Chiral Heterocyclic Ligands. XI. Self-assembly and X-Ray Crystal Structures of Chiral Silver Coordination Polymers of (S)-(-)-Nicotine

Three chiral coordination polymers have been prepared by reaction of (S)-(-)-nicotine with silver(I) salts. X-Ray crystal structure determinations revealed that these all contain polymer chains in which the nicotine molecule acts as a bridging ligand between four-coordinate silver atoms. In one case additional bridging by nitrate anions leads to a three-dimensional network structure

Book Reviews

Michael Bane. White Boy Singin' the Blues: The Black Roots of White Rock. New York: Penguin Books, 1982. Pp. 269. Paper, $5.95. Review by Phillip McGuire of the University of North Carolina at Wilmington. Alan M. Kraut. The Huddled Masses: The Immigrant in American Society, 1880- 1921. Arlington Heights, Illinois: Harlan Davidson, Inc., 1982. Pp. xi, 212. Paper,$7.95. Review by William L. Downard of Saint Joseph's College (Indiana). Gerald R. Baydo, ed. The Evolution of Mass Culture in America, 1877 to the Present. Arlington Heights,  Illinois: Forum Press, 1982. Pp. 209. Paper, $9.95. Review by Michael L. Berger of St. Mary's College of Maryland. Michael D. Richards. Europe, 1900-1980: A Brief History. Arlington Heights, Illinois: Forum Press, 1982. Pp. 276. Paper,$11.95. Review by Larry D. Wilcox of the University of Toledo. Walter Laqueur. The Terrible Secret: Suppression of the Truth About Hitler's "Final Solution." New York: Penguin Books, 1980. Pp. 262. Paper, $5.95. Review by Robert H. Welborn of Clayton Junior College. Deborah Gorham. The Victorian Girl and the Feminine Ideal. Bloomington: Indiana University Press, 1982. Pp. 223. Cloth,$20.00. Review by C. Ashley Ellefson of SUNY-Cortland. Frank F. Mathias. G.I. Jive: An Army Bandsman in World War II. Lexington: University Press of Kentucky, 1982. Pp. xii, 227. Cloth, $17.50. Review by Thomas F. Armstrong of Georgie College. David E. Kyvig and Myron A. Marty. Nearby History: Exploring the Past Around You. Nashville: The American Assocation for State and Local History, 1982. Pp. xiii, 300. Cloth,$15.95. Review by William E. Gibbs of New Mexico Military Institute. Glenn C. Altschuler. Race, Ethnicity, and Class in American Social Thought, 1865-1919. Arlington Heights, Illinois: Harlan Davidson, Inc., 1982. Pp. xv, 141. Paper, $6.95. Review by George D. King of the University of Minnesota. Archimedes L.A. Patti. Why Vietnam? Prelude to America's Albatross. Berkeley: University of California Press , 1980. Pp. xx, 612. Paper,$10.95; Hugh Higgins. Vietnam. Exeter, New Hampshire: Heinemann Educational Books, Inc., 1982. Second edition. Pp. 180. Paper, $7.50. Review by Frank A. Burdick of SUNY-Cortland. Robert A. Hayes. The Brazilian World. Arlington Heights, Illinois: Forum Press, 1982. Pp. 87. Paper,$5.75; John Francis Bannon. The Colonial World of Latin America. Arlington Heights, Illinois: Forum Press, 1982. Pp. 89. Paper, $5.75. Review by W. James Miller of Louisiana State University-Shreveport. Robert Brugger, ed. Our Selves/Our Past: Psychological Approaches to American History. Baltimore: Johns Hopkins University Press, 1981. Pp. xiii, 416. Cloth,$26.50; Paper, $8.95. Review by Thomas T. Lewis of Mount Senario College. Edward Wagenknecht. American Profile, 1900-1909. Amherst: University of Massachusetts Press, 1982. Pp. 376. Cloth,$22.50; Paper, $10.00. Review by Hansel Martin of Justin F. Kimball High School and Mountain View College, Dallas, Texas. &nbsp

Proteomic Analysis of Colorectal Cancer: Prefractionation Strategies Using two-Dimensional Free-Flow Electrophoresis

This review deals with the application of a new prefractionation tool, free-flow electrophoresis (FFE), for proteomic analysis of colorectal cancer (CRC). CRC is a leading cause of cancer death in the Western world. Early detection is the single most important factor influencing outcome of CRC patients. If identified while the disease is still localized, CRC is treatable. To improve outcomes for CRC patients there is a pressing need to identify biomarkers for early detection (diagnostic markers), prognosis (prognostic indicators), tumour responses (predictive markers) and disease recurrence (monitoring markers). Despite recent advances in the use of genomic analysis for risk assessment, in the area of biomarker identification genomic methods alone have yet to produce reliable candidate markers for CRC. For this reason, attention is being directed towards proteomics as a complementary analytical tool for biomarker identification. Here we describe a proteomics separation tool, which uses a combination of continuous FFE, a liquid-based isoelectric focusing technique, in the first dimension, followed by rapid reversed-phase HPLC (1–6 min/analysis) in the second dimension. We have optimized imaging software to present the FFE/RP-HPLC data in a virtual 2D gel-like format. The advantage of this liquid based fractionation system over traditional gel-based fractionation systems is the ability to fractionate large quantity protein samples. Unlike 2D gels, the method is applicable to both high-Mr proteins and small peptides, which are difficult to separate, and in the case of peptides, are not retained in standard 2D gels

Book Reviews

Michael Bane. White Boy Singin' the Blues: The Black Roots of White Rock. New York: Penguin Books, 1982. Pp. 269. Paper, $5.95. Review by Phillip McGuire of the University of North Carolina at Wilmington. Alan M. Kraut. The Huddled Masses: The Immigrant in American Society, 1880- 1921. Arlington Heights, Illinois: Harlan Davidson, Inc., 1982. Pp. xi, 212. Paper,$7.95. Review by William L. Downard of Saint Joseph's College (Indiana). Gerald R. Baydo, ed. The Evolution of Mass Culture in America, 1877 to the Present. Arlington Heights,  Illinois: Forum Press, 1982. Pp. 209. Paper, $9.95. Review by Michael L. Berger of St. Mary's College of Maryland. Michael D. Richards. Europe, 1900-1980: A Brief History. Arlington Heights, Illinois: Forum Press, 1982. Pp. 276. Paper,$11.95. Review by Larry D. Wilcox of the University of Toledo. Walter Laqueur. The Terrible Secret: Suppression of the Truth About Hitler's "Final Solution." New York: Penguin Books, 1980. Pp. 262. Paper, $5.95. Review by Robert H. Welborn of Clayton Junior College. Deborah Gorham. The Victorian Girl and the Feminine Ideal. Bloomington: Indiana University Press, 1982. Pp. 223. Cloth,$20.00. Review by C. Ashley Ellefson of SUNY-Cortland. Frank F. Mathias. G.I. Jive: An Army Bandsman in World War II. Lexington: University Press of Kentucky, 1982. Pp. xii, 227. Cloth, $17.50. Review by Thomas F. Armstrong of Georgie College. David E. Kyvig and Myron A. Marty. Nearby History: Exploring the Past Around You. Nashville: The American Assocation for State and Local History, 1982. Pp. xiii, 300. Cloth,$15.95. Review by William E. Gibbs of New Mexico Military Institute. Glenn C. Altschuler. Race, Ethnicity, and Class in American Social Thought, 1865-1919. Arlington Heights, Illinois: Harlan Davidson, Inc., 1982. Pp. xv, 141. Paper, $6.95. Review by George D. King of the University of Minnesota. Archimedes L.A. Patti. Why Vietnam? Prelude to America's Albatross. Berkeley: University of California Press , 1980. Pp. xx, 612. Paper,$10.95; Hugh Higgins. Vietnam. Exeter, New Hampshire: Heinemann Educational Books, Inc., 1982. Second edition. Pp. 180. Paper, $7.50. Review by Frank A. Burdick of SUNY-Cortland. Robert A. Hayes. The Brazilian World. Arlington Heights, Illinois: Forum Press, 1982. Pp. 87. Paper,$5.75; John Francis Bannon. The Colonial World of Latin America. Arlington Heights, Illinois: Forum Press, 1982. Pp. 89. Paper, $5.75. Review by W. James Miller of Louisiana State University-Shreveport. Robert Brugger, ed. Our Selves/Our Past: Psychological Approaches to American History. Baltimore: Johns Hopkins University Press, 1981. Pp. xiii, 416. Cloth,$26.50; Paper, $8.95. Review by Thomas T. Lewis of Mount Senario College. Edward Wagenknecht. American Profile, 1900-1909. Amherst: University of Massachusetts Press, 1982. Pp. 376. Cloth,$22.50; Paper, $10.00. Review by Hansel Martin of Justin F. Kimball High School and Mountain View College, Dallas, Texas.</jats:p

Book Reviews

James Stuart Olsen. The Ethnic Dimension in American History. New York: St. Martin's Press, 1979. Pp. xxv, 440:- Cloth, $14.95; paper,$7.95; A. C. Hepburn, ed. Minorities in History. New York: St. Martin's Press, 1979. Pp. 251 . Cloth, $27.50. Review by John F. Sutherland of Manchester (Connecticut) Community College. David Burner, Eugene Genovese, and Forrest McDonald. The American People. St. James, New York: Revisionary Press, 1980. Cloth,$20.95; paper, $16.95. Review by Thomas T. Lewis of Mount Senario College. Richard E. Beringer. Historical Analysis: Contemporary Approaches to Clio's Craft. New York: John Wiley and Sonds, 1978. Pp. xii, 317. Paper,$12.95. Review by Martha H. Swain of Texas Woman's University. John T. Marcus. Sub Specie Historiae: Essays in the Manifestation of Historical and Moral Consciousness. Cranbury, New Jersey: Associated University Presses, 1980. Pp. 325. Cloth, $22.50. Review by David D. Joyce of The University of Tulsa. A. K. Dickinson and P. J. Lee. History Teaching and Historical Understanding. Exeter, New Hampshire: Heinemann Educational Books, Inc., 1978 . Pp. viii, 176. Paper,$10.95. Review by Jayme A. Sokolow of Texas Tech University. Richard W. Hull. Modern Africa: Change and Continuity. Englewood Cliffs, New Jersey: Prentice-Hall, Inc., 1980. Pp. xii, 274. Paper, $9.95. Review by Thomas O'Toole of Western Carolina University. Clayton Roberts and David Roberts. A History of England. 2 volumes. Englewood Cliffs, New Jersey: Prentice-Hall, 1980. Pp. 891. Paper,$13.95 per volume. Review by Eugene E. Kuzirian of The University of Texas at El Paso. Alex de Jonge. The Weimar Chronicle: Prelude to Hitler. New York: New American Library, 1978 . Pp . 256 . Paper, $5.95. Review by Helmut J. Schmeller of Fort Hays State University. A. J. P. Taylor. The War Lords. New York: Penguin Books, 1976. Pp. 189. Paper,$3.95. Review by Clarence B. Davis of The College of Charleston. History Broadsheets. Exeter, New Hampshire: Heinemann Educational Books, 1978, 1979. $5.00 per packet. Review by Jacob L. Susskind of The Pennsylvania State University/ The Capitol Campus. Robert L. Heilbroner. The Economic Transformation of America. New York: Harcourt, Brace, Jovanovich, 1977. Pp. 276. Paper,$9.95; Henry C. Dethloff. Americans and Free Enterprise. Englewood Cliffs, New Jersey: Prentice-Hall, 1979. Pp, 336. Cloth, $13.95; Susan Previant Lee and Peter Passell. A New Economic View of American History. New York: W. W. Norton, 1979. Pp. 410. Cloth,$18.95; paper, $9.95; Martin L. Primack and James F. Willis. An Economic History of the United States. Menlo Park, Carlifornia: The Benjamin Cummings Publishing Company, 1980. Pp. 462. Cloth.$16.95. Review by William L. Downard of Saint Joseph's College, Indiana. John Chester Miller. The Wolf by the Ears: Thomas Jefferson and Slavery. New York: New American Library, 1977. Pp. xiv, 323. Paper, 5.95. Review by Larry R. Morrison of Virginia Polytechnic Institute & State University. Edmund Morris. The Rise of Theodore Roosevelt. New York: Ballantine Books, 1979. Pp. 886. Paper, 8.95. Review by Marvin Reed of Collegeville, Pennsylvania. Ellis W. Hawley. The Great War and the Search for Modern Order: A History of the American People and Their Institutions, 1917-1933. New York: St. Martin's Press, 1979. Pp. xvi, 264. Cloth, $12.95; paper,$4.95; Gerald D. Nash. The Great Depression and World War II: Organizaing America, 1933-1945. New York: St. Martin's Press, 1980. Pp. xvi, 1976. Clotch, $12.95; paper,$4.95. Review by Howard W. Smith of Spring Hill College. William L. Griffen and John Marciano. Teaching the Vietnam War. Montclair, New Jersey: Allanheld, Osmun, 1979. Pp. xx, 183. Paper, $6.50. Review by Frank J. Rader of SUNY Empire State College. Michael V. Namorato, ed. Have We Overcome? Race Relations Since Brown. Jackson, Mississippi: University Press Of Mississippi, 1979. Pp. xix, 232. Cloth,$15.00; paper, $7.95. Review by Gary J. Hunter of Glassboro State College.</jats:p