Symptomatic huge pericardial cyst: a case report

Alar kıkırdaklar burnun alt 1/3 bölümünde yer alan kıkırdaklardır. Burnun uç kısmının desteği, şekli ve simetrisi bu kıkırdaklar tarafından sağlanmaktadır. Alar kıkırdakların şekli, büyüklüğü ve pozisyonu burun tipinin şeklini belirlediği gibi aynı zamanda burnun solunum fonksiyonunda da etkilidir Alar kıkırdakların büyüklük ve şekli kişiden kişiye farklılık gösterir. Fakat yokluğu oldukça nadir rastlanan bir durumdur. Genellikle travma ve enfeksiyon gibi nedenlere bağlıdır. Burun alar kıkırdaklarının yokluğu hem estetik açıdan nazal tipte şekil bozukluğuna hem de solunum fonksiyon bozukluğu problemlerine neden olur. Bu çalışmada, 37 yaşında burun tıkanıklığı şikâyeti ile başvuran, açık teknik septorinoplasti ameliyatı sırasında sağ alar kıkırdak kısmi yokluğu tespit edilen bayan hasta sunulmuş ve alar kıkırdak yokluğunun tedavisi tartışılmıştır.Alar cartilages are located in the lower 1/3 area of the nose. These cartilages are providing support, symmetry and contour to the nasal tip. The shape, size and position of alar cartilages are important both for the shape of the nasal tip and also for functional breathing. The size and shape of alar cartilages are different from person to person. But, congenital isolated absence of alar cartilage is seen very rarely. Trauma and infection are most common etiological causes. Alar cartilages agenesis of noses causes both aesthetic problems due to deformity of the nasal tip's shape and breathing functional problems. Here, we present a case of 37 year-old woman who has partial isolated right alar cartilage agenesis which has diagnosed at open technique septorhinoplasty; also the treatment of alar cartilages agenesis are discussed

What do we know about energy drinks?

Energy drinks are popular among young individuals andmarketed to college students, athletes, and active individualsbetween the ages of 21 and 35 years. In the beginningconsumption of energy drinks can significantlyimprove physical and mental performance. Energy drinkscontain a mixture of compounds, of which caffeine, guarana,and herbal supplements such as ginkgo and ginsengare major components. Unfortunately, the body ofliterature is limited and it is not known whether these improvementsare due to the caffeine other herbal ingredients.Severe clinical manifestations may occur after useof energy drinks with alcohol The aim of this article is risingawareness about the ingredients of energy drinks andclinical manifestations that may occur after usage and updateabout knowledge.Key words: Energy drinks, energy drinks ingredients,clinical manifestation

Children's Foreign Language Anxiety Scale: Preliminary Tests of Reliability and Validity

Foreign language anxiety (FLA), which constitutes a serious problem in the foreign language learning process, has been mainly seen as a research issue regarding adult language learners, while it has been overlooked in children. This is because there is a lack of appropriate tools to measure FLA among children, whereas there are many studies on the scales that aim to measure anxiety levels among adult learners. Thus, the current study aims to conduct the preliminary tests of reliability and validity of the Children's Foreign Language Anxiety Scale (CFLAS) and to report on the pilot examination of reliability, validity and factor structure of the CFLAS. The findings of the pilot study show that CFLAS is a reliable and valid tool to measure FLA levels among children who learn English as a foreign language (EFL) within the age range of 7-12 in a Turkish EFL context

Clinical, genetic, and outcome characteristics of pediatric patients with primary hemophagocytic lymphohistiocytosis

Objectİive: In this study, we sought to describe the clinical, laboratory, and genetic characteristics of patients diagnosed with primary hemophagocytic lymphohistiocytosis. Thus, we aimed to evaluate the early diagnosis and appropriate treatment options for pediatric hemophagocytic lymphohistiocytosis patients. Materials and Methods: Medical records of 9 patients diagnosed with primary hemophagocytic lymphohistiocytosis between November 2013 and December 2019 were analyzed retrospectively. Clinical, genetic, and laboratory characteristics, family histories, initial complaints, physical examination findings, age at diagnosis, treatment choices, and clinical follow-up of all patients were investigated. Results: The mean age at diagnosis was 11 months (range: 1.5 months to 17 years). Genetic analysis was performed in all patients, and a disease-related mutation was detected in 8 (89%) of them. Among clinical features, 6 (66%) patients had fever, 5 (56%) had splenomegaly, 4 (44%) had lymphadenopathy, 4 (44%) had skin rash, and 4 (44%) had neurological findings. Hemophagocytosis was observed in the bone marrow samples of 6 (66%) patients. Disease remission was achieved in 7 (78%) patients. Hematopoietic stem cell transplantation was performed in 7 (78%) patients. Conclusion: Hemophagocytic lymphohistiocytosis may present with different clinical symptoms that can cause a significant diagnostic delay. The only curative treatment option in primary hemophagocytic lymphohistiocytosis patients is hematopoietic stem cell transplantation. The chemotherapy should be started as early as possible, in order to achieve a disease remission. Patients should be referred to the appropriate bone marrow transplant center for hematopoietic stem cell transplantation as soon as they reach the disease remission

Biological activities and DNA interactions of aqueous extract of Phlomis linearis (Boiss. & Bal.)

Phlomis linearis Boiss. & Bal. of the Lamiaceae family is one of the endemic species in Turkey, i.e., growing in the east, central, and southeast parts of Anatolia and used for herbal tea. This study was designed to identify the biochemical and bioactivity properties of this endemic species by DPPH scavenging activity, metal chelating activity, total phenolic content, HPLC-DAD analysis, and MTT assay. Furthermore, the plant extract was evaluated for its antimicrobial activity against bacteria and fungi by using the microdilution method. The interactions between extract and plasmid DNA and their restriction endonuclease reactions were investigated by agarose gel electrophoresis. To support our hypothesis, we performed a molecular docking analysis. The DPPH scavenging activity of the plant extract was 53.86 ± 0.50 µg/ml in terms of IC50 value. The IC50 value of the plant extract was determined as 14.71 ± 4.01 mg/ml for metal chelating assay. The phenolic content of the extract was 231.55 ± 2.11 mg/g dry weight expressed as gallic acid equivalents (GAE). HPLC-DAD results revealed that the phenolic compounds were mainly derivatives of rosmarinic acid, chlorogenic acid, luteolin, luteolin-7-glycoside, luteolin derivatives, rutin derivatives, and apigenin derivatives. Besides, the cytotoxic activity of the plant extract against L929 fibroblast, H1299 non-small-cell lung carcinoma, and Caco-2 colorectal adenocarcinoma cell lines was determined by MTT assay. Phenolic content and molecular docking results correlated with each other

Effects of immunosuppressive drugs on COVID-19 severity in patients with autoimmune hepatitis

Background: We investigated associations between baseline use of immunosuppressive drugs and severity of Coronavirus Disease 2019 (COVID-19) in autoimmune hepatitis (AIH). Patients and methods: Data of AIH patients with laboratory confirmed COVID-19 were retrospectively collected from 15 countries. The outcomes of AIH patients who were on immunosuppression at the time of COVID-19 were compared to patients who were not on AIH medication. The clinical courses of COVID-19 were classified as (i)-no hospitalization, (ii)-hospitalization without oxygen supplementation, (iii)-hospitalization with oxygen supplementation by nasal cannula or mask, (iv)-intensive care unit (ICU) admission with non-invasive mechanical ventilation, (v)-ICU admission with invasive mechanical ventilation or (vi)-death and analysed using ordinal logistic regression. Results: We included 254 AIH patients (79.5%, female) with a median age of 50 (range, 17-85) years. At the onset of COVID-19, 234 patients (92.1%) were on treatment with glucocorticoids (n = 156), thiopurines (n = 151), mycophenolate mofetil (n = 22) or tacrolimus (n = 16), alone or in combinations. Overall, 94 (37%) patients were hospitalized and 18 (7.1%) patients died. Use of systemic glucocorticoids (adjusted odds ratio [aOR] 4.73, 95% CI 1.12-25.89) and thiopurines (aOR 4.78, 95% CI 1.33-23.50) for AIH was associated with worse COVID-19 severity, after adjusting for age-sex, comorbidities and presence of cirrhosis. Baseline treatment with mycophenolate mofetil (aOR 3.56, 95% CI 0.76-20.56) and tacrolimus (aOR 4.09, 95% CI 0.69-27.00) were also associated with more severe COVID-19 courses in a smaller subset of treated patients. Conclusion: Baseline treatment with systemic glucocorticoids or thiopurines prior to the onset of COVID-19 was significantly associated with COVID-19 severity in patients with AIH.Fil: Efe, Cumali. Harran University Hospita; TurquíaFil: Lammert, Craig. University School of Medicine Indianapolis; Estados UnidosFil: Taşçılar, Koray. Universitat Erlangen-Nuremberg; AlemaniaFil: Dhanasekaran, Renumathy. University of Stanford; Estados UnidosFil: Ebik, Berat. Gazi Yasargil Education And Research Hospital; TurquíaFil: Higuera de la Tijera, Fatima. Hospital General de México; MéxicoFil: Calışkan, Ali R.. No especifíca;Fil: Peralta, Mirta. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Gerussi, Alessio. Università degli Studi di Milano; ItaliaFil: Massoumi, Hatef. No especifíca;Fil: Catana, Andreea M.. Harvard Medical School; Estados UnidosFil: Purnak, Tugrul. University of Texas; Estados UnidosFil: Rigamonti, Cristina. Università del Piemonte Orientale ; ItaliaFil: Aldana, Andres J. G.. Fundacion Santa Fe de Bogota; ColombiaFil: Khakoo, Nidah. Miami University; Estados UnidosFil: Nazal, Leyla. Clinica Las Condes; ChileFil: Frager, Shalom. Montefiore Medical Center; Estados UnidosFil: Demir, Nurhan. Haseki Training And Research Hospital; TurquíaFil: Irak, Kader. Kanuni Sultan Suleyman Training And Research Hospital; TurquíaFil: Melekoğlu Ellik, Zeynep. Ankara University Medical Faculty; TurquíaFil: Kacmaz, Hüseyin. Adıyaman University; TurquíaFil: Balaban, Yasemin. Hacettepe University; TurquíaFil: Atay, Kadri. No especifíca;Fil: Eren, Fatih. No especifíca;Fil: Alvares da-Silva, Mario R.. Universidade Federal do Rio Grande do Sul; BrasilFil: Cristoferi, Laura. Università degli Studi di Milano; ItaliaFil: Urzua, Álvaro. Universidad de Chile; ChileFil: Eşkazan, Tuğçe. Cerrahpaşa School of Medicine; TurquíaFil: Magro, Bianca. No especifíca;Fil: Snijders, Romee. No especifíca;Fil: Barutçu, Sezgin. No especifíca;Fil: Lytvyak, Ellina. University of Alberta; CanadáFil: Zazueta, Godolfino M.. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Demirezer Bolat, Aylin. Ankara City Hospital; TurquíaFil: Aydın, Mesut. Van Yuzuncu Yil University; TurquíaFil: Amorós Martín, Alexandra Noemí. No especifíca;Fil: De Martin, Eleonora. No especifíca;Fil: Ekin, Nazım. No especifíca;Fil: Yıldırım, Sümeyra. No especifíca;Fil: Yavuz, Ahmet. No especifíca;Fil: Bıyık, Murat. Necmettin Erbakan University; TurquíaFil: Narro, Graciela C.. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Bıyık, Murat. Uludag University; TurquíaFil: Kıyıcı, Murat. No especifíca;Fil: Kahramanoğlu Aksoy, Evrim. No especifíca;Fil: Vincent, Maria. No especifíca;Fil: Carr, Rotonya M.. University of Pennsylvania; Estados UnidosFil: Günşar, Fulya. No especifíca;Fil: Reyes, Eira C.. Hepatology Unit. Hospital Militar Central de México; MéxicoFil: Harputluoğlu, Murat. Inönü University School of Medicine; TurquíaFil: Aloman, Costica. Rush University Medical Center; Estados UnidosFil: Gatselis, Nikolaos K.. University Hospital Of Larissa; GreciaFil: Üstündağ, Yücel. No especifíca;Fil: Brahm, Javier. Clinica Las Condes; ChileFil: Vargas, Nataly C. E.. Hospital Nacional Almanzor Aguinaga Asenjo; PerúFil: Güzelbulut, Fatih. No especifíca;Fil: Garcia, Sandro R.. Hospital Iv Víctor Lazarte Echegaray; PerúFil: Aguirre, Jonathan. Hospital Angeles del Pedregal; MéxicoFil: Anders, Margarita. Hospital Alemán; ArgentinaFil: Ratusnu, Natalia. Hospital Regional de Ushuaia; ArgentinaFil: Hatemi, Ibrahim. No especifíca;Fil: Mendizabal, Manuel. Universidad Austral; ArgentinaFil: Floreani, Annarosa. Università di Padova; ItaliaFil: Fagiuoli, Stefano. No especifíca;Fil: Silva, Marcelo. Universidad Austral; ArgentinaFil: Idilman, Ramazan. No especifíca;Fil: Satapathy, Sanjaya K.. No especifíca;Fil: Silveira, Marina. University of Yale. School of Medicine; Estados UnidosFil: Drenth, Joost P. H.. No especifíca;Fil: Dalekos, George N.. No especifíca;Fil: N.Assis, David. University of Yale. School of Medicine; Estados UnidosFil: Björnsson, Einar. No especifíca;Fil: Boyer, James L.. University of Yale. School of Medicine; Estados UnidosFil: Yoshida, Eric M.. University of British Columbia; CanadáFil: Invernizzi, Pietro. Università degli Studi di Milano; ItaliaFil: Levy, Cynthia. University of Miami; Estados UnidosFil: Montano Loza, Aldo J.. University of Alberta; CanadáFil: Schiano, Thomas D.. No especifíca;Fil: Ridruejo, Ezequiel. Universidad Austral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Wahlin, Staffan. No especifíca

Modernist Elements in Novel and Story of Füruzan

Bu çalışma romana yansımasının sınırları kesin olarak çizilememiş olan modernizmin genel hatlarını belirleme ve romana yansıyan teknik unsurları ortaya koyabilme amacıyla hazırlanmıştır. Çalışmanın bir diğer amacı ise belirlenen modernist unsurların Füruzan'ın öykü ve romanlarındaki örneklerine ulaşmaktır. Genel manada üç kısımdan oluşan çalışmamızın giriş kısmında modernizmin doğuşu ve modernizm teorisi hakkında detaylı bilgi verilmiştir. Birinci bölümde yazarın kısa biyografisi verilip eserleri tanıtıldıktan sonra ikinci bölümde eserlerine yansıyan modernist unsurlar ele alınmış ve örneklendirilmiştir. Çalışmanın üçüncü ve son bölümünde ise modernizmin teknik unsurları ele alınmış sonrasında yine Füruzan'ın eserlerinden örneklerle bu unsurlar açıklanmıştır. Çalışmamızın Füruzan'ın eserlerine bakış noktasında katkı sağlamasını ve modernizmin Türk edebiyatına yansımaları konusunda da aydınlatıcı olmasını umuyoruz.This work is preparad to delermine genaral outlines of modernism of which reflection to novel couldn't been drawn definitely and to put forward technical element reflected to novel. Another aim of work is to receive examples of determined modernism elements in Füruzan's story and novels. Genaraly, in introduction of ourwork which consists of three parts, detailed information is given about birth of modernism and theory of modernism. At first part after giving a brier biograpy of writer and introducing her works, at second part modernist elements that reflected to her works were discussed and illustrated. At third and last part of work technial elements og modernism were dicussed then these elements were explanied with examples from Füruzan's works. We hope that ourwork will be acontribution at apoint view to Füruzan's works and reflective about reflections of modernism in Turkish literature

Konaklama işletmelerinde fiyatlama stratejileri

Konu ile ilgili çalışmada fiyatlandırma stratejisi ve fiyatlandırma yöntemlerinin otelcilik sektöründe çalışanlar tarafından nasıl bir algısı olduğu üzerine bir analiz yapılmıştır. Öncesinde turizm ve otelcilik kavramları üzerinde durulmuş olup, akabinde genel anlamda fiyatlandırma stratejisi ve fiyatlandırma yöntemleri konuları turizm alanında detaylıca irdelenmiştir. Son bölümde ise otel işletme yöneticilerinin bu iki konu ile ilgili algıları analiz edilmiştir. Türkiye’de halk tarafından ‘Bacasız Endüstri’ olarak tanımladığı turizm sektörünün ülkemize her anlamda olumlu etkileri bulunmaktadır. Turizm kavramının en önemli iki faktörü insan ve konaklama olup, bu iki olgu birbirini tamamlamaktadır. Otel işletmeleri için ürünlerinin değerinde satılması, otel doluluklarının yüksek olması arzusu ve piyasadaki rakip işletmelerden iş çalabilmek çok önemli olup, işletmenin piyasada kenini nasıl konumlandırdığı ile ilgilidir. Bu aşamada işletme yöneticilerinin fiyat ile ilgili doğru ve zamanında analiz yapabilmeleri ve hızlı aksiyon alabilmeleri işletme açısından önemlidir. -------------------- In related work, pricing and pricing strategy in the hospitality industry there is a perception by employees of an analysis of the methods reviewed. Hospitality and tourism are focused on the concepts of prior and, subsequently, in the general sense, the issues of pricing strategy and pricing methods in the field of tourism have been analysed in detail. In the last chapter, these two issues were analyzed regarding the perceptions of management team of the hotel. There is positive impact of tourism industry which is named as ‘Bacasız Endüstri’ by Turkish people to our country. The two most important factors of the concept of tourism accommodation and whether it is human, these two concepts complement each other. The sale of products for worth of Hotel Enterprises, hotel and high-availability business from competing businesses desire to be on the market to be able to steal very important how to position yourself in the market is related to the business. At this stage, the business managers to make timely and accurate analysis related to price, and so you can take quick action is important for business

Konaklama işletmelerinde fiyatlama stratejileri

Konu ile ilgili çalışmada fiyatlandırma stratejisi ve fiyatlandırma yöntemlerinin otelcilik sektöründe çalışanlar tarafından nasıl bir algısı olduğu üzerine bir analiz yapılmıştır. Öncesinde turizm ve otelcilik kavramları üzerinde durulmuş olup, akabinde genel anlamda fiyatlandırma stratejisi ve fiyatlandırma yöntemleri konuları turizm alanında detaylıca irdelenmiştir. Son bölümde ise otel işletme yöneticilerinin bu iki konu ile ilgili algıları analiz edilmiştir. Türkiye’de halk tarafından ‘Bacasız Endüstri’ olarak tanımladığı turizm sektörünün ülkemize her anlamda olumlu etkileri bulunmaktadır. Turizm kavramının en önemli iki faktörü insan ve konaklama olup, bu iki olgu birbirini tamamlamaktadır.Otel işletmeleri için ürünlerinin değerinde satılması, otel doluluklarının yüksek olması arzusu ve piyasadaki rakip işletmelerden iş çalabilmek çok önemli olup, işletmenin piyasada kenini nasıl konumlandırdığı ile ilgilidir. Bu aşamada işletme yöneticilerinin fiyat ile ilgili doğru ve zamanında analiz yapabilmeleri ve hızlı aksiyon alabilmeleri işletme açısından önemlidir.--------------------In related work, pricing and pricing strategy in the hospitality industry there is a perception by employees of an analysis of the methods reviewed. Hospitality and tourism are focused on the concepts of prior and, subsequently, in the general sense, the issues of pricing strategy and pricing methods in the field of tourism have been analysed in detail. In the last chapter, these two issues were analyzed regarding the perceptions of management team of the hotel. There is positive impact of tourism industry which is named as ‘Bacasız Endüstri’ by Turkish people to our country. The two most important factors of the concept of tourism accommodation and whether it is human, these two concepts complement each other. The sale of products for worth of Hotel Enterprises, hotel and high-availability business from competing businesses desire to be on the market to be able to steal very important how to position yourself in the market is related to the business. At this stage, the business managers to make timely and accurate analysis related to price, and so you can take quick action is important for business

Digital clubbing may be an indicator of systemic atherosclerosis even at microvascular level

WOS: 000314345000014Background: Presence of any relationship between digital clubbing and microvascular atherosclerosis was tried to be understood. Methods: Cases with digital clubbing and controls were studied. Results: The study included 104 cases with clubbing and 120 controls. Mean age of clubbing cases was 49.2 years, and there was a male predominance (81.7%) among them. There were significantly higher prevalences of smoking and chronic obstructive pulmonary disease (COPD) in the clubbing group (69.2 versus 41.6% and 27.8 versus 10.8%, respectively, p<0.001 for both). Although body mass index (BMI), weight, and fasting plasma glucose (FPG) were lower in the clubbing group, the differences were nonsignificant probably due to the small sample sizes. Although the negative effect of small sample sizes, prevalence of type 2 diabetes mellitus (DM) and mean value of systolic blood pressure (BP) were significanlty lower in the clubbing group (12.5 versus 21.6% and 127.6 versus 136.9 mmHg, respectively, p<0.05 for both). On the other hand, prevalence of coronary heart disease (CHD) and/or peripheric artery disease (PAD) were significantly higher in the clubbing group (7.6 versus 0.0%, p<0.01). Conclusions: There are significant relationships between digital clubbing and smoking, COPD, and CHD and/or PAD probably due to strong atherosclerotic effects of smoking with highly suspected atherosclerotic background of COPD. Whereas the BMI, weight, FPG, systolic BP, and prevalence of DM are inversely related with digital clubbing probably due to suppressor effects of smoking on appetite. So clubbing may be a significant indicator of systemic atherosclerosis even at microvascular level