ALFVÉNIC FLUCTUATIONS DISSIPATION

Nonlinear cascade of low-frequency Alfvénic fluctuations (AFs) is regarded as one of the candidate energy sources that heat plasma during the non-adiabatic expansion of interplanetary coronal mass ejections (ICMEs). However, AFs inside ICMEs were seldom reported in the literature. In this study, we investigate AFs inside ICMEs using observations from Voyager 2 between 1 and 6 au. It has been found that AFs with a high degree of Alfvénicity frequently occurred inside ICMEs for almost all of the identified ICMEs (30 out of 33 ICMEs) and for 12.6% of the ICME time interval. As ICMEs expand and move outward, the percentage of AF duration decays linearly in general. The occurrence rate of AFs inside ICMEs is much less than that in ambient solar wind, especially within 4.75 au. AFs inside ICMEs are more frequently presented in the center and at the boundaries of ICMEs. In addition, the proton temperature inside ICME has a similar "W"-shaped distribution. These findings suggest significant contribution of AFs on local plasma heating inside ICMEs

Efficient Energy Conversion through Vortex Arrays in the Turbulent Magnetosheath

Turbulence is often enhanced when transmitted through a collisionless plasma shock. We investigate how the enhanced turbulent energy in the Earth's magnetosheath effectively dissipates via vortex arrays. This research topic is of great importance as it relates to particle energization at astrophysical shocks across the universe. Wave modes and intermittent coherent structures are the key candidate mechanisms for energy conversion in turbulent plasmas. Here, by comparing in-situ measurements in the Earth's magnetosheath with a theoretical model, we find the existence of vortex arrays at the transition between the downstream regions of the Earth's bow shock. Vortex arrays consist of quasi-orthogonal kinetic waves and exhibit both high volumetric filling factors and strong local energy conversion, thereby showing a greater dissipative energization than traditional waves and coherent structures. Therefore, we propose that vortex arrays are a promising mechanism for efficient energy conversion in the sheath regions downstream of astrophysical shocks

Housefly (Musca domestica) and blow fly (Protophormia terraenovae) as vectors of bacteria carrying colistin resistance genes

Flies have the capacity to transfer pathogens between different environments, acting as one of the most important vectors of human diseases worldwide. In this study, we trapped flies on a university campus and tested them for mobile resistance genes against colistin, a last-resort antibiotic in human medicine for treating clinical infections caused by multidrug-resistant Gram-negative bacteria. Quantitative PCR assays we developed showed that 34.1% of Musca domestica (86/252) and 51.1% of Protophormia terraenovae (23/45) isolates were positive for the mcr-1 gene, 1.2% of M. domestica (3/252) and 2.2% of P. terraenovae (2.2%, 1/45) isolates were positive for mcr-2, and 5.2% of M. domestica (13/252) and 44.4% of P. terraenovae (20/45) isolates were positive for mcr-3. Overall, 4.8% (9/189) of bacteria isolated from the flies were positive for the mcr-1 gene (Escherichia coli: 8.3%, 4/48; Enterobacter cloacae: 12.5%, 1/8; Providencia alcalifaciens: 11.8%, 2/17; Providencia stuartii: 4.9%, 2/41), while none were positive for mcr-2 and mcr-3. Four mcr-1positive isolates (two P. stuartii and two P. alcalifaciens) from blow flies trapped near a dumpster had a MIC for colistin above 4 mg/ml. This study reports mcr-1 carriage in Providencia spp. and detection of mcr-2 and mcr-3 after their initial identification in Belgium and China, respectively. This study suggests that flies might contribute significantly to the dissemination of bacteria, carrying these genes into a large variety of ecological niches. Further studies are warranted to explore the roles that flies might play in the spread of colistin resistance genes. IMPORTANCE Antimicrobial resistance is recognized as one of the most serious global threats to human health. An option for treatment of the Gram-negative ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) bacteria with multiple drug resistance was the reintroduction of the older antibiotic colistin. However, a mobile colistin resistance gene (mcr-1) has recently been found to occur widely; very recently, two other colistin resistance genes (mcr-2 and mcr-3) have been identified in Belgium and China, respectively. In this study, we report the presence of colistin resistance genes in flies. This study also reports the carriage of colistin resistance genes in the genus Providencia and detection of mcr-2 and mcr-3 after their initial identification. This study will stimulate more in-depth studies to fully elucidate the transmission mechanisms of the colistin resistance genes and their interaction

Newly identified colistin resistance genes, mcr-4 and mcr-5, from upper and lower alimentary tract of pigs and poultry in China

Antimicrobial resistance against colistin has emerged worldwide threatening the efficacy of one of the last-resort antimicrobials used for the treatment of Enterobacteriaceae. To investigate the presence of the recently identified colistin resistance genes (mcr-4, mcr-5) in China, we established PCRs to detect mcr-4 and mcr-5 on 213 anal and 1,339 nasal swabs from apparently healthy pigs (n = 1,454) in nine provinces, and 1,696 cloacal and 1,647 oropharyngeal samples from poultry (n = 1,836) at live-bird markets in 24 provinces of China. The prevalence of the mcr-4 in swine swabs (41.4%; 642/1,552) was significantly higher than in swabs from poultry (11.5%; 384/3,343). The mcr-4 gene was found in geese (49.5%, 54/109), chickens (17.2%, 257/1,498), pigeons (17.2%, 17/99) and ducks (15.4%, 20/130). In a similar trend, the prevalence of the mcr-5 in swine swabs (33.1%; 514/1552) was significantly higher than in swabs from poultry (5.6%; 187/3,343). The mcr-5 was identified in geese (17.4%, 19/109), chickens (9.9%, 148/1,498), ducks (7.7%, 10/130) and pigeons (3%, 3/99). The mcr-4 prevalence in the nasal swabs from pigs (59.2%, 58/98) was significantly higher than that in anal swabs (29.6%, 29/98) (P<0.001). Similarly, the mcr-5 prevalence in the nasal swabs from pigs (61.2%, 60/98) was significantly higher than in anal swabs (44.9%, 44/98) (P = 0.02), and significantly higher in oropharyngeal swabs (7.2%, 109/1,507) than in the cloacal swabs (3.7%, 56/1,507) (P<0.001). This study further confirms the presence of the mcr-4 and mcr-5 in animals and indicates these genes are prevalent and widespread in food producing animals (pig and poultry) in China. Future studies are needed to characterize the bacteria carrying the mcr-4 and mcr-5 and their locations on plasmids and/or the bacterial chromosomes, and determine co-resistances in the mcr-4 and mcr-5 positive strains

Dynamical Variations of the Global COVID-19 Pandemic Based on a SEICR Disease Model: A New Approach of Yi Hua Jie Mu

The ongoing coronavirus disease 2019 (COVID-19) pandemic has caused more than 150 million cases of infection to date and poses a serious threat to global public health. In this study, global COVID-19 data were used to examine the dynamical variations from the perspectives of immunity and contact of 84 countries across the five climate regions: tropical, arid, temperate, and cold. A new approach named Yi Hua Jie Mu is proposed to obtain the transmission rates based on the COVID-19 data between the countries with the same climate region over the Northern Hemisphere and Southern Hemisphere. Our results suggest that the COVID-19 pandemic will persist over a long period of time or enter into regular circulation in multiple periods of 1–2 years. Moreover, based on the simulated results by the COVID-19 data, it is found that the temperate and cold climate regions have higher infection rates than the tropical and arid climate regions, which indicates that climate may modulate the transmission of COVID-19. The role of the climate on the COVID-19 variations should be concluded with more data and more cautions. The non-pharmaceutical interventions still play the key role in controlling and prevention this global pandemic

Author Correction: CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing.

The originally published version of this Article contained several errors in Figure 2, panel a: the basepair register in SL3-4 of yeast U1 snRNA was depicted incorrectly; the basepair for A287-U295 in yeast U1 snRNA was erroneously present; basepairs for U84-G119, G309-U532, A288-U295 and U289-A294 in yeast U1 snRNA were missing; the bulging nucleotide in SL3 of human U1 snRNA was depicted as G instead of C; and the dashed boxes defining the 5' ss binding site and Sm site in both human and yeast snRNAs were not drawn accurately. These have now been corrected in both the PDF and HTML versions of the Article

Energy transfer of imbalanced Alfvénic turbulence in the heliosphere

Imbalanced Alfvénic turbulence is a universal process playing a crucial role in energy transfer in space,  astrophysical, and laboratory plasmas. A fundamental and long-lasting question about the imbalanced Alfvénic turbulence is how and through which mechanism the energy transfers between scales. Here, we show that the energy transfer of imbalanced Alfvénic turbulence is completed by coherent interactions between Alfvén waves and co-propagating anomalous fluctuations. These anomalous fluctuations are generated by nonlinear couplings instead of linear reflection. We also reveal that the energy transfer of the waves and the anomalous fluctuations is carried out mainly through local-scale and large-scale nonlinear interactions, respectively, responsible for their bifurcated power-law spectra. This work unveils the energy transfer physics of imbalanced Alfvénic turbulence, and advances the understanding of imbalanced Alfvénic turbulence observed by Parker Solar Probe in the inner heliosphere

Observations of rapidly growing whistler waves in front of space plasma shock

Whistler mode wave is a fundamental perturbation of electromagnetic fields and plasmas in various environments including planetary space, laboratory and astrophysics. The origin and evolution of the waves are a long-standing question due to the limited instrumental capability in resolving highly variable plasma and electromagnetic fields. Here, we analyse data with the high time resolution from the multi-scale magnetospheric spacecraft in the weak magnetic environment (i.e., foreshock) enabling a relatively long gyro-period of whistler mode wave. Moreover, we develop a novel approach to separate the three-dimensional fluctuating electron velocity distributions from their background, and have successfully captured the coherent resonance between electrons and electromagnetic fields at high frequency, providing the resultant growth rate of unstable whistler waves. Regarding the energy origin for the waves, the ion distributions are found to also play crucial roles in determining the eigenmode disturbances of fields and electrons. The quantification of wave growth rate can significantly advance the understandings of the wave evolution and the energy conversion with particles

A multispacecraft study of a small flux rope entrained by rolling back magnetic field lines

We present a small flux rope (SFR) with smooth magnetic field rotations entrained by rolling back magnetic field lines around 1 AU. Such SFRs have only been seldom reported in the literature. This SFR was adjacent to a heliospheric plasma sheet (HPS), which is defined as a high plasma beta region in the vicinity of a heliospheric current sheet. Even though the SFR and HPS have different plasma beta, they possess similar plasma signatures (such as temperature, density, and bulk speed), density ratio of alpha particleâ toâ proton (Nα/Np), and heavy ion ionization states, which imply that they may have a similar origin in the corona. The composition and the configuration of the rolling back magnetic field lines suggested that the SFR originated from the streamer belt through interchange reconnection. The origin processes of the SFR are presented here. Combining the observations of STEREO and ACE, the SFR was shown to have an axis tilted to the ecliptic plane and the radius may vary with different spatial positions. In this study, we suggest that interchange reconnection can play an important role for the origin of, at least, some SFRs and slow solar wind.Key PointsCompositional data are used to diagnose the origin of the SFR in this studyInterchange reconnection can play an important role for the origin of some SFRs and slow solar windSpacecraft may miss the in situ SFRs due to their morphologiesPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138376/1/jgra53590_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138376/2/jgra53590.pd