30,673 research outputs found
The part-through surface crack in an elastic plate
Tensile stretching and bending of elastic plate containing surface crac
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Chromosome positioning is largely unaffected in lymphoblastoid cell lines containing emerin or A-type lamin mutations
Gene-poor human chromosomes are reproducibly found at the nuclear periphery in proliferating cells.
There are a number of inner nuclear envelope proteins that may have roles in chromosome location and
anchorage, e.g. emerin and A-type lamins. In the last decade, a number of diseases associated with tissue
degeneration and premature aging have been linked with mutations in lamin A or emerin. These are
termed laminopathies, withmutations in emerin causing Emery–Dreifuss muscular dystrophy. Despite highly
aberrant nuclear distributions of A-type lamins and emerin in lymphoblastoid cell lines derived from patients
with emerin or lamin A mutations, little or no change in chromosome location was detected
Hepatocellular Carcinoma and Associated Clinical Features in Latino and Caucasian Patients from a Single Center.
INTRODUCTION AND AIM:Hepatocellular carcinoma (HCC) is the most common type of liver cancer in adults and has seen a rapid increase in incidence in the United States. Racial and ethnic differences in HCC incidence have been observed, with Latinos showing the greatest increase over the past four decades, highlighting a concerning health disparity. The goal of the present study was to compare the clinical features at the time of diagnosis of HCC in Latino and Caucasian patients. MATERIAL AND METHODS:We retrospectively screened a total of 556 charts of Latino and Caucasian patients with HCC. RESULTS:The mean age of HCC diagnosis was not significantly different between Latinos and Caucasians, but Latinos presented with higher body mass index (BMI). Rates of hypertension, diabetes, and hyperlipidemia were similar in the two groups. The most common etiology of liver disease was alcohol drinking in Latinos, and chronic hepatitis C in Caucasian patients. Non-Alcoholic Steatohepatitis (NASH) was the associated diagnosis in 8.6% of Latinos and 4.7% of Caucasians. Interestingly, alpha-fetoprotein (AFP) levels at time of diagnosis were higher in Latino patients compared to Caucasians, but this difference was evident only in male patients. Multifocal HCC was slightly more frequent in Latinos, but the two groups had similar cancerous vascular invasion. Latino patients also presented with higher rates of both ascites and hepatic encephalopathy. CONCLUSION:Latino and Caucasian patients with HCC present with a different profile of etiologies, but cancer features appear to be more severe in Latinos
Subharmonic gap structure in short ballistic graphene junctions
We present a theoretical analysis of the current-voltage characteristics of a
ballistic superconductor-normal-superconductor (SNS) junction, in which a strip
of graphene is coupled to two superconducting electrodes. We focus in the
short-junction regime, where the length of the strip is much smaller than
superconducting coherence length. We show that the differential conductance
exhibits a very rich subharmonic gap structure which can be modulated by means
of a gate voltage. On approaching the Dirac point the conductance normalized by
the normal-state conductance is identical to that of a short diffusive SNS
junction.Comment: revtex4, 4 pages, 4 figure
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Controlled Local Properties in the Same Part with Sintaflex A New Elastomer Powder Material for the SLS Process
A new powder material for the SLS (Selective Laser Sintering) process was recently released.
The material is a result of fruitful research programs involving industry and university. The
well known and widely used DuraFomâ„¢ (PA12) and theCastFormâ„¢ (PS) SLS-materials were
developed by the same team.
In the search for new powder materials many properties of the candidate polymer, e.g. the
pulverization, the laser absorption and sintering parameters have to be tuned carefully. Previous
Elastomer options materials were poor in strength, detailing, and long-term use. The new
product overcomes most of the known deficits. It open completely new practices in many
branches like: automotive, house appliances, office equipment, foot ware, medical, and many
more. The Sintaflex has a Shore hardness variability 45-75 A and Elongation up to around
300%. The attainable yield strength range is 1.3 - 4.2 MPa. The resolution on the SLS part is up
to 0.6 mm. It is positioned in good agreement compared with other commonly used injection
plastics.
Furthermore, the appeal of all SFF process beside geometry and complexity is thought in
varying locally the mechanical properties. Some published patents make suggestions in this
direction. The new material, due to the particular properties range in function of the sintering
parameter, allows first time to realize this wish. The generated part has controlled variable local
properties; a new and unique opportunity opens for the SLS process.
The paper describes the basic material properties. Further the main sintering parameters are
describes and indications on machine settings are given. RP (Rapid Prototyping) applications
and the recent practical experience are illustrated. Distinctive examples of local variable
properties in the same part and given limits are shown. Some conclusions are stated.Mechanical Engineerin
A computational scheme to evaluate Hamaker constants of molecules with practical size and anisotropy
We propose a computational scheme to evaluate Hamaker constants, , of
molecules with practical sizes and anisotropies. Upon the increasing
feasibility of diffusion Monte Carlo (DMC) methods to evaluate binding curves
for such molecules to extract the constants, we discussed how to treat the
averaging over anisotropy and how to correct the bias due to the
non-additivity. We have developed a computational procedure for dealing with
the anisotropy and reducing statistical errors and biases in DMC valuations,
based on possible validations on predicted . We applied the scheme to
cyclohexasilane molecule, SiH, used in 'printed electronics'
fabrications, getting [zJ], being in plausible range
supported even by other possible extrapolations. The scheme provided here would
open a way to use handy {\it ab initio} evaluations to predict wettabilities as
in the form of materials informatics over broader molecules.Comment: The manuscript was revised according to review comment
Analysis of the feasibility of an experiment to measure carbon monoxide in the atmosphere
The feasibility of measuring atmospheric carbon monoxide from a remote platform using the correlation interferometry technique was considered. It has been determined that CO data can be obtained with an accuracy of 10 percent using this technique on the first overtone band of CO at 2.3 mu. That band has been found to be much more suitable than the stronger fundamental band at 4.6 mu. Calculations for both wavelengths are presented which illustrate the effects of atmospheric temperature profiles, inversion layers, ground temperature and emissivity, CO profile, reflectivity, and atmospheric pressure. The applicable radiative transfer theory on which these calculations are based is described together with the principles of the technique
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