Chromatographic separation and identification of some peptides in partial hydroylsates of gelatin

Recently we have been engaged in a study of the chemical structure of collagen and gelatin with the object of determining the sequence of the amino acid residues in the polypeptide chains of these proteins. In the course of this study we have made considerable progress in the chromatographic analysis of complex mixtures of peptides and we have isolated and identified several simple peptides which occur in partial hydrolysates of gelatin. The initial separation of the mixture into zones of one or more peptides has been made on a column of ion exchange resin; further separation of the peptides in each zone has been achieved by chromatographing in the form of dinitrophenyl (DNP) peptides on columns of silicic acid-Celite. It is to be hoped that the particular combination of chromatographic methods which has been successfully used in the present study will be helpful in the resolution of the complex mixtures which result from the partial hydrolysis of other proteins

Supervising the Beginning Teacher (1959)

Presents an experimental training program initiated at Bank Street in 1955. Although Bank Street had been preparing college graduates for teaching in an intensive one-year program, faculty questioned whether they could put more teachers into elementary classrooms sooner, for they felt the societal pressures of a growing teacher shortage and questioning of the need for teacher education at all. What follows is a description of the experimental training program in which novice students without teaching experience enter Bank Street in the fall semester, and emerge in the spring carrying full teaching responsibility. The key component? Advisement.https://educate.bankstreet.edu/thinkers/1004/thumbnail.jp

Postnatal development of the mucosal immune system and consequences on health in adulthood

The intestinal microbiota is a dynamic multifaceted ecosystem which has evolved a complex and mutually beneficial relationship with the mammalian host. The contribution to host fitness is evident, but in recent years it has become apparent that these commensal microorganisms may exert far more influence over health and disease than previously thought. The gut microbiota are implicated in many aspects of biological function, such as metabolism, angiogenesis and immune development: disruption, especially during the neonatal period, which may impose life-long penalty. Elimination of the microbiota appears difficult, but manipulation of the ratios and dominance of composite populations can be achieved by alterations in diet, rearing environment, antibiotics and/or probiotics. Components of the intestinal microbiota are frequently documented to affect normal function of the mucosal immune system in experimental animals and in domesticated, agricultural species. However, it is not always clear that the effects described are sufficiently well understood to provide a sound basis for commercial intervention. Some microbial interventions may be beneficial to the host under particular circumstances, while detrimental during others. It is essential that we further our understanding of the complex and intricate host-commensal relationship to avoid causing more long-term damage than advantag

Sexual Exploitation in the Digital Age: Non-Consensual Pornography and What Washington Can Do to Stop It

https://digitalcommons.law.uw.edu/techclinic/1001/thumbnail.jp

Teachers' and children's personal epistemologies for moral education: Case studies in early years elementary education

While there is strong interest in teaching values in Australia and internationally there is little focus on young children’s moral values learning in the classroom. Research shows that personal epistemology influences teaching and learning in a range of education contexts, including moral education. This study examines relationships between personal epistemologies (children’s and teachers’), pedagogies, and school contexts for moral learning in two early years classrooms. Interviews with teachers and children and analysis of school policy revealed clear patterns of personal epistemologies and pedagogies within each school. A whole school approach to understanding personal epistemologies and practice for moral values learning is suggested

Circular 64

Treatment of Alaska-produced food products by ionizing radiation may benefit the seafood and agricultural industries and the Alaskan consumer. A feasibility study to evaluate the potential social and economic benefits and risks as well as the costs of using the process in Alaska on Alaskan products is being coordinated by the Institute of Northern Engineering. A research and development project to determine effects on the quality o f Alaskan products could be the next phase in the introduction o f a new food-preservation technique to Alaska

Cryptocurrencies: An Introduction for Policy Makers

Cryptocurrencies are open-source, peer-to-peer digital currencies. Two of their most distinctive features include the use of public key cryptography to secure transactions and create additional currency units, as well as the decentralized nature of their digital payment systems. The underlying technical system which all cryptocurrencies are modelled after is that of the original cryptocurrency, Bitcoin. Bitcoin was created by “Satoshi Nakamoto” a person or group credited with writing the first paper on the digital currency in 2008. Certain key elements differentiate cryptocurrencies from traditional electronic currency systems such as electronic banking and PayPal, most notably their decentralized control mechanisms. That is, traditional methods involve a single entity recording, verifying, and ensuring transactions. With many cryptocurrencies, including Bitcoin, past transactions are recorded on a public ledger and verification of transactions is outsourced to users. Bitcoin and other cryptocurrencies provide users many benefits, including ease of digital transactions, lower transaction costs, and enhanced privacy. However, these benefits come with concerns regarding consumer protection and fraud deterrence. Three pressure points persist: the irretrievability problem (the inability to call back a bitcoin once it has been transferred), bitcoin mining malware, and exchange services. Also problematic is the lack of uniformity from state-to-state regarding cryptocurrencies’ (predominately Bitcoin’s) categorization as either currency or property. Defining cryptocurrencies as currency facilitates its use as a method of exchange, while categorizing it as property may be easier for tax collection purposes. Bitcoin’s encrypted nature problematizes the digital currency as abandoned property. Traditionally, abandoned property reverts to the state after a statutorily set period of time. In instances of cash, gold, etc. this is fairly easy – ownership of the valuable goods transfers to the state after the statutory period. Generally, banks and financial institutions are required by state laws to retain a customer’s property for a period of time, usually five years, before the property will escheat to the state. However, Bitcoin creates circumstances in which the value of the abandoned property is permanently lost rather than transferred to the state. Finally, a fear concerning Bitcoin and other digital currencies is the potential for use in criminal activity. The pseudonymous nature of the transactions, the ease with which funds can be transferred across geographical distances, and the inherent risk in the currency have fueled hesitation and fear. This paper defines cryptocurrencies, Bitcoin, and explains the processes and vulnerabilities facing Bitcoin user, as well as the currency’s potential as a tool for criminal activity. Additionally, each section concludes with policy suggestions to help inform legislators and general audiences on the nature and Bitcoin, as well as provide insights into the digital currency’s’ general usage. Note: This paper was prepared for general education purposes by students in the University of Washington School of Law\u27s Technology Law and Public Policy Clinic, under the guidance of Professor William Covingtonhttps://digitalcommons.law.uw.edu/techclinic/1006/thumbnail.jp

Likelihood of ‘falling through the net’ relates to contemporary prevalence of gestational diabetes. Reply to Ikomi A, Mannan S, Anthony R, Kiss S

This project was not supported by any specific funding. Claire Meek receives salary funding from the European Union Seventh Framework Programme (FP7/2007-2013; grant agreement n° 266408) and from the Wellcome Trust Translational Medicine and Therapeutics Programme which is funded by the Wellcome Trust in association with Glaxo SmithKline.This is the author accepted manuscript. The final version is available from Springer via http://dx.doi.org/10.1007/s00125-015-3737-

Oral surgery referrals at a UK dental hospital in the context of a managed vlinical network: a mixed-methods study

Background and aims: To inform the first Welsh OS Managed Clinical Network (MCN), a mixed-methods study investigated existing patterns, quality, suitability and reasons for referral to secondary care at the University Dental Hospital in Wales. Materials and methods: A random sample of 298 OS referrals were studied over a six-month period. Data recording proforma included details on referral practitioner, patient and referral diagnosis. Referrals were categorised by Levels of complexity (Levels 1, 2 and 3) and face-to-face, semi-structured and audio-recorded interviews were conducted with five frequent referrers. Results: The age range of patients was between 1 and 92 years, with over 58% (n=174) female. Majority of referrals (80%) were from GDPs. Top six practices accounted for a fifth (21%) of referrals, with three of these practices were corporate dental chains. Approximately, a third of referrals were categorised as Level 1 (37%), Level 2 (33%) and Level 3 (30%) complexity. 16% provided no medical history, and only 13% included supporting radiographs. Five themes emerged as reasons for oral surgery referrals: contract limitations, perception that new graduates lack OS practical skills, communication, practice resources and risk. Conclusions: Priorities for the Wales OS MCN are to reduce inappropriate referrals to secondary care and to ensure quality referrals. Introduction of the pan-Wales electronic Referral Management System in May 2019 is welcome in this context. The newly formed Health Education and Improvement Wales, with lead roles in education, training and shaping the healthcare workforce, will form a vital part in tackling barriers for safe OS in primary care