The α2 HS glycoprotein receptor on lymphocytes transformed by Epstein—Barr virus

AbstractThe α2HS glycoprotein receptor form lymphocytes transformed by Epstein—Barr Virus was isolated by affinity chromatography. The protein receptor has a monomer Mr of 48 000, which is similar to the Epstein—Barr virus-determined nuclear antigen (EBNA), and pI = 7.2. Like EBNA the 48 000 Mr component in unfractionated labelled detergent solubilised cell supernatants also binds DNA. These results may suggest some similarity between the α2HS receptor and EBNA

Unitary relation between a harmonic oscillator of time-dependent frequency and a simple harmonic oscillator with and without an inverse-square potential

The unitary operator which transforms a harmonic oscillator system of time-dependent frequency into that of a simple harmonic oscillator of different time-scale is found, with and without an inverse-square potential. It is shown that for both cases, this operator can be used in finding complete sets of wave functions of a generalized harmonic oscillator system from the well-known sets of the simple harmonic oscillator. Exact invariants of the time-dependent systems can also be obtained from the constant Hamiltonians of unit mass and frequency by making use of this unitary transformation. The geometric phases for the wave functions of a generalized harmonic oscillator with an inverse-square potential are given.Comment: Phys. Rev. A (Brief Report), in pres

Probing Pulsar Winds Using Inverse Compton Scattering

We investigate the effects of inverse Compton scattering by electrons and positrons in the unshocked winds of rotationally-powered binary pulsars. This process can scatter low energy target photons to produce gamma rays with energies from MeV to TeV. The binary radio pulsars PSR B1259-63 and PSR J0045-73 are both in close eccentric orbits around bright main sequence stars which provide a huge density of low energy target photons. The inverse Compton scattering process transfers momentum from the pulsar wind to the scattered photons, and therefore provides a drag which tends to decelerate the pulsar wind. We present detailed calculations of the dynamics of a pulsar wind which is undergoing inverse Compton scattering, showing that the deceleration of the wind of PSR B1259-63 due to `inverse Compton drag' is small, but that this process may confine the wind of PSR J0045-73 before it attains pressure balance with the outflow of its companion star. We calculate the spectra and light curves of the resulting inverse Compton emission from PSR B1259-63 and show that if the size of the pulsar wind nebula is comparable to the binary separation, then the gamma-ray emission from the unshocked wind may be detectable by atmospheric Cerenkov detectors or by the new generation of satellite-borne gamma-ray detectors such as INTEGRAL and GLAST. This mechanism may therefore provide a direct probe of the freely-expanding regions of pulsar winds, previously thought to be invisible.Comment: To be published in Astroparticle Physics. 27 pages, 5 figure

Dynamical Dark Energy simulations: high accuracy Power Spectra at high redshift

Accurate predictions on non--linear power spectra, at various redshift z, will be a basic tool to interpret cosmological data from next generation mass probes, so obtaining key information on Dark Energy nature. This calls for high precision simulations, covering the whole functional space of w(z) state equations and taking also into account the admitted ranges of other cosmological parameters; surely a difficult task. A procedure was however suggested, able to match the spectra at z=0, up to k~3, hMpc^{-1}, in cosmologies with an (almost) arbitrary w(z), by making recourse to the results of N-body simulations with w = const. In this paper we extend such procedure to high redshift and test our approach through a series of N-body gravitational simulations of various models, including a model closely fitting WMAP5 and complementary data. Our approach detects w= const. models, whose spectra meet the requirement within 1% at z=0 and perform even better at higher redshift, where they are close to a permil precision. Available Halofit expressions, extended to (constant) w \neq -1 are unfortunately unsuitable to fit the spectra of the physical models considered here. Their extension to cover the desired range should be however feasible, and this will enable us to match spectra from any DE state equation.Comment: method definitely improved in semplicity and efficacy,accepted for publication on JCA

Inverse Compton Emission of TeV Gamma Rays from PSR B1259-63

We derive light curves for the hard gamma-ray emission, at energies up to several TeV, expected from the unique pulsar/Be-star binary system PSR B1259-63. This is the only known system in our galaxy in which a radio pulsar is orbiting a main sequence star. We show that inverse Compton emission from the electrons and positrons in the shocked pulsar wind, scattering target photons from the Be star, produces a flux of hard gamma-rays that should be above the sensitivity threshold of present day atmospheric Cerenkov detectors. Furthermore, we predict that the flux of hard gamma-rays produced via this mechanism has a characteristic variation with orbital phase that should be observable, and which is not expected from any other mechanism.Comment: To be published in Astroparticle Physics. 24 pages, 8 figure

Novel approach to the study of quantum effects in the early universe

We develop a theoretical frame for the study of classical and quantum gravitational waves based on the properties of a nonlinear ordinary differential equation for a function $\sigma(\eta)$ of the conformal time $\eta$, called the auxiliary field equation. At the classical level, $\sigma(\eta)$ can be expressed by means of two independent solutions of the ''master equation'' to which the perturbed Einstein equations for the gravitational waves can be reduced. At the quantum level, all the significant physical quantities can be formulated using Bogolubov transformations and the operator quadratic Hamiltonian corresponding to the classical version of a damped parametrically excited oscillator where the varying mass is replaced by the square cosmological scale factor $a^{2}(\eta)$. A quantum approach to the generation of gravitational waves is proposed on the grounds of the previous $\eta-$dependent Hamiltonian. An estimate in terms of $\sigma(\eta)$ and $a(\eta)$ of the destruction of quantum coherence due to the gravitational evolution and an exact expression for the phase of a gravitational wave corresponding to any value of $\eta$ are also obtained. We conclude by discussing a few applications to quasi-de Sitter and standard de Sitter scenarios.Comment: 20 pages, to appear on PRD. Already published background material has been either settled up in a more compact form or eliminate

Neutron scattering and molecular correlations in a supercooled liquid

We show that the intermediate scattering function $S_n(q,t)$ for neutron scattering (ns) can be expanded naturely with respect to a set of molecular correlation functions that give a complete description of the translational and orientational two-point correlations in the liquid. The general properties of this expansion are discussed with special focus on the $q$-dependence and hints for a (partial) determination of the molecular correlation functions from neutron scattering results are given. The resulting representation of the static structure factor $S_n(q)$ is studied in detail for a model system using data from a molecular dynamics simulation of a supercooled liquid of rigid diatomic molecules. The comparison between the exact result for $S_n(q)$ and different approximations that result from a truncation of the series representation demonstrates its good convergence for the given model system. On the other hand it shows explicitly that the coupling between translational (TDOF) and orientational degrees of freedom (ODOF) of each molecule and rotational motion of different molecules can not be neglected in the supercooled regime.Further we report the existence of a prepeak in the ns-static structure factor of the examined fragile glassformer, demonstrating that prepeaks can occur even in the most simple molecular liquids. Besides examining the dependence of the prepeak on the scattering length and the temperature we use the expansion of $S_n(q)$ into molecular correlation functions to point out intermediate range orientational order as its principle origin.Comment: 13 pages, 7 figure

Genetic architecture of dispersal behaviour in the post-harvest pest and model organism Tribolium castaneum

Dispersal behaviour is an important aspect of the life-history of animals. However, the genetic architecture of dispersal-related traits is often obscure or unknown, even in well studied species. Tribolium castaneum is a globally significant post-harvest pest and established model organism, yet studies of its dispersal have shown ambiguous results and the genetic basis of this behaviour remains unresolved. We combine experimental evolution and agent-based modelling to investigate the number of loci underlying dispersal in T. castaneum, and whether the trait is sex-linked. Our findings demonstrate rapid evolution of dispersal behaviour under selection. We find no evidence of sex-biases in the dispersal behaviour of the offspring of crosses, supporting an autosomal genetic basis of the trait. Moreover, simulated data approximates experimental data under simulated scenarios where the dispersal trait is controlled by one or few loci, but not many loci. Levels of dispersal in experimentally inbred lines, compared with simulations, indicate that a single locus model is not well supported. Taken together, these lines of evidence support an oligogenic architecture underlying dispersal in Tribolium castaneum. These results have implications for applied pest management and for our understanding of the evolution of dispersal in the coleoptera, the world’s most species-rich order

The role of high-field magnetic resonance imaging in parkinsonian disorders:Pushing the boundaries forward

Historically, magnetic resonance imaging (MRI) has contributed little to the study of Parkinson's disease (PD), but modern MRI approaches have unveiled several complementary markers that are useful for research and clinical applications. Iron- and neuromelanin-sensitive MRI detect qualitative changes in the substantia nigra. Quantitative MRI markers can be derived from diffusion weighted and iron-sensitive imaging or volumetry. Functional brain alterations at rest or during task performance have been captured with functional and arterial spin labeling perfusion MRI. These markers are useful for the diagnosis of PD and atypical parkinsonism, to track disease progression from the premotor stages of these diseases and to better understand the neurobiological basis of clinical deficits. A current research goal using MRI is to generate time-dependent models of the evolution of PD biomarkers that can help understand neurodegeneration and provide reliable markers for therapeutic trials. This article reviews recent advances in MRI biomarker research at high-field (3T) and ultra high field-imaging (7T) in PD and atypical parkinsonism. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society