How do women business owners define success and what are the psychological factors that enable them to succeed?

This thesis aims to examine how women define success as business owners and the psychological factors that can help them succeed, particularly in the early years of running a business. In the context of increasing levels of business ownership there is an increasing recognition that less women than men start a business and the measures that are used to determine business success are dominated by an economic focus. Limited research has been conducted which specifically looks at how women define business success, in their own terms, and the psychological factors that help them succeed. Research examining women business owners in the UK is particularly lacking. Using a mixed-methods approach, this thesis examines how business success is defined and measured by women and the specific psychological factors, namely personality characteristics, competencies and values that help success. To address the aims of this thesis, two studies were conducted. The first study was a systematic literature review (n = 17) which examined the psychological factors and measures of success conducted in research. The results suggested that the dominant measure of business success is economic in basis, which is unlikely to be a surprise as a large proportion of the studies were conducted in the US. None of the studies specifically asked participants to define business success and none looked at the crucial first three years of business ownership, when the business can be at its most vulnerable. Many of the studies looked at aspects of personality in relation to business performance success, with entrepreneurial self-efficacy and creativity being the dominant focus. None of the studies explored the triumvirate of personality, competencies or values, and none of the studies specifically or explicitly discuss the role that one’s personal values might play in succeeding as a business owner. Therefore, the second study using a qualitative design, examined how women business owners in the UK, in the first three years of their business, defined success and the factors that enabled them to navigate the ups and downs of business ownership, something that felt even more pertinent in the midst of the Covid19 pandemic. The findings showed that women tended to define and measure their success in non-economic terms. Some aspects of personality and competencies married with findings from the first study and the second study provides a helpful, more in-depth insight into the lived experiences of women business owners. In particular, this is the first known study that specifically and explicitly looked at the role values may play in business success. This thesis provides novel insights into how women define business success and the psychological factors that may help them in the early years of starting and running a business. Taken together, these findings could help inform the development of evidence-based interventions to help women looking to start a business. The implications for further research and practice are also discussed

A Dual-Readout F2 Assay That Combines Fluorescence Resonance Energy Transfer and Fluorescence Polarization for Monitoring Bimolecular Interactions

Forster (fluorescence) resonance energy transfer (FRET) and fluorescence polarization (FP) are widely used technologies for monitoring bimolecular interactions and have been extensively used in high-throughput screening (HTS) for probe and drug discovery. Despite their popularity in HTS, it has been recognized that different assay technologies may generate different hit lists for the same biochemical interaction. Due to the high cost of large-scale HTS campaigns, one has to make a critical choice to employee one assay platform for a particular HTS. Here we report the design and development of a dual-readout HTS assay that combines two assay technologies into one system using the Mcl-1 and Noxa BH3 peptide interaction as a model system. In this system, both FP and FRET signals were simultaneously monitored from one reaction, which is termed -Dual-Readout F2 assay- with F2 for FP and FRET. This dual-readout technology has been optimized in a 1,536-well ultra-HTS format for the discovery of Mcl-1 protein inhibitors and achieved a robust performance. This F2 assay was further validated by screening a library of 102,255 compounds. As two assay platforms are utilized for the same target simultaneously, hit information is enriched without increasing the screening cost. This strategy can be generally extended to other FP-based assays and is expected to enrich primary HTS information and enhance the hit quality of HTS campaigns.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90469/1/adt-2E2010-2E0292.pd

Imprints, [Vol. 5]

This 1989 edition includes winners of the T. E. Ferguson writing Contest, two honorable mentions, and a number of other entries that we felt deserved to be published. I would like to give special thanks to all the judges of the Ferguson Writing Contest who helped make this publication possible, and especially to Dr. Patricia Russell, who one again proved to be an invaluable asset. Her dedication and love for the organization and all it stands for has made this one of the most successful years ever.https://scholarworks.sfasu.edu/imprints/1000/thumbnail.jp

Information Competencies for Students in Design Disciplines

Information Competencies for Students in Design Disciplines, for the first time, compiles a list of core information literacy skills for students. Divided into basic, intermediate, and advanced skills in each design discipline, this set of competencies is an invaluable aid to librarians as they strive to define and delimit information literacy skills for students in design disciplines. These competencies are intended to facilitate a systematic means of integrating information literacy skills into the core curriculum of design students, as well as to open lines of communication with faculty as to how competencies can be integrated into specific course goals. The authors developed Information Competencies for Students in Design Disciplines with previously established information literacy standards at its foundation. The ACRL Information Literacy Competency Standards for Higher Education as well as specific standards in other disciplines such as Information Literacy Standards for Science and Engineering/Technology were consulted in the creation of these standards

Widespread movement of invasive cattle fever ticks (Rhipicephalus microplus) in southern Texas leads to shared local infestations on cattle and deer

Background: Rhipicephalus (Boophilus) microplus is a highly-invasive tick that transmits the cattle parasites (Babesia bovis and B. bigemina) that cause cattle fever. R. microplus and Babesia are endemic in Mexico and ticks persist in the United States inside a narrow tick eradication quarantine area (TEQA) along the Rio Grande. This containment area is threatened by unregulated movements of illegal cattle and wildlife like white-tailed deer (WTD; Odocoileus virginianus). Methods: Using 11 microsatellite loci we genotyped 1,247 R. microplus from 63 Texas collections, including outbreak infestations from outside the TEQA. We used population genetic analyses to test hypotheses about ecological persistence, tick movement, and impacts of the eradication program in southern Texas. We tested acaricide resistance with larval packet tests (LPTs) on 47 collections. Results: LPTs revealed acaricide resistance in 15/47 collections (32%); 11 were outside the TEQA and three were resistant to multiple acaricides. Some collections highly resistant to permethrin were found on cattle and WTD. Analysis of genetic differentiation over time at seven properties revealed local gene pools with very low levels of differentiation (F-ST 0.00-0.05), indicating persistence over timespans of up to 29 months. However, in one neighborhood differentiation varied greatly over a 12-month period (F-ST 0.03-0.13), suggesting recurring immigration from distinct sources as another persistence mechanism. Ticks collected from cattle and WTD at the same location are not differentiated (F-ST = 0), implicating ticks from WTD as a source of ticks on cattle (and vice versa) and emphasizing the importance of WTD to tick control strategies. We identified four major genetic groups (K = 4) using Bayesian population assignment, suggesting multiple introductions to Texas. Conclusions: Two dispersal mechanisms give rise to new tick infestations: 1) frequent short-distance dispersal from the TEQA; and 2) rare long-distance, human-mediated dispersal from populations outside our study area, probably Mexico. The threat of cattle fever tick transport into Texas is increased by acaricide resistance and the ability of R. microplus to utilize WTD as an alternate host. Population genetic analyses may provide a powerful tool for tracking invasions in other parts of the world where these ticks are established

Atypical audiovisual speech integration in infants at risk for autism

The language difficulties often seen in individuals with autism might stem from an inability to integrate audiovisual information, a skill important for language development. We investigated whether 9-month-old siblings of older children with autism, who are at an increased risk of developing autism, are able to integrate audiovisual speech cues. We used an eye-tracker to record where infants looked when shown a screen displaying two faces of the same model, where one face is articulating/ba/and the other/ga/, with one face congruent with the syllable sound being presented simultaneously, the other face incongruent. This method was successful in showing that infants at low risk can integrate audiovisual speech: they looked for the same amount of time at the mouths in both the fusible visual/ga/− audio/ba/and the congruent visual/ba/− audio/ba/displays, indicating that the auditory and visual streams fuse into a McGurk-type of syllabic percept in the incongruent condition. It also showed that low-risk infants could perceive a mismatch between auditory and visual cues: they looked longer at the mouth in the mismatched, non-fusible visual/ba/− audio/ga/display compared with the congruent visual/ga/− audio/ga/display, demonstrating that they perceive an uncommon, and therefore interesting, speech-like percept when looking at the incongruent mouth (repeated ANOVA: displays x fusion/mismatch conditions interaction: F(1,16) = 17.153, p = 0.001). The looking behaviour of high-risk infants did not differ according to the type of display, suggesting difficulties in matching auditory and visual information (repeated ANOVA, displays x conditions interaction: F(1,25) = 0.09, p = 0.767), in contrast to low-risk infants (repeated ANOVA: displays x conditions x low/high-risk groups interaction: F(1,41) = 4.466, p = 0.041). In some cases this reduced ability might lead to the poor communication skills characteristic of autism

Schistosoma mansoni : use of a fluorescent indicator to detect nitric oxide and related species in living parasites

Author Posting. © The Authors, 2005. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Experimental Parasitology 113 (2006): 130-133, doi:10.1016/j.exppara.2005.12.013.Nitric oxide (NO) is synthesized enzymatically by nitric oxide synthase (NOS). Several groups have previously presented evidence for NOS activity and immunoreactivity in several parasitic platyhelminths, including schistosomes. Here, we use 4,5-diaminofluorescein-2 diacetate (DAF-2 DA), a fluorescent indicator of NO, to detect NO in living schistosomes. In adult worms, DAF-2 fluorescence is found selectively in epithelial-like cells. Fluorescence increases when worms are incubated in L-arginine, the precursor of NO synthesis, and decreases dramatically in the presence of the NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME), indicating that predicted NO release may be NOS-dependent, and that enzymatic NO signaling pathways may play an important role in schistosome physiology.This work was supported by NIH grant NS 39103 and NSF grants 0304569 (LLM), and NIH grant AI 40522 and the Neal Cornell Research Fund at the Marine Biological Laboratory (RMG)