Nonlocal First-Order Hamilton-Jacobi Equations Modelling Dislocations Dynamics

We study nonlocal first-order equations arising in the theory of dislocations. We prove the existence and uniqueness of the solutions of these equations in the case of positive and negative velocities, under suitable regularity assumptions on the initial data and the velocity. These results are based on new $L^1$-type estimates on the viscosity solutions of first-order Hamilton-Jacobi Equations appearing in the so-called ``level-sets approach''. Our work is inspired by and simplifies a recent work of Alvarez, Cardaliaguet and Monneau

Statistical Modelling of Fishing Activities in the North Atlantic

This paper deals with the issue of modeling daily catches of fishing boats in the Grand Bank fishing grounds. We have data on catches per species for a number of vessels collected by the European Union in the context of the North Atlantic Fisheries Organization. Many variables can be thought to influence the amount caught: a number of ship characteristics (such as the size of the ship, the fishing technique used, the mesh size of the nets, etc.), are obvious candidates, but one can also consider the season or the actual location of the catch. In all, our database leads to 23 possible regressors, resulting in a set of 8:4£106 possible linear regression models. Prediction of future catches and posterior inference will be based on Bayesian model averaging, using a Markov Chain Monte Carlo Model Composition (MC3) approach. Particular attention is paid to the elicitation of the prior and the prediction of catch for single and aggregated observations.

A Novel Internet-Based Reaction Monitoring, Control and Autonomous Self-Optimization Platform for Chemical Synthesis

We have developed a modular software system that enables researchers to monitor and control chemical reactions via the internet, using any device from any location in the world. It facilitates the automation of synthetic procedures and is able to autonomously self-optimize reaction parameters to find the best conditions meeting customizable, multi-component optimization functions. In this report, we demonstrate its utility as applied to reaction automation to maximize the output from a fixed volume of catalyst. We also showcase its ability to optimize a three dimension heterogeneous catalytic reaction and a five dimension Appel reaction against various target functions.We are grateful to the Woolf Fisher Trust (D.E.F), Pfizer Worldwide Research and Development (C.B.) and EPSRC (S.V.L., grant codes EP/K009494/1, EP/M004120/1 and EP/K039520/1) for financial assistance.This is the final version of the article. It was first available from American Chemical Society via http://dx.doi.org/10.1021/acs.oprd.5b0031

Statistical Modelling of Fishing Activities in the North Atlantic

This paper deals with the issue of modeling daily catches of fishing boats in the Grand Bank fishing grounds. We have data on catches per species for a number of vessels collected by the European Union in the context of the North Atlantic Fisheries Organization. Many variables can be thought to influence the amount caught: a number of ship characteristics (such as the size of the ship, the fishing technique used, the mesh size of the nets, etc.), are obvious candidates, but one can also consider the season or the actual location of the catch. In all, our database leads to 23 possible regressors, resulting in a set of 8:4£106 possible linear regression models. Prediction of future catches and posterior inference will be based on Bayesian model averaging, using a Markov Chain Monte Carlo Model Composition (MC3) approach. Particular attention is paid to the elicitation of the prior and the prediction of catch for single and aggregated observations.

Application of High Performance Photoinitiating Systems for Holographic Grating Recording

In this chapter, a compilation of different systems able to photogenerate active radicals toward polymerization reaction( type I, type II and three component photoinitiating systems) for application in holographic grating recording when associated to monomers is reviewed. In particular, the visible curable system is associated to fluorinated acrylate monomers formulation for creation of transmission gratings. The PIS efficiencies are presented in term of diffraction grating yields and compared to photopolymerization experiments. The special case of photocyclic initiating systems is described in details, its influence on the grating built up being discussed on the basis of selected mixtures using visible dyes, electron donors (e.g. amines), electron acceptors (e.g. iodonium salts) or hydrogen donors as coinitiators. The role of the photochemical properties of dye on the performance of the holographic recording material is investigated through time resolved and steady state spectroscopic studies of the PIS (e.g. nanosecond laser flash photolysis), to highlight the photochemistry underlying active radicals photogeneration. In order to get more insight into the hologram formation, grating formation curves were compared to those of monomer to polymer conversion obtained by real time Fourier transform infrared spectroscopy (RTFTIR). This work outlines the importance of the coupling between the photoinitiating system (i.e. the photochemical reactions) and the holographic resin

Detecting the direction of a signal on high-dimensional spheres: Non-null and Le Cam optimality results

We consider one of the most important problems in directional statistics, namely the problem of testing the null hypothesis that the spike direction $\theta$ of a Fisher-von Mises-Langevin distribution on the $p$-dimensional unit hypersphere is equal to a given direction $\theta_0$. After a reduction through invariance arguments, we derive local asymptotic normality (LAN) results in a general high-dimensional framework where the dimension $p_n$ goes to infinity at an arbitrary rate with the sample size $n$, and where the concentration $\kappa_n$ behaves in a completely free way with $n$, which offers a spectrum of problems ranging from arbitrarily easy to arbitrarily challenging ones. We identify various asymptotic regimes, depending on the convergence/divergence properties of $(\kappa_n)$, that yield different contiguity rates and different limiting experiments. In each regime, we derive Le Cam optimal tests under specified $\kappa_n$ and we compute, from the Le Cam third lemma, asymptotic powers of the classical Watson test under contiguous alternatives. We further establish LAN results with respect to both spike direction and concentration, which allows us to discuss optimality also under unspecified $\kappa_n$. To investigate the non-null behavior of the Watson test outside the parametric framework above, we derive its local asymptotic powers through martingale CLTs in the broader, semiparametric, model of rotationally symmetric distributions. A Monte Carlo study shows that the finite-sample behaviors of the various tests remarkably agree with our asymptotic results.Comment: 47 pages, 4 figure

Total synthesis and biological evaluation of the tetramic acid based natural product harzianic acid and its stereoisomers

Financial support for this project was provided by Cancer Research UK (Grant No. C21383/A6950)The bioactive natural product harzianic acid was prepared for the first time in just six steps (longest linear sequence) with an overall yield of 22%. The identification of conditions to telescope amide bond formation and a Lacey-Dieckmann reaction into one pot proved important. The three stereoisomers of harzianic acid were also prepared, providing material for comparison of their biological activity. While all of the isomers promoted root growth, improved antifungal activity was unexpectedly associated with isomers in the enantiomeric series opposite that of harzianic acid.Publisher PDFPeer reviewe

Expression profiling of snoRNAs in normal hematopoiesis and AML

Key Points A subset of snoRNAs is expressed in a developmental- and lineage-specific manner during human hematopoiesis. Neither host gene expression nor alternative splicing accounted for the observed differential expression of snoRNAs in a subset of AML.</jats:p

TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus

Funding: This work was supported by the Francis Crick Institute which receives its core funding from Cancer Research UK (FC001220), the UK Medical Research Council (FC001220), and the Wellcome Trust (FC001200). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments We are indebted to The Francis Crick Institute Flow Cytometry facility, and in particular Bhavik Patel, Graham Preece, Wayne Turnbull and Phil Hobson. We would also like to thank The Francis Crick Institute Procedural Service Section for production of GA lines and Biological Services, especially Trisha Norton, Keith Williams and Adebambo Adekoya for animal husbandry and technical support; to Riccardo Guidi for constructive discussions and technical assistance. We would like to thank Gitta Stockinger and AhR Immunity Laboratory for providing technical support and reagents throughout this study. We also thank Richard Rance and the Wellcome Trust Sanger Institute’s 454 pyrosequencing team for generating 16S rRNA gene data.Peer reviewedPublisher PD